Quantification of adenovirus species B and C viremia by real-time PCR in adults and children undergoing stem cell transplantation.

Abstract:

:Adenovirus infection during stem cell transplantation is associated with high morbidity and mortality. Adenovirus species B and C have been the main causes for these infections; however, epidemiological details about the species are still unclear. To clarify the contributions of species B and C adenovirus, the DNA was tested serially by quantitative real-time PCR in peripheral blood, stool and urine of 32 patients (16 adults and 16 children) undergoing stem cell transplantation. Adenovirus species B viremia was detected in 10 of 16 adult and 6 of 16 pediatric transplant recipients. Adenovirus species C viremia was also detected simultaneously in five adult and three pediatric recipients. The stool and urine of patients with adenovirus viremia were also positive for the same adenovirus species as in blood. In contrast, in none of 50 healthy adult controls was adenovirus species B or C viremia detected. Among patients who developed adenovirus viremia, one adult recipient developed disseminated disease and died from multiple organ failure. The remaining patients experienced fever of several degrees and/or diarrhea during the period of adenovirus viremia; however, they all recovered without antiviral therapy. The results indicated that stem cell transplantation was frequently associated with adenovirus species B or C viremia, although it did not always cause serious infectious complications.

journal_name

J Med Virol

authors

Takayama R,Hatakeyama N,Suzuki N,Yamamoto M,Hayashi T,Ikeda Y,Ikeda H,Nagano H,Ishida T,Tsutsumi H

doi

10.1002/jmv.20796

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

278-84

issue

3

eissn

0146-6615

issn

1096-9071

journal_volume

79

pub_type

杂志文章
  • The difference in mortality between adult patients with laboratory documented Influenza A and B, a single centre retrospective observational study.

    abstract:BACKGROUND:Seasonal influenza is an annual occurrence that leads to large community outbreaks and increased hospitalisation. A number of studies have suggested that influenza A (FLUAV) is associated with increased rates of hospitalisation and mortality compared to influenza B (FLUBV). This study compared demographic an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26600

    authors: Mabayoje DA,Cutino-Moguel T,Haigh J,Wilks M,Welch CA,Melzer M

    更新日期:2020-10-15 00:00:00

  • Review: Occult hepatitis C virus infection: still remains a controversy.

    abstract::Occult hepatitis C virus (HCV) infection is characterized by the presence of HCV RNA in the liver cells or peripheral blood mononuclear cells of the patients whose serum samples test negative for HCV RNA, with or without presence of HCV antibodies. The present study reviews the existing literature on the persistence o...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.23979

    authors: Vidimliski PD,Nikolov I,Geshkovska NM,Dimovski A,Rostaing L,Sikole A

    更新日期:2014-09-01 00:00:00

  • Distribution of BK polyomavirus genotypes in Tunisian renal transplant recipients.

    abstract::BK polyomavirus (BKV) is a ubiquitous virus in humans that remains latent in the urogenital tract after a primary infection during childhood. The virus, which is reactivated frequently and excreted in urine, can cause nephropathy in renal transplant recipients. BKV sequences are classified into four subtypes (I-IV). S...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22035

    authors: Boukoum H,Nahdi I,Foulongne V,Zallema D,Aloui S,Achour A,Segondy M,Aouni M

    更新日期:2011-04-01 00:00:00

  • miR-150-mediated increase in glucose uptake in HIV-infected cells.

    abstract::Replication of HIV-1 inside host cells is dependent on both viral and host factors. MicroRNAs are small noncoding RNAs that regulate protein synthesis. MicroRNAs may control viral replication either by directly targeting the viral genome or indirectly through cellular proteins that are required during the viral lifecy...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26755

    authors: Dubey RC,Alam NB,Gaur R

    更新日期:2020-12-24 00:00:00

  • Characterization of a nucleic acid probe for the diagnosis of human coronavirus 229E infections.

    abstract::A cDNA copy of the HCV229E nucleocapsid protein gene was isolated and characterized. Sequence analysis predicts a nucleocapsid polypeptide of 389 amino acids with a molecular weight (mol. wt.) of 43,450. Single strand RNA probes derived from the cDNA copy hybridize specifically to HCV229E RNA and approximately 50 pg o...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310216

    authors: Myint S,Harmsen D,Raabe T,Siddell SG

    更新日期:1990-06-01 00:00:00

  • Evaluation of a reduced dose of hepatitis B vaccine administered intradermally.

    abstract::Intradermal inoculation of hepatitis B vaccine (HBsAg subtype adw) caused no side effects, but the vaccine was less immunogenic than following intramuscular administration. Intradermal inoculation does not, therefore, offer a major advantage to the generally used intramuscular immunization. A single multisite intrader...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140105

    authors: Zoulek G,Lorbeer B,Jilg W,Deinhardt F

    更新日期:1984-01-01 00:00:00

  • ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.

    abstract::It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26319

    authors: Torre-Fuentes L,Matías-Guiu J,Hernández-Lorenzo L,Montero-Escribano P,Pytel V,Porta-Etessam J,Gómez-Pinedo U,Matías-Guiu JA

