Fulminant demyelinating encephalomyelitis associated with productive HHV-6 infection in an immunocompetent adult.

Abstract:

:Human herpesvirus 6 (HHV-6), the etiologic agent of roseola in young children, has been reported to be detectable in the brain of many neurologically normal adults, although regional localization to plaques of multiple sclerosis has also been demonstrated. Large amounts of this virus were present in multifocal demyelinating white matter lesions of fulminant encephalomyelitis with seizures in a 21-year-old woman with normal immune parameters. Brain biopsy after 3 weeks of neurologic deterioration revealed a viral etiology by light and electron microscopy; the virus was identified as HHV-6 by immunohistochemistry and by polymerase chain reaction (PCR) amplification in biopsy and autopsy specimens.

journal_name

J Med Virol

authors

Novoa LJ,Nagra RM,Nakawatase T,Edwards-Lee T,Tourtellotte WW,Cornford ME

doi

10.1002/(sici)1096-9071(199707)52:3<301::aid-jmv11

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

301-8

issue

3

eissn

0146-6615

issn

1096-9071

pii

10.1002/(SICI)1096-9071(199707)52:3<301::AID-JMV11

journal_volume

52

pub_type

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