Association of RANTES -403 G/A, -28 C/G and In1.1 T/C polymorphism with HIV-1 transmission and progression among North Indians.

Abstract:

:The relationships between host immune factors and HIV-1 disease progression are still in dispute. The RANTES SNPs exhibit distinct ethnic distribution and are associated with different effects on the course of HIV infection. Therefore, impact of RANTES gene polymorphism on HIV-1 transmission and progression needs to be evaluated. The RANTES genotypes were identified by PCR-RFLP method and confirmed by sequencing in HIV-1 seronegative (HSN; n=315), HIV-1 exposed seronegative (HES; n=47) and HIV-1 seropositive (HSP; n=196) patients classified into different clinical stages (i.e. Stages I, II, III). Fisher exact test was used for statistical analysis and Arlequin software for haplotype analysis. RANTES allele -403G, -28C and In1.1 T were the predominant allele in the subject studied. HSP group have higher frequency of RANTES In1.1 T allele compared with HSN (91.32% vs. 86.19%; P=0.013) and HES (91.32% vs. 78.72%; P=0.001). Higher frequency of RANTES In1.1 C allele in Stage III was observed, compared with Stage I (14.28% vs. 6.39%) and was significantly associated with high risk (P=0.047, OR=2.439, C.I.=1.061-5.609). Haplotype II (ACT) was significantly higher in HSP compared with HSN (9.69% vs. 1.58%) and associated with high risk (P<0.001, OR=6.655, C.I.=2.443-18.132). There were no significant differences in RANTES -403 A/G and -28 C/G genotype and allele distribution in all the groups compared. Our results implicate that RANTES In1.1 T allele and haplotype II (ACT) may be a risk factor for HIV-1 transmission while RANTES In1.1 C allele may be risk factor for disease progression among North Indians.

journal_name

J Med Virol

authors

Rathore A,Chatterjee A,Sivarama P,Yamamoto N,Singhal PK,Dhole TN

doi

10.1002/jmv.21201

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

1133-41

issue

7

eissn

0146-6615

issn

1096-9071

journal_volume

80

pub_type

杂志文章
  • Seroprevalence of hepatitis B virus infection in children in Taipei, 1989: five years after a mass hepatitis B vaccination program.

    abstract::A nationwide hepatitis B vaccination program was launched in Taiwan in 1984. To study the impact of this ongoing program on hepatitis B virus (HBV) infection, a follow-up seroepidemiologic study was carried out in 1989 in a Taipei district where pre-vaccination seroepidemiology had been studied. HBV markers were studi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890340205

    authors: Tsen YJ,Chang MH,Hsu HY,Lee CY,Sung JL,Chen DS

    更新日期:1991-06-01 00:00:00

  • First case of focal epilepsy associated with SARS-coronavirus-2.

    abstract::A healthy patient presented to Klinikum Altmühlfranken Weißenburg Hospital, Germany, with two morning attacks of painful muscle spasm in the left upper and lower limbs, without altered consciousness. Full examinations, radiological imaging, electroencephalography, lumbar puncture, and autoimmune profile were either no...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26113

    authors: Elgamasy S,Kamel MG,Ghozy S,Khalil A,Morra ME,Islam SMS

    更新日期:2020-10-01 00:00:00

  • Nested polymerase chain reaction for detection of human immunodeficiency virus type 1 DNA in clinical specimens.

    abstract::A highly sensitive two-step polymerase chain reaction (PCR) method was evaluated for detection of human immunodeficiency virus type 1 (HIV-1) DNA in clinical specimens. The product resulting from the first amplification reaction is used as the template for the second PCR with an internal (nested) primer pair. Even whe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380304

    authors: Zazzi M,Romano L,Brasini A,Valensin PE

    更新日期:1992-11-01 00:00:00

  • Increased replication of respiratory syncytial virus in the presence of cytokeratin 8 and 18.

    abstract::Previously, it was reported that productive viral infection, viral protein synthesis, and viral RNA replication of respiratory syncytial virus (RSV) operated efficiently in two human epithelial cell lines (HEp-2 and A549), but not in a human mast-cell line, HMC-1. Based on these observations, it was hypothesized that ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23196

    authors: Shirato K,Ujike M,Kawase M,Matsuyama S

    更新日期:2012-02-01 00:00:00

  • Prevalence and types of drug-resistant variants in Chinese patients with acute hepatitis B.

