Investigation of measles and rubella outbreaks in Tamil Nadu, India-2003.

Abstract:

:The aims of the present study were to confirm measles outbreaks by detection of measles-specific IgM antibodies, isolation of measles virus, and genetic characterization to document the circulating genotypes in Tamil Nadu. Eight outbreaks were reported from six districts of Tamil Nadu, India during the period Jan-Dec 2003. Blood samples were collected for serology, urine, and throat swabs for virus isolation. Genotypic characterization of measles isolates was based on the sequence of the N gene. All the clinically suspected outbreaks (n = 8) were confirmed by serology; six out of the eight as measles and two as combination of measles and rubella highlighting the need to carry out rubella serology on measles-negative samples. Genetic characterization of three isolates obtained revealed one as genotype D4 and two as D8. Measles genotypes D4 and D8 were found to circulate in three districts of Tamil Nadu. It is necessary to be aware of the circulating genotypes within the geographical area. The information would be valuable to evaluate control measures and identify viral transmission and importation.

journal_name

J Med Virol

authors

Ramamurty N,Raja D,Gunasekaran P,Varalakshmi E,Mohana S,Jin L

doi

10.1002/jmv.20569

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

508-13

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

78

pub_type

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