ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.

Abstract:

:It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently available. This study addresses the apparently reasonable hypothesis that variants of these genes may modulate viral infectivity, making some individuals more vulnerable than others. Through whole-exome sequencing, the frequency of exonic variants of the ACE2, TMPRSS2, and Furin genes was analyzed in relation to presence or absence of SARS-CoV-2 infection in a familial multiple sclerosis cohort including 120 individuals from Madrid. The ACE2 gene showed a low level of polymorphism, and none variant was significantly associated with SARS-CoV-2 infection. These variants have previously been detected in Italy. While TMPRSS2 is highly polymorphic, the variants found do not coincide with those described in other studies, with the exception of rs75603675, which may be associated with SARS-CoV-2 infection. The synonymous variants rs61735792 and rs61735794 showed a significant association with infection. Despite the limited number of patients with SARS-CoV-2 infection, some variants, especially in TMPRSS2, may be associated with COVID-19.

journal_name

J Med Virol

authors

Torre-Fuentes L,Matías-Guiu J,Hernández-Lorenzo L,Montero-Escribano P,Pytel V,Porta-Etessam J,Gómez-Pinedo U,Matías-Guiu JA

doi

10.1002/jmv.26319

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

863-869

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

93

pub_type

杂志文章
  • Development of strategies for screening, predicting, and diagnosing intrauterine HBV infection in infants born to HBsAg positive mothers.

    abstract::This study aimed at developing strategies for screening, predicting, and diagnosing intrauterine HBV infection in infants born to HBsAg positive mothers. A total of 1,360 infants born to 1,355 HBsAg positive mothers were followed for 1 year. All newborn infants received active and passive immunization within 24 hr aft...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23667

    authors: Yin YZ,Zhang J,Wu LL,Zhou J,Zhang PZ,Zhou SS

    更新日期:2013-10-01 00:00:00

  • Seroprevalence of six different viruses among pregnant women and blood donors in rural and urban Burkina Faso: A comparative analysis.

    abstract::A seroprevalence study was carried out of six different human pathogenic viruses, namely human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell leukemia virus (HTLV), human herpesvirus type 8 (HHV-8), and dengue virus among pregnant women and blood donors from rural (Nouna) ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20593

    authors: Collenberg E,Ouedraogo T,Ganamé J,Fickenscher H,Kynast-Wolf G,Becher H,Kouyaté B,Kräusslich HG,Sangaré L,Tebit DM

    更新日期:2006-05-01 00:00:00

  • Human platelet antigens polymorphisms; association to the development of liver fibrosis in patients with chronic hepatitis C.

    abstract::Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25423

    authors: Ghasemi A,Zadsar M,Shaiegan M,Samiei S,Namvar A,Rasouli M,Moosanejad M

    更新日期:2020-01-01 00:00:00

  • No evidence of Polyomavirus and EBV infections in Italian patients with mixed cryoglobulinemia infected chronically with HCV.

    abstract::Mixed cryoglobulinemia is a lymphoproliferative disorder associated with hepatitis C virus (HCV). In patients chronically affected by HCV the prevalence of mixed cryoglobulinemia is variable ranging from 0% to 56%. To verify whether polyomaviruses (PyV) play a role in this disorder a total of 222 blood samples from 63...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23867

    authors: Comar M,Zanotta N,Del Savio R,Vascotto F,Calabrese N,Zorat F,Pozzato G

    更新日期:2014-04-01 00:00:00

  • Interferon-alpha therapy for chronic hepatitis B: early response related to pre-treatment changes in viral replication.

    abstract::Chronic hepatitis B patients with low pre-treatment HBeAg (and HBV-DNA) levels are more likely to respond to interferon-alpha therapy. In retrospect, this low level of HBeAg may have been reached just before the start of therapy. Pre-treatment changes in HBeAg levels were studied in 121 patients undergoing interferon-...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Heijtink RA,Janssen HL,Hop WC,Osterhaus AD,Schalm SW

    更新日期:2001-03-01 00:00:00

  • Norovirus infections and seroprevalence of genotype GII.4-specific antibodies in a Spanish population.

