Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo.

Abstract:

:Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal-treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.

journal_name

J Med Virol

authors

Niu JZ,Wang YY,Qiao M,Gowans E,Edwards P,Thyagarajan SP,Gust I,Locarnini S

doi

10.1002/jmv.1890320404

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

212-8

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

32

pub_type

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