Changes in antibody titers to hepatitis C virus following interferon therapy for chronic infection.

Abstract:

:The use of quantitative assays for hepatitis C virus specific antibodies (anti-HCV) as a prognostic marker was evaluated in 31 patients with chronic hepatitis C treated with interferon (IFN). Changes in titers of serum HCV-RNA and anti-HCV antibodies; anti-C11 (anti-core), anti-C100 (anti-NS3), and anti-C7 (anti-NS3) were investigated. Recombinant IFN-alpha 2a was administered and the patients were followed for more than 1 year. The patients were classified into three groups according to their responses to IFN: 11 sustained responders with continuous normalizations of serum alanine aminotransferase (ALT) levels; 14 transient responders with transient decreases in ALT; and six nonresponders who had no changes in ALT levels. Ten of 11 sustained responders had a continuous decrease in anti-C11 titers after completion of treatment, decreasing to less than half of pretreatment titers. No patients in the other two groups had a continuous decrease in anti-C11 titers. Although sustained responders had decreases in anti-C100 and anti-C7 titers after IFN therapy, these titers also decreased in some patients in the other two groups. HCV-RNA was not detected in the sera of 10 of 11 sustained responders following IFN therapy. In contrast, while 9 of 10 transient and non-responders had a decrease or disappearance of HCV-RNA at the completion of therapy, they had increased levels thereafter. These results indicate that anti-HCV-core (anti-C11) titers most closely reflect the status of HCV replication. A quantitative assay for anti-HCV-core antibody can be used as a predictive marker of remission in IFN-treated patients with chronic hepatitis C.

journal_name

J Med Virol

authors

Urushihara A,Sodeyama T,Matsumoto A,Tanaka E

doi

10.1002/jmv.1890420405

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

348-56

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

42

pub_type

杂志文章
  • Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease.

    abstract::Hepatitis C virus (HCV) genotypes help to tailor the treatment response, but their influence on the disease severity and association with hepatic steatosis is not well understood. The prevalence of HCV genotypes and their correlation with the histopathological severity of liver disease and steatosis in Indian patients...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20561

    authors: Hissar SS,Goyal A,Kumar M,Pandey C,Suneetha PV,Sood A,Midha V,Sakhuja P,Malhotra V,Sarin SK

    更新日期:2006-04-01 00:00:00

  • Detection of HPV types and neutralizing antibodies in Gansu province, China.

    abstract::A total of 82 samples from patients with cervical cancer (Group 1) and 50 samples from patients with other genital diseases (Group 2) were collected in Gansu, China. All 132 samples were tested for HPV DNA with a typing kit that can detect 21 types of HPV, and also tested for neutralizing antibodies against HPV-16, -1...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21435

    authors: Wu X,Zhang C,Feng S,Liu C,Li Y,Yang Y,Gao J,Li H,Meng S,Li L,Zhang Y,Hu X,Wu X,Lin L,Li X,Wang Y

    更新日期:2009-04-01 00:00:00

  • Correlation of high-risk human papillomavirus genotypes persistence and risk of residual or recurrent cervical disease after surgical treatment.

    abstract::The evidence on genotype-specific risk in women infected with human papillomavirus (HPV) with normal cytology and the importance of the distinction of high-risk (HR)-HPV genotypes in the management of low-grade lesions suggest that the distinction of HR-HPV genotypes has the potential to improve the follow-up of patie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21198

    authors: Venturoli S,Ambretti S,Cricca M,Leo E,Costa S,Musiani M,Zerbini M

    更新日期:2008-08-01 00:00:00

  • Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high-risk population.

    abstract::Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22057

    authors: Ili CG,Brebi P,López J,García P,Leal P,Suarez E,Roa JC

    更新日期:2011-05-01 00:00:00

  • Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China.

    abstract::Co-infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) has been shown to be associated with a more severe form of acute and chronic hepatitis. Cloning and expression of recombinant HDV antigen (rHDAg) in Escherichiacoli are described. Using purified rHDAg, a cost-effective indirect anti-HDV enzyme-l...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23212

    authors: Shen L,Gu Y,Sun L,Yang Y,Wang F,Li Y,Bi S

    更新日期:2012-03-01 00:00:00

  • Prevalence of CMV antibodies among women of childbearing age in different social environments in southern Israel.

