Abstract:
:This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Borghi E,Pagani E,Mancuso R,Delbue S,Valli M,Mazziotti R,Giordano L,Micheli R,Ferrante Pdoi
10.1002/jmv.20285keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
427-9issue
3eissn
0146-6615issn
1096-9071journal_volume
75pub_type
杂志文章abstract::Analysis of the HIV-1 V3 quasispecies present in an individual at the time of seroconversion was carried out. The polymerase chain reaction (PCR) was used to amplify proviral HIV-1 DNA extracted from peripheral blood mononuclear cells from a patient who was viraemic (p24 = 15 pg/ml) and had an equivocal HIV-1 antibody...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410403
更新日期:1993-12-01 00:00:00
abstract::Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and -positive men who have sex with men (MSM)? MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24898
更新日期:2018-01-01 00:00:00
abstract::Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22057
更新日期:2011-05-01 00:00:00
abstract::Travel influences the spread of non-B subtypes of HIV in Europe. The aim of this study was to assess whether the spread of non-B subtypes occurred in Croatia, a country with a low level HIV infection. Phylogenetic analysis of the reverse transcriptase and protease genes was undertaken in 145 Croatian patients with the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21433
更新日期:2009-04-01 00:00:00
abstract::This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study used both the medical data and the blood sam...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26215
更新日期:2020-06-24 00:00:00
abstract::Total RNA from normal adult woodchucks was analyzed using membrane arrays containing human cDNA clones, and the gene expression patterns were compared to human liver. Various hybridization and wash conditions were examined. In both the woodchuck and human livers, 352 genes were identified as highly expressed (Z-scores...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20186
更新日期:2004-10-01 00:00:00
abstract::The relationship of pre-bone-marrow transplant recipient and donor cytomegalovirus (CMV) antibody level to post-transplant recipient CMV excretion was investigated. CMV excretion was found to be related to pre-transplant recipient serological status, but not to level of antibody. This therefore contrasts with herpes s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890330409
更新日期:1991-04-01 00:00:00
abstract::The criterion standard for the diagnosis of occult hepatitis C virus (HCV) infection is detection of HCV-RNA in liver cells. However, because of the invasive nature of liver biopsy, other methods have been studied. The present study aimed to identify subjects with occult HCV-4 infection among healthy sexual partners o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24074
更新日期:2015-03-01 00:00:00
abstract::Human metapneumovirus (hMPV) is considered an important cause of acute respiratory infections. hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of havin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23477
更新日期:2013-03-01 00:00:00
abstract::Isolated reactivity to hepatitis B virus (HBV) core antigen (anti-HBc) is observed relatively frequently in immunocompromised individuals, intravenous drug abusers (IVDA), and in the presence of HCV infection. The reason for the lack of HBsAg is not clear. The aim of the present study was to investigate which factors ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1052
更新日期:2001-07-01 00:00:00
abstract::Hepatitis A virus infections have been reported recently among hemophilic patients in Italy and Germany, leading to speculation that infectious hepatitis A virus (HAV) might have been present in some factor VIII concentrates. In both cases, the implicated factor concentrates had been treated by a solvent/detergent met...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410113
更新日期:1993-09-01 00:00:00
abstract::Occult hepatitis C virus (HCV) infection is characterized by the presence of HCV RNA in the liver cells or peripheral blood mononuclear cells of the patients whose serum samples test negative for HCV RNA, with or without presence of HCV antibodies. The present study reviews the existing literature on the persistence o...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.23979
更新日期:2014-09-01 00:00:00
abstract::Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within the context of certain flanking bases (CpG motifs) have been shown to induce potent innate and adaptive immune responses. Vaginal delivery of CpG ODN alone protects mice from vaginal herpes simplex virus type-2 (HSV-2) challenge. He...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10518
更新日期:2003-12-01 00:00:00
abstract::To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidir...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25354
更新日期:2019-03-01 00:00:00
abstract::Recent studies have identified epithelial cell populations in human livers that are similar to the "oval cells" and "transitional cells" seen in rat livers during the early stages of chemical carcinogenesis. It has been suggested that these cells might be precursors of hepatocytes and theoretically could be involved i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430304
