Molecular epidemiology of HIV-1 among the HIV infected people of Manipur, Northeastern India: Emergence of unique recombinant forms.

Abstract:

:According to the Joint National Programme on HIV/AIDS (UNAIDS), the northeastern region of India has the highest HIV prevalence in the country. This study was conducted to determine the current HIV-1 molecular epidemiology of Manipur, a state in northeast India. Blood samples from HIV-1 seropositive subjects were collected between June 2011 and February 2014. The partial regions of HIV-1 genes; pol and tat-vpu-env were independently amplified, sequenced, analyzed, and genotyped. Based on all sequences generated from 110 samples using pol and/or tat-vpu-env gene, the overall HIV-1 genotypes distribution of Manipur was as follows: 65.45% (72/110) subtype C, 32.73% (36/110) unique recombinant forms (URFs), and 1.82% (2/110) subtype B. The distribution of HIV-1 genotypes among the risk groups was: heterosexual: 58.33% (35/60) subtype C, 38.33% (23/60) URFs, and 3.34% (2/60) subtype B; intravenous drug users (IDUs): 85.36% (35/41) subtype C, 9.76% (4/41) URFs, and 4.88% (2/41) subtype B; mother to child (MTC): 50% (3/6) URFs and 50% (3/6) subtype C and blood transfusion: 100% (3/3) subtype C. The findings for the first time revealed the emergence of URFs of HIV-1 in Manipur which is predominant among the sexual and MTC risk groups as compared to IDUs. Taking together, this study illustrated that Manipur is the "recombinant hotspot of HIV" of India. The results will provide the clinical importance for continuous monitoring of HIV-infections in order to design appropriate prevention measures to limit the spread of new HIV infections.

journal_name

J Med Virol

authors

Sharma AL,Singh TR,Devi KR,Singh LS

doi

10.1002/jmv.24738

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

989-999

issue

6

eissn

0146-6615

issn

1096-9071

journal_volume

89

pub_type

杂志文章
  • Human cytomegalovirus envelope glycoprotein B, H, and N polymorphisms among infants of Shanghai area in China.

    abstract::Human cytomegalovirus (HCMV) is the leading cause of congenital infection and an opportunistic pathogen capable of establishing lifelong latency. In the present study, we aimed to investigate the distribution of glycoprotein B, H, and N in infants of Shanghai and correlate the genotype with active and latent HCMV infe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26210

    authors: Dong N,Cao L,Su L,Lu L,Dong Z,Xu M,Xu J

    更新日期:2020-06-21 00:00:00

  • Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore.

    abstract::During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10393

    authors: Lim CS,Chan KP,Goh KT,Chow VT

    更新日期:2003-06-01 00:00:00

  • Human papillomavirus infection among women with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test.

    abstract::Limited data are available describing human papillomavirus (HPV) genotype distribution among females with cytological abnormalities in Switzerland. Cervical cell specimens obtained from 5,318 women were screened routinely by liquid-based Pap smear. All specimens with cellular abnormalities were analyzed subsequently f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22126

    authors: Dobec M,Bannwart F,Kilgus S,Kaeppeli F,Cassinotti P

    更新日期:2011-08-01 00:00:00

  • Recombinant Newcastle Disease virus capsids displaying enterovirus 71 VP1 fragment induce a strong immune response in rabbits.

    abstract::The complete VP1 protein of EV71 was truncated into six segments and fused to the C-terminal ends of full-length nucleocapsid protein (NPfl) and truncated NP (NPt; lacks 20% amino acid residues from its C-terminal end) of newcastle disease virus (NDV). Western blot analysis using anti-VP1 rabbit serum showed that the ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20668

    authors: Sivasamugham LA,Cardosa MJ,Tan WS,Yusoff K

    更新日期:2006-08-01 00:00:00

  • Molecular epidemiology of human bocavirus infection in hospitalized children with acute gastroenteritis in South Africa, 2009-2015.

