Immunogenicity of wild and attenuated varicella-zoster virus strains in rhesus monkeys.

Abstract:

:Thirty susceptible rhesus monkeys were inoculated with cell-free varicella-zoster virus strain OKA or strain KMcC. Both wild and attenuated strains were used. No clinical signs characteristic of human varicella were seen in any of the animals. Virus was not isolated from throat swabs, blood, or cerebrospinal fluid. Antibodies were measured by an enhanced plaque neutralization test. The wild and attenuated OKA strains produced comparable levels of antibodies for 3 months after inoculation. Attenuated KMcC strains produced lower titers than the wild strain. On rechallenge 3 months after primary inoculation animals boostered with the attenuated OKA strain developed significantly higher antibody titers than animals receiving the wild strain. Animals primed and challenged with the attenuated KMcC strains showed significantly lower antibody titers than animals which received the wild strain. The results indicate that the immunogenicity of attenuated OKA and KMcC strains in rhesus monkeys parallels the experience obtained with these strains in humans.

journal_name

J Med Virol

authors

Asano Y,Albrecht P,Behr DE,Neff BJ,Vickers JH,Rastogi SC

doi

10.1002/jmv.1890140403

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

305-12

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

14

pub_type

杂志文章
  • Herpesvirus detection and cytokine levels (IL-10, IL-6, and IFN-γ) in ocular fluid from Tunisian immunocompetent patients with uveitis.

    abstract::Human herpesviruses (HHVs) are involved in the pathogenesis of different types of uveitis. Cytokine response plays an important role in virus-induced immunopathology. This study aimed to investigate the incidence of HHVs in aqueous humor samples of immunocompetent patients with suspected viral uveitis and cytokine (IL...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23708

    authors: Nahdi I,Abdelwahed RB,Boukoum H,Bressollette-Bodin C,Attia S,Yahia SB,Fisson S,Khairallah M,Aouni M

    更新日期:2013-12-01 00:00:00

  • Clinical relevance and genotypes of circulating noroviruses in northern Taiwan, 2006-2011.

    abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23728

    authors: Tsai CN,Lin CY,Lin CW,Shih KC,Chiu CH,Chen SY

    更新日期:2014-02-01 00:00:00

  • Regulation of p14ARF expression by HPV-18 E6 variants.

    abstract::A common causative agent for uterine cervical cancer is the human papillomavirus type 18 (HPV-18) which has three phylogenic variants: Asian-Amerindian, European, and African. Each variant shows significant molecular differences in the E6 gene. E6 oncoprotein is a negative regulator of tumor suppressor protein p53, he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23568

    authors: Vazquez-Vega S,Sanchez-Suarez LP,Andrade-Cruz R,Castellanos-Juarez E,Contreras-Paredes A,Lizano-Soberon M,Garcia-Carranca A,Benitez Bribiesca L

    更新日期:2013-07-01 00:00:00

  • Prevalence of human papillomaviruses in patients with head and neck squamous cell carcinoma in Lithuania and Belarus.

    abstract::Overall, head and neck sqamous cell carcinoma accounts for more than 550,000 cases annually worldwide. It is well known that human papillomavirus (HPV) is the main risk factor for cervical cancer development. As the incidence and the mortality of cervical cancer are closely related to the HPV prevalence, we hypothesiz...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23750

    authors: Gudleviciene Z,Didziapetriene J,Mackeviciene I,Cicenas S,Smolyakova R,Zhukavetc A

    更新日期:2014-03-01 00:00:00

  • Polymorphism of the capsid L1 gene of human papillomavirus types 31, 33, and 35.

    abstract::The L1 gene encodes for the major capsid protein of human papillomaviruses (HPV). There is limited information on the polymorphism of L1 for types related to HPV-16. This report explores the polymorphism of L1 in phylogenetically related types 31, 33, and 35 compared to HPV-16. Genital specimens collected from 732 HIV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21777

    authors: Cornut G,Gagnon S,Hankins C,Money D,Pourreaux K,Franco EL,Coutlée F,Canadian Women's HIV Study Group.

