Abstract:
:In October 1977 an outbreak of acute infectious diarrhea occurred in an infant home in the city of Sapporo, Japan. Of 34 residents aged two to 20 months, 26 (77%) suffered from diarrhea. In ten of these patients the diarrhea was accompanied by vomiting. Electron microscopic examinations revealed typical calicivirus particles in eight faecal specimens, seven of which were from the group of 26 affected patients (28%) and one of which was from the group of eight infants without symptoms (13%). Immune electron microscopy tests for antibody responses against one of the isolated strains of calicivirus were carried out on 27 paired pre- and post-outbreak sera. Seroconversions were demonstrated in 18 of 19 (95%) affected infants and in six of eight (75%) unaffected infants. One patient with lack of antibody response was the youngest child--two months old. Periodic surveys on enteric viruses circulating in the home revealed that calicivirus was specifically associated with the outbreak of gastroenteritis. These observations provide further evidence for the causative role of calicivirus in acute gastroenteritis in children.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Chiba S,Sakuma Y,Kogasaka R,Akihara M,Horino K,Nakao T,Fukui Sdoi
10.1002/jmv.1890040402subject
Has Abstractpub_date
1979-01-01 00:00:00pages
249-54issue
4eissn
0146-6615issn
1096-9071journal_volume
4pub_type
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