    更新日期:2021-02-01 00:00:00

  • Modification of rotavirus multiplex RT-PCR for the detection of G12 strains based on characterization of emerging G12 rotavirus strains from South India.

    abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20872

    authors: Banerjee I,Ramani S,Primrose B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

    更新日期:2007-09-01 00:00:00

  • Novel application of a point mutation assay: evidence for transmission of hepatitis B viruses with precore mutations and their detection in infants with fulminant hepatitis B.

    abstract::Mutations of the precore region of hepatitis B virus (HBV) genome have been associated with fulminant and severe chronic hepatitis. However uncertainty remains about the clinical significance and transmissibility of these mutant strains. A point mutation assay (PMA) was developed to identify qualitatively and quantita...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440105

    authors: Hawkins AE,Gilson RJ,Beath SV,Boxall EH,Kelly DA,Tedder RS,Weller IV

    更新日期:1994-09-01 00:00:00

  • Identification and characterization of enteric adenoviruses in infants and children hospitalized for acute gastroenteritis.

    abstract::Enteric adenoviruses are important etiological agents associated with sporadic infections and outbreaks of acute gastroenteritis in infants and children. Fecal samples were collected from 439 hospitalized patients in the years 2005-2007 from Pune, Aurangabad, and Nagpur cities of western India to identify the most pre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21331

    authors: Verma H,Chitambar SD,Varanasi G

    更新日期:2009-01-01 00:00:00

  • Presence of Betapapillomavirus in Kaposi sarcoma lesions.

    abstract::Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23944

    authors: Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen B

    更新日期:2014-09-01 00:00:00

  • Molecular Characterization of Non-Polio Enteroviruses Isolated from Acute Flaccid Paralysis Patients in Uganda.

    abstract::Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AF...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26804

    authors: Tushabe P,Howard W,Bwogi J,Birungi M,Eliku JP,Kakooza P,Bukenya H,Namuwulya P,Gaizi J,Tibanagwa M,Kabaliisa T,Mulindwa J,Muhanguzi D,Suchard M,Gumede N,Bakamutumaho B

    更新日期:2021-01-17 00:00:00

  • Nucleotide sequence of hepatitis B virus isolated from subjects without serum anti-hepatitis B core antibody.

    abstract::The nucleotide sequences of the precore/core and X open reading frames (ORFs) of hepatitis B virus (HBV) were studied in four subjects who were serologically negative for anti-hepatitis B core antibody. These subjects were positive for serum hepatitis B surface antigen and were considered to be asymptomatic HBV carrie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460306

    authors: Gotoh K,Mima S,Uchida T,Shikata T,Yoshizawa K,Irie M,Mizui M

    更新日期:1995-07-01 00:00:00

  • Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

    abstract::Studies of hepatitis B virus (HBV) infection in non-human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV infectivity in serial stages of acu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21320

    authors: Tabuchi A,Tanaka J,Katayama K,Mizui M,Matsukura H,Yugi H,Shimada T,Miyakawa Y,Yoshizawa H

    更新日期:2008-12-01 00:00:00

  • Molecular epidemiology of HIV-1 among the HIV infected people of Manipur, Northeastern India: Emergence of unique recombinant forms.

    abstract::According to the Joint National Programme on HIV/AIDS (UNAIDS), the northeastern region of India has the highest HIV prevalence in the country. This study was conducted to determine the current HIV-1 molecular epidemiology of Manipur, a state in northeast India. Blood samples from HIV-1 seropositive subjects were coll...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24738

    authors: Sharma AL,Singh TR,Devi KR,Singh LS

    更新日期:2017-06-01 00:00:00

  • Establishing diagnostic criteria for occult hepatitis B virus infections in community based populations.

    abstract::Present diagnostic criteria for occult hepatitis B virus (HBV) infection requires blood or liver samples to test positive for at least two HBV DNA targets in hepatitis B surface antigen (HBsAg) negative individuals. These criteria were derived from studies involving referred or selected patient populations. The object...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23813

    authors: Minuk GY,Huynh C,Uhanova J,Osiowy C

    更新日期:2014-01-01 00:00:00

  • JCV/BKV and SV40 viral load in lymphoid tissues of young immunocompetent children from an area of north-east Italy.

    abstract::Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be a possible reservoir. The role of tonsil, ade...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21786

    authors: Comar M,Zanotta N,Bovenzi M,Campello C

    更新日期:2010-07-01 00:00:00

  • Potential of large "first generation" human-to-human transmission of 2019-nCoV.

    abstract::To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok...

    journal_title:Journal of medical virology

    pub_type: 评论,杂志文章

    doi:10.1002/jmv.25693

    authors: Li X,Zai J,Wang X,Li Y

    更新日期:2020-04-01 00:00:00

  • Selection of drug-resistant HIV-1 during the early phase of viral decay is uncommon in treatment-naïve patients initiated on a three- or four-drug antiretroviral regimen including lamivudine.