    abstract::Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated with AGE in South Africa (SA). Between April 2009 and April 2015, 3765 stool specimens were colle...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25634

    authors: Netshikweta R,Chidamba L,Nadan S,Taylor MB,Page NA

    更新日期:2020-08-01 00:00:00

  • Prevalence and types of drug-resistant variants in Chinese patients with acute hepatitis B.

    abstract::The presence of therapy-associated hepatitis B virus (HBV) variants is the main drawback of antiviral therapy for HBV infection. Moreover, drug-resistant variants are more insensitive to a second agent and more therapy-associated mutations will be present. To apply better nucleos(t)ide analogues (NA) and reduce the oc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24006

    authors: Su F,Dai J,Yang S,Jiang X,Cui X,Ning H,Li J,Huang M

    更新日期:2015-09-01 00:00:00

  • Comparison of characteristics between patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA and those with GBV-C/HGV E2-antibody in patients with hemophilia.

    abstract::We compared characteristics of patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA to those of patients with GBV-C/HGV E2-antibody. GBV-C/HGV RNA and GBV-C/HGV antibody were assayed in 83 persons with hemophilia using a reverse transcription-polymerase chain reaction and an enzyme-linked immunosorbent assay, re...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200001)60:1<34::aid-jmv6>3

    authors: Toyoda H,Takahashi I,Fukuda Y,Hayakawa T,Takamatsu J

    更新日期:2000-01-01 00:00:00

  • Infectivity titration of a prototype strain of hepatitis E virus in cynomolgus monkeys.

    abstract::The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430207

    authors: Tsarev SA,Tsareva TS,Emerson SU,Yarbough PO,Legters LJ,Moskal T,Purcell RH

    更新日期:1994-06-01 00:00:00

  • Genetic variability of German hepatitis C virus isolates.

    abstract::Heterogeneity of hepatitis C viral (HCV) genomes of several isolates from different countries has been reported, but there is little information on HCV isolates for the Federal Republic of Germany. Therefore, the nucleotide (nt) and deduced amino acid (aa) sequences of interesting parts of the viral genome derived fro...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400407

    authors: Müller HM,Pfaff E,Goeser T,Theilmann L

    更新日期:1993-08-01 00:00:00

  • Non-A, Non-B hepatitis virus: identification of a core antigen-antibody system that cross reacts with hepatitis B core antigen and antibody.

    abstract::Using immunodiffusion, a major cross-reactivity had been previously demonstrated between hepatitis B(HBe/3 Ag) and the antigen reported in the serum on non A, non-B hepatitis patients, therefore redesignated NANBe Ag. By direct immunofluorescence a new antigen associated with, but distinct from, NANBe Ag has now been ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890080103

    authors: Trépo C,Vitvitski L,Hantz O

    更新日期:1981-01-01 00:00:00

  • Distribution of genital wart human papillomavirus genotypes in China: a multi-center study.

    abstract::Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts acro...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.23646

    authors: Chang L,Ci P,Shi J,Zhai K,Feng X,Colombara D,Wang W,Qiao Y,Chen W,Wu Y

    更新日期:2013-10-01 00:00:00

  • Response to antiviral treatment in patients infected with hepatitis B virus genotypes E-H.

    abstract::No data on antiviral response of HBV genotypes E-H are available so far although these HBV genotypes contribute significantly to the global HBV burden. Of 49 patients with HBV genotypes E-H, 23 received interferon (IFN)-alpha, 12 nucleos(t)ide analogues and 14 patients were untreated. HBV genotype was determined by di...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21588

    authors: Erhardt A,Göbel T,Ludwig A,Lau GK,Marcellin P,van Bömmel F,Heinzel-Pleines U,Adams O,Häussinger D

    更新日期:2009-10-01 00:00:00

  • Human platelet antigens polymorphisms; association to the development of liver fibrosis in patients with chronic hepatitis C.

    abstract::Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25423

    authors: Ghasemi A,Zadsar M,Shaiegan M,Samiei S,Namvar A,Rasouli M,Moosanejad M

    更新日期:2020-01-01 00:00:00

  • Current seroepidemiology of hepatitis D virus infection among hepatitis B surface antigen carriers of general and high-risk populations in Taiwan.

