Phylogenetic analysis of the complete genome of 11 BKV isolates obtained from allogenic stem cell transplant recipients in Ireland.

Abstract:

:BK polyomavirus (family Polyomaviridae) may cause hemorrhagic cystitis (BKV-HC) in hematopoietic stem cell transplant recipients. Eleven complete BKV genomes (GenBank accession numbers: JN192431-JN192441) were sequenced from urine samples of allogenic hematopoietic stem cell transplant recipients and compared to complete BKV genomes in the published literature. Of the 11 isolates, seven (64%) were subgroup Ib-1, three (27%) isolates belonged to subgroup Ib-2 and a single isolate belonged to subtype III. The analysis of single-nucleotide polymorphisms in this study showed that isolates could be subclassified into subtypes I-IV and subgroups Ib-1 and Ib-2 on the basis of VP1 of the first part of the Large T-antigen (LTag). The non-coding control region (NCCR) of the 11 isolates was also sequenced. These sequences showed that there was consistent sequence homology within subgroups Ib-1 and Ib-2. Two new mutations were described in the isolates, G→C at O(84) in isolate SJH-LG-310, and a deletion at R(2-7) in isolate SJH-LG-309. No known transcription factor is thought to be present at the site of either of these mutations. There were no rearrangements seen in isolates and this may be because the patients were not followed up over time. There were five nucleotide positions at which subgroup Ib-1 isolated differed from subgroup Ib-2 isolates in the NCCR sequence, O(41) , P(18) , P(31) , R(4) , and S(18) . The mutation O(41) is present in the promoter granulocyte/macrophage stimulating factor) gene and the P(31) mutation is present in the NF-1 gene.

journal_name

J Med Virol

authors

Drew RJ,Walsh A,Laoi BN,Crowley B

doi

10.1002/jmv.23240

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1037-48

issue

7

eissn

0146-6615

issn

1096-9071

journal_volume

84

pub_type

杂志文章
  • Hepatitis C virus genotype 4 in Southern and Central Spain does not originate from recent foreign migration waves.

    abstract::Hepatitis C virus genotype 4 (HCV-4) is highly prevalent in Spain, but the information on the molecular characterization of HCV-4 in this region is scarce. Due to this, the molecular characteristics and the evolution of HCV-4 infection in Seville were analyzed (Southern Spain) and compared them with samples from Madri...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23657

    authors: Di Lello FA,Neukam K,Parra-Sanchez M,Plaza Z,Soriano V,Cifuentes C,Mira JA,Poveda E,Pineda JA

    更新日期:2013-10-01 00:00:00

  • Epstein-Barr virus reactivation associated with diminished cell-mediated immunity in antarctic expeditioners.

    abstract::Epstein-Barr virus (EBV) reactivation and cell-mediated immune (CMI) responses were followed in 16 Antarctic expeditioners during winter-over isolation at 2 Australian National Antarctic Research Expedition stations. Delayed-type hypersensitivity (DTH) skin testing was used as an indicator of the CMI response, that wa...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200006)61:2<235::aid-jmv10

    authors: Mehta SK,Pierson DL,Cooley H,Dubow R,Lugg D

    更新日期:2000-06-01 00:00:00

  • Detection of viruses in weekly stool specimens collected during the first 2 years of life: A pilot study of five healthy Australian infants in the rotavirus vaccine era.

    abstract::Several viruses are associated with gastroenteritis in infants. This pilot study, nested within a larger community-based project of early childhood infections, collected daily symptom data and 511 weekly stool samples from five healthy, fully vaccinated, term infants from birth until their second birthday. Real-time P...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24716

    authors: Ye S,Whiley DM,Ware RS,Sloots TP,Kirkwood CD,Grimwood K,Lambert SB

    更新日期:2017-05-01 00:00:00

  • Selection of drug-resistant HIV-1 during the early phase of viral decay is uncommon in treatment-naïve patients initiated on a three- or four-drug antiretroviral regimen including lamivudine.

