Abstract:
:Multiple determinants are involved in the progression of human papillomavirus (HPV)-infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLA-DRB1 polymorphism, high-risk HPV infection, and the development of cervical neoplasia in southern Chinese. Three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade II, 154 grade III, and 173 invasive cancers) and 323 controls were recruited for HLA-DRB1 typing by a sequence-based approach. Cervical specimens were collected for HPV detection by a consensus primer-based polymerase chain reaction, and with the type of HPV identified by hybridization with type-specific oligonucleotide probes. A protective effect of HLA-DRB1*12 for cervical neoplasia was observed, and with stronger associations when subgroup analyses were carried out for patients infected with HPV16 and HPV58. The protective effect of HLA-DRB1*13 that had been reported from other populations was not observed. The data obtained in this study showed that HLA-DRB1*03 conferred a higher risk for HPV18-infected, but not for HPV16-, HPV52-, or HPV58-infected cervical lesions. Although, HPV52 was reported as uncommon worldwide, it was found to be the second most prevalent type in the southern Chinese population. However, no additional risk association was observed when subgroup analyses were performed for HPV52-infected patients. The current study shows that, among southern Chinese, the outcome of HPV-infected cervical lesions is associated with HLA-DRB1 polymorphism. These associations often vary with the type of HPV infection.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Chan PK,Cheung TH,Lin CK,Siu SS,Yim SF,Lo KW,Cheung JL,Tam AO,Tang JWdoi
10.1002/jmv.20805subject
Has Abstractpub_date
2007-07-01 00:00:00pages
970-6issue
7eissn
0146-6615issn
1096-9071journal_volume
79pub_type
杂志文章abstract::Identification of high-risk HPV genotypes in patients is essential for vaccination and prevention programs while the geographic distribution of cervical cancer varies widely. HPV 16 is the major cause of cervical cancer followed by HPV 18, HPV 31, HPV 52, or HPV 58 depending on geographic area. In this study, the dist...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23769
更新日期:2014-04-01 00:00:00
abstract::The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21227
更新日期:2008-09-01 00:00:00
abstract::Maternal injection drug use and peripheral blood mononuclear cell infection by hepatitis C virus are important risk factors for perinatal transmission of the virus. The aim of present study was to evaluate the independent association of these two factors on perinatal transmission. Forty-eight consecutive mothers who t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21023
更新日期:2008-01-01 00:00:00
abstract::A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44,827 of the Smith MCMV BAC, was attenuated in replication both in tis...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21211
更新日期:2008-07-01 00:00:00
abstract::An enzyme immunoassay utilizing a fluorogenic substrate (EIFA) was employed to compare humoral antibody responses to purified virion and dense body antigens in human cytomegalovirus (CMV) infections. Results of these antibody assays were also compared to those obtained by plaque reduction neutralization and complement...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890060204
更新日期:1980-01-01 00:00:00
abstract::Ideally, long-term lamivudine therapy should not induce tyrosine-methionine-aspartate-aspartate (YMDD) mutants (reverse transcription [rt]; rt M204I/V) in patients with chronic hepatitis B. There is little or no information on the clinical features of patients who do not develop such mutants. We analyzed 368 patients ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21681
更新日期:2010-04-01 00:00:00
abstract::Hepatitis C virus (HCV) is a single-stranded RNA virus related to the Flaviviridae family, and striking nucleotide sequence diversity has been reported among HCV isolates from different geographic areas. To study the distribution HCV genotypes among disease group in Korea, we subtyped HCV using the method of Okamoto e...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199605)49:1<55::AID-JMV9>3
更新日期:1996-05-01 00:00:00
abstract::Norovirus is one of the major causes of outbreaks and sporadic cases of acute gastroenteritis in young children worldwide. Obtaining local baseline information regarding this virus is important for developing and evaluating prevention strategies of norovirus transmission in children. The age, seasonal distribution and...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21569
更新日期:2009-10-01 00:00:00
abstract::A novel coronavirus associated with acute respiratory disease (named SARS-CoV-2) is recently identified in Wuhan city, China, spread rapidly worldwide. Early identification of this novel coronavirus by molecular tools is critical for surveillance and control of the epidemic outbreak. We aimed to establish a simple met...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26171
更新日期:2020-11-01 00:00:00
abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23436
更新日期:2013-01-01 00:00:00
abstract::Hepatitis A incidence has been decreasing in Brazil since child vaccination was implemented in 2014. This trend was interrupted by an outbreak among adult male in São Paulo in 2017. This study was outlined to estimate whether the increase of hepatitis A cases among adult men in Brazil was restricted to São Paulo. Case...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25694
更新日期:2020-08-01 00:00:00
abstract::The replication strategy of a human serotype 1 rotavirus, adapted to rapid growth in CV-1 cells, was investigated. A single cycle growth curve revealed eclipse and latent periods of 3 and 4 hours, respectively. Although the extent of reduction of host cell protein synthesis was directly related to the multiplicity of ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890250113
更新日期:1988-05-01 00:00:00
abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23728
更新日期:2014-02-01 00:00:00
abstract::Infection with human polyomaviruses BKV and JCV is asymptomatic, and lifelong and widespread, among the general population. However, in the setting of immunosuppression, secondary to medications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specime...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21559