    更新日期:2010-07-01 00:00:00

  • Characterization of pandemic influenza A (H1N1) virus hemagglutinin specific polyclonal antibodies for biosensor applications.

    abstract::In this study, recombinant hemagglutinin protein (rH1N1HA) of Pandemic influenza virus and polyclonal antibodies against it for biosensor applications have been characterized. For rapid and high sensitive detection of H1N1 virus or its antibodies, PCR-free and label free detection method based on a surface plasmon res...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23753

    authors: Athmaram TN,Saraswat S,Sikarwar B,Verma SK,Singh AK,Boopathi M

    更新日期:2014-03-01 00:00:00

  • First case of focal epilepsy associated with SARS-coronavirus-2.

    abstract::A healthy patient presented to Klinikum Altmühlfranken Weißenburg Hospital, Germany, with two morning attacks of painful muscle spasm in the left upper and lower limbs, without altered consciousness. Full examinations, radiological imaging, electroencephalography, lumbar puncture, and autoimmune profile were either no...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26113

    authors: Elgamasy S,Kamel MG,Ghozy S,Khalil A,Morra ME,Islam SMS

    更新日期:2020-10-01 00:00:00

  • Human papillomavirus genotype detection and viral load in paired genital and urine samples from both females and males.

    abstract::The ability to detect type-specific high risk HPV (HR-HPV) infections in samples from females and males is important for monitoring the epidemiology of HPV and the impact of vaccination. Type-specific detection concordance between paired urine and genital samples from females (n = 264) undergoing routine colposcopy an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22167

    authors: Bissett SL,Howell-Jones R,Swift C,De Silva N,Biscornet L,Parry JV,Saunders NA,Nathan M,Soldan K,Szarewski A,Cuzick J,Beddows S

    更新日期:2011-10-01 00:00:00

  • Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.

    abstract::Interleukin 6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells, including hepatocytes. Previous studies have shown that serum IL-6 levels are increased in hepatitis B patients. However, the role of IL-6 in modulating the anti-hepatitis B viru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25382

    authors: Yang K,Guan S,Zhang H,Chen Z

    更新日期:2019-05-01 00:00:00

  • Characteristics of lamivudine-resistant hepatitis B virus (HBV) strains with and without breakthrough hepatitis in patients with chronic hepatitis B evaluated by serial HBV full-genome sequences.

    abstract::Lamivudine therapy often causes breakthrough of hepatitis B virus (HBV) DNA and breakthrough hepatitis. The aim of this study was to determine the viral factors that relate to HBV-DNA breakthrough with and without breakthrough hepatitis. Among 82 patients with chronic hepatitis B (CHB) who received lamivudine at a dos...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20915

    authors: Horiike N,Duong TN,Michitaka K,Joko K,Hiasa Y,Konishi I,Yano M,Onji M

    更新日期:2007-07-01 00:00:00

  • Fulminant demyelinating encephalomyelitis associated with productive HHV-6 infection in an immunocompetent adult.

    abstract::Human herpesvirus 6 (HHV-6), the etiologic agent of roseola in young children, has been reported to be detectable in the brain of many neurologically normal adults, although regional localization to plaques of multiple sclerosis has also been demonstrated. Large amounts of this virus were present in multifocal demyeli...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199707)52:3<301::aid-jmv11

    authors: Novoa LJ,Nagra RM,Nakawatase T,Edwards-Lee T,Tourtellotte WW,Cornford ME

    更新日期:1997-07-01 00:00:00

  • Molecular epidemiology of HIV-1 among the HIV infected people of Manipur, Northeastern India: Emergence of unique recombinant forms.

    abstract::According to the Joint National Programme on HIV/AIDS (UNAIDS), the northeastern region of India has the highest HIV prevalence in the country. This study was conducted to determine the current HIV-1 molecular epidemiology of Manipur, a state in northeast India. Blood samples from HIV-1 seropositive subjects were coll...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24738

    authors: Sharma AL,Singh TR,Devi KR,Singh LS

    更新日期:2017-06-01 00:00:00

  • Close relationship between immunoglobulin secreting-cells and Epstein-Barr virus reservoir in patients infected with HIV.