    abstract::The prevalence rate of IgG antibodies to cytomegalovirus (CMV) was determined in a sample of 567 women of childbearing age in the southern part of Israel by the immunoperoxidase assay to membrane antigen (IPAMA) technique. Urban Jewish women of Afro-Asian origin showed significantly higher rates of seropositivity than...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890240104

    authors: Urkin J,Sarov B,Naggan L,Haikin H,Sarov I

    更新日期:1988-01-01 00:00:00

  • Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.

    abstract::Increased expression of inducible nitric oxide synthase (iNOS) has been found in inflammatory myocardial disease and increased production of nitric oxide (NO) has both an inhibitory effect on virus replication and a cytotoxic effect on host cells. To investigate the relationship between severity of enteroviral myocard...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1033

    authors: Bevan AL,Zhang H,Li Y,Archard LC

    更新日期:2001-06-01 00:00:00

  • Growth of human immunodeficiency virus I in cultured cells in the absence of the CD4 antigen.

    abstract::The ability of a variety of epithelial, embryonal, placental, and neuronal cells to express the CD4 antigen and to be infected by human immunodeficiency virus 1 (HIV-1) was examined. Only two (IMR-32 and HeLa-T4) expressed CD4 detectable by indirect immunofluorescence, and both were infectable by HIV-1. Two others, a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890350308

    authors: Morrison NK,McCarthy K,Hart CA

    更新日期:1991-11-01 00:00:00

  • Detection of human papillomavirus in esophageal carcinoma.

    abstract::The aim of the study was to assess the prevalence of human papillomavirus (HPV) in the esophagus in the coastal region of Eastern Guangdong, Southern China, an area with a high incidence of esophageal carcinoma. Fresh surgical resection esophageal specimens were obtained from 176 esophageal carcinoma patients admitted...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10219

    authors: Shen ZY,Hu SP,Lu LC,Tang CZ,Kuang ZS,Zhong SP,Zeng Y

    更新日期:2002-11-01 00:00:00

  • Use of N-acetylethyleneimine [AEI] for the inactivation of Semliki Forest virus in vitro.

    abstract::N-Acetylethyleneimine (AEI) was used to inactivate the avirulent Togavirus Semliki Forest virus (A774 strain) grown in chick embryo, Vero, and brain cell cultures. The purity of the virus preparation affected the kinetics of inactivation. The rate of inactivation increased with a rise in temperature from 5 to 40 degre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890190409

    authors: Amor S,Webb HE

    更新日期:1986-08-01 00:00:00

  • Persistence of high-risk human papillomavirus infection in a population-based cohort of Danish women.

    abstract::Persisting human papillomavirus (HPV) infection is a critical step in cervical carcinogenesis. This study was conducted to determine the type-specific HPV persistence and risk factors for persistence of high-risk HPV infections in a large cohort of Danish women. The study was based on a population-based prospective co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21750

    authors: Nielsen A,Kjaer SK,Munk C,Osler M,Iftner T

    更新日期:2010-04-01 00:00:00

  • Humoral immune response to virions and dense bodies of human cytomegalovirus determined by enzyme immunofluorescence assay.

    abstract::An enzyme immunoassay utilizing a fluorogenic substrate (EIFA) was employed to compare humoral antibody responses to purified virion and dense body antigens in human cytomegalovirus (CMV) infections. Results of these antibody assays were also compared to those obtained by plaque reduction neutralization and complement...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890060204

    authors: Forghani B,Schmidt NJ

    更新日期:1980-01-01 00:00:00

  • Detection of serum antibody responses to RIT 4237 rotavirus vaccine by ELISA and neutralization assays.

    abstract::Immunoglobulin class-specific determination by ELISA and a virus neutralization test (NT) were compared for the detection of the serum antibody responses after vaccination of infants with the RIT 4237 rotavirus vaccine (of bovine origin). A capture method was applied for specific IgM determination by ELISA because of ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890210306

    authors: Delem A,Vesikari T

    更新日期:1987-03-01 00:00:00

  • The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases.