更新日期:2009-09-01 00:00:00
abstract::SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26561
更新日期:2020-09-28 00:00:00
abstract::The Balkan Peninsula and Bulgaria in particular, is a well-known endemic region for Crimean-Congo hemorrhagic fever (CCHF). This study describes the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) among tick populations from areas, previously recognized with emerging cases of CCHF disease in humans. These ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23214
更新日期:2012-04-01 00:00:00
abstract::The occurrence of HIV infection among drug-users in Italy between 1990 and 2000 is described; the data concern drug-users attending a nation-wide network consisting of 510 public drug-treatment centres. We included only individuals with written documentation of an HIV-test result. Of the 1,299,972 attendees, 54.5% had...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20054
更新日期:2004-05-01 00:00:00
abstract::Human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) are both retroviruses with similar routes of transmission. A number of reports suggest variable clinical outcomes in HIV and HTLV co-infected individuals. There is no published information regarding the prevalence of HIV and HTLV co-infectio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20336
更新日期:2005-06-01 00:00:00
abstract::This prospective study aimed to determine factors associated with detection of very low-level viremia in patients infected with HIV-1 with virological success following HAART introduction. Fifty-seven patients, mostly (n = 51, 89%) treated with a protease inhibitor-based regimen, were included and followed for 2 years...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23553
更新日期:2013-06-01 00:00:00
abstract::Hantavirus infection during pregnancy can influence both maternal and fetal outcomes. Here, we describe four cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant Chinese women. The HFRS put these women at increased risk for severe illness, despite the patients' symptomologies in the onset phase were simil...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24856
更新日期:2017-10-01 00:00:00
abstract::The effect of protamine, atropine, selenocystamine, taxifolin, and catechin on the infectivity and antigenicity of the cell culture-adapted hepatitis A virus (HAV) strain CF 53 was studied. The toxicity on uninfected PLC/PRF/5 cells was examined for each antiviral compound by morphological and biochemical methods, in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890220108
更新日期:1987-05-01 00:00:00
abstract::Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes. The disease is characterized by fever, headache, rash, severe joint, and muscle pain. To evaluate the disease burden in the population and the effectiveness of public health measures, periodic seroprevalence surveys are esse...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25581
更新日期:2020-01-01 00:00:00
abstract::Present diagnostic criteria for occult hepatitis B virus (HBV) infection requires blood or liver samples to test positive for at least two HBV DNA targets in hepatitis B surface antigen (HBsAg) negative individuals. These criteria were derived from studies involving referred or selected patient populations. The object...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23813
更新日期:2014-01-01 00:00:00
abstract::A novel real-time PCR assay system was developed to quantify the cytomegalovirus (CMV) genome load. The real-time PCR assay could detect from 6 to over 10(6) copies of CMV-DNA with a wide linear range. The virus load of immunocompromised patients with symptomatic CMV infections was quantified and compared to that of a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200004)60:4<455::aid-jmv14
更新日期:2000-04-01 00:00:00
abstract::At present eight hepatitis B virus (HBV) genotypes have been characterized: A to H. The most common genotype in Northern Europe is genotype A. So far there is no record of the specific HBV genotype distribution in Iceland. Iceland has a small population whose homogeneity has changed due to increasing migration during ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20480
更新日期:2005-12-01 00:00:00
abstract::Because in situ/filter hybridisation is not sensitive enough and because classical polymerase chain reaction (PCR) protocols are generally not sufficiently reproducible and specific, there is little accurate information on the prevalence of human papillomaviruses (HPV) 16, 18, and 33 infections in women without dyskar...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890360409
更新日期:1992-04-01 00:00:00
abstract::Hepatitis E virus sequences were detected by RT-PCR in 14/15 (93%) of untreated sewage samples from Edinburgh, Scotland, UK. Phylogenetic analysis of amplicons at limiting dilution revealed the co-circulation of multiple variants of HEV-3, with a pattern of diversity matching that observed in a local cohort of HEV-inf...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24403
更新日期:2016-05-01 00:00:00
abstract::HIV diagnosis at the point-of-care or in resource-limited settings poses considerable challenges due to time and cost limitations. Currently, nucleic acid-based tests are the only reliable method for diagnosing recent infections during the window period post-infection and pre-seroconversion, but these tests are only s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21490
更新日期:2009-06-01 00:00:00
abstract::Until recently, human cytomegalovirus (hCMV) infection and anti-CMV treatment in transplanted patients have been monitored essentially by pp65 antigenemia, which is time-consuming and requires experienced operators. For the last two years, pp65 antigenemia levels have tended to be lower than previously in our laborato...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20326
更新日期:2005-05-01 00:00:00
abstract::The objective of this study was to determine the use of immune-complex dissociated (ICD) p24 antigen detection for the diagnosis and prognosis of HIV-1 infection in Ugandan children. Plasma collected prospectively from children born to HIV-1 infected Ugandan women was stored and later analyzed for the presence of neut...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200012)62:4<426::aid-jmv6>3.0.co
更新日期:2000-12-01 00:00:00