    abstract::The presence of therapy-associated hepatitis B virus (HBV) variants is the main drawback of antiviral therapy for HBV infection. Moreover, drug-resistant variants are more insensitive to a second agent and more therapy-associated mutations will be present. To apply better nucleos(t)ide analogues (NA) and reduce the oc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24006

    authors: Su F,Dai J,Yang S,Jiang X,Cui X,Ning H,Li J,Huang M

    更新日期:2015-09-01 00:00:00

  • Comparative efficacy, pharmacokinetic, pharmacodynamic activity, and interferon stimulated gene expression of different interferon formulations in HIV/HCV genotype-1 infected patients.

    abstract::The effect of different formulations of interferon on therapeutic response in patients coinfected with HIV and HCV is unclear. In this study, the safety, tolerability, viral kinetics (VK) modeling and host responses among HIV/HCV coinfected patients treated with pegylated-IFN or albinterferon alfa-2b (AlbIFN) with wei...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23773

    authors: Osinusi A,Bon D,Nelson A,Lee YJ,Poonia S,Shivakumar B,Cai SY,Wood B,Haagmans B,Lempicki R,Herrmann E,Sneller M,Polis M,Masur H,Kottilil S

    更新日期:2014-02-01 00:00:00

  • Expression of hepatitis B surface and core antigens and transforming growth factor-alpha in "oval cells" of the liver in patients with hepatocellular carcinoma.

    abstract::Recent studies have identified epithelial cell populations in human livers that are similar to the "oval cells" and "transitional cells" seen in rat livers during the early stages of chemical carcinogenesis. It has been suggested that these cells might be precursors of hepatocytes and theoretically could be involved i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430304

    authors: Hsia CC,Thorgeirsson SS,Tabor E

    更新日期:1994-07-01 00:00:00

  • Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.

    abstract::To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneous...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890450404

    authors: Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G

    更新日期:1995-04-01 00:00:00

  • Cell-mediated immunity in respiratory syncytial virus disease.

    abstract::Systemic cell-mediated responses to respiratory syncytial (RS) virus were detected, using a whole blood transformation assay, in 10 of 28 infants and children with RS virus infections during the period 1-14 days postadmission. Cell-mediated responses were unrelated to the age of the patient or the severity of illness....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130112

    authors: Scott R,Pullan CR,Scott M,McQuillin J

    更新日期:1984-01-01 00:00:00

  • Seroprevalence of anti-WNV IgG antibodies and WNV-RNA in Egyptian blood donors.

    abstract::Transmission of West Nile virus (WNV) from asymptomatic donors has been reported during blood transfusions and organ transplants in humans. In this work, we aimed to investigate the presence of WNV antibody and WNV RNA in blood donors to evaluate the sero-prevalence of WNV and risk for WNV transmission. One hundred an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24682

    authors: Youssef SR,Eissa DG,Abo-Shady RA,Aly Fouad NT,Kattab DK,Fathey H,Abdullaha Elewa AA,Reda DM

    更新日期:2017-08-01 00:00:00

  • Is there any relationship between Toll-like receptor 3 c.1377C/T and -7C/A polymorphisms and susceptibility to Crimean Congo hemorrhagic fever?

    abstract::Crimean-Congo hemorrhagic fever (CCHF) is an infectious disease that is caused by CCHF virus. A family of transmembrane receptors called as Toll-like receptors (TLRs) selectively acts in recognizing a wide range of microbial components and endogenous molecules released by damaged tissue and have been preserved through...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24519

    authors: Engin A,Arslan S,Özbilüm N,Bakir M

    更新日期:2016-10-01 00:00:00

  • Characterization of new epidemic strains of influenza B virus by using neutralizing monoclonal antibodies.

    abstract::During the 1998-1999 influenza season, two distinct influenza B virus Yamagata group strains were isolated from the patients of a private clinic. Each responded differently to monoclonal antibodies (Mabs) 5H4 and 8B3 on staining, and hemagglutination inhibition and neutralizing tests. When the analysis of nucleotide s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2099

    authors: Nakagawa N,Kubota R,Morikawa S,Nakagawa T,Baba K,Okuno Y

    更新日期:2001-12-01 00:00:00

  • LAP+ Treg is a better biomarker than total Treg in viral myocarditis.

