Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals.

abstract：:DNA plasmids are potent inducers of long-lasting antigen-specific CTL responses. Little is known about the distribution of antigen-specific CD8+ T cells in the lymphoid tissue and the non-lymphoid tissue after DNA immunization. HBsAg-specific CD8+ T cells in peripheral blood mononuclear cells, spleen, lymph nodes, and...

journal_title：Journal of medical virology

authors： Qu D,Lanier G,Yuan ZH,Wen YM,Howard CR,Ahmed R

更新日期：2008-02-01 00:00:00

abstract：:The use of quantitative assays for hepatitis C virus specific antibodies (anti-HCV) as a prognostic marker was evaluated in 31 patients with chronic hepatitis C treated with interferon (IFN). Changes in titers of serum HCV-RNA and anti-HCV antibodies; anti-C11 (anti-core), anti-C100 (anti-NS3), and anti-C7 (anti-NS3) ...

journal_title：Journal of medical virology

authors： Urushihara A,Sodeyama T,Matsumoto A,Tanaka E

更新日期：1994-04-01 00:00:00

abstract：:The TD97 strain vaccine virus was prepared from the Tanabe strain measles virus by low-temperature passages in primary cell cultures and ultraviolet (UV) mutagenesis. The TD97 strain exhibited the following characteristics: highly temperature sensitive, neither multiplying nor forming any plaques at 40 degrees C in Ve...

journal_title：Journal of medical virology

authors： Suzuki K,Morita M,Katoh M,Kidokoro M,Saika S,Yoshizawa S,Hashizume S,Horiuchi K,Okabe N,Shinozaki T

更新日期：1990-11-01 00:00:00

abstract：:The temporal distribution and clinical severity of rotavirus VP7 serotypes 1, 2, 3, and 4 recovered from 427 Venezuelan children with acute gastroenteritis over a period of 11 years were studied. Rotavirus VP7 serotype was established by ELISA serotyping in 298 (69.78%) of the specimens while the serotype of the remai...

journal_title：Journal of medical virology

authors： White L,García D,Boher Y,Blanco M,Pérez M,Romer H,Flores J,Pérez-Schael I

更新日期：1991-06-01 00:00:00

abstract：:Despite prolonged undetectable plasma viral load some HIV-1 infected patients have been reported to develop resistance-associated mutations leading to treatment failure. The mechanisms for this phenomenon and the point of origin for residual viral evolution are still not elucidated. In order to quantify cell-associate...

journal_title：Journal of medical virology

authors： Kupfer B,Matz B,Däumer MP,Roden F,Rockstroh JK,Qurishi N,Spengler U,Kaiser R

更新日期：2007-10-01 00:00:00

abstract：:Herpesviruses produce assembly proteins (AP) that act as scaffolding proteins for the assembly of the viral capsids. The products of the assemblin gene, which encodes both maturational protease and AP, have been established for herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (CMV). We cloned an inframe O...

journal_title：Journal of medical virology

authors： Garcia-Valcarcel M,Fowler WJ,Harper DR,Jeffries DJ,Layton GT

更新日期：1997-12-01 00:00:00

abstract：:Population-specific epidemiological data on human papillomavirus (HPV) infection are essential for formulating strategies to prevent cervical cancer. The age-specific prevalence of HPV infection was determined among 1,600 women enrolled for cervical screening in Macao. A U-shaped age-specific prevalence curve with a f...

journal_title：Journal of medical virology

authors： Yip YC,Ngai KL,Vong HT,Tzang LC,Ji S,Yang M,Chan PK

更新日期：2010-10-01 00:00:00

abstract：:Lentiviral vectors are prime candidate vectors for gene transfer into dividing and non-dividing cells, including neuronal cells and stem cells. For safety, HIV-2 lentiviral vectors may be better suited for gene transfer in humans than HIV-1 lentiviral vectors. HIV-2 vectors cross-packaged in HIV-1 cores may be even sa...

journal_title：Journal of medical virology

authors： D'Costa J,Harvey-White J,Qasba P,Limaye A,Kaneski CR,Davis-Warren A,Brady RO,Bankiewicz KS,Major EO,Arya SK

更新日期：2003-10-01 00:00:00

abstract：:Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...

journal_title：Journal of medical virology

authors： de Silva LM,Cloonan MJ

更新日期：1991-09-01 00:00:00

abstract：:Immune-specific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95% of HSV-seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 1981]. However, herpes virus-induced immune-specific IFN was produced by PBML from only 33 of 48 (68.8%) pe...

journal_title：Journal of medical virology

authors： Green JA,Weiss PN,Yeh TJ,Spruance SL

更新日期：1985-07-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) can lead to a massive cytokine release. The use of the anti-interleukin-6 receptor monoclonal antibody tocilizumab (TCZ) has been proposed in this hyperinflammatory phase, although supporting evidence is limited. We retrospectively analyzed 88 consecutive patients with COVID-19 pneu...