    abstract::Genotype II.4 noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis in children and adults worldwide. The prevalence of different NoV genotypes causing outbreaks and sporadic cases of acute gastroenteritis in the region of Valencia, Spain, during a 4-year period (2008-11) was investigated. NoVs were...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24112

    authors: Carmona-Vicente N,Fernández-Jiménez M,Ribes JM,Téllez-Castillo CJ,Khodayar-Pardo P,Rodríguez-Diaz J,Buesa J

    更新日期:2015-04-01 00:00:00

  • Acute viral hepatitis types E, A, and B singly and in combination in acute liver failure in children in north India.

    abstract::The aetiological agents responsible for, and the outcome of, acute liver failure were investigated prospectively in 44 children (29 males, 15 females) attending a tertiary health care facility in India. The children were between the ages of 2 months and 13 years. Studies for viral infections and other etiologies could...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199603)48:3<215::AID-JMV1>

    authors: Arora NK,Nanda SK,Gulati S,Ansari IH,Chawla MK,Gupta SD,Panda SK

    更新日期:1996-03-01 00:00:00

  • Comparison of the hypervariable region of hepatitis C virus genomes in plasma and liver.

    abstract::Nucleotide sequences of the hypervariable region of hepatitis C virus genomes obtained from plasma change rapidly during the course of infection and are believed to play a part in immunological escape and consequently in the development of persistent infection. It is not known, however, whether these changes also occu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460103

    authors: Sakamoto N,Enomoto N,Kurosaki M,Asahina Y,Maekawa S,Koizumi K,Sakuma I,Murakami T,Marumo F,Sato C

    更新日期:1995-05-01 00:00:00

  • Polymerase chain reaction assay for hepatitis C virus RNA using a single tube for reverse transcription and serial rounds of amplification with nested primer pairs.

    abstract::A procedure is described for the detection of hepatitis C virus (HCV) RNA in blood by means of the polymerase chain reaction (PCR) in which the reverse transcription step and two rounds of amplification are carried out in a single tube. This results in fewer manipulations, reduced risk of contamination, and economy of...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380312

    authors: Lin HJ,Shi N,Mizokami M,Hollinger FB

    更新日期:1992-11-01 00:00:00

  • Four putative subtypes of human parvovirus B19 based on amino acid polymorphism in the C-terminal region of non-structural protein.

    abstract::The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509-4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorph...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200009)62:1<60::aid-jmv10>3.0.co

    authors: Fukada K,Matumoto K,Takakura F,Yamaki M,Sato H,Okochi K,Maeda Y

    更新日期:2000-09-01 00:00:00

  • Genotypic and phenotypic analysis of the env gene from South African HIV-1 subtype B and C isolates.

    abstract::The objective of the study was to assess the genotypic and phenotypic properties of 18 viral strains from human immunodeficiency virus-1 (HIV-1) positive patients and to identify subtype C isolates for vaccine design strategies. All the isolates were non-syncytium-inducing (NSI) in both the primary and MT-2 cell cultu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10199

    authors: Treurnicht FK,Smith TL,Engelbrecht S,Claassen M,Robson BA,Zeier M,van Rensburg EJ

    更新日期:2002-10-01 00:00:00

  • Emergence of G3 and G9 rotavirus and increased incidence of mixed infections in the southern region of Ireland 2001-2004.

    abstract::Two hundred and thirty fecal specimens were collected from children (up to 5 years of age) admitted with suspected rotaviral gastroenteritis at four Irish hospitals (Cork University Hospital, Mercy Hospital, Cork, Waterford Regional Hospital, and Kerry General Hospital) in the southern region of Ireland, between 2001 ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20494

    authors: Reidy N,O'Halloran F,Fanning S,Cryan B,O'Shea H

    更新日期:2005-12-01 00:00:00

  • Molecular epidemiology of hepatitis A in St. Petersburg, Russia, 1997-2003.

