Different HIV-1 env frames: gp120 and ASP (antisense protein) biosynthesis, and theirs co-variation tropic amino acid signatures in X4- and R5-viruses.

Abstract:

:Antisense protein (ASP) is the new actor of viral life of Human Immunodeficiency Virus type 1 (HIV-1) although proposed above 20 years ago. The asp ORF is into complementary strand of the gp120/gp41 junction of env gene. The ASP biological role remains little known. Knowing the Env markers of viral tropism, a dataset of sequences (660 strains) was used to analyze the hypothetical ASP involvement in CCR5 (R5) and/or CXCR4 (X4) co-receptor interaction. Preliminarily, prevalence of ASP and gp120V3 mutations was performed; following association among mutations were elaborate. The classical V3 tropic-signatures were confirmed, and 36 R5- and 22 X4-tropic ASP mutations were found. Moreover, by analyzing the ASP sequences, 36 out of 179 amino acid positions significantly associated with different co-receptor usage were found. Several statistically significant associations between gp120V3 and ASP mutations were observed. The dendrogram showed the existence of a cluster associated with R5-usage and a large cluster associated with X4-usage. These results show that gp120V3 and specific amino acid changes in ASP are associated together with CXCR4 and/or CCR5-usage. These findings implement previous observations on unclear ASP functions. J. Med. Virol. 89:112-122, 2017. © 2016 Wiley Periodicals, Inc.

journal_name

J Med Virol

authors

Dimonte S

doi

10.1002/jmv.24611

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

112-122

issue

1

eissn

0146-6615

issn

1096-9071

journal_volume

89

pub_type

杂志文章
  • Genotyping of acute hepatitis a virus isolates from China, 2003-2008.

    abstract::Hepatitis A virus (HAV) is usually transmitted by an oral-fecal route and is prevalent not only in developing countries but also in developed countries. In the present study, the phylogenetic characterization of the VP1/2A junction region (321 nucleotides) of China HAV isolates was examined. Anti-HAV IgM-positive seru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22086

    authors: Cao J,Bi S,Meng Q,Shen L,Zheng H,Zhang Y

    更新日期:2011-07-01 00:00:00

  • Hepatitis C virus genotype 4d in Southern Italy: reconstruction of its origin and spread by a phylodynamic analysis.

    abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23384

    authors: Ciccozzi M,Equestre M,Costantino A,Marascio N,Quirino A,Lo Presti A,Cella E,Bruni R,Liberto MC,Focà A,Pisani G,Zehender G,Ciccaglione AR

    更新日期:2012-10-01 00:00:00

  • Accentuated antibody response to paramyxoviruses in individuals infected with human immunodeficiency virus.

    abstract::Sera from 31 human immunodeficiency virus (HIV)-infected patients, representing different clinical stages of HIV infection, were assayed for antibodies against measles and mumps viruses by various serological tests and compared to 23 healthy controls. Sera from four patients (two primary, one asymptomatic, and one acq...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890260107

    authors: Kövamees J,Sheshberadaran H,Chiodi F,Schwartz S,Orvell C,Fenyö EM,Norrby E

    更新日期:1988-09-01 00:00:00

  • Genetic variability of respiratory syncytial virus A in hospitalized children in the last five consecutive winter seasons in Central Spain.

    abstract::Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestati...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24703

    authors: Calderón A,Pozo F,Calvo C,García-García M,González-Esguevillas M,Molinero M,Casas I

    更新日期:2017-05-01 00:00:00

  • Relative frequency of human rotavirus VP4 (P) genotypes recovered over a ten-year period from South African children with diarrhea.

    abstract::The relative frequency and distribution of the VP4 (P) genotypes of 227 human rotavirus field strains were investigated in South Africa. The stool samples were collected between 1984-1993 from infants and young children with diarrhea at Ga-Rankuwa Hospital, Pretoria, South Africa. The RNA was extracted from stools, he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470102

    authors: Mphahlele MJ,Steele AD

    更新日期:1995-09-01 00:00:00

  • Hepatitis C virus antibodies among risk groups in a South African area endemic for hepatitis B virus.

    abstract::The prevalence of anti-HCV was studied in a South African area endemic for hepatitis B virus. A total of 35,685 volunteer blood donors (22,034 whites, 9,218 Asians, 3,077 Africans, 1,356 coloureds), 71 haemophiliacs, 84 chronic dialysis patients, 100 antenatal attenders, 212 nurses, and 20 HIV-positive male homosexual...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400113

    authors: Soni PN,Tait DR,Kenoyer DG,Fernandes-Costa F,Naicker S,Gopaul W,Simjee AE

    更新日期:1993-05-01 00:00:00

  • The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway.

    abstract::The infection of enterovirus 71 (EV71) resulted in hand, foot, and mouth disease and may lead to severe nervous system damage and even fatalities. There are no effective drugs to treat the EV71 virus and it is crucial to find novel drugs against it. Polysaccharide isolated from Durvillaea antarctica green algae has an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26693

    authors: Xu T,Li Y,Wu HL,Chen H,Wu H,Guo M,Zhao M,Wang C,Lin T,Lin Z,Chen D,Xiang W,Zhu B

