Convalescent plasma transfusion for the treatment of COVID-19: Systematic review.

Abstract:

:The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the first systematic review on convalescent plasma on clinically relevant outcomes in individuals with COVID-19. PubMed, EMBASE, and Medline databases were searched upto 19 April 2020. All records were screened as per the protocol eligibility criteria. We included five studies reporting CPT to COVID-19 patients. The main findings from available data are as follows: (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. Based on the limited scientific data, CPT therapy in COVID-19 patients appears safe, clinically effective, and reduces mortality. Well-designed large multicenter clinical trial studies should be conducted urgently to establish the efficacy of CPT to COVID-19 patients.

journal_name

J Med Virol

authors

Rajendran K,Krishnasamy N,Rangarajan J,Rathinam J,Natarajan M,Ramachandran A

doi

10.1002/jmv.25961

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1475-1483

issue

9

eissn

0146-6615

issn

1096-9071

journal_volume

92

pub_type

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