Detection of occult hepatitis C virus among healthy spouses of patients with HCV infection.

Abstract:

:The criterion standard for the diagnosis of occult hepatitis C virus (HCV) infection is detection of HCV-RNA in liver cells. However, because of the invasive nature of liver biopsy, other methods have been studied. The present study aimed to identify subjects with occult HCV-4 infection among healthy sexual partners of patients with chronic HCV-4 infection by detecting HCV-RNA in peripheral blood mononuclear cells (PBMCs) using real-time polymerase chain reaction (PCR). Fifty healthy Egyptian spouses of patients with chronic HCV-4 infection were included in this study. Real-time PCR was used to detect HCV-RNA in PBMCs in all the study subjects. The prevalence of occult HCV-4 infection was 4%, and a statistically significant higher prevalence was found among patients with a history of sexually transmitted infection. The results of the present study indicate the importance of intra-spousal transmission of HCV-4 infection, especially in subjects with a history of sexually transmitted infection.

journal_name

J Med Virol

authors

El Shazly Y,Hemida K,Rafik M,Al Swaff R,Ali-Eldin ZA,GadAllah S

doi

10.1002/jmv.24074

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

424-7

issue

3

eissn

0146-6615

issn

1096-9071

journal_volume

87

pub_type

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