journal_title：Journal of medical virology

authors： Fernández-Ruiz M,López-Medrano F,Pérez-Jacoiste Asín MA,Maestro de la Calle G,Bueno H,Caro-Teller JM,Catalán M,de la Calle C,García-García R,Gómez C,Laguna-Goya R,Lizasoáin M,Martínez-López J,Origüen J,Pablos JL,Ripoll M,

更新日期：2021-02-01 00:00:00

abstract：:Interferon alpha (IFN-alpha) therapy is currently the treatment of choice for chronic hepatitis C (HCV) infection, but it fails to achieve a sustained response in approximately 75% of those treated. The factors which determine whether or not an individual will respond to IFN-alpha are uncertain, although a number of p...

journal_title：Journal of medical virology

authors： Garson JA,Brillanti S,Whitby K,Foli M,Deaville R,Masci C,Miglioli M,Barbara L

更新日期：1995-03-01 00:00:00

abstract：:An attempt was made to identify factors influencing the cumulative probability of an increased alanine aminotransferase (ALT) level and hepatocarcinogenesis in hepatitis C patients with a normal ALT level initially. A total of 398 consecutive patients with a normal ALT level initially for 6 months or more and follow-u...

journal_title：Journal of medical virology

authors： Kumada T,Toyoda H,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Kanamori A,Atsumi H,Takagi M,Nakano S,Arakawa T,Fujimori M

更新日期：2009-03-01 00:00:00

abstract：:The ability to detect type-specific high risk HPV (HR-HPV) infections in samples from females and males is important for monitoring the epidemiology of HPV and the impact of vaccination. Type-specific detection concordance between paired urine and genital samples from females (n = 264) undergoing routine colposcopy an...

journal_title：Journal of medical virology

authors： Bissett SL,Howell-Jones R,Swift C,De Silva N,Biscornet L,Parry JV,Saunders NA,Nathan M,Soldan K,Szarewski A,Cuzick J,Beddows S

更新日期：2011-10-01 00:00:00

abstract：:It has been generally believed that the Epstein-Barr virus (EBV)-encoded small RNA 1 and 2 (EBER1 and EBER2) genes are conserved as two families that correlated with type 1 (B95-8) and type 2 (AG876 or P3HR-1) EBV strains. EBER polymorphism and its association with EBV-associated disease have not received much attenti...

journal_title：Journal of medical virology

authors： Wang Y,Zhang X,Chao Y,Jia Y,Xing X,Luo B

更新日期：2010-05-01 00:00:00

abstract：:Hepatitis B virus (HBV) genotypes impact treatment outcomes and disease progression. The current genotyping methods have limitations in patients with low HBV viral load. In this study, a more sensitive assay has been developed for determining the HBV genotype in HBV DNA suppressed patients. Fifty-five serum samples fr...

journal_title：Journal of medical virology

authors： Liu Y,May L,Liu X,Martin R,Svarovskaia E,Gaggar A,Mo H,Feierbach B

更新日期：2020-07-01 00:00:00

abstract：:Cytomegalovirus (CMV) has been implicated in vascular pathologies and may warrant inclusion in cardiovascular predictive algorithms. We addressed this in healthy older adults and renal transplant recipients (RTR) as they retain a high burden of CMV. RTR (n  =  45) stable more than 2 years after transplantation and 58 ...

journal_title：Journal of medical virology

authors： Affandi JS,Lee S,Chih H,Brook E,Waters S,Howson P,Reid CM,Irish A,Price P

更新日期：2020-02-04 00:00:00

abstract：:It remains unclear if China's current HIV antibody testing algorithm misses a substantial number of HIV infected individuals. Of 196 specimens with indeterminate or negative results on HIV western blot (WB) retrospectively examined by HIV-1 nucleic acid test (NAT), 67.57% (75/111) of indeterminate WB samples, and 16.4...

journal_title：Journal of medical virology

authors： Liu MQ,Zhu ZR,Kong WH,Tang L,Peng JS,Wang X,Xu J,Schilling RF,Cai T,Zhou W

更新日期：2016-08-01 00:00:00

abstract：:Rotaviruses were detected via electron microscopy in fecal specimens collected from school children during an outbreak of diarrhea and from a sporadic case in 1993 in Japan. All of the viruses were found to belong to human group C rotavirus by reverse passive hemagglutination assay (RPHA). These viruses replicated wel...