    abstract::Individuals infected with HIV have higher circulating Epstein-Barr virus (EBV) DNA load compared to healthy carriers. This study investigated whether level of spontaneous immunoglobulin secreting cells, one of the major hallmarks of HIV infection, is associated with an increase of EBV DNA load in PBMCs and the spontan...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23762

    authors: Ouedraogo DE,Tuaillon E,Rubbo PA,Bollore K,Foulongne V,Reynes J,Vendrell JP

    更新日期:2014-01-01 00:00:00

  • The estimation of prevalence and risk factors of hepatitis B virus infection among blood donors in Chengdu, China.

    abstract::The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24339

    authors: Zhong L,Xi G,Zhang L,Liu S,Wan L,Yu L,Zhou M,Zhang J,He Y

    更新日期:2016-02-01 00:00:00

  • Phylogenetic analysis of the complete genome of 11 BKV isolates obtained from allogenic stem cell transplant recipients in Ireland.

    abstract::BK polyomavirus (family Polyomaviridae) may cause hemorrhagic cystitis (BKV-HC) in hematopoietic stem cell transplant recipients. Eleven complete BKV genomes (GenBank accession numbers: JN192431-JN192441) were sequenced from urine samples of allogenic hematopoietic stem cell transplant recipients and compared to compl...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23240

    authors: Drew RJ,Walsh A,Laoi BN,Crowley B

    更新日期:2012-07-01 00:00:00

  • Infection of a human retinal pigment epithelial cell line with human herpesvirus 6 variant A.

    abstract::A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucle...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Arao Y,Soushi S,Sato Y,Moriishi E,Ando Y,Yamada M,Padilla J,Uno F,Nii S,Kurata T

    更新日期:1997-10-01 00:00:00

  • HDV infection in immigrant populations.

    abstract:AIMS:Little data have been published so far on the epidemiological aspects of hepatitis D virus (HDV) infection in immigrant populations and even poorer is the information on the virological, phylogenetic, and clinical aspects of this infection in these populations. This review article, aimed primarily at physicians ca...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.25570

    authors: Coppola N,Alessio L,Onorato L,Sagnelli C,Sagnelli E,Pisaturo M

    更新日期:2019-12-01 00:00:00

  • Activation of a varicella-zoster virus-specific IgA response during acute Epstein-Barr virus infection.

    abstract::The influence of an acute Epstein-Barr virus (EBV) infection on the serological parameters of persistent varicella-zoster virus (VZV) and herpes simplex virus (HSV) was studied. Sera from 161 patients with infectious mononucleosis caused by EBV and 178 age-matched controls were tested for HSV- and VZV-specific IgA. 98...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440308

    authors: Karner W,Bauer G

    更新日期:1994-11-01 00:00:00

  • DNA of mouse mammary tumor virus-like virus is present in human tumors influenced by hormones.

    abstract::Mouse mammary tumor virus (MMTV) is a hormonally regulated, oncogenic virus of mice. MMTV-like virus DNA has previously been detected in human breast cancers, liver disease, and liver cancers. It is hypothesized that local hormonal effects might be of primary importance in determining MMTV-like virus detection in huma...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21754

    authors: Johal H,Faedo M,Faltas J,Lau A,Mousina R,Cozzi P,Defazio A,Rawlinson WD

    更新日期:2010-05-01 00:00:00

  • Absence of HTLV I from New Zealand.

    abstract::Sera from 1,943 individuals from Auckland, New Zealand, were tested for the presence of serum antibodies to human T cell lymphotropic virus I (HTLV I), mainly with an enzyme-linked immunosorbent assay (ELISA) with cell extracts as target antigen. The individuals tested were blood donors and mostly Caucasian, but inclu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890220410

    authors: Reddy D,Okochi K,Woodfield DG,Judd W

    更新日期:1987-08-01 00:00:00

  • Hepatitis E viral infection regulates estrogen signaling pathways: Inhibition of the cAMPK-PKA-CREB and PI3K-AKT-mTOR signaling pathways.

    abstract::Hepatitis E virus (HEV) infection has become a global concern with high mortality rates among pregnant women, especially those in their third trimester of pregnancy. Estrogen plays an important role in mediating the body, regulating physiological and pathological processes. Estrogen is activated by binding to estrogen...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26641

    authors: Gong S,Hao X,Bi Y,Yang C,Wang W,Mickael HK,Zhang Y,Chen S,Qian Z,Huang F,Wei D,Yu W

