Foscarnet therapy in chronic hepatitis B virus E antigen carriers.

Abstract:

:Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral-specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV-DNA seropositivity greater than 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biopsy received either a continuous infusion of foscarnet at 0.15 mg/kg/min for 7 days or 180 mg/kg/day divided into three daily boluses for 2 weeks. In all eight, HBV-DNA levels fell during therapy (median, 401 pg/40 microliters serum; range, 4-3, 100) vs. pretreatment levels (median, 533 pg/40 microliters; range, 30-4, 175), but in none was HBV-DNA undetectable at any stage. Within 1 month, the HBV-DNA had risen to pretreatment levels in all but one patient (with the lowest pretreatment level), who cleared HBeAg and developed anti-HBe within 3 months. Two further patients were anti-HBe positive at 6 months, but their pretreatment serum HBV-DNA levels were already low, suggesting a high probability of spontaneous seroconversion. Toxicity was not evident with the continuous infusion, but for those receiving IV bolus therapy, serum creatinine and phosphate levels rose in three of four patients, necessitating a 25% dose reduction. There was no difference in the effect on serum HBV-DNA between the two regimes. We conclude that foscarnet has only modest antiviral activity in chronic HBV carriers.

journal_name

J Med Virol

authors

Bain VG,Daniels HM,Chanas A,Alexander GJ,Williams R

doi

10.1002/jmv.1890290214

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

152-5

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

29

pub_type

杂志文章
  • Hepatitis C virus infection of mononuclear cells from peripheral blood and liver infiltrates in chronically infected patients.

    abstract::The mechanisms underlying chronicity of hepatitis C virus (HCV) infection are poorly understood, but the importance of impaired viral clearance by the immune system has been suggested. The prevalence of HCV infection of peripheral blood mononuclear cells (PBMC) was in investigated in 34 persistently infected patients ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470112

    authors: Zignego AL,De Carli M,Monti M,Careccia G,La Villa G,Giannini C,D'Elios MM,Del Prete G,Gentilini P

    更新日期:1995-09-01 00:00:00

  • Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

    abstract::The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21366

    authors: Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

    更新日期:2009-01-01 00:00:00

  • Human metapneumovirus infection: Diagnostic impact of radiologic imaging.

    abstract:BACKGROUND:Human metapneumovirus (hMPV) is a recently detected virus, which can cause mild to severe respiratory tract infections. Through this study, we aimed to detail the outcomes of hMPV infections. MATERIALS/METHODS:Between January 2012 and November 2017, patients who had hMPV detected in nasopharyngeal or bronch...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25402

    authors: Keske Ş,Gümüş T,Köymen T,Sandıkçı S,Tabak L,Ergönül Ö

    更新日期:2019-06-01 00:00:00

  • The detection of SRAS-CoV-2 in outpatient clinics and public facilities during the COVID19 pandemic.

    abstract::The transmission of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can occur through airborne route, in addition to contaminated surfaces and objects. In hospitals, it has been confirmed by several studies that SRAS-CoV-2 can contaminate surfaces and medical equipment especially in hospitals dedicat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26819

    authors: Elbadawy HM,Khattab A,Alalawi A,Aljohani F,Sundogji H,Mahmoud AS,Abouzied M,Eltahir HM,Alahmadey Z,Bahashwan S,Suliman BA

    更新日期:2021-01-26 00:00:00

  • Low HBV-DNA levels in end-stage renal disease patients with HBeAg-negative chronic hepatitis B.

    abstract::In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20691

    authors: Moutinho RS,Perez RM,Medina-Pestana JO,Figueiredo MS,Koide S,Alberto FL,Silva AE,Ferraz ML

    更新日期:2006-10-01 00:00:00

  • Neutralization epitope diversity of coxsackievirus B4 isolates detected by monoclonal antibodies.

