Abstract:
:Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple viral reactivations simultaneously in 24 patients undergoing auto-HSCT between September 2010 and December 2012. Weekly whole blood samples were collected from pre- to 42 days post-HSCT, and tested for the following 13 viruses; herpes simplex virus 1 (HSV-1), HSV-2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), HHV-7, HHV-8, adeno virus (ADV), BK virus (BKV), JC virus (JCV), parvovirus B19 (B19V), and hepatitis B virus (HBV). Fifteen (63%) patients had at least one type of viral reactivation. HHV6 (n = 10; 41.7%) was most frequently detected followed by EBV (n = 7; 29.2%). HHV-6 peaked on day 21 after HSCT and promptly declined. In addition, HBV, CMV, HHV7, and B19V were each detected in one patient. HHV6 reactivation was detected in almost half the auto-HSCT patients, which was similar to the incidence in allo-HSCT patients. The incidence of EBV was unexpectedly high. Viral infections in patients undergoing auto-HSCT were higher than previously reported in other studies. Although there were no particular complications of viral infection, we should pay attention to possible viral reactivations in auto-HSCT patients. J. Med. Virol. 89:358-362, 2017. © 2016 Wiley Periodicals, Inc.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Inazawa N,Hori T,Nojima M,Saito M,Igarashi K,Yamamoto M,Shimizu N,Yoto Y,Tsutsumi Hdoi
10.1002/jmv.24621subject
Has Abstractpub_date
2017-02-01 00:00:00pages
358-362issue
2eissn
0146-6615issn
1096-9071journal_volume
89pub_type
杂志文章abstract::The increased incidence of a enterovirus infections observed in patients with type 1 diabetes preceding the development of the clinical disease could be partially explained by variation in the genes coding for enterovirus receptors. We carried out sequence analysis of the most common enterovirus receptor molecules in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10352
更新日期:2003-05-01 00:00:00
abstract:AIMS:Little data have been published so far on the epidemiological aspects of hepatitis D virus (HDV) infection in immigrant populations and even poorer is the information on the virological, phylogenetic, and clinical aspects of this infection in these populations. This review article, aimed primarily at physicians ca...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.25570
更新日期:2019-12-01 00:00:00
abstract::Rotavirus is the most common etiological cause of acute viral gastroenteritis in infants and young children worldwide, yet its role in the adult population is less well understood. We have recently identified rotavirus as the causative agent of severe diarrhea in adults, specifically in two gastroenteritis outbreaks i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20671
更新日期:2006-08-01 00:00:00
abstract::The emergence of drug-resistant variants during antiretroviral therapy is a serious obstacle to sustained suppression of the human immunodeficiency virus type 1 (HIV-1). For that reason, resistance assays are essential to guide clinicians in the selection of optimal treatment regimens. Genotypic assays are less expens...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20770
更新日期:2007-02-01 00:00:00
abstract::A quantitative polymerase chain reaction (PCR) assay for hepatitis C viral RNA (HCV-RNA) was used to monitor viraemia levels in six patients at multiple time points before, during, and after interferon therapy for chronic non-A, non-B hepatitis (NANBH). Prior to therapy, serum HCV-RNA was detected in all patients at a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890370311
更新日期:1992-07-01 00:00:00
abstract::A multiplex polymerase chain reaction (PCR) assay that is capable of detecting and typing six serotypes of respiratory adenovirus (Ad) was developed, using multiple sets of type-specific primers. The detection of each different serotype depended on distinguishing different numbers and sizes of amplification products o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2174
更新日期:2002-04-01 00:00:00
abstract::West Nile virus (WNV) activity has fluctuated in the south-central United States since its introduction. Seasonal outbreaks are common, with three in Oklahoma during 2003, 2007, and 2012. Morbidity and mortality rates vary during each outbreak. Long-term neurologic sequelae in association with West Nile virus disease ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24235
更新日期:2015-10-01 00:00:00
abstract::Resistance to adamantanes for treating influenza A(H3N2) has increased dramatically, worldwide, over the past 5 years. A comprehensive 10-year data set on the rise of adamantane-resistance in Hong Kong is reported. Nucleotide sequences encoding the M2-ion channel of influenza A(H3N2) were obtained from 281 H3N2 isolat...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21155
更新日期:2008-05-01 00:00:00
abstract::Critical cases of coronavirus disease 2019 (COVID-19) are associated with a high risk of mortality. It remains unclear why patients with the same critical condition have different outcomes. We aimed to explore relevant factors that may affect the prognosis of critical COVID-19 patients. Six critical COVID-19 inpatient...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26181
更新日期:2020-11-01 00:00:00
abstract::Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130208
更新日期:1984-01-01 00:00:00
abstract::To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidir...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25354
更新日期:2019-03-01 00:00:00