    abstract::Therapy failure due to drug resistance development is a common phenomenon in HIV-infected patients. However, when the drug pressure leads to the earliest selection of drug-resistant HIV-1 populations is still unclear. In this study, the extent to which selection of the HIV-1 reverse transcriptase M184I/V mutations occ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21363

    authors: Bergroth T,Ekici H,Gisslén M,Loes SK,Goh LE,Freedman A,Lampe F,Johnson MA,Sönnerborg A

    更新日期:2009-01-01 00:00:00

  • ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.

    abstract::Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24844

    authors: El Raziky M,Zayed NA,Abdel Baki A,Mansour SA,Shahin RMH

    更新日期:2017-10-01 00:00:00

  • Serological examination of human herpesvirus 6 and 7 in patients with coronary artery disease.

    abstract::Fifty-three (96%) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91%) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96%) and 53 (98%), respectively. No statistical difference in the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10134

    authors: Ihira M,Yoshikawa T,Ishii J,Nomura M,Hishida H,Ohashi M,Enomoto Y,Suga S,Iida K,Saito Y,Nishiyama Y,Asano Y

    更新日期:2002-08-01 00:00:00

  • Surveillance of measles in the Sudan using filter paper blood samples.

    abstract::Dried blood spots collected on filter paper are considered potential clinical specimens for measles surveillance because of their ease of collection, storage, and transport. The usefulness of these samples for surveillance of measles was evaluated in a field setting. Blood spots were collected by finger-prick from 316...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20136

    authors: El Mubarak HS,Yüksel S,Mustafa OM,Ibrahim SA,Osterhaus AD,de Swart RL

    更新日期:2004-08-01 00:00:00

  • Laboratory confirmation of congenital rubella syndrome in infants: an eye hospital based investigation.

    abstract::A total of 190 specimens from South Indian children aged 0-59 months with ocular anomalies consistent with suspected congenital rubella syndrome (CRS) were investigated. Twenty-six of the 65 infants (40%) were confirmed as CRS by detection of rubella specific IgM. Rubella RNA was detected in 41 samples from 26 infants...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21097

    authors: Rajasundari TA,Sundaresan P,Vijayalakshmi P,Brown DW,Jin L

    更新日期:2008-03-01 00:00:00

  • Presence of Betapapillomavirus in Kaposi sarcoma lesions.

    abstract::Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23944

    authors: Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen B

    更新日期:2014-09-01 00:00:00

  • Attenuated Junin virus infection in Callithrix jacchus.

    abstract::Twenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID50 of the attenuated XJC13 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420-day period. In order to carry out virologi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890150112

    authors: Avila MM,Frigerio MJ,Weber EL,Rondinone S,Samoilovich SR,Laguens RP,de Guerrero LB,Weissenbacher MC

    更新日期:1985-01-01 00:00:00

  • Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study.

    abstract::Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24279

    authors: Chu HY,Englund JA,Huang D,Scott E,Chan JD,Jain R,Pottinger PS,Lynch JB,Dellit TH,Jerome KR,Kuypers J

    更新日期:2015-12-01 00:00:00

  • Detection of human immunodeficiency virus (HIV) genome from the lymphocytes of homosexual men.

    abstract::Human immunodeficiency virus (HIV) is the primary etiological agent of acquired immunodeficiency syndrome (AIDS). This virus can be transmitted by blood or blood products. Homosexual males (HM) are regarded as one of the high-risk groups for AIDS. Lymphocytes obtained from HM were used for cocultivation with fresh HIV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890230404

    authors: Lee YS,Baker L

    更新日期:1987-12-01 00:00:00

  • Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adults.

    abstract::Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16

    authors: Falsey AR,Walsh EE,Looney RJ,Kolassa JE,Formica MA,Criddle MC,Hall WJ

    更新日期:1999-10-01 00:00:00

  • Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system.

    abstract::A line of hepatitis C virus (HCV) transgenic mice was established previously that was mediated by Cre/loxP system using HCV cDNA, including core, E1, E2 and NS2 genes. Intravenous infection of a recombinant adenovirus that expresses Cre DNA recombinase (AxCANCre) induced HCV structural protein expression in the liver ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200011)62:3<308::aid-jmv2>3.0.co

    authors: Wakita T,Katsume A,Kato J,Taya C,Yonekawa H,Kanegae Y,Saito I,Hayashi Y,Koike M,Miyamoto M,Hiasa Y,Kohara M

