当前位置： SCI文献检索 > JOURNAL OF MEDICAL VIROLOGY期刊下所有文献 > Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

Abstract：

:The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant populations in the rebounding plasma viral loads after therapy interruption. Since, different HIV quasispecies tend to compartmentalize in various cell types and tissue locations in patients during chronic infection, the phylogenetic relationships between HIV sequences amplified from residual plasma viruses and CD4 T cells of five patients on long-term suppressive therapy were examined. Three of these patients stopped therapy voluntarily for 3 weeks, but only one of them demonstrated viral load rebound in plasma. In phylogenetic analyses, the residual plasma viruses were found to be distinct genetically from the majority of CD4 T cell-associated virus populations in four of five patients. The compartmental analyses revealed that in all patients, plasma- and CD4 T cell-derived viral sequences were compartmentalized separately. Interestingly, the plasma sequences obtained before and after HAART-off in two patients were produced apparently from the same compartment, which was different from the circulating CD4 T cell-compartment. These results suggest the possibility that residual plasma viruses in patients on long-term suppressive HAART may be produced persistently from a cellular source yet to be identified, and are capable of spreading quickly in vivo, accounting for the rapid rebound of viral loads in plasma after therapy interruption.

journal_name

J Med Virol

journal_title

Journal of medical virology

authors

Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

doi

10.1002/jmv.21366

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

9-15

issue

1

eissn

0146-6615

issn

1096-9071

journal_volume

81

pub_type

杂志文章

相关文献

JOURNAL OF MEDICAL VIROLOGY文献大全
  • Atypical presentation of human bocavirus: Severe respiratory tract infection complicated with encephalopathy.

    abstract：:Human bocavirus (HBOV) has been reported as a worldwide distributed respiratory pathogen. It has also been associated with encephalitis recently by detection of the virus in cerebrospinal fluid (CSF) of patients presented with encephalitis. This retrospective study aimed to present clinical features of HBOV infections...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.24263

    authors： Akturk H,Sık G,Salman N,Sutcu M,Tatli B,Ciblak MA,Erol OB,Torun SH,Citak A,Somer A

    更新日期：2015-11-01 00:00:00

  • Association of the G4 rotavirus genotype with gastroenteritis in adults.

    abstract：:Rotavirus is the most common etiological cause of acute viral gastroenteritis in infants and young children worldwide, yet its role in the adult population is less well understood. We have recently identified rotavirus as the causative agent of severe diarrhea in adults, specifically in two gastroenteritis outbreaks i...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.20671

    authors： Feeney SA,Mitchell SJ,Mitchell F,Wyatt DE,Fairley D,McCaughey C,Coyle PV,O'Neill HJ

    更新日期：2006-08-01 00:00:00

  • Interferon-alpha therapy for chronic hepatitis B: early response related to pre-treatment changes in viral replication.

    abstract：:Chronic hepatitis B patients with low pre-treatment HBeAg (and HBV-DNA) levels are more likely to respond to interferon-alpha therapy. In retrospect, this low level of HBeAg may have been reached just before the start of therapy. Pre-treatment changes in HBeAg levels were studied in 121 patients undergoing interferon-...

    journal_title：Journal of medical virology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Heijtink RA,Janssen HL,Hop WC,Osterhaus AD,Schalm SW

    更新日期：2001-03-01 00:00:00

  • Minimal reactivation of Kaposi's sarcoma-associated herpesvirus by corticosteroids in latently infected B cell lines.

    abstract：:Corticosteroid use in transplant recipients increases the incidence and severity of Kaposi's sarcoma (KS), a disease associated with KS-associated herpesvirus (KSHV) infection. Recently, the prototypic corticosteroid, hydrocortisone, was shown to directly induce lytic cycle reactivation of KSHV in latently-infected BC...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.2155

    authors： Zoeteweij JP,Rinderknecht AS,Davis DA,Yarchoan R,Blauvelt A

    更新日期：2002-03-01 00:00:00

  • Hepatitis E virus genotype 1f outbreak in Bangladesh, 2018.

    abstract：:Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.26739

    authors： Baki AA,Haque W,Giti S,Khan AA,Rahman MM,Jubaida N,Rahman M

    更新日期：2020-12-17 00:00:00

  • Increased susceptibility of human respiratory syncytial virus to neutralization by anti-fusion protein antibodies on adaptation to replication in cell culture.

    abstract：:Subgroup A respiratory syncytial viruses present in respiratory secretions and low passage level cell culture isolates were found to be markedly less susceptible to neutralization with monoclonal antibodies (MAbs) to the F glycoprotein than the cell culture adapted A2 virus strain. Low passage virus isolates collected...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.20892

    authors： Marsh R,Connor A,Gias E,Toms GL

    更新日期：2007-06-01 00:00:00

  • Evaluation of the clinical usefulness of COBAS AMPLICOR HCV MONITOR assay (ver2.0): Comparison with AMPLICOR HCV MONITOR assay (ver1.0) and HCV core protein level.

    abstract：:The quantitation of serum levels of hepatitis C virus (HCV) RNA in chronic hepatitis C has been regarded as one of the most important indicators for the outcome of interferon (IFN) therapy. The AMPLICOR HCV MONITOR version 1.0 (AMPLICOR v1.0) assay is widely used for the evaluation of the HCV level. A new generation a...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.10209

    authors： Kawai S,Yokosuka O,Imazeki F,Saisho H,Mizuno C

    更新日期：2002-11-01 00:00:00

  • Transfusion-acquired cytomegalovirus infection in children in a hyperendemic area.

    abstract：:Thirty-nine children without previous cytomegalovirus (CMV) infection received blood transfusion in the National Taiwan University Hospital. The overall transfusion-acquired CMV infection rate was 36% (14/39). Donor CMV seropositive rate was 70%. None of the nine children who had received seronegative blood became inf...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890360110

    authors： Lee PI,Chang MH,Hwu WL,Kao CL,Lee CY

    更新日期：1992-01-01 00:00:00

  • Human immune response to Puumala virus glycoproteins and nucleocapsid protein expressed in mammalian cells.

    abstract：:Puumala hantavirus (PUUV) glycoproteins G1 and G2 and nucleocapsid protein (N) were expressed in BHK-21 cells by transfection of a plasmid producing a recombinant alphavirus replicon. Coexpression of G1 and G2 from separate constructