Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C.

Abstract:

:Interferon alpha (IFN-alpha) therapy is currently the treatment of choice for chronic hepatitis C (HCV) infection, but it fails to achieve a sustained response in approximately 75% of those treated. The factors which determine whether or not an individual will respond to IFN-alpha are uncertain, although a number of potentially predictive factors have been proposed. In this study a wide range of clinical, demographic, and virological parameters were evaluated in relation to therapeutic outcome in a group of 30 Italian patients with chronic hepatitis C. All patients received 3 MU leukocyte-derived IFN-alpha three times a week for 6 months and were then followed prospectively for at least 12 months. 53% of patients responded initially, but a sustained response was observed in only 17%. Responders were found to be significantly younger than nonresponders (45.6 +/- 3.1 vs. 55.4 +/- 2.7), and less frequently cirrhotic (2/16 vs. 7/14). Sustained responders had a mean pretreatment HCV-RNA titer approximately tenfold lower than that of those who did not have a sustained response, but the difference was not statistically significant. HCV genotype was found to be significantly associated with both initial and sustained response. Patients infected with HCV-2a were more likely to respond (89%) than those who were infected with HCV-1b (37%), and they were also more likely to sustain that response (33% vs. 6%).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Med Virol

authors

Garson JA,Brillanti S,Whitby K,Foli M,Deaville R,Masci C,Miglioli M,Barbara L

doi

10.1002/jmv.1890450320

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

348-53

issue

3

eissn

0146-6615

issn

1096-9071

journal_volume

45

pub_type

临床试验,杂志文章
  • Development of a novel glycated protein-based fibrosis prediction score for determination of significant liver fibrosis in HCV-infected patients, a preliminary study.

    abstract::The current study aimed to investigate the diagnostic value of glycated albumin (GA), glycated hemoglobin (HbA1c), and a number of routine biomarkers as noninvasive indicators of liver fibrosis in patients with chronic hepatitis C (CHC). One hundred patients with CHC were subjected to full medical history and examinat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26204

    authors: Abo El-Khair SM,El-Alfy HA,Elsamanoudy AZ,Elhammady D,Abd-Elfattah N,Eldeek B,Farid K

    更新日期:2020-06-19 00:00:00

  • Eighteen-year follow-up cohort study on hepatitis B and C virus infections related long-term prognosis among hemodialysis patients in Hiroshima.

    abstract::This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study used both the medical data and the blood sam...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26215

    authors: Ko K,Nagashima S,Yamamoto C,Takahashi K,Matsuo J,Ohisa M,Akita T,Matyakubov J,Mirzaev U,Katayama K,Masaki T,Tanaka J

    更新日期:2020-06-24 00:00:00

  • False RIA IgM titres to herpes simplex virus and cytomegalovirus: factors causing them, and their absorption by protein A-Sepharose/IgG-protein A-Sepharose.

    abstract::A method for the absorption of false radioimmunoassay (RIA) IgM titres against herpes simplex virus (HSV) and cytomegalovirus (CMV) is presented. The serum specimens were absorbed by a mixture of protein A-Sepharose and protein A-Sepharose saturated with normal human gamma globulin (PAS/IgG). The detection of rheumato...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890100302

    authors: Torfason EG,Diderholm H

    更新日期:1982-01-01 00:00:00

  • Growth of human immunodeficiency virus I in cultured cells in the absence of the CD4 antigen.

    abstract::The ability of a variety of epithelial, embryonal, placental, and neuronal cells to express the CD4 antigen and to be infected by human immunodeficiency virus 1 (HIV-1) was examined. Only two (IMR-32 and HeLa-T4) expressed CD4 detectable by indirect immunofluorescence, and both were infectable by HIV-1. Two others, a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890350308

    authors: Morrison NK,McCarthy K,Hart CA

    更新日期:1991-11-01 00:00:00

  • Altered expression of CXCR3 and CCR6 and their ligands in HTLV-1 carriers and HAM/TSP patients.

    abstract::Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were me...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24779

    authors: Rafatpanah H,Felegari M,Azarpazhooh MR,Vakili R,Rajaei T,Hampson I,Hassanshahi G,Valizadeh N,Gerayli S,Hamid F,Zamanian S,MollaHosseini F,Rezaee SA

    更新日期:2017-08-01 00:00:00

  • Seroprevalence rates of BKV, JCV, and MCPyV polyomaviruses in the general Czech Republic population.

