Abstract:
:Respiratory viruses were identified by the polymerase chain reaction (PCR) in more than 4,200 specimens collected during 2002 and 2003 in Victoria, Australia from patients admitted to hospitals or participating in an influenza surveillance program. Influenza viruses and picornaviruses were important causes of morbidity in both years. Additional testing of picornavirus-positive samples suggested that rhinoviruses but not enteroviruses were more likely to be associated with respiratory symptoms, irrespective of the season in which they circulated. Detection of influenza viruses was strongly associated with the clinical symptoms of cough, fever, and fatigue; but each of the other respiratory viruses occasionally caused these symptoms or was responsible for symptoms severe enough to require hospitalization. Human coronaviruses HCoV-OC43 and HCoV-229E circulated at low levels throughout the study period with peak activity in winter, but overall did not circulate as widely as has often been reported for these agents. Evidence for the human metapneumovirus (hMPV) was only sought in the second year of the study and revealed low-level circulation of this virus, mainly in the cooler months among the very young and adult populations. The detection rate of all viruses declined with increasing age of the patient, particularly in hospital patients. Infection with more than one respiratory virus occurred in a small number of patients; picornaviruses were most commonly implicated in these dual infections.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Druce J,Tran T,Kelly H,Kaye M,Chibo D,Kostecki R,Amiri A,Catton M,Birch Cdoi
10.1002/jmv.20246keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
122-9issue
1eissn
0146-6615issn
1096-9071journal_volume
75pub_type
杂志文章abstract::Distinct human papillomavirus (HPV) 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional variants of HPV 18 would be of great importance for evolutionary, epidemiological, and biological analysis. In this regard, the sequence variations of E6 gene we...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26283
更新日期:2020-07-09 00:00:00
abstract::HCV strains belonging to genotype 4 may be gaining endemicity across Continental Europe but the extent of their spread in the United Kingdom is unknown. Sera referred from patients attending hospitals in England between 2004 through 2008 were characterised. A total of 243 sera carried HCV genotype 4. The most common s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24069
更新日期:2015-03-01 00:00:00
abstract::Human metapneumovirus (hMPV) has been described as circulating among the Uruguayan population at least since 1998 based on serologic evidence. However, no isolation attempts, molecular detection, or genetic studies have been carried out so far in the country. In the present study, molecular detection of circulating hM...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21752
更新日期:2010-05-01 00:00:00
abstract::Palatine tonsils have been observed to harbor several distinct respiratory and herpesviruses in separate studies. In this study, the presence of these viruses in palatine tonsils was comprehensively studied in both children and adults. A cross-sectional analysis of 181 patients (median age 22 years; range, 2.6-66) ope...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26245
更新日期:2020-06-30 00:00:00
abstract::Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated with AGE in South Africa (SA). Between April 2009 and April 2015, 3765 stool specimens were colle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25634
更新日期:2020-08-01 00:00:00
abstract::Deletions and insertions in the hepatitis B virus (HBV) X region have been associated with severe forms of liver disease, including hepatocellular carcinoma (HCC). However, the molecular epidemiologic features of this virus have been described rarely. Deletions and insertions in the X region were determined by direct ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21938
更新日期:2011-01-01 00:00:00
abstract::The Balkan Peninsula and Bulgaria in particular, is a well-known endemic region for Crimean-Congo hemorrhagic fever (CCHF). This study describes the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) among tick populations from areas, previously recognized with emerging cases of CCHF disease in humans. These ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23214
更新日期:2012-04-01 00:00:00
abstract::Herpes simplex virus can be quantitatively recovered from vaginal tampons suspended in tissue culture medium and stored over a wide range of temperatures. Because herpes simplex virus is stable for several days with refrigeration or after freezing, this method of culture of cervicovaginal virus lends itself to epidemi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890030306
更新日期:1979-01-01 00:00:00
abstract::Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatia...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25395
更新日期:2019-06-01 00:00:00
abstract::During 2002, several epidemics of aseptic meningitis were attributed to echovirus 13 in Korea. The causative agents of these outbreaks were isolated and identified using rhabdosarcoma cells, HEp-2 and Buffalo green monkey kidney cells, and a neutralization test using monospecific antiserum. Fifty-four echovirus 13 iso...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10543
更新日期:2004-07-01 00:00:00
abstract::We developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression. An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequences and used to gene...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::To define better the human immune response to individual structural proteins of human cytomegalovirus (HCMV), 55 human sera with different IgG and IgM titres were studied for their reactivity with HCMV structural polypeptides separated by SDS-PAGE and electrotransferred to nitrocellulose paper. The results obtained sh...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170403
更新日期:1985-12-01 00:00:00