    abstract::Therapy failure due to drug resistance development is a common phenomenon in HIV-infected patients. However, when the drug pressure leads to the earliest selection of drug-resistant HIV-1 populations is still unclear. In this study, the extent to which selection of the HIV-1 reverse transcriptase M184I/V mutations occ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21363

    authors: Bergroth T,Ekici H,Gisslén M,Loes SK,Goh LE,Freedman A,Lampe F,Johnson MA,Sönnerborg A

    更新日期:2009-01-01 00:00:00

  • HBeAg-negative chronic hepatitis patients should be monitored more strictly: a cross-sectional retrospective study on antiviral treatment-naïve patients.

    abstract:AIM:To investigate the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative/treatment naïve subjects with low hepatitis B virus (HBV) DNA levels (<10(4)  copies/ml) and low alanine aminotransferase (ALT) levels (<2 × upper limit of normal) in patients with HBV-related hepatocellular carcinoma (HCC)....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24217

    authors: Zeng DW,Dong J,Zhang JM,Zhu YY,Jiang JJ,Liu YR

    更新日期:2015-10-01 00:00:00

  • Natural histories of hepatitis C virus infection in men and women simulated by the Markov model.

    abstract::The Markov model was introduced to simulate natural histories of hepatitis C virus (HCV) infection in men and women. The data set was constructed on 942 HCV carriers who were examined at least once a year without receiving antiviral therapies. Based on 2,251 patient-year data, the probabilities of transition between a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10406

    authors: Tanaka J,Kumada H,Ikeda K,Chayama K,Mizui M,Hino K,Katayama K,Kumagai J,Komiya Y,Miyakawa Y,Yoshizawa H

    更新日期:2003-07-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470418

    authors: Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期:1995-12-01 00:00:00

  • Screening for possible failure of herpes simplex virus PCR in cerebrospinal fluid for the diagnosis of herpes simplex encephalitis.

    abstract::The objectives of this study were to evaluate the reliability of herpes simplex virus (HSV) PCR testing in cerebrospinal fluid (CSF) for the detection of herpes simplex encephalitis. This was done by examining retrospectively the clinical follow-up of a large group of patients tested routinely by HSV-PCR. In addition,...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1082

    authors: Puchhammer-Stöckl E,Presterl E,Croÿ C,Aberle S,Popow-Kraupp T,Kundi M,Hofmann H,Wenninger U,Gödl I

    更新日期:2001-08-01 00:00:00

  • A two dose combined hepatitis A and B vaccine in Chinese youngsters.

    abstract::This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Lee SD,Chan CY,Yu MI,Wang YJ,Chang FY,Lo KJ,Safary A

    更新日期:1999-09-01 00:00:00

  • Brief report: parainfluenza virus type 3 infections: findings in Sydney and some observations on variations in seasonality world-wide.

    abstract::Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890350105

    authors: de Silva LM,Cloonan MJ

    更新日期:1991-09-01 00:00:00

  • Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

    abstract::The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21366

    authors: Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

    更新日期:2009-01-01 00:00:00

  • Genotyping and characterization of the geographical distribution of tick-borne encephalitis virus variants with a set of molecular probes.

    abstract::A panel of deoxyoligonucleotide probes for studying the genetic variability and genotyping of Tick-borne encephalitis virus (TBEV) strains by molecular hybridization of nucleic acids (MHNA) was created. This panel allows to estimate the genetic structure of individual TBEV strains, as the targets for probes are both v...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21765

    authors: Demina TV,Dzhioev YP,Verkhozina MM,Kozlova IV,Tkachev SE,Plyusnin A,Doroshchenko EK,Lisak OV,Zlobin VI

    更新日期:2010-05-01 00:00:00

  • Hepatitis C virus genotype 4 in England: diversity and demographic associations.

    abstract::HCV strains belonging to genotype 4 may be gaining endemicity across Continental Europe but the extent of their spread in the United Kingdom is unknown. Sera referred from patients attending hospitals in England between 2004 through 2008 were characterised. A total of 243 sera carried HCV genotype 4. The most common s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24069

    authors: Ngui SL,Brant L,Markov PV,Tung JP,Pybus OG,Teo CG,Ramsay ME

    更新日期:2015-03-01 00:00:00

  • Association of hepatitis E virus with an outbreak of hepatitis in Pakistan: serologic responses and pattern of virus excretion.

    abstract::Hepatitis E virus (HEV), a positive-strand RNA agent, has been associated with enterically transmitted non-A, non-B hepatitis in Asia, Africa, and Mexico. To evaluate the role of HEV in an outbreak of hepatitis in Pakistan, we used immune electron microscopy to detect 1) antibody to HEV, for evidence of infection, and...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890360205

    authors: Ticehurst J,Popkin TJ,Bryan JP,Innis BL,Duncan JF,Ahmed A,Iqbal M,Malik I,Kapikian AZ,Legters LJ

    更新日期:1992-02-01 00:00:00

  • Diagnostic impact of the genetic variability of the hepatitis B virus surface antigen gene.

    abstract::The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Genotyping studies show that the genetic diversity of HBV is very high even in industrialized countries. The analytical sensitivity of HBsAg and anti-HBs assays may be dependent on H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20610

    authors: Weber B

    更新日期:2006-01-01 00:00:00