journal_title：Journal of medical virology

authors： Shinozaki K,Yamanaka T,Tokieda M,Shirasawa H,Simizu B

更新日期：1996-01-01 00:00:00

abstract：:We developed an immunoperoxidase staining test to detect structural antigens of BK virus (BKV) in Vero cell cultures. This test was used to examine the neutralizing activity of human and immunized animal sera. It was shown that sera positive for BKV antibodies measured by hemagglutination inhibition test and enzyme-li...

journal_title：Journal of medical virology

authors： Flaegstad T,Traavik T,Christie KE,Joergensen J

更新日期：1986-07-01 00:00:00

abstract：:Knowledge of the current epidemiology of chronic liver disease in Italy is mostly obsolete and fragmentary for the lack of up-to-date consistent data. In 2001, a 6-month prevalence study was undertaken in 79 hospitals to assess the characteristics of chronic liver disease in Italy. Both prevalent and incident cases we...

journal_title：Journal of medical virology

authors： Sagnelli E,Stroffolini T,Mele A,Almasio P,Coppola N,Ferrigno L,Scolastico C,Onofrio M,Imparato M,Filippini P

更新日期：2005-04-01 00:00:00

abstract：:The severe acute respiratory syndrome (SARS) leads to severe injury in the lungs with multiple factors, though the pathogenesis is still largely unclear. This paper describes the particular analyses of the transcriptome of human lung tissue that was infected by SARS-associated coronavirus (SARS-CoV). Random primers we...

journal_title：Journal of medical virology

authors： Wu H,Wang J,Deng R,Xing K,Xiong Y,Huang J,He X,Wang X

更新日期：2011-04-01 00:00:00

abstract：:In 2000, we monitored the course and persistence of human papillomavirus (HPV) infection in 54 women who were HPV positive and free of any cytological disease using HPV-DNA genotyping with a linear array assay (baseline). The impact of HPV infection on development of cervical cytological abnormality (dyskaryosis) was ...

journal_title：Journal of medical virology

authors： Cuschieri KS,Whitley MJ,Cubie HA

更新日期：2004-05-01 00:00:00

abstract：:Hepatitis D virus (HDV) infection can cause severe acute and chronic liver disease in patients infected with hepatitis B virus (HBV). Despite the significant decline in the global HDV infection, it remains a major health concern in some countries. This study aimed to investigate the prevalence and clinical features of...

journal_title：Journal of medical virology

authors： Kim HS,Kim SJ,Park HW,Shin WG,Kim KH,Lee JH,Kim HY,Jang MK

更新日期：2011-07-01 00:00:00

abstract：:Serial blood and faecal samples were collected from patients and family contacts during an outbreak of hepatitis A in a village and tested by a solid-phase competitive type radioimmunoassay for hepatitis A antigen and hepatitis A antibody. The amount and duration of excretion of hepatitis A antigen was correlated with...

journal_title：Journal of medical virology

authors： Frösner GG,Overby LR,Flehmig B,Gerth HJ,Haas H,Decker RH,Ling CM,Zuckerman AJ,Frösner HR

更新日期：1977-01-01 00:00:00

abstract：:Development of hepatitis B virus (HBV)-resistant strains following nucleos(t)ide analog treatment is a major medical concern. This report describes a case of an adult patient with chronic HBV infection, sequentially treated with the nucleos(t)ide analogues, lamivudine, adefovir, and entecavir. During monotherapy with ...

journal_title：Journal of medical virology

authors： Rodriguez-Frias F,Jardi R,Schaper M,Gimferrer M,Elefsiniotis I,Tabernero D,Esteban R,Buti M

更新日期：2007-11-01 00:00:00

abstract：:A one-year study of rotavirus prevalence was carried out using electron microscopy in Gabon, equatorial Africa. One hundred fifty-six nonhospitalized diarrheic children up to 10 years of age and 115 age-matched controls were investigated together with diarrheic adults and children over 10 years of age. Rotaviruses wer...

journal_title：Journal of medical virology

authors： Sitbon M,Lecerf A,Garin Y,Ivanoff B

更新日期：1985-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in immunocompromised patients, such as renal transplant recipients. Analysis of the gene encoding the envelope glycoprotein B (gB) showed that clinical isolates adopted one of the sequence configurations, permitting the isolates to be assigned a ...

journal_title：Journal of medical virology

authors： Carraro E,Granato CF

更新日期：2003-06-01 00:00:00

abstract：:To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneous...

journal_title：Journal of medical virology

authors： Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G

更新日期：1995-04-01 00:00:00

abstract：:A total of 102,600 upper respiratory infections (URI) were recorded among young military conscripts in the Finnish Defence Forces during the study period from October 1991 to March 1994. This period covered three outbreaks caused by H3N2-subtype influenza A virus and one outbreak of influenza B. During the 1991/92 out...

journal_title：Journal of medical virology

authors： Pyhälä R,Visakorpi R,Ikonen N,Kleemola M

更新日期：2004-02-01 00:00:00