abstract::The relationships between host immune factors and HIV-1 disease progression are still in dispute. The RANTES SNPs exhibit distinct ethnic distribution and are associated with different effects on the course of HIV infection. Therefore, impact of RANTES gene polymorphism on HIV-1 transmission and progression needs to b...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21201
更新日期:2008-07-01 00:00:00
abstract::Little is known on the association between clinical factors and coronavirus disease 2019 (COVID-19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26601
更新日期:2020-10-15 00:00:00
abstract::Epstein-Barr virus is present in the saliva of most persistently infected individuals and is generally thought to be spread by close oral contact. However, there are now several reports of EBV in genital secretions, suggesting the possibility of sexual transmission between adults. The present study was undertaken to i...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.20682
更新日期:2006-09-01 00:00:00
abstract::In order to assess the current seroepidemiology of hepatitis D virus (HDV) infection in Taiwan where hepatitis B virus (HBV) is hyperendemic, a total of 756 voluntary blood donors, 641 prostitutes, 1,014 patients with sexually transmitted diseases (STDs), and 628 drug abusers were studied. Radioimmunoassays were used ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380205
更新日期:1992-10-01 00:00:00
abstract::Previously, it was reported that productive viral infection, viral protein synthesis, and viral RNA replication of respiratory syncytial virus (RSV) operated efficiently in two human epithelial cell lines (HEp-2 and A549), but not in a human mast-cell line, HMC-1. Based on these observations, it was hypothesized that ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23196
更新日期:2012-02-01 00:00:00
abstract::The efficacy of interferon (IFN) monotherapy for non-responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who received low-dose intermittent IFN-...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21224
更新日期:2008-08-01 00:00:00
abstract::Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24844
更新日期:2017-10-01 00:00:00
abstract::To determine the influence of ageing per se as well as of priming histories on the antibody response to influenza vaccination, haemagglutination inhibition (HI), ELISA IgG, IgA, IgM and neutralizing antibody titres were studied in 43 healthy young subjects (mean age 23 years) and 55 healthy elderly people (mean age 79...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199805)55:1<82::aid-jmv13>
更新日期:1998-05-01 00:00:00
abstract::JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Cz...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23841
更新日期:2014-09-01 00:00:00
abstract::Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in immunocompromised patients, such as renal transplant recipients. Analysis of the gene encoding the envelope glycoprotein B (gB) showed that clinical isolates adopted one of the sequence configurations, permitting the isolates to be assigned a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10383
更新日期:2003-06-01 00:00:00
abstract::Plenty of serologic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed so far, thus documenting the importance of evaluating the relevant features of the immune response to this viral agent. The performance of these assays is currently under investigation. Amongst them, LIAISON®...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26605
更新日期:2020-10-16 00:00:00
abstract::Increased expression of inducible nitric oxide synthase (iNOS) has been found in inflammatory myocardial disease and increased production of nitric oxide (NO) has both an inhibitory effect on virus replication and a cytotoxic effect on host cells. To investigate the relationship between severity of enteroviral myocard...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1033
更新日期:2001-06-01 00:00:00
abstract::Human herpesvirus 6 (HHV-6) is classified as two distinct species: HHV-6A and B. HHV-6B infection can cause several clinical manifestations in transplant recipients including encephalitis, bone marrow suppression, and pneumonitis. In contrast to HHV-6B, the clinical features of HHV-6A infection remain largely undefine...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24513
更新日期:2016-09-01 00:00:00
abstract::Human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) are both retroviruses with similar routes of transmission. A number of reports suggest variable clinical outcomes in HIV and HTLV co-infected individuals. There is no published information regarding the prevalence of HIV and HTLV co-infectio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20336
更新日期:2005-06-01 00:00:00
abstract::There is an obvious concern globally regarding the fact about the emerging coronavirus 2019 novel coronavirus (2019-nCoV) as a worldwide public health threat. As the outbreak of COVID-19 causes by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progresses within China and beyond, rapidly available epi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25743
更新日期:2020-06-01 00:00:00
abstract::An attempt was made to identify factors influencing the cumulative probability of an increased alanine aminotransferase (ALT) level and hepatocarcinogenesis in hepatitis C patients with a normal ALT level initially. A total of 398 consecutive patients with a normal ALT level initially for 6 months or more and follow-u...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21342
更新日期:2009-03-01 00:00:00
abstract::In order to assess the efficacy of interferon-alpha on hepatitis C viral RNA in patients with chronic hepatitis C, we analyzed the levels of HCV RNA in sera and liver tissues of 16 patients pre- and posttreatment using a semiquantitative polymerase chain reaction method. Fifteen of 16 patients were positive for anti-H...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/jmv.1890400114
更新日期:1993-05-01 00:00:00
abstract::Flow cytometric analysis of CD4(+) and CD8(+) T cells specific to human cytomegalovirus (CMV) was undertaken in seven patients with congenital CMV infection, six healthy infants who had acquired infection, and six CMV-seropositive adults. Intracellular cytokine assays showed that 0.03-2.23% of CD4(+) T cells in the he...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10477
更新日期:2003-10-01 00:00:00