    更新日期:2020-11-24 00:00:00

  • Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients.

    abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890080406

    authors: Ukkonen P,Granström ML,Räsänen J,Salonen EM,Penttinen K

    更新日期:1981-01-01 00:00:00

  • Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear cells.

    abstract::Human T-lymphotropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia and is characterized by long periods of clinical latency with low levels of viral production. Transcription of HTLV-1 is controlled through sequences in the promoter and enhancer regions of the long terminal repeat of the integrated prov...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Newbound GC,O'Rourke JP,Collins ND,Andrews JM,DeWille J,Lairmore MD

    更新日期:2000-10-01 00:00:00

  • Prevalence and types of drug-resistant variants in Chinese patients with acute hepatitis B.

    abstract::The presence of therapy-associated hepatitis B virus (HBV) variants is the main drawback of antiviral therapy for HBV infection. Moreover, drug-resistant variants are more insensitive to a second agent and more therapy-associated mutations will be present. To apply better nucleos(t)ide analogues (NA) and reduce the oc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24006

    authors: Su F,Dai J,Yang S,Jiang X,Cui X,Ning H,Li J,Huang M

    更新日期:2015-09-01 00:00:00

  • Use of N-acetylethyleneimine [AEI] for the inactivation of Semliki Forest virus in vitro.

    abstract::N-Acetylethyleneimine (AEI) was used to inactivate the avirulent Togavirus Semliki Forest virus (A774 strain) grown in chick embryo, Vero, and brain cell cultures. The purity of the virus preparation affected the kinetics of inactivation. The rate of inactivation increased with a rise in temperature from 5 to 40 degre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890190409

    authors: Amor S,Webb HE

    更新日期:1986-08-01 00:00:00

  • Genomic analysis of the Chinese genotype 1F rubella virus that disappeared after 2002 in China.

    abstract::Genotype 1F was likely localized geographically to China as it has not been reported elsewhere. In this study, whole genome sequences of two rubella 1F virus isolates were completed. Both viruses contained 9,761 nt with a single nucleotide deletion in the intergenic region, compared to the NCBI rubella reference seque...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23936

    authors: Zhu Z,Chen MH,Abernathy E,Zhou S,Wang C,Icenogle J,Xu W

    更新日期:2014-12-01 00:00:00

  • HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro.

    abstract::Lentiviral vectors are prime candidate vectors for gene transfer into dividing and non-dividing cells, including neuronal cells and stem cells. For safety, HIV-2 lentiviral vectors may be better suited for gene transfer in humans than HIV-1 lentiviral vectors. HIV-2 vectors cross-packaged in HIV-1 cores may be even sa...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10467

    authors: D'Costa J,Harvey-White J,Qasba P,Limaye A,Kaneski CR,Davis-Warren A,Brady RO,Bankiewicz KS,Major EO,Arya SK

    更新日期:2003-10-01 00:00:00

  • Molecular analysis of HPV 16 E6I/E6II spliced mRNAs and correlation with the viral physical state and the grade of the cervical lesion.

    abstract::The presence of HPV 16 E6*I/E6*II spliced transcripts, in cervical lesions of different grade, was analyzed to characterize the transcription pattern. The presence and amount of spliced transcripts were correlated with DNA viral markers such as E2/E6 ratio and physical state. The detection of HPV 16 E6*I/E6*II mRNAs w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21496

    authors: Cricca M,Venturoli S,Leo E,Costa S,Musiani M,Zerbini M

    更新日期:2009-07-01 00:00:00

  • Enterovirus infection in children attending two outpatient clinics in Zhejiang Province, China.

    abstract::Enteroviruses are responsible for hand, foot, and mouth disease, and have caused many deaths in China during recent years. But the natural history of enterovirus infection in children, especially asymptomatic children, is not yet clear. From April 2011 to May 2012, 505 stool and throat swab samples of children attendi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23884

    authors: Cai J,Lv H,Lin J,Chen Z,Fang C,Han J

    更新日期:2014-09-01 00:00:00

  • Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71.

    abstract::Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case-control study aimed to assess the association of single-nucleotid...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25349

    authors: Li YP,Deng HL,Xu LH,Wang MQ,Li M,Zhang X,Dang SS

    更新日期:2019-04-01 00:00:00

  • Transmission of hepatitis C virus in an orthopedic hospital ward.

    abstract::Healthcare-associated infections with hepatitis C virus (HCV) hitherto have been observed mainly in hemodialysis settings as well as in hematology and oncology wards. In this communication, molecular and epidemiologic investigations to elucidate an HCV outbreak in an orthopedic ward are reported. One hundred and thirt...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21394

    authors: Ross RS,Viazov S,Khudyakov YE,Xia GL,Lin Y,Holzmann H,Sebesta C,Roggendorf M,Janata O

    更新日期:2009-02-01 00:00:00

  • Hepatitis C infection, Cognition, and inflammation in an Egyptian sample.

