Abstract:
:To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic change of a sparse or mild degree and which differed from that seen in rodents infected with Creutzfeldt-Jakob disease, the presence of unconventional pathogens in the tested inocula can be ruled out.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Tateishi J,Tsuji Sdoi
10.1002/jmv.1890160103subject
Has Abstractpub_date
1985-05-01 00:00:00pages
11-5issue
1eissn
0146-6615issn
1096-9071journal_volume
16pub_type
杂志文章abstract::Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance. Over 700 physicians from 75% of basic administrative units of Taiwan participated in the "Sentinel Physician Surveillance of Infectious Disease" and reported weekly to the Center ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21006
更新日期:2007-12-01 00:00:00
abstract::The molecular epidemiology of hepatitis A virus (HAV) strains circulating in the St. Petersburg and Karelia regions was studied during 1997-2003. Hepatitis A virus RNA was isolated from both clinical samples (stools or sera) and environmental samples (sewage water). RT-PCR was carried out using different primer pairs ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20843
更新日期:2007-06-01 00:00:00
abstract::Recently, it was demonstrated that the Varicella-zoster virus (VZV) infection led to an activation of MAP kinases. The viral protein encoded by ORF61 is a major effector of JNK/SAPK and p38/MAPK phosphorylation. ORF61 shows homology to HSV-1 ICP0, a multifunctional protein that influences the activity of c-Jun in infe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20373
更新日期:2005-07-01 00:00:00
abstract::Hepatitis E is endemic in India. It was recently noted that although all the Indian human hepatitis E virus (HEV) isolates (1976-2001) were placed in genotype I, the swine HEV recovered from western India (2000) belonged to genotype IV. This was in contrast to reports from the United States and Taiwan wherein both hum...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10301
更新日期:2003-03-01 00:00:00
abstract::Lamivudine therapy often causes breakthrough of hepatitis B virus (HBV) DNA and breakthrough hepatitis. The aim of this study was to determine the viral factors that relate to HBV-DNA breakthrough with and without breakthrough hepatitis. Among 82 patients with chronic hepatitis B (CHB) who received lamivudine at a dos...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20915
更新日期:2007-07-01 00:00:00
abstract::Recently, several clusters of hepatitis A have been observed among hemophiliacs linked to factor VIII concentrates treated for virus inactivation solely with the solvent/detergent (S/D) method, a procedure that does not affect nonenveloped viruses such as the hepatitis A virus (HAV). A new outbreak of hepatitis A in s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199902)57:2<91::aid-jmv1>3
更新日期:1999-02-01 00:00:00
abstract::We studied the role of sexual transmission in the epidemiology of HCV by a cross-sectional study comparing prostitutes and HCV seropositive and seronegative sexual clients recruited from the bordellos of the docks of Santos, São Paulo State. The average age in the prostitute group was 27.2 years. The median time spent...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::HIV-1 replicative activity and its relation to the clinical and immunological evolution of infection was studied in a group of 150 HIV-1 seropositive Italian i.v. drug abusers over a 1 year period. HIV-1 was isolated from 90 (60%) subjects; two groups of isolates were distinguished, according to replicative activity "...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890320411
更新日期:1990-12-01 00:00:00
abstract::Phylogenetic analysis was performed on hepatitis B virus (HBV) strains obtained from 86 hepatitis B surface antigen (HBsAg) positive donors from Thailand originating throughout the country. Based on the S gene, 87.5% of strains were of genotype C while 10.5% were of genotype B, with all genotype B strains obtained fro...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23363
更新日期:2012-10-01 00:00:00
abstract::Transmission of rotavirus infection was studied in a birth cohort of children based in an urban slum in Vellore and their familial contacts. Contemporaneous samples from index patients and their familial contacts were collected for analysis in three different settings. Firstly, samples were collected from familial con...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21263
更新日期:2008-10-01 00:00:00
abstract::Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatia...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25395
更新日期:2019-06-01 00:00:00
abstract::Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBV-DNA after a self-limited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBV-DNA was tested by polymerase chain reaction (P...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20073
更新日期:2004-06-01 00:00:00
abstract::Mouse mammary tumor virus (MMTV) is a hormonally regulated, oncogenic virus of mice. MMTV-like virus DNA has previously been detected in human breast cancers, liver disease, and liver cancers. It is hypothesized that local hormonal effects might be of primary importance in determining MMTV-like virus detection in huma...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21754
更新日期:2010-05-01 00:00:00
abstract::Many of the small round human fecal viruses implicated in outbreaks of nonbacterial gastroenteritis have been collected together and examined under the electron microscope. Negatively stained preparations without the addition of antibody were used so that the surface morphology of the virus particles remained clearly ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890090403