    更新日期:2020-10-31 00:00:00

  • Pet veterinarians have no increased risk of hepatitis E compared to the general population.

    abstract::The discovery of autochthonous hepatitis E in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis E virus (HEV) circulation. In these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for HEV. More...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23927

    authors: Mesquita JR,Valente-Gomes G,Conceição-Neto N,Nascimento MS

    更新日期:2014-06-01 00:00:00

  • Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways.

    abstract::Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20896

    authors: Ding L,Li L,Yang J,Zhou S,Li W,Tang M,Shi Y,Yi W,Cao Y

    更新日期:2007-08-01 00:00:00

  • Evidence of intrafamilial transmission of rotavirus in a birth cohort in South India.

    abstract::Transmission of rotavirus infection was studied in a birth cohort of children based in an urban slum in Vellore and their familial contacts. Contemporaneous samples from index patients and their familial contacts were collected for analysis in three different settings. Firstly, samples were collected from familial con...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21263

    authors: Banerjee I,Primrose Gladstone B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

    更新日期:2008-10-01 00:00:00

  • Profile of pre-S deletions in the natural history of chronic hepatitis B infection.

    abstract::It have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21901

    authors: Yeung P,Wong DK,Lai CL,Fung J,Seto WK,Yuen MF

    更新日期:2010-11-01 00:00:00

  • Detection of human cytomegalovirus early and late antigen and DNA production in cell culture and the effects of dimethyl sulfoxide, dexamethasone, and DNA inhibitors on early antigen induction.

    abstract::Recently a conventional method for the laboratory diagnosis of human cytomegalovirus (HCMV) infection was improved by using centrifugation culture to enhance viral adsorption and by detecting HCMV early antigen and DNA. Comparison of the sensitivity of three rapid methods using commercial diagnostic reagents for the d...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890300204

    authors: Li SB,Fong CK

    更新日期:1990-02-01 00:00:00

  • Polymerase chain reaction assay for hepatitis C virus RNA using a single tube for reverse transcription and serial rounds of amplification with nested primer pairs.

    abstract::A procedure is described for the detection of hepatitis C virus (HCV) RNA in blood by means of the polymerase chain reaction (PCR) in which the reverse transcription step and two rounds of amplification are carried out in a single tube. This results in fewer manipulations, reduced risk of contamination, and economy of...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380312

    authors: Lin HJ,Shi N,Mizokami M,Hollinger FB

    更新日期:1992-11-01 00:00:00

  • Co-circulation in a single biome of the Juquitiba and Araraquara hantavirus detected in human sera in a sub-tropical region of Brazil.

    abstract::Hantaviruses is an emerging infectious disease. Although HCPS has been reported in several regions of Brazil, more cases of HCPS have recently been reported in Minas Gerais than in any other state. In 2009, we analyzed 27 samples presenting antibodies against hantaviruses. These samples originated from 688 symptomatic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24118

    authors: de Araujo J,Duré AI,Negrão R,Ometto T,Thomazelli LM,Durigon EL

    更新日期:2015-05-01 00:00:00

  • Long term response to interferon treatment in chronic hepatitis C patients is associated with a significant reduction in anti-E1 envelope antibody titers.

    abstract::Interferon (IFN) alfa has been used widely for the treatment of chronic hepatitis C virus (HCV) infections but only a small number of patients treated have shown a sustained biochemical and virological response. Anti-envelope E1 and E2 antibody titers were assessed retrospectively before, during, and after treatment w...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Depraetere S,Van Kerschaever E,Van Vlierberghe H,Elewaut A,Brouwer JT,Niesters HG,Schalm SW,Maertens G,Leroux-Roels G

    更新日期:2000-02-01 00:00:00

  • Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients.

    abstract::Deletions and insertions in the hepatitis B virus (HBV) X region have been associated with severe forms of liver disease, including hepatocellular carcinoma (HCC). However, the molecular epidemiologic features of this virus have been described rarely. Deletions and insertions in the X region were determined by direct ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21938

    authors: Lee SA,Mun HS,Kim H,Lee HK,Kim BJ,Hwang ES,Kook YH,Kim BJ

    更新日期:2011-01-01 00:00:00