    abstract::Chronic hepatitis C (HCV) infection is associated with cognitive impairments which might be mediated through a secondary inflammatory cascade. Egypt has an unusually high prevalence of HCV monoinfections and is an ideal site for the study of the isolated effects of HCV infection. Therefore, in a hospital-based cross-s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21879

    authors: Farag NH,Rashed HA,Hassan M,Darweesh A,Shehata M,Hassanein T,Mills PJ

    更新日期:2011-02-01 00:00:00

  • Fraction-specific populations of the hypervariable region of the hepatitis C virus in a patient with cryoglobulinemia.

    abstract::Nucleotide sequences of the hypervariable region (HVR) of the E2/NS1 gene of hepatitis C virus (HCV), which are now thought to contain epitopes for neutralizing antibodies, were compared between antibody-bound HCV and free HCV in a patient with type II cryoglobulinemia. Antibody-bound HCV was immunoprecipitated with a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460418

    authors: Kurosaki M,Enomoto N,Nouchi T,Sakuma I,Marumo F,Sato C

    更新日期:1995-08-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470418

    authors: Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期:1995-12-01 00:00:00

  • Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo.

    abstract::Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890320404

    authors: Niu JZ,Wang YY,Qiao M,Gowans E,Edwards P,Thyagarajan SP,Gust I,Locarnini S

    更新日期:1990-12-01 00:00:00

  • Typing of human papillomaviruses in condylomata acuminata from Greece.

    abstract::DNA samples from recurrent condylomata acuminata biopsies of Greek males and females were examined for the presence of human papillomavirus (HPV) DNA using high-stringency Southern blot hybridization analysis. Of the twenty-six biopsies, 25 were positive for the HPV 6/11-related DNA sequences, and when further analyze...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420311

    authors: Labropoulou V,Balamotis A,Tosca A,Rotola A,Mavromara-Nazos P

    更新日期:1994-03-01 00:00:00

  • Prevalence of genital, oral, and anal HPV infection among STI patients in Italy.

    abstract::Human papillomavirus (HPV) is a carcinogenic agent responsible for tumor development in many sexually involved tissues. We present a survey on the prevalence of HPV infection in a risk population for sexually transmitted infections (STIs). The studied population was formed by 125 STI clinic attendees, who took part in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24746

    authors: Ciccarese G,Herzum A,Rebora A,Drago F

    更新日期:2017-06-01 00:00:00

  • Efficacy of PCR and other diagnostic methods for the detection of respiratory adenoviral infections.

    abstract::Five methods were evaluated for the detection of adenovirus directly from nasopharyngeal aspirates (NPA), including conventional and rapid virus culture, two antigen detection tests, and the polymerase chain reaction (PCR). NPA specimens were obtained from 269 military conscripts suffering from an acute respiratory in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Räty R,Kleemola M,Melén K,Stenvik M,Julkunen I

    更新日期:1999-09-01 00:00:00

  • HPV types and variants among cervical cancer tumors in three regions of Tunisia.

    abstract::Cervical cancer is the second most common cancer among Tunisian women, and the incidence rates vary by region. Three Tunisian registries report age-standardized rates of 6.3/10(5) in the central region, 5.4/10(5) in the north, and 2.7/10(5) in the south. High-risk human papillomavirus (HPV) types and their variants di...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22011

    authors: KrennHrubec K,Mrad K,Sriha B,Ben Ayed F,Bottalico DM,Ostolaza J,Smith B,Tchaikovska T,Soliman AS,Burk RD

    更新日期:2011-04-01 00:00:00

  • Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period.

    abstract::In eight patients with biopsy-confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA-P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA-P activity fluctuated. No correlation was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>

    authors: Heijtink RA,van der Waart M,Weimar W,Schalm SW,Masurel N

    更新日期:1980-01-01 00:00:00

  • Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV.

    abstract::The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24169

    authors: Azadmanesh K,Mohraz M,Kazemimanesh M,Aghakhani A,Foroughi M,Banifazl M,Eslamifar A,Ramezani A

    更新日期:2015-07-01 00:00:00

  • Isolation of rhinoviruses and coronaviruses from 38 colds in adults.

    abstract::Nasal washings were collected from 27 normal adults during 38 naturally acquired colds. The washings were exhaustively tested using tissue cultures, organ cultures and electron microscopy. Washings yielding no identifiable agent were inoculated into human volunteers, and further specimens obtained from the latter were...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890050306

    authors: Larson HE,Reed SE,Tyrrell DA

    更新日期:1980-01-01 00:00:00

  • Synthesis of human rotavirus polypeptides in cell culture.

    abstract::The replication strategy of a human serotype 1 rotavirus, adapted to rapid growth in CV-1 cells, was investigated. A single cycle growth curve revealed eclipse and latent periods of 3 and 4 hours, respectively. Although the extent of reduction of host cell protein synthesis was directly related to the multiplicity of ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890250113

    authors: Heath RL,Birch CJ

    更新日期:1988-05-01 00:00:00

  • Profile of pre-S deletions in the natural history of chronic hepatitis B infection.

    abstract::It have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21901

    authors: Yeung P,Wong DK,Lai CL,Fung J,Seto WK,Yuen MF

    更新日期:2010-11-01 00:00:00