更新日期:1982-01-01 00:00:00
abstract::The various strains of human polyomavirus BK (BKV) show a marked heterogeneity in the non-coding control region (NCCR), which includes the origin of replication and the regulatory region for early and late transcription. A new BKV strain (DDP, U91605) was identified by direct detection and sequencing of PCR products o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199908)58:4<413::aid-jmv15
更新日期:1999-08-01 00:00:00
abstract::Coinfections with multiple types of human papillomavirus (HPV) occur in cervical adenocarcinoma (ADC). However, it remains unclear the clustering patterns of multiple types in HPV coinfections and relevant factors in ADC. A total of 718 paraffin-embedded ADC specimens were collected in China and tested for HPV genotyp...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25553
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25454
更新日期:2019-07-01 00:00:00
abstract::The infection of enterovirus 71 (EV71) resulted in hand, foot, and mouth disease and may lead to severe nervous system damage and even fatalities. There are no effective drugs to treat the EV71 virus and it is crucial to find novel drugs against it. Polysaccharide isolated from Durvillaea antarctica green algae has an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26693
更新日期:2020-11-24 00:00:00
abstract::Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, broke out in Wuhan, China, and is spreading throughout the world. A new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group of the International...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25762
更新日期:2020-06-01 00:00:00
abstract::Human peripheral blood mononuclear cell (PBMC) proliferative responses to live respiratory syncytial (RS) virus, formalin-inactivated RS (Fl-RS) virus, RS virus F (fusion) protein, and RS virus G (attachment) protein were assessed. All donors responded to challenge with whole RS virus antigens and F and G proteins. F ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199607)49:3<161::AID-JMV2>
更新日期:1996-07-01 00:00:00
abstract::A sensitive and specific nonradioactive in situ hybridization method capable of detecting single-copy integrated hepatitis B virus (HBV) DNA sequences in hepatocellular carcinoma (HCC) cell lines was developed. In situ hybridization of biotinylated HBV (adr, adw) DNA probes with nine different human HCC cell lines wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890300407
更新日期:1990-04-01 00:00:00
abstract::The occurrence of viral coinfections in childhood pneumonia has received little attention, probably because suitable detection methods have been lacking. Between November 2004 and October 2006, the presence of 14 respiratory viruses in children aged less than 3 years old with community-acquired pneumonia were investig...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21271
更新日期:2008-10-01 00:00:00
abstract::Nineteen Chinese patients with chronic hepatitis B virus (HBV) infection, seropositive for HBV e antigen (HBeAg) and HBV DNA on at least three occasions in 6 months, were randomised to receive either recombinant human interferon-gamma (rIFN gamma) 0.1 mg/m2 intramuscularly thrice weekly for 16 weeks (n = 11) or no ant...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jmv.1890340310
更新日期:1991-07-01 00:00:00
abstract::Most dengue virus (DENV) infections remain asymptomatic. This increases the risk of DENV transfusion transmission (TT-DENV) during outbreaks. We evaluated DENV viremia in 8475 blood donations assembled in minipools for the presence of DENV RNA. The tested samples were obtained between February and May, 2016, during a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26619
更新日期:2020-10-22 00:00:00
abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23436
更新日期:2013-01-01 00:00:00
abstract::Guinea pig infection with a highly passaged XJ prototype strain of Junín virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junín antigens as shown by im...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890150208
更新日期:1985-02-01 00:00:00
abstract::Eastern equine encephalitis (EEE) is rare, but the most severe of the mosquito-borne encephalitides in the United States with a high case fatality rate of 30%. Here, we present a patient with EEE. EEE virus causes sporadic human disease in the Eastern parts of the United States, but the case we describe was a Scottish...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21379
更新日期:2009-02-01 00:00:00
abstract::Intradermal inoculation of hepatitis B vaccine (HBsAg subtype adw) caused no side effects, but the vaccine was less immunogenic than following intramuscular administration. Intradermal inoculation does not, therefore, offer a major advantage to the generally used intramuscular immunization. A single multisite intrader...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890140105
更新日期:1984-01-01 00:00:00
abstract::The plaque reduction neutralization test (PRNT) has been used routinely in serological studies with such arenaviruses as Junin, Machupo, and Parana. However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test wi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890220110
更新日期:1987-05-01 00:00:00
abstract::Human metapneumovirus (hMPV) has been described as circulating among the Uruguayan population at least since 1998 based on serologic evidence. However, no isolation attempts, molecular detection, or genetic studies have been carried out so far in the country. In the present study, molecular detection of circulating hM...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21752
更新日期:2010-05-01 00:00:00