    abstract::Knowledge of the current epidemiology of chronic liver disease in Italy is mostly obsolete and fragmentary for the lack of up-to-date consistent data. In 2001, a 6-month prevalence study was undertaken in 79 hospitals to assess the characteristics of chronic liver disease in Italy. Both prevalent and incident cases we...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.20313

    authors: Sagnelli E,Stroffolini T,Mele A,Almasio P,Coppola N,Ferrigno L,Scolastico C,Onofrio M,Imparato M,Filippini P

    更新日期:2005-04-01 00:00:00

  • Anal HPV 16 and 18 viral load: A comparison between HIV-negative and -positive MSM and association with persistence.

    abstract::Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and -positive men who have sex with men (MSM)? MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24898

    authors: Marra E,King A,van Logchem E,van der Weele P,Mooij SH,Heijman T,Meijer CJLM,Verhagen DWM,van der Sande MAB,Schim van der Loeff MF

    更新日期:2018-01-01 00:00:00

  • Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data.

    abstract::Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance. Over 700 physicians from 75% of basic administrative units of Taiwan participated in the "Sentinel Physician Surveillance of Infectious Disease" and reported weekly to the Center ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21006

    authors: Tseng FC,Huang HC,Chi CY,Lin TL,Liu CC,Jian JW,Hsu LC,Wu HS,Yang JY,Chang YW,Wang HC,Hsu YW,Su IJ,Wang JR,CDC-Taiwan Virology Reference Laboratories and Sentinel Physician Network.

    更新日期:2007-12-01 00:00:00

  • Lack of effect of a booster dose of influenza vaccine in hemodialysis patients.

    abstract::To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20936

    authors: Tanzi E,Amendola A,Pariani E,Zappa A,Colzani D,Logias F,Perego A,Zanetti AR

    更新日期:2007-08-01 00:00:00

  • Towards developing HIV-2 lentivirus-based retroviral vectors for gene therapy: dual gene expression in the context of HIV-2 LTR and Tat.

    abstract::Because of the distinct ability of retroviruses to integrate into the target cell genome and thus achieve long-term expression, retrovirus vectors hold great promise for stable gene transfer. Such vectors derived from human immunodeficiency retroviruses (HIVs) and other lentiviruses are envisioned to possess several a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199802)54:2<118::aid-jmv9>

    authors: Sadaie MR,Zamani M,Whang S,Sistron N,Arya SK

    更新日期:1998-02-01 00:00:00

  • Pet veterinarians have no increased risk of hepatitis E compared to the general population.

    abstract::The discovery of autochthonous hepatitis E in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis E virus (HEV) circulation. In these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for HEV. More...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23927

    authors: Mesquita JR,Valente-Gomes G,Conceição-Neto N,Nascimento MS

    更新日期:2014-06-01 00:00:00

  • Comparative trial of acyclovir and vidarabine in disseminated varicella-zoster virus infections in immunocompromised patients.

    abstract::A comparative assessment of vidarabine and acyclovir in the treatment of varicella and disseminated zoster in immunosuppressed patients was undertaken. Thirty-eight immunosuppressed patients with varicella (N = 18) or disseminated zoster (N = 20) were treated intravenously with 10 mg/kg/day of vidarabine or 30 mg/kg/d...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jmv.1890200205

    authors: Vildé JL,Bricaire F,Leport C,Renaudie M,Brun-Vézinet F

    更新日期:1986-10-01 00:00:00

  • Genetic variability of hepatitis B and C viruses in Brazilian patients with and without hepatocellular carcinoma.

    abstract::Most cases of hepatocellular carcinoma (HCC) are due to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection worldwide. The aim of this study was to determine the viral genotypes and frequency of 17 mutations (15 for HBV and 2 for HCV), described previously as able to influence the course of chronic li...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23837

    authors: Araujo OC,Barros JJ,do Ó KM,Nabuco LC,Luz CA,Perez RM,Niel C,Villela-Nogueira CA,Araujo NM

    更新日期:2014-02-01 00:00:00

  • Norovirus infections and seroprevalence of genotype GII.4-specific antibodies in a Spanish population.

    abstract::Genotype II.4 noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis in children and adults worldwide. The prevalence of different NoV genotypes causing outbreaks and sporadic cases of acute gastroenteritis in the region of Valencia, Spain, during a 4-year period (2008-11) was investigated. NoVs were...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24112

    authors: Carmona-Vicente N,Fernández-Jiménez M,Ribes JM,Téllez-Castillo CJ,Khodayar-Pardo P,Rodríguez-Diaz J,Buesa J