    abstract::Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, whi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25378

    authors: Wang X,Ge J,Chen R

    更新日期:2019-05-01 00:00:00

  • Excretion of hepatitis A virus in the stools of hospitalized hepatitis patients.

    abstract::A study was carried out to determine whether hepatitis A virus (HAV) can be detected in the stools of patients hospitalized for HAV infection. Acute phase samples of whole blood and stool, as well as completed questionnaires, were obtained from 31 patients hospitalized at any of 13 hospitals in the Phoenix metropolita...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890090207

    authors: Carl M,Kantor RJ,Webster HM,Fields HA,Maynard JE

    更新日期:1982-01-01 00:00:00

  • Human papillomavirus genotypes and their association with cervical neoplasia in a cohort of Western Australian women.

    abstract::Human papillomavirus (HPV) is known to be the cause of almost all cervical cancers. The genotypes have been classified into high and low risk types according to their oncogenic potential. However, data for many of the genotypes are limited and some (HPV-26, 53, and 66) have no agreed status. A study was undertaken to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20330

    authors: Brestovac B,Harnett GB,Smith DW,Shellam GR,Frost FA

    更新日期:2005-05-01 00:00:00

  • Prevalence of the mutational pattern E44D/A and/or V118I in the reverse transcriptase (RT) gene of HIV-1 in relation to treatment with nucleoside analogue RT inhibitors.

    abstract::It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIV-1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation. The prevalence of this mutational pattern was studied in HIV-1 isolates obtained from 280 patients. These...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2145

    authors: Montes B,Segondy M

    更新日期:2002-03-01 00:00:00

  • The correlation of TNF alpha levels with the lipid profile of dengue patients.

    abstract::Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the Northwest of Mexico. We found statistically important diffe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25056

    authors: Osuna-Ramos JF,Rendón-Aguilar H,Reyes-Ruiz JM,Del Ángel RM,Romero-Utrilla A,Ríos-Burgueño ER,Velarde-Rodriguez I,Velarde-Félix JS

    更新日期:2018-06-01 00:00:00

  • Poliovirus serotype 2 and coxsackievirus A promote the natural recombination of poliovirus.

    abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25620

    authors: Qian Y,Pu X,Yu Y,Yu X,Kong L,Liu L,Wang H,Shen H

    更新日期:2020-03-01 00:00:00

  • Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes.

    abstract::This retrospective study investigated and characterized the YMDD motif of the hepatitis B virus (HBV) reverse transcriptase (RT) gene, in sequential samples of 17 South African patients with chronic hepatitis B infection on lamivudine treatment. The profile of HBV genotypes as well as the genetic variability of pre-co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21479

    authors: Selabe SG,Song E,Burnett RJ,Mphahlele MJ

    更新日期:2009-06-01 00:00:00

  • The use of human sewage screening for community surveillance of hepatitis E virus in the UK.

    abstract::Hepatitis E virus sequences were detected by RT-PCR in 14/15 (93%) of untreated sewage samples from Edinburgh, Scotland, UK. Phylogenetic analysis of amplicons at limiting dilution revealed the co-circulation of multiple variants of HEV-3, with a pattern of diversity matching that observed in a local cohort of HEV-inf...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24403

    authors: Smith DB,Paddy JO,Simmonds P

    更新日期:2016-05-01 00:00:00

  • Molecular characterization of group A rotavirus found in elderly patients in Ireland; predominance of G1P[8], continued presence of G9P[8], and emergence of G2P[4].

    abstract::Rotavirus is a major cause of gastroenteritis in young children worldwide. There have been several recent reports concerning rotavirus isolation from adults, particularly in the elderly, presenting with gastroenteritis. In this study, the authors report on rotavirus outbreaks in five separate elderly care facilities b...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23416

    authors: Gunn L,Feeney SA,Cashman O,Collins PJ,Coyle PV,O'Shea H

    更新日期:2012-12-01 00:00:00

  • Human papillomavirus DNA and anti-HPV secretory IgA antibodies in cytologically normal cervical specimens.

    abstract::Cervical specimens collected from 163 cytologically healthy women were screened for the presence of human papillomavirus (HPV) DNA and anti-HPV secretory IgA antibodies. HPV DNA was detected by a general primer mediated polymerase chain reaction (PCR), which amplifies a conserved region from the L1 ORF of genital HPVs...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430219

    authors: Veress G,Kónya J,Csiky-Mészáros T,Czeglédy J,Gergely L

    更新日期:1994-06-01 00:00:00

  • Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucrose.