    abstract::In order to assess the current seroepidemiology of hepatitis D virus (HDV) infection in Taiwan where hepatitis B virus (HBV) is hyperendemic, a total of 756 voluntary blood donors, 641 prostitutes, 1,014 patients with sexually transmitted diseases (STDs), and 628 drug abusers were studied. Radioimmunoassays were used ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380205

    authors: Chen CJ,Tseng SF,Lu CF,Lin HC,You SL,Chen CS,Hwang SJ,Hsieh SF,Hsu ST

    更新日期:1992-10-01 00:00:00

  • Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells.

    abstract::Human herpesvirus 6 (HHV-6) and human immunodeficiency virus type 1 (HIV-1) may interact during transplacental transmission of HIV-1. The placental syncytiotrophoblast layer serves as the first line of defense of the fetus against viruses. Patterns of replication of HHV-6 variant A (HHV-6A) and HIV-1 were analyzed in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2194

    authors: Csoma E,Bácsi A,Liu X,Szabó J,Ebbesen P,Beck Z,Kónya J,Andirkó I,Nagy E,Tóth FD

    更新日期:2002-05-01 00:00:00

  • Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study.

    abstract::Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24279

    authors: Chu HY,Englund JA,Huang D,Scott E,Chan JD,Jain R,Pottinger PS,Lynch JB,Dellit TH,Jerome KR,Kuypers J

    更新日期:2015-12-01 00:00:00

  • Use of a generic polymerase chain reaction assay detecting human T-lymphotropic virus (HTLV) types I, II and divergent simian strains in the evaluation of individuals with indeterminate HTLV serology.

    abstract::In countries with a low prevalence of human T-lymphotropic virus (HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-ind...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Vandamme AM,Van Laethem K,Liu HF,Van Brussel M,Delaporte E,de Castro Costa CM,Fleischer C,Taylor G,Bertazzoni U,Desmyter J,Goubau P

    更新日期:1997-05-01 00:00:00

  • Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue.

    abstract::An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890330107

    authors: Kajino K,Ohta Y,Miyamura T,Saito I

    更新日期:1991-01-01 00:00:00

  • Rapid detection of varicella-zoster virus in clinical specimens using monoclonal antibodies on shell vials and smears.

    abstract::Monoclonal antibodies were used for detecting varicella-zoster virus (VZV) by immunofluorescence (IF) in clinical specimens inoculated on shell vial cultures. Vesicles of 74 patients with varicella or herpes zoster-like eruptions were tested by this method and by conventional cell culture. Further diagnostic tests wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890280102

    authors: Schirm J,Meulenberg JJ,Pastoor GW,van Voorst Vader PC,Schröder FP

    更新日期:1989-05-01 00:00:00

  • Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter.

    abstract::The S RNA genome segment of hantaviruses carried by Arvicolinae and Sigmodontinae rodents encodes the nucleocapsid (N) protein and has an overlapping (+1) open reading frame (ORF) for a putative nonstructural protein (NSs). The aim of this study was to determine whether the ORF is functional. A protein corresponding t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20948

    authors: Jääskeläinen KM,Kaukinen P,Minskaya ES,Plyusnina A,Vapalahti O,Elliott RM,Weber F,Vaheri A,Plyusnin A

    更新日期:2007-10-01 00:00:00

  • Immunogenicity of wild and attenuated varicella-zoster virus strains in rhesus monkeys.

    abstract::Thirty susceptible rhesus monkeys were inoculated with cell-free varicella-zoster virus strain OKA or strain KMcC. Both wild and attenuated strains were used. No clinical signs characteristic of human varicella were seen in any of the animals. Virus was not isolated from throat swabs, blood, or cerebrospinal fluid. An...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140403

    authors: Asano Y,Albrecht P,Behr DE,Neff BJ,Vickers JH,Rastogi SC

    更新日期:1984-01-01 00:00:00

  • A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg "a" determinant.