    abstract::JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Cz...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23841

    authors: Sroller V,Hamšíková E,Ludvíková V,Vochozková P,Kojzarová M,Fraiberk M,Saláková M,Morávková A,Forstová J,Němečková S

    更新日期:2014-09-01 00:00:00

  • Prevalence of antibodies to enteroviruses and varicella-zoster virus among residents and overseas volunteers at agricultural settlements in Israel.

    abstract::Within the framework of a comprehensive study of the correlation between enteric diseases and wastewater utilization in agricultural settlements (kibbutzim) the prevalence of several viral antibodies was examined among kibbutz residents and overseas volunteers. The latter were assumed to be a group highly susceptible ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200211

    authors: Margalith M,Fattal B,Shuval HI,Morag A

    更新日期:1986-10-01 00:00:00

  • Colposcopy, punch biopsy, in situ DNA hybridization, and the polymerase chain reaction in searching for genital human papillomavirus (HPV) infections in women with normal PAP smears.

    abstract::To assess the prevalence of HPV infection in the genital tracts of women with normal PAP smears, a random series of 109 women was reexamined using colposcopy, a further PAP smear, and punch biopsies taken from the cervix (in 33 cases), vagina (212 cases), and anus (20 cases). The biopsy material was examined using rou...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310404

    authors: Syrjänen S,Saastamoinen J,Chang FJ,Ji HX,Syrjänen K

    更新日期:1990-08-01 00:00:00

  • Intratonsillar detection of 27 distinct viruses: A cross-sectional study.

    abstract::Palatine tonsils have been observed to harbor several distinct respiratory and herpesviruses in separate studies. In this study, the presence of these viruses in palatine tonsils was comprehensively studied in both children and adults. A cross-sectional analysis of 181 patients (median age 22 years; range, 2.6-66) ope...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26245

    authors: Silvoniemi A,Mikola E,Ivaska L,Jeskanen M,Löyttyniemi E,Puhakka T,Vuorinen T,Jartti T

    更新日期:2020-06-30 00:00:00

  • The detection of SRAS-CoV-2 in outpatient clinics and public facilities during the COVID19 pandemic.

    abstract::The transmission of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can occur through airborne route, in addition to contaminated surfaces and objects. In hospitals, it has been confirmed by several studies that SRAS-CoV-2 can contaminate surfaces and medical equipment especially in hospitals dedicat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26819

    authors: Elbadawy HM,Khattab A,Alalawi A,Aljohani F,Sundogji H,Mahmoud AS,Abouzied M,Eltahir HM,Alahmadey Z,Bahashwan S,Suliman BA

    更新日期:2021-01-26 00:00:00

  • Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.

    abstract::The substitution of amino acid (aa) 70 of arginine for glutamine and/or that of aa91 of leucine for methionine in the core protein in patients infected with hepatitis C virus (HCV) genotype 1b is associated with a poor response to pegylated interferon and ribavirin. Factors influencing these substitutions were sought ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21629

    authors: Kobayashi M,Akuta N,Suzuki F,Hosaka T,Sezaki H,Kobayashi M,Suzuki Y,Arase Y,Ikeda K,Watahiki S,Mineta R,Iwasaki S,Miyakawa Y,Kumada H

    更新日期:2010-01-01 00:00:00

  • Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers.

    abstract::The ability of dengue virus-infected human monocyte-derived macrophages to induce permeability changes in primary human umbilical vein endothelial cells was investigated. Supernatants from dengue virus type 2-infected monocyte-derived macrophages increased permeability in human umbilical vein endothelial cell monolaye...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10340

    authors: Carr JM,Hocking H,Bunting K,Wright PJ,Davidson A,Gamble J,Burrell CJ,Li P

    更新日期:2003-04-01 00:00:00

  • Two gastroenteritis outbreaks caused by sapovirus in Shenzhen, China.

    abstract::Human sapoviruses (SaVs) are a common cause of the acute gastroenteritis epidemic worldwide, and SaV outbreaks and infections have become more frequent in recent years. Since the end of December, 2015 to December, 2016, 2 gastroenteritis outbreaks occurred in 2 kindergarten classes (outbreaks A and B) in the Baoan dis...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25236

    authors: Wang Md J,Li PhD Y,Kong Md X,Li PhD H,Zhang Ba Q,Jin PhD M,Wang PhD Y,Duan PhD Z

    更新日期:2018-11-01 00:00:00

  • Prevalence of abnormal anal cytology in women infected with HIV.