    abstract::Physicochemical and molecular characterization studies of hepatitis C virus (HCV), the major causative agent of parenterally transmitted non-A, non-B hepatitis (PT-NANBH), strongly suggest that it is a pesti-/flavivirus-like virus. Additional studies show that the buoyant density of plasma-derived HCV in sucrose is si...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890340315

    authors: Bradley D,McCaustland K,Krawczynski K,Spelbring J,Humphrey C,Cook EH

    更新日期:1991-07-01 00:00:00

  • Characterization of pandemic influenza A (H1N1) virus hemagglutinin specific polyclonal antibodies for biosensor applications.

    abstract::In this study, recombinant hemagglutinin protein (rH1N1HA) of Pandemic influenza virus and polyclonal antibodies against it for biosensor applications have been characterized. For rapid and high sensitive detection of H1N1 virus or its antibodies, PCR-free and label free detection method based on a surface plasmon res...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23753

    authors: Athmaram TN,Saraswat S,Sikarwar B,Verma SK,Singh AK,Boopathi M

    更新日期:2014-03-01 00:00:00

  • Characteristics of lamivudine-resistant hepatitis B virus (HBV) strains with and without breakthrough hepatitis in patients with chronic hepatitis B evaluated by serial HBV full-genome sequences.

    abstract::Lamivudine therapy often causes breakthrough of hepatitis B virus (HBV) DNA and breakthrough hepatitis. The aim of this study was to determine the viral factors that relate to HBV-DNA breakthrough with and without breakthrough hepatitis. Among 82 patients with chronic hepatitis B (CHB) who received lamivudine at a dos...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20915

    authors: Horiike N,Duong TN,Michitaka K,Joko K,Hiasa Y,Konishi I,Yano M,Onji M

    更新日期:2007-07-01 00:00:00

  • Virus receptors for polymerized human albumin: a prognostic marker in HBeAg-positive chronic hepatitis type B?

    abstract::Seventeen out of 30 patients with chronic hepatitis type B with hepatitis B e antigen (HBeAg) in serum remained persistently positive for e antigen, while 13 seroconverted to antibody (anti-HBe) when followed over a period of one to five years. Initial levels of serum hepatitis B virus (HBV) markers, such as the hepat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890100208

    authors: Alberti A,Pontisso P,Realdi G

    更新日期:1982-01-01 00:00:00

  • A prospective longitudinal study of BK virus infection in 120 Czech renal transplant recipients.

    abstract::Polyomavirus BK (BKV) is a common human polyomavirus that rarely causes clinical symptoms in immunocompetent individuals. However, BK virus reactivation occurs in 20-40% of kidney transplant patients and 1-10% of cases present with BK virus-associated nephropathy (BKVN) and reduced kidney allograft survival. In this s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22106

    authors: Girmanova E,Brabcova I,Bandur S,Hribova P,Skibova J,Viklicky O

    更新日期:2011-08-01 00:00:00

  • Influence of antigenic drift on the intensity of influenza outbreaks: upper respiratory tract infections of military conscripts in Finland.

    abstract::A total of 102,600 upper respiratory infections (URI) were recorded among young military conscripts in the Finnish Defence Forces during the study period from October 1991 to March 1994. This period covered three outbreaks caused by H3N2-subtype influenza A virus and one outbreak of influenza B. During the 1991/92 out...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10552

    authors: Pyhälä R,Visakorpi R,Ikonen N,Kleemola M

    更新日期:2004-02-01 00:00:00

  • Effect of age on serum immunoglobulin G subclass antibody responses to inactivated influenza virus vaccine.

    abstract::We previously reported an age-associated impairment of serum immunoglobulin G (IgG) antibody responses to inactivated influenza virus vaccine. The present study extends these observations by examining the IgG subclass distribution of vaccine responses measured by enzyme linked immunosorbent assay in healthy adults age...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430111

    authors: Powers DC

    更新日期:1994-05-01 00:00:00

  • Genetic variability of respiratory syncytial virus A in hospitalized children in the last five consecutive winter seasons in Central Spain.

    abstract::Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestati...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24703

    authors: Calderón A,Pozo F,Calvo C,García-García M,González-Esguevillas M,Molinero M,Casas I

    更新日期:2017-05-01 00:00:00