abstract::Human papillomavirus (HPV) is known to be the cause of almost all cervical cancers. The genotypes have been classified into high and low risk types according to their oncogenic potential. However, data for many of the genotypes are limited and some (HPV-26, 53, and 66) have no agreed status. A study was undertaken to ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20330
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25454
更新日期:2019-07-01 00:00:00
abstract::There is an obvious concern globally regarding the fact about the emerging coronavirus 2019 novel coronavirus (2019-nCoV) as a worldwide public health threat. As the outbreak of COVID-19 causes by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progresses within China and beyond, rapidly available epi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25743
更新日期:2020-06-01 00:00:00
abstract::Hepatitis C virus (HCV) variation in specific T-cell epitopes may represent a mechanism of viral persistence in chronic infection. We examined the HCV non-structural protein 3 (NS3), including the immunologically relevant epitopes HCV NS3-2 KLVALGINAV (human leukocyte antigen [HLA]-A2-restricted) and HCV NS3-1391 LIFC...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20036
更新日期:2004-04-01 00:00:00
abstract::Immune correlates of protection against human cytomegalovirus (HCMV) infection are still debated. This study aimed to investigate which arm of the immune response plays a major role in protection against HCMV infection in kidney transplant recipients (n = 40) and heart transplant recipients (n = 12). Overall, patients...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25225
更新日期:2018-10-01 00:00:00
abstract::Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26739
更新日期:2020-12-17 00:00:00
abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20872
更新日期:2007-09-01 00:00:00
abstract::Self-limited involvement of the central nervous system (CNS) is a relatively common complication of primary infection with human herpesvirus six (HHV-6) in normal children. We describe an HIV-infected infant who developed fulminant encephalitis as a complication of HHV-6 infection. Immunohistochemical staining of CNS ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890450309
更新日期:1995-03-01 00:00:00
abstract::Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20896
更新日期:2007-08-01 00:00:00
abstract::Epstein-Barr virus (EBV) serology continues to be the first diagnostic test when infectious mononucleosis is suspected. Due to possible mild immunosuppression in competitive athletes, EBV reactivation determined by increases in salivary viral load have been identified as one possible cause in recurrent respiratory inf...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23253
更新日期:2012-09-01 00:00:00
abstract::It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26319
更新日期:2021-02-01 00:00:00
abstract::Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in seria...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>
更新日期:1996-04-01 00:00:00
abstract::Stool specimens from 334 infants and young children hospitalized with diarrhea in the General Hospital, Kuala Lumpur, Malaysia between August and November, 1987 were analyzed for the presence of rotavirus double-stranded (ds) RNA by polyacrylamide gel electrophoresis. Of the 334 specimens analyzed, 32 (9.6%) were posi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430302
更新日期:1994-07-01 00:00:00
abstract::Human herpesvirus 6 (HHV-6), the etiologic agent of roseola in young children, has been reported to be detectable in the brain of many neurologically normal adults, although regional localization to plaques of multiple sclerosis has also been demonstrated. Large amounts of this virus were present in multifocal demyeli...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199707)52:3<301::aid-jmv11
更新日期:1997-07-01 00:00:00
abstract::The prevalence of anti-HCV was studied in a South African area endemic for hepatitis B virus. A total of 35,685 volunteer blood donors (22,034 whites, 9,218 Asians, 3,077 Africans, 1,356 coloureds), 71 haemophiliacs, 84 chronic dialysis patients, 100 antenatal attenders, 212 nurses, and 20 HIV-positive male homosexual...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890400113
更新日期:1993-05-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi's sarcoma, causes malignancies frequently in patients with acquired immunodeficiency syndrome. In the United States and Europe, KSHV infection is common among men who have sex with men. However, the seroprevalence of KSHV among men who have ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23558
更新日期:2013-06-01 00:00:00
abstract::Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25390
更新日期:2019-05-01 00:00:00
abstract::In this study, we aimed to investigate the changes of lymphocyte subsets (CD3+ , CD4+ , CD8+ ) and inflammatory factors (interleukin-6 [IL-6], hypersensitive C-reactive protein [HS-CRP], and procalcitonin [PCT]) of alveolar lavage fluid in patients with severe corona virus-2019 (COVID-19) pneumonia and their clinical ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26827
更新日期:2021-01-28 00:00:00
abstract::The quantification of human immunodeficiency virus type 1 (HIV-1) RNA or hepatitis C virus (HCV) RNA has been facilitated by adapting a spin column procedure for sample preparation and the use of chemiluminescent detection of polymerase chain reaction (PCR) products in microtiter plate format. All materials were comme...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00