    abstract::Only recently have we begun to fully realize the diversity of virions within a single human isolate of the group B Coxsackieviruses. These intratypic (strain) differences may be one of the important factors influencing pathogenesis, e.g., myocarditis vs. pancreatitis. Yet, until the virion strains within a type can be...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200103

    authors: Webb SR,Kearse KP,Foulke CL,Hartig PC,Prabhakar BS

    更新日期:1986-09-01 00:00:00

  • Laboratory and epidemiologic assessment of a recent influenza B outbreak.

    abstract::A viral surveillance system in Nashville detected an outbreak of influenza B that occurred between January and March 1986. Paired sera from 32 individuals with culture-documented influenza B illness were tested using three serologic assays. Enzyme-linked immunosorbent assay (ELISA) using purified hemagglutinin-neurami...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jmv.1890250313

    authors: King JC Jr,Haugh CJ,Dupont WD,Thompson JM,Wright PF,Edwards KM

    更新日期:1988-07-01 00:00:00

  • Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children.

    abstract::Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, usin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24127

    authors: Nilsson AL,Vaziri-Sani F,Broberg P,Elfaitouri A,Pipkorn R,Blomberg J,Ivarsson SA,Elding Larsson H,Lernmark Å

    更新日期:2015-07-01 00:00:00

  • Gastroenterology manifestations and COVID-19 outcomes: A meta-analysis of 25,252 cohorts among the first and second waves.

    abstract:BACKGROUND AND AIM:A meta-analysis was performed to identify COVID-19 patients presenting with gastrointestinal (GI) symptoms during the first and second pandemic waves and investigate their association with the disease outcomes. METHODS:A systematic search in PubMed, Scopus, Web of Science, ScienceDirect, and EMBASE ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26836

    authors: Elshazli RM,Kline A,Elgaml A,Aboutaleb MH,Salim MM,Omar M,Munshi R,Mankowski N,Hussein MH,Attia AS,Toraih EA,Settin A,Killackey M,Fawzy MS,Kandil E

    更新日期:2021-02-02 00:00:00

  • Endogenous levels of mRNA for IFNs and IFN-related genes in hepatic biopsies of chronic HCV-infected and non-alcoholic steatohepatitis patients.

    abstract::To investigate the intra-hepatic activation of the IFN system in patients affected by chronic HCV-infection in comparison with that observed in a non-infectious liver disease such as non-alcoholic steatohepatitis, we measured the liver steady state mRNA levels of interferon-alpha, interferon-beta and interferon-gamma ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10433

    authors: Abbate I,Romano M,Longo R,Cappiello G,Lo Iacono O,Di Marco V,Paparella C,Spano A,Capobianchi MR

    更新日期:2003-08-01 00:00:00

  • Molecular epidemiology of human bocavirus infection in hospitalized children with acute gastroenteritis in South Africa, 2009-2015.

    abstract::Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated with AGE in South Africa (SA). Between April 2009 and April 2015, 3765 stool specimens were colle...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25634

    authors: Netshikweta R,Chidamba L,Nadan S,Taylor MB,Page NA

    更新日期:2020-08-01 00:00:00

  • Circulating immune complexes in chronic hepatitis C.

    abstract::For assessing the role of circulating immune complexes (CIC) in chronic hepatitis C, the relative frequency of CIC was determined in 54 patients with chronic hepatitis C, 15 asymptomatic hepatitis C virus (HCV) carriers, and 54 healthy controls. IgM and IgG containing CIC were studied using both C1q and conglutinin (K...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460104

    authors: Tsai JF,Jeng JE,Chang WY,Ho MS,Lin ZY,Tsai JH

    更新日期:1995-05-01 00:00:00

  • Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient.

    abstract::Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cul...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890340207

    authors: Farrar GH,Roff MA,Amin T,Ball J,Parrett AM,Battacharyya U,Booth J,Wansbrough-Jones MH,Greenaway PJ

    更新日期:1991-06-01 00:00:00

  • Presence of Betapapillomavirus in Kaposi sarcoma lesions.

    abstract::Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23944

    authors: Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen B

    更新日期:2014-09-01 00:00:00

  • Severe metapneumovirus infections among immunocompetent and immunocompromised patients admitted to hospital with respiratory infection.