    更新日期:2000-11-01 00:00:00

  • HBeAg and anti-HBe detection by radioimmunoassay: correlation with vertical transmission of hepatitis B virus in Taiwan.

    abstract::A sensitive radioimmunoassay technique was used to detect hepatitis B e antigen (HBeAg). A strong correlation was found between HBeAg positivity of the serum of hepatitis B surface antigen (HBsAg) carrier women in Taiwan and the subsequent development of surface antigenemia in their babies. All babies who became chron...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890030310

    authors: Stevens CE,Neurath RA,Beasley RP,Szmuness W

    更新日期:1979-01-01 00:00:00

  • Low HBV-DNA levels in end-stage renal disease patients with HBeAg-negative chronic hepatitis B.

    abstract::In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20691

    authors: Moutinho RS,Perez RM,Medina-Pestana JO,Figueiredo MS,Koide S,Alberto FL,Silva AE,Ferraz ML

    更新日期:2006-10-01 00:00:00

  • Genomic analysis of the Chinese genotype 1F rubella virus that disappeared after 2002 in China.

    abstract::Genotype 1F was likely localized geographically to China as it has not been reported elsewhere. In this study, whole genome sequences of two rubella 1F virus isolates were completed. Both viruses contained 9,761 nt with a single nucleotide deletion in the intergenic region, compared to the NCBI rubella reference seque...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23936

    authors: Zhu Z,Chen MH,Abernathy E,Zhou S,Wang C,Icenogle J,Xu W

    更新日期:2014-12-01 00:00:00

  • Co-circulation in a single biome of the Juquitiba and Araraquara hantavirus detected in human sera in a sub-tropical region of Brazil.

    abstract::Hantaviruses is an emerging infectious disease. Although HCPS has been reported in several regions of Brazil, more cases of HCPS have recently been reported in Minas Gerais than in any other state. In 2009, we analyzed 27 samples presenting antibodies against hantaviruses. These samples originated from 688 symptomatic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24118

    authors: de Araujo J,Duré AI,Negrão R,Ometto T,Thomazelli LM,Durigon EL

    更新日期:2015-05-01 00:00:00

  • Molecular epidemiology of rotavirus gastroenteritis in Japan during 2014-2015: Characterization of re-emerging G2P[4] after rotavirus vaccine introduction.

    abstract::Rotavirus vaccines have been available in Japan since 2011. This study conducted to monitor the trend of group A rotavirus (RVA) genotypes 3 years after vaccine introduction. A total of, 539 fecal samples were collected from children with acute gastroenteritis in six regions during July 2014-June 2015. Among them, 178...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25067

    authors: Khandoker N,Thongprachum A,Takanashi S,Okitsu S,Nishimura S,Kikuta H,Yamamoto A,Sugita K,Baba T,Kobayashi M,Hayakawa S,Mizuguchi M,Ushijima H

    更新日期:2018-06-01 00:00:00

  • Pre-existing YMDD mutants in treatment-naïve patients with chronic hepatitis B are not selected during lamivudine therapy.

    abstract::Although the rate at which mutations in the tyrosine-methionine-aspartate-aspartate (YMDD) motif of hepatitis B virus polymerase form is high during prolonged lamivudine (LAM) therapy, these mutations sometimes occur naturally in treatment-naïve patients with chronic hepatitis B. The prevalence of natural YMDD mutants...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23191

    authors: Lee SH,Kim HS,Byun IS,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2012-02-01 00:00:00

  • Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003.

    abstract::Respiratory viruses were identified by the polymerase chain reaction (PCR) in more than 4,200 specimens collected during 2002 and 2003 in Victoria, Australia from patients admitted to hospitals or participating in an influenza surveillance program. Influenza viruses and picornaviruses were important causes of morbidit...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20246

    authors: Druce J,Tran T,Kelly H,Kaye M,Chibo D,Kostecki R,Amiri A,Catton M,Birch C

    更新日期:2005-01-01 00:00:00

  • Reconnaissance of the candidate genes involved in the pathogenesis of human immunodeficiency virus and targeted by antiretroviral therapy.