    abstract::Anal cancer is a rare disease. Nevertheless, it may be a reason for concern among groups in which its incidence is increasing: those who engage in anoreceptive intercourse, promiscuous persons, and those with sexually transmitted infections (HPV and HIV). The aim of this study was to evaluate the prevalence of abnorma...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23346

    authors: Chaves EB,Folgierini H,Capp E,von Eye Corleta H

    更新日期:2012-09-01 00:00:00

  • Dominant replication of either virus in dual infection with hepatitis viruses B and C.

    abstract::To characterize the state of dual infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), HBV-DNA and HCV-RNA levels were determined by spot hybridization or polymerase chain reaction in the sera of patients who were positive for both hepatitis B surface antigen and HCV antibody. Among 27 patients who show...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890450222

    authors: Koike K,Yasuda K,Yotsuyanagi H,Moriya K,Hino K,Kurokawa K,Iino S

    更新日期:1995-02-01 00:00:00

  • A comparative study of strains of Ebola virus isolated from southern Sudan and northern Zaire in 1976.

    abstract::During the 1976 Ebola virus outbreak in Sudan, the investigations team gained the impression that fewer haemorrhagic manifestations and few fatalities occurred during the later stages of the epidemic after the virus had undergone several generations in man. This impression was also noted in guinea pigs experimentally ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890060205

    authors: Bowen ET,Platt GS,Lloyd G,Raymond RT,Simpson DI

    更新日期:1980-01-01 00:00:00

  • Prediction of the virological response to etravirine in clinical practice: Comparison of three genotype algorithms.

    abstract::The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21461

    authors: Cotte L,Trabaud MA,Tardy JC,Brochier C,Gilibert RP,Miailhes P,Trépo C,André P

    更新日期:2009-04-01 00:00:00

  • Hepatitis C virus genotypes in different regions of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan).

    abstract::The prevalence of HCV genotypes in four republics of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan) was investigated. Overall, 197 HCV isolates from 66 blood donors and 131 patients with chronic hepatitis were typed. Viral sequences from sera of infected subjects were amplified by nested RT-PCR usi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Viazov S,Kuzin S,Paladi N,Tchernovetsky M,Isaeva E,Mazhul L,Vasychova F,Widell A,Roggendorf M

    更新日期:1997-09-01 00:00:00

  • High prevalence of GB virus C strains genetically related to strains with Asian origin in Nicaraguan hemophiliacs.

    abstract::The presence of hepatitis GB virus C (GBV-C), also known as hepatitis G virus (HGV), and hepatitis C virus (HCV) were investigated in sera from 45 hemophiliacs from nine locations in Nicaragua using a nested polymerase chain reaction (PCR). Primers used to detect GBV-C and HCV derived from the helicase region and 5'UT...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: González-Pérez MA,Norder H,Bergström A,Lopéz E,Visoná KA,Magnius LO

    更新日期:1997-06-01 00:00:00

  • Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children.

    abstract::Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, usin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24127

    authors: Nilsson AL,Vaziri-Sani F,Broberg P,Elfaitouri A,Pipkorn R,Blomberg J,Ivarsson SA,Elding Larsson H,Lernmark Å

    更新日期:2015-07-01 00:00:00

  • Molecular and epidemiological characteristics of blood-borne virus infections among recent immigrants in Spain.

    abstract::The increased immigration from developing regions to Western countries raises public health concerns related to blood-borne viruses. The prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-lymphotropic virus (HTLV) infections among recent immigrants attending...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20744

    authors: Toro C,Jiménez V,Rodríguez C,Del Romero J,Rodés B,Holguín A,Alvarez P,García-Campello M,Gómez-Hernando C,Guelar A,Sheldon J,de Mendoza C,Simón A,Soriano V

    更新日期:2006-12-01 00:00:00

  • Incidence and prognosis of cytomegalovirus infections following allogenic bone marrow transplantation.

    abstract::The incidence and the outcome of cytomegalovirus (CMV) infections were evaluated in 83 adult recipients of allogenic bone marrow transplantation. Virological and serological surveillance was performed weekly for 3 months posttransplant, and then every other week or every month until 1 year. CMV infection occurred in 4...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890230412

    authors: Guyotat D,Gibert R,Chomel J,Archimbaud E,Bossard S,Maupas J,Fiere D,Aymard M

