Detection of flavivirus antibodies in human serum by epitope-blocking immunoassay.

Abstract:

:Human flavivirus group-reactive, dengue complex-reactive, and encephalitis virus complex-reactive antibodies were detected using epitope-blocking immunoassays in which the binding of selected mouse monoclonal antibodies to flavivirus antigens was blocked by human serum. When late (greater than 6 months after illness) convalescent sera were tested, the epitope-blocking immunoassays were superior to the hemagglutination inhibition test and comparable to the plaque reduction neutralization for identifying subjects immune to dengue, to Japanese encephalitis, or both viruses.

journal_name

J Med Virol

authors

Burke DS,Nisalak A,Gentry MK

doi

10.1002/jmv.1890230209

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

165-73

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

23

pub_type

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