更新日期:1994-07-01 00:00:00
abstract::The detection of hepatitis B virus (HBV) DNA plays a critical role in determining the level of viral replication in HBV-infected patients. However, how to select appropriate HBV DNA detection method, low-sensitivity (ls) and hypersensitivity (hs) remains unclear. In this study, hepatitis B surface antigen (HBsAg), hep...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25271
更新日期:2019-02-01 00:00:00
abstract::One hundred thirty-two strains of adenovirus type 7 were isolated in Hiroshima City during the period 1995-1999. About 80% of the viruses were isolated from patients with respiratory illness, and about 70% were isolated from children younger than 6 years old. DNA restriction analysis was performed on 58 of the 132 iso...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10287
更新日期:2003-02-01 00:00:00
abstract::Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV-infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger receptor class B t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22042
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25454
更新日期:2019-07-01 00:00:00
abstract::A cDNA copy of the HCV229E nucleocapsid protein gene was isolated and characterized. Sequence analysis predicts a nucleocapsid polypeptide of 389 amino acids with a molecular weight (mol. wt.) of 43,450. Single strand RNA probes derived from the cDNA copy hybridize specifically to HCV229E RNA and approximately 50 pg o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310216
更新日期:1990-06-01 00:00:00
abstract::The seroprevalence of hepatitis A antibodies in travellers attending London Travel Clinics increases with age and screening may eliminate the need for vaccination at present for approximately 40% of adults. The duration of protection by current hepatitis A vaccine(s) is still to be established. ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440414
更新日期:1994-12-01 00:00:00
abstract::Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21299
更新日期:2008-11-01 00:00:00
abstract::To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890160103
更新日期:1985-05-01 00:00:00
abstract::A combined hepatitis A and B vaccine is available since 1996. Two separate open-label primary studies evaluated the immunogenicity and safety of this hepatitis A and B vaccine (720 EI.U of HAV and 20 µg of HBsAg) in 306 healthy subjects aged 17-43 years who received three doses of the vaccine following a 0, 1, and 6 m...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22264
更新日期:2012-01-01 00:00:00
abstract::The polymerase chain reaction (RNA-PCR) was used for specific detection of respiratory syncytial virus (RSV) genomes in clinical specimens. A set of primers was selected from conserved regions of the 1B and N genes for detection of both subgroups. The primers were found to be RSV specific, all RSV strains generated a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440115
更新日期:1994-09-01 00:00:00
abstract::Interleukin 6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells, including hepatocytes. Previous studies have shown that serum IL-6 levels are increased in hepatitis B patients. However, the role of IL-6 in modulating the anti-hepatitis B viru...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25382
更新日期:2019-05-01 00:00:00
abstract::The incidence of perinatal transmission of hepatitis B virus (HBV) depends on the HBeAg/anti-HBe status of the mother. While children of HBeAg-positive mothers have a 90% probability of acquiring a chronic hepatitis B virus carrier state, babies of anti-HBe-positive mothers are more likely to develop fulminant hepatit...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470408
更新日期:1995-12-01 00:00:00
abstract::Enzyme immunoassay (EIA) for parainfluenza virus type 1, 2, and 3 antibodies was compared with the complement fixation test (CF) as a diagnostic method in 180 patients with respiratory symptoms. The CF test detected rises in parainfluenza virus antibodies in 30 cases, whereas EIA detected 47 rises. Patients with antib...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890140212
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Acute respiratory infection (ARI) is a leading cause of morbidity and mortality in children in low and middle-income countries. Human metapneumovirus (hMPV) is one of the most common viral etiological agents for ARIs in children. OBJECTIVES:In this study, we explored the genotypic diversity and the epidemio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25351
更新日期:2019-04-01 00:00:00
abstract::To assess the prevalence of HPV infection in the genital tracts of women with normal PAP smears, a random series of 109 women was reexamined using colposcopy, a further PAP smear, and punch biopsies taken from the cervix (in 33 cases), vagina (212 cases), and anus (20 cases). The biopsy material was examined using rou...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310404
更新日期:1990-08-01 00:00:00