    abstract::Human metapneumovirus (hMPV) is considered an important cause of acute respiratory infections. hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of havin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23477

    authors: Souza JS,Watanabe A,Carraro E,Granato C,Bellei N

    更新日期:2013-03-01 00:00:00

  • A comparison of epidemiologic and immunologic features of bronchiolitis caused by influenza virus and respiratory syncytial virus.

    abstract::We studied epidemiologic and immunologic factors in infants with bronchiolitis caused by influenza virus. The proportion of these infants who were male and who had an immediate family member with a history of asthma was similar to that of a control group of infants with respiratory syncytial virus (RSV) bronchiolitis....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20268

    authors: Garofalo RP,Hintz KH,Hill V,Patti J,Ogra PL,Welliver RC Sr

    更新日期:2005-02-01 00:00:00

  • Replication of enhancer-deficient amphotropic murine leukemia virus in human fibrosarcoma but not in primary human fibroblasts.

    abstract::Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species including humans and is a potential contaminant in MLV vector preparations for human gene transfer studies. In general, MLV replication depends on the expression of viral genes under the control of 75 bp enhancer elements in the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10202

    authors: Reuss FU,Berdel B,Heber R,Bantel-Schaal U

    更新日期:2002-10-01 00:00:00

  • Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients.

    abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890080406

    authors: Ukkonen P,Granström ML,Räsänen J,Salonen EM,Penttinen K

    更新日期:1981-01-01 00:00:00

  • Infection of simian B lymphoblastoid cells with simian immunodeficiency virus is associated with upregulation of CD23 and CD40 cell surface markers.

    abstract::Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV) induce polyclonal B-cell activation and are associated with the appearance of lymphomas in their respective hosts in either the presence or the absence of other co-infecting viruses such as Epstein-Barr virus (EBV). However, the pathogen...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10179

    authors: Titti F,Zamarchi R,Maggiorella MT,Sernicola L,Geraci A,Negri DR,Borsetti A,Menin C,D'Andrea E,Modesti A,Masuelli L,Verani P,Chieco-Bianchi L,Amadori A

    更新日期:2002-09-01 00:00:00

  • Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese.

    abstract::Multiple determinants are involved in the progression of human papillomavirus (HPV)-infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLA-DRB1 polymorphism, high-risk HPV infection, and the development of cervical n...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20805

    authors: Chan PK,Cheung TH,Lin CK,Siu SS,Yim SF,Lo KW,Cheung JL,Tam AO,Tang JW

    更新日期:2007-07-01 00:00:00

  • Swine HEV infection in south India and phylogenetic analysis (1985-1999).

    abstract::Hepatitis E is endemic in India. It was recently noted that although all the Indian human hepatitis E virus (HEV) isolates (1976-2001) were placed in genotype I, the swine HEV recovered from western India (2000) belonged to genotype IV. This was in contrast to reports from the United States and Taiwan wherein both hum...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10301

    authors: Arankalle VA,Chobe LP,Walimbe AM,Yergolkar PN,Jacob GP

    更新日期:2003-03-01 00:00:00

  • Application of a modified loop-mediated isothermal amplification kit for detecting Norovirus genogroups I and II.

    abstract::Norovirus is a major etiologic agent in worldwide outbreaks of gastroenteritis associated with food as well as person-to-person transmission. The ubiquitous nature of Norovirus necessitates simple and rapid detection methods with high accuracy and sensitivity. To this end, several investigators have evaluated the usef...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21626

    authors: Yoda T,Suzuki Y,Yamazaki K,Sakon N,Kanki M,Kase T,Takahashi K,Inoue K

    更新日期:2009-12-01 00:00:00

  • Comparison of a rapid culture method combining an immunoperoxidase test and a group specific anti-VP1 monoclonal antibody with conventional virus isolation techniques for routine detection of enteroviruses in stools.