    更新日期:1987-12-01 00:00:00

  • Development and application of a one-step real-time RT-PCR using a minor-groove-binding probe for the detection of a novel bunyavirus in clinical specimens.

    abstract::A highly sensitive one-step real-time RT-PCR method using a minor-groove-binding (MGB) probe was developed for detection and quantitation of severe febrile with thrombocytopenia syndrome virus (SFTSV). The assay could discriminate SFTSV infection from other related viral diseases in human with a minimum detection limi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23415

    authors: Li Z,Cui L,Zhou M,Qi X,Bao C,Hu J,Shan J,Wu B,Wang S,Guo X,Jiao Y,Tang F,Wang H

    更新日期:2013-02-01 00:00:00

  • Monitoring of patients for cytomegalovirus after organ transplantation by centrifugation culture and PCR.

    abstract::A modified centrifugation culture technique and a polymerase chain reaction (PCR) is described for detection of early antigen and IE antigen DNA, respectively, for rapid and sensitive monitoring of active cytomegalovirus (HCMV) infection after organ transplantation. In a preliminary study, 541 clinical specimens (bloo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380404

    authors: Prösch S,Kimel V,Dawydowa I,Krüger DH

    更新日期:1992-12-01 00:00:00

  • LAP+ Treg is a better biomarker than total Treg in viral myocarditis.

    abstract::Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, whi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25378

    authors: Wang X,Ge J,Chen R

    更新日期:2019-05-01 00:00:00

  • Dynamic study of HBsAg and HBeAg in saliva samples from patients with hepatitis B infection: diagnostic and epidemiological significance.

    abstract::Analysis of 505 cases history of patients among men with viral hepatitis demonstrates that HBV infected patients represent 68.9% of the total and that a non-parenteral rate of transmission is the most likely means of hepatitis B infection. Saliva and serum testing for the presence of specific HBV markers (HBsAg, HBeAg...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200008)61:4<433::aid-jmv4>3.0.co

    authors: Zhevachevsky NG,Nomokonova NY,Beklemishev AB,Belov GF

    更新日期:2000-08-01 00:00:00

  • Heterogeneous nature of HIV-1 recombinants spreading in Spain.

    abstract::HIV-1 infections due to non-B subtypes are increasing rapidly in number and spreading across Europe. The genetic nature of HIV-1 non-B variants containing subtype G sequences at the protease (PR)-coding region are described from 48 unrelated subjects living in Spain. Phylogenetic analyses of the HIV-1 reverse transcri...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20280

    authors: Holguín A,Alvarez A,Soriano V

    更新日期:2005-03-01 00:00:00

  • Detection of varicella-zoster virus DNA in 414 human trigeminal ganglia from cadavers by the polymerase chain reaction: a comparison of the detection rate of varicella-zoster virus and herpes simplex virus type 1.

    abstract::Investigation of varicella-zoster virus (VZV) is important epidemiologically, and determination of its prevalence rate in human trigeminal ganglia is important to provide surveillance data. To date, studies on VZV detection in trigeminal ganglia have used specimens obtained from a relatively limited number of cadavers...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21687

    authors: Inoue H,Motani-Saitoh H,Sakurada K,Ikegaya H,Yajima D,Hayakawa M,Sato Y,Otsuka K,Kobayashi K,Nagasawa S,Iwase H

    更新日期:2010-02-01 00:00:00

  • Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID-19 pneumonia patients.

    abstract::To recognize the period of exaggerated cytokine response in patients with coronavirus disease 2019 (COVID-19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. The data of 12 adult COVID-19 pneumonia patients who were followed in the inpatient clinics of Biruni University Med...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26111

    authors: Borku Uysal B,Ikitimur H,Yavuzer S,Ikitimur B,Uysal H,Islamoglu MS,Ozcan E,Aktepe E,Yavuzer H,Cengiz M

    更新日期:2020-11-01 00:00:00

  • Seroprevalence of six different viruses among pregnant women and blood donors in rural and urban Burkina Faso: A comparative analysis.

    abstract::A seroprevalence study was carried out of six different human pathogenic viruses, namely human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell leukemia virus (HTLV), human herpesvirus type 8 (HHV-8), and dengue virus among pregnant women and blood donors from rural (Nouna) ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20593

    authors: Collenberg E,Ouedraogo T,Ganamé J,Fickenscher H,Kynast-Wolf G,Becher H,Kouyaté B,Kräusslich HG,Sangaré L,Tebit DM

    更新日期:2006-05-01 00:00:00