Abstract:
:Group A rotaviruses are the main cause of acute gastroenteritis in children worldwide. The intermediate capsid protein VP6 encoded by segment 6 of the dsRNA genome is the major structural component of the virus and it is highly antigenic and immunogenic. VP6 is responsible for group and subgroup (SG) specificities, allowing classification of group A rotavirus into SG I, SG II, SG I + II, and SG non-I-non-II. VP6-encoding gene of 154 group A human rotavirus samples of different G and P genotypes recovered from children in three cities of Central West region of Brazil was amplified by reverse transcription-polymerase chain reaction followed by sequencing and phylogenetic analysis. Two distinct genetic groups could be recognized: VP6 genogroups I and II. Sequences analysis also revealed that all samples identified as VP6 genogroup I were associated with NSP4 genotype A, whereas samples identified as VP6 genogroup II were associated with NSP4 genotype B. This is the first study in Central West region regarding genetic variability of the VP6 gene. Further molecular surveillance of rotavirus strains is needed to understand better the occurrence of VP6 gene diversity in Brazil and the significance of VP6 for the control and prevention of rotavirus gastroenteritis.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Tavares Tde M,de Brito WM,Fiaccadori FS,Parente JA,da Costa PS,Giugliano LG,Andreasi MS,Soares CM,Cardoso Dddoi
10.1002/jmv.21306subject
Has Abstractpub_date
2008-11-01 00:00:00pages
2034-9issue
11eissn
0146-6615issn
1096-9071journal_volume
80pub_type
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