    abstract::In order to shorten the time required for the detection of enteroviruses in stool specimens, an 18-h immunoperoxidase test combining low-speed centrifugation and the use of a group specific anti-VP1 monoclonal antibody (5-D8/1, Dako) was developed. This rapid culture assay (RCA) was compared blindly to a conventional ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199803)54:3<204::aid-jmv11

    authors: Bourlet T,Gharbi J,Omar S,Aouni M,Pozzetto B

    更新日期:1998-03-01 00:00:00

  • Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter.

    abstract::The S RNA genome segment of hantaviruses carried by Arvicolinae and Sigmodontinae rodents encodes the nucleocapsid (N) protein and has an overlapping (+1) open reading frame (ORF) for a putative nonstructural protein (NSs). The aim of this study was to determine whether the ORF is functional. A protein corresponding t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20948

    authors: Jääskeläinen KM,Kaukinen P,Minskaya ES,Plyusnina A,Vapalahti O,Elliott RM,Weber F,Vaheri A,Plyusnin A

    更新日期:2007-10-01 00:00:00

  • Natural and artificial immunity to varicella zoster virus.

    abstract::The live varicella vaccine has been recommended for use in immunocompromised subjects and in adults who are susceptible to chickenpox. However, we do not know how humoral and cell-mediated immune responses induced after vaccination differed from those obtained after natural infection. To answer this, 45 previously inf...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890250207

    authors: Ndumbe PM,Cradock-Watson J,Levinsky RJ

    更新日期:1988-06-01 00:00:00

  • Human papillomavirus DNA and anti-HPV secretory IgA antibodies in cytologically normal cervical specimens.

    abstract::Cervical specimens collected from 163 cytologically healthy women were screened for the presence of human papillomavirus (HPV) DNA and anti-HPV secretory IgA antibodies. HPV DNA was detected by a general primer mediated polymerase chain reaction (PCR), which amplifies a conserved region from the L1 ORF of genital HPVs...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430219

    authors: Veress G,Kónya J,Csiky-Mészáros T,Czeglédy J,Gergely L

    更新日期:1994-06-01 00:00:00

  • HPV types and variants among cervical cancer tumors in three regions of Tunisia.

    abstract::Cervical cancer is the second most common cancer among Tunisian women, and the incidence rates vary by region. Three Tunisian registries report age-standardized rates of 6.3/10(5) in the central region, 5.4/10(5) in the north, and 2.7/10(5) in the south. High-risk human papillomavirus (HPV) types and their variants di...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22011

    authors: KrennHrubec K,Mrad K,Sriha B,Ben Ayed F,Bottalico DM,Ostolaza J,Smith B,Tchaikovska T,Soliman AS,Burk RD

    更新日期:2011-04-01 00:00:00

  • Eyeglasses in Wonderland of COVID-19.

    abstract::A recent cohort study1 at Suizhou in China identified that the proportion of subjects who wore eyeglasses was lower in hospitalized patients with coronavirus disease 2019 (COVID-19) than in the general population. This article is protected by copyright. All rights reserved. ...

    journal_title:Journal of medical virology

    pub_type: 信件

    doi:10.1002/jmv.26845

    authors: Takagi H

    更新日期:2021-02-02 00:00:00

  • Comparison of the efficacy of sofosbuvir plus ribavirin in Chinese patients with genotype 3a or 3b HCV infection.

    abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25454

    authors: Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

    更新日期:2019-07-01 00:00:00

  • Human papillomavirus genotypes distribution in cervical samples from Uruguayan women.

    abstract::Persistent infection with high-risk human papillomavirus (HPV) causes cervical preneoplasic lesions and invasive cervical cancer. This study evaluated the prevalence and distribution of HPV genotypes in cervical exfoliated cells from Uruguayan women. Five hundred sixty-eight cervical specimens were examined by PCR usi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23479

    authors: Ramas V,Mirazo S,Bonilla S,Mendoza L,Lago O,Basiletti J,González J,Picconi MA,Arbiza J

    更新日期:2013-05-01 00:00:00