    abstract::The emergence of variants in the outer envelope proteins of hepatitis B virus (HBV) are found among individuals vaccinated against HBV and asymptomatic carriers of the infection. For example, children in The Gambia vaccinated against hepatitis B may show serological evidence of breakthrough infections, particularly if...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199908)58:4<346::aid-jmv5>

    authors: Karthigesu VD,Allison LM,Ferguson M,Howard CR

    更新日期:1999-08-01 00:00:00

  • Benefits of random-priming: exhaustive survey of a cDNA library from lung tissue of a SARS patient.

    abstract::The severe acute respiratory syndrome (SARS) leads to severe injury in the lungs with multiple factors, though the pathogenesis is still largely unclear. This paper describes the particular analyses of the transcriptome of human lung tissue that was infected by SARS-associated coronavirus (SARS-CoV). Random primers we...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22012

    authors: Wu H,Wang J,Deng R,Xing K,Xiong Y,Huang J,He X,Wang X

    更新日期:2011-04-01 00:00:00

  • Monoclonal antibody recognizing pre-S(2) epitope of hepatitis B virus: characterization of pre-S(2) epitope and anti-pre-S(2) antibody.

    abstract::A hybrid cell line producing monoclonal antibodies recognizing an epitope encoded by the pre-(S)2 region of hepatitis B virus (HBV) genome was obtained by fusion of mouse myeloma cells with lymphocytes from mice immunized with HBV. The monoclonal antibody Mo-F124 secreted from the hybrid line reacted with the pre-S(2)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200204

    authors: Budkowska A,Riottot MM,Dubreuil P,Lazizi Y,Brechot C,Sobczak E,Petit MA,Pillot J

    更新日期:1986-10-01 00:00:00

  • Expression and characterization of a soluble rubella virus E1 envelope protein.

    abstract::Individual specific antigenic rubella virus (RV) structural proteins are required for accurate serological diagnosis of acute and congenital rubella infections as well as rubella immune status. The RV envelope glycoprotein E1 is the major target antigen and plays an important role in viral-specific immune responses. T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440214

    authors: Seto NO,Gillam S

    更新日期:1994-10-01 00:00:00

  • Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period.

    abstract::In eight patients with biopsy-confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA-P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA-P activity fluctuated. No correlation was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>

    authors: Heijtink RA,van der Waart M,Weimar W,Schalm SW,Masurel N

    更新日期:1980-01-01 00:00:00

  • Serological studies of an enterically transmitted non-A, non-B hepatitis in Somalia.

    abstract::An outbreak of an acute sporadic viral hepatitis occurring at three villages in the lower Shebli region of southern Somalia was studied. Sera were examined for antibodies to hepatitis E virus (HEV) antigen by a recently developed enzyme-linked immunosorbent assay. The prevalence of anti-HEV ranged from 77.8% to 94.0% ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400309

    authors: Mushahwar IK,Dawson GJ,Bile KM,Magnius LO

    更新日期:1993-07-01 00:00:00

  • The diagnosis of SARS-CoV2 pneumonia: A review of laboratory and radiological testing results.

    abstract::The rapid emergence of coronavirus disease 2019 (COVID-19) has necessitated the implementation of diverse pandemic control strategies throughout the world. To effectively control the spread of this disease, it is essential that it be diagnosed at an early stage so that patients can be reliably quarantined such that di...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26081

    authors: Zheng Z,Yao Z,Wu K,Zheng J

    更新日期:2020-11-01 00:00:00

  • Prevalence of human parechoviruses in central nervous system infections in children: a retrospective study in Shanghai, China.

    abstract::Human parechoviruses (HPeV) are associated with central nervous system (CNS) infections and sepsis-like illnesses. However, data from China are not available. The aim of this study was to determine the prevalence, age, and seasonal distributions and genotypes of HPeV infections in children with CNS related disease in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23449

    authors: Zhong H,Lin Y,Su L,Cao L,Xu M,Xu J

    更新日期:2013-02-01 00:00:00

  • Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital.

    abstract::There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21819

    authors: Arden KE,Chang AB,Lambert SB,Nissen MD,Sloots TP,Mackay IM

    更新日期:2010-08-01 00:00:00