    abstract::The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)-infected subjects by antiretroviral drugs. High-throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treatment pathways. In this study, we performed a gene-enrichment analysis...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25549

    authors: Mozhgani SH,Zarei Ghobadi M,Behnam Rad M,Farzanehpour M,Behzadian F

    更新日期:2019-12-01 00:00:00

  • Immunohistological detection of human herpes virus 6 in formalin-fixed, paraffin-embedded lung tissues.

    abstract::Human herpes virus type 6 (HHV-6) infection is widespread in healthy individuals. The only definite disease association is with exanthem subitum in infants though the virus has been linked with a variety of other diseases including interstitial pneumonitis in bone marrow allograft recipients. In order to investigate t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890410204

    authors: Pitalia AK,Liu-Yin JA,Freemont AJ,Morris DJ,Fitzmaurice RJ

    更新日期:1993-10-01 00:00:00

  • Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of Echovirus 11.

    abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890090202

    authors: Mertens T,Hager H,Eggers HJ

    更新日期:1982-01-01 00:00:00

  • Experimental infection of nonenveloped DNA virus (TTV) in rhesus monkey.

    abstract::Virus fragments homologous to TTV were detected previously from an enterically transmitted outbreak of non-A-E hepatitis [Luo et al., 1999]. To test the susceptibility of the Rhesus monkey to this virus and to establish its transmission routes, 6 Rhesus monkeys were inoculated, 3 orally and another 3 intravenously. Th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26

    authors: Luo K,Liang W,He H,Yang S,Wang Y,Xiao H,Liu D,Zhang L

    更新日期:2000-05-01 00:00:00

  • Characterization of in vitro dengue virus resistance to carrageenan.

    abstract::The λ-carrageenan (λ-car) is a potent and selective inhibitor of dengue virus (DENV) infection targeted to virus adsorption and internalization, due to the structural similarities with the mammalian cell receptor heparan sulfate. To further characterize the antiviral activity of λ-car, the selection and the phenotypic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24457

    authors: Talarico LB,Damonte EB

    更新日期:2016-07-01 00:00:00

  • Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay.

    abstract::Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24621

    authors: Inazawa N,Hori T,Nojima M,Saito M,Igarashi K,Yamamoto M,Shimizu N,Yoto Y,Tsutsumi H

    更新日期:2017-02-01 00:00:00

  • Increased susceptibility of human respiratory syncytial virus to neutralization by anti-fusion protein antibodies on adaptation to replication in cell culture.

    abstract::Subgroup A respiratory syncytial viruses present in respiratory secretions and low passage level cell culture isolates were found to be markedly less susceptible to neutralization with monoclonal antibodies (MAbs) to the F glycoprotein than the cell culture adapted A2 virus strain. Low passage virus isolates collected...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20892

    authors: Marsh R,Connor A,Gias E,Toms GL

    更新日期:2007-06-01 00:00:00

  • Isolation and molecular identification of echovirus 13 isolated from patients of aseptic meningitis in Korea, 2002.

    abstract::During 2002, several epidemics of aseptic meningitis were attributed to echovirus 13 in Korea. The causative agents of these outbreaks were isolated and identified using rhabdosarcoma cells, HEp-2 and Buffalo green monkey kidney cells, and a neutralization test using monospecific antiserum. Fifty-four echovirus 13 iso...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10543

    authors: Cheon DS,Lee J,Lee K,Lee S,Park K,Ahn J,Jee Y,Yoon J,Cho H

    更新日期:2004-07-01 00:00:00

  • Novel application of a point mutation assay: evidence for transmission of hepatitis B viruses with precore mutations and their detection in infants with fulminant hepatitis B.

    abstract::Mutations of the precore region of hepatitis B virus (HBV) genome have been associated with fulminant and severe chronic hepatitis. However uncertainty remains about the clinical significance and transmissibility of these mutant strains. A point mutation assay (PMA) was developed to identify qualitatively and quantita...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440105

    authors: Hawkins AE,Gilson RJ,Beath SV,Boxall EH,Kelly DA,Tedder RS,Weller IV

    更新日期:1994-09-01 00:00:00