    更新日期:2015-04-01 00:00:00

  • Mapping T-cell epitopes of rubella virus structural proteins E1, E2, and C recognized by T-cell lines and clones derived from infected and immunized populations.

    abstract::To design a safe and effective synthetic peptide vaccine against rubella virus (RV) infection, it is necessary to identify immunodominant T-cell epitopes of RV structural proteins. To define such epitopes, 49 overlapping synthetic peptides (17-34 residues in length) corresponding to more than 95% of the amino acid seq...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400302

    authors: Ou D,Chong P,Tingle AJ,Gillam S

    更新日期:1993-07-01 00:00:00

  • Frequent detection of cell-associated HIV-1 RNA in patients with plasma viral load

    abstract::Despite prolonged undetectable plasma viral load some HIV-1 infected patients have been reported to develop resistance-associated mutations leading to treatment failure. The mechanisms for this phenomenon and the point of origin for residual viral evolution are still not elucidated. In order to quantify cell-associate...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20993

    authors: Kupfer B,Matz B,Däumer MP,Roden F,Rockstroh JK,Qurishi N,Spengler U,Kaiser R

    更新日期:2007-10-01 00:00:00

  • Risk factors and clinical characteristics of patients with nosocomial influenza A infection.

    abstract::Influenza is a public health burden, responsible for more than half a million deaths worldwide each year and explosive outbreaks in-hospital care units. At present, little is known about clinical characteristics and outcomes with nosocomial influenza infection. To assess clinical characteristics and outcome between no...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25652

    authors: Naudion P,Lepiller Q,Bouiller K

    更新日期:2020-08-01 00:00:00

  • Comparison of the efficacy of sofosbuvir plus ribavirin in Chinese patients with genotype 3a or 3b HCV infection.

    abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25454

    authors: Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

    更新日期:2019-07-01 00:00:00

  • Surveillance of measles in the Sudan using filter paper blood samples.

    abstract::Dried blood spots collected on filter paper are considered potential clinical specimens for measles surveillance because of their ease of collection, storage, and transport. The usefulness of these samples for surveillance of measles was evaluated in a field setting. Blood spots were collected by finger-prick from 316...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20136

    authors: El Mubarak HS,Yüksel S,Mustafa OM,Ibrahim SA,Osterhaus AD,de Swart RL

    更新日期:2004-08-01 00:00:00

  • DNA of mouse mammary tumor virus-like virus is present in human tumors influenced by hormones.

    abstract::Mouse mammary tumor virus (MMTV) is a hormonally regulated, oncogenic virus of mice. MMTV-like virus DNA has previously been detected in human breast cancers, liver disease, and liver cancers. It is hypothesized that local hormonal effects might be of primary importance in determining MMTV-like virus detection in huma...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21754

    authors: Johal H,Faedo M,Faltas J,Lau A,Mousina R,Cozzi P,Defazio A,Rawlinson WD

    更新日期:2010-05-01 00:00:00

  • Epidemiological features and viral shedding in children with SARS-CoV-2 infection.

    abstract::A pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection broke out all over the world; however, epidemiological data and viral shedding in pediatric patients are limited. We conducted a retrospective, multicenter study, and followed-up with all children from the families with SARS-CoV-2 inf...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.26180

    authors: Hua CZ,Miao ZP,Zheng JS,Huang Q,Sun QF,Lu HP,Su FF,Wang WH,Huang LP,Chen DQ,Xu ZW,Ji LD,Zhang HP,Yang XW,Li MH,Mao YY,Ying MZ,Ye S,Shu Q,Chen EF,Liang JF,Wang W,Chen ZM,Li W,Fu JF

    更新日期:2020-11-01 00:00:00

  • Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment.

    abstract::The putative interferon sensitivity determining region (ISDR) in the NS5a region of the hepatitis C virus (HCV) was analyzed in 13 interferon alpha (IFN-alpha) treated patients representing genotypes 1a, 1b, and 2b. These patients had previously been followed longitudinally during treatment with respect to viral load ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199809)56:1<33::aid-jmv6>3

    authors: Odeberg J,Yun Z,Sönnerborg A,Weiland O,Lundeberg J

    更新日期:1998-09-01 00:00:00