    abstract::The molecular epidemiology of hepatitis A virus (HAV) strains circulating in the St. Petersburg and Karelia regions was studied during 1997-2003. Hepatitis A virus RNA was isolated from both clinical samples (stools or sera) and environmental samples (sewage water). RT-PCR was carried out using different primer pairs ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20843

    authors: Davidkin I,Zheleznova N,Jokinen S,Gorchakova O,Broman M,Mukomolov S

    更新日期:2007-06-01 00:00:00

  • Treatment with cytotoxic immunosuppression agents increases urinary excretion of JCV in patients with autoimmune disease.

    abstract::Human JC virus is ubiquitous in human populations and is reactivated frequently in immunosuppressed patients. Fifty-one patients with autoimmune disease receiving immunomodulating therapy were evaluated to study the possible relationship between immunosuppression and JCV viruria. Patients were divided into cytotoxic a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200012)62:4<505::aid-jmv16>3.0.c

    authors: Wang M,Tsai RT,Ou WC,Lin CK,Tsay GJ,Chang H,Chang D

    更新日期:2000-12-01 00:00:00

  • Significance of postnatal mother-to-child transmission of human T-lymphotropic virus type-I on the development of adult T-cell leukemia/lymphoma.

    abstract::In order to shed light on the mode of HTLV-I infection by mother-to-child transmission, we examined sera of school children in a highly endemic town on two separate occasions at a 6-year interval. The carrier rates in ages 15-17, 8.7 and 2.1%, were significantly higher than that in ages 6-8, 1.7 and 0.4%, in studies. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200307

    authors: Sugiyama H,Doi H,Yamaguchi K,Tsuji Y,Miyamoto T,Hino S

    更新日期:1986-11-01 00:00:00

  • Congenital and perinatal infection with Junin virus in guinea pigs.

    abstract::Junin virus infection in guinea pigs is known to be similar to human Argentine hemorrhagic fever (AHF). The guinea pig was chosen as a model for transplacental transmission of Junin virus, as both guinea pig and man have a similar placental structure. Pregnant guinea pigs were infected with the pathogenic XJ strain of...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890110210

    authors: Sangiorgio P,Weissenbacher MC

    更新日期:1983-01-01 00:00:00

  • Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge.

    abstract::Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within the context of certain flanking bases (CpG motifs) have been shown to induce potent innate and adaptive immune responses. Vaginal delivery of CpG ODN alone protects mice from vaginal herpes simplex virus type-2 (HSV-2) challenge. He...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10518

    authors: Sajic D,Ashkar AA,Patrick AJ,McCluskie MJ,Davis HL,Levine KL,Holl R,Rosenthal KL

    更新日期:2003-12-01 00:00:00

  • Role of Calomys musculinus peritoneal macrophages in age-related resistance to Junin virus infection.

    abstract::In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890180311

    authors: Coulombié FC,Alché LE,Lampuri JS,Coto CE

    更新日期:1986-03-01 00:00:00

  • Prevalence of CMV antibodies among women of childbearing age in different social environments in southern Israel.

    abstract::The prevalence rate of IgG antibodies to cytomegalovirus (CMV) was determined in a sample of 567 women of childbearing age in the southern part of Israel by the immunoperoxidase assay to membrane antigen (IPAMA) technique. Urban Jewish women of Afro-Asian origin showed significantly higher rates of seropositivity than...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890240104

    authors: Urkin J,Sarov B,Naggan L,Haikin H,Sarov I

    更新日期:1988-01-01 00:00:00

  • Epidemiology of 11 respiratory RNA viruses in a cohort of hospitalized children in Riyadh, Saudi Arabia.

    abstract::Respiratory tract infections are a principal cause of illness and mortality in children worldwide and mostly caused by viruses. In this study, the epidemiology of 11 respiratory RNA viruses was investigated in a cohort of hospitalized children at a tertiary referral center in Riyadh from February 2008 to March 2009 us...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24435

    authors: Amer HM,Alshaman MS,Farrag MA,Hamad ME,Alsaadi MM,Almajhdi FN

    更新日期:2016-06-01 00:00:00

  • Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period.

    abstract::In eight patients with biopsy-confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA-P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA-P activity fluctuated. No correlation was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>

    authors: Heijtink RA,van der Waart M,Weimar W,Schalm SW,Masurel N

    更新日期:1980-01-01 00:00:00

  • Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010.

    abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23436

    authors: Than VT,Kang H,Lim I,Kim W

    更新日期:2013-01-01 00:00:00

  • Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.

    abstract::Increased expression of inducible nitric oxide synthase (iNOS) has been found in inflammatory myocardial disease and increased production of nitric oxide (NO) has both an inhibitory effect on virus replication and a cytotoxic effect on host cells. To investigate the relationship between severity of enteroviral myocard...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1033

    authors: Bevan AL,Zhang H,Li Y,Archard LC

    更新日期:2001-06-01 00:00:00

  • Allele-specific conventional reverse-transcription polymerase chain reaction as a screening assay for discriminating influenza a H1N1 (H275Y) oseltamivir-resistant and wild-type viruses.

    abstract::In early 2008, a sudden increase in oseltamivir (Tamiflu)-resistant influenza A H1N1 viruses was reported from several European countries. This resistant virus has spread globally and accounted for more than 95% of H1N1 viruses isolated in the following influenza season. A continuous close monitoring on the prevalence...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21783

    authors: Ngai KL,Lam WY,Lee N,Leung TF,Hui DS,Chan PK

    更新日期:2010-08-01 00:00:00

  • Typing of human papillomaviruses in condylomata acuminata from Greece.

    abstract::DNA samples from recurrent condylomata acuminata biopsies of Greek males and females were examined for the presence of human papillomavirus (HPV) DNA using high-stringency Southern blot hybridization analysis. Of the twenty-six biopsies, 25 were positive for the HPV 6/11-related DNA sequences, and when further analyze...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420311

    authors: Labropoulou V,Balamotis A,Tosca A,Rotola A,Mavromara-Nazos P

    更新日期:1994-03-01 00:00:00

  • Development and validation of a new serum standard for the measurement of anti-HEV antibodies in animals.

    abstract::Although hepatitis E virus (HEV) infection is a zoonosis, there is, currently, no standardized assay for quantitatively measuring anti-HEV antibody levels in HEV animal reservoirs. In this study, anti-HEV antibody positive serum from a rabbit (RS26) was calibrated by dose-response parallel line assay using the World H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24651

    authors: Zhang Y,Wang L,Zeng H,Gong W,Wang L,Zhuang H

    更新日期:2017-03-01 00:00:00

  • HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan.

    abstract::Few studies have examined the etiology of hepatocellular carcinoma (HCC) in patients without hepatitis virus infection. We evaluated the role of occult hepatitis B virus (HBV) infection in the development of HCC in Japanese patients without hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C antigen (ant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10514

    authors: Tamori A,Nishiguchi S,Kubo S,Narimatsu T,Habu D,Takeda T,Hirohashi K,Shiomi S

    更新日期:2003-12-01 00:00:00

  • Effects of drug resistance on viral load in patients failing antiretroviral therapy.

    abstract::Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect. In this study, w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20582

    authors: Machouf N,Thomas R,Nguyen VK,Trottier B,Boulassel MR,Wainberg MA,Routy JP

    更新日期:2006-05-01 00:00:00

  • Genetic characterization of measles viruses that circulated in Thailand from 1998 to 2008.

    abstract::During the period between 1998 and 2008, 48 representative measles viruses (MeVs) circulating in Thailand were subjected to genetic characterization. Three genotypes, G2, D5, and D9 were detected. The results suggested that measles genotype D5, which has been circulating since at least 1998, is the endemic genotype in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23249

    authors: Pattamadilok S,Incomserb P,Primsirikunawut A,Lukebua A,Rota PA,Sawanpanyalert P

    更新日期:2012-05-01 00:00:00

  • Genetic variability of German hepatitis C virus isolates.

    abstract::Heterogeneity of hepatitis C viral (HCV) genomes of several isolates from different countries has been reported, but there is little information on HCV isolates for the Federal Republic of Germany. Therefore, the nucleotide (nt) and deduced amino acid (aa) sequences of interesting parts of the viral genome derived fro...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400407

    authors: Müller HM,Pfaff E,Goeser T,Theilmann L

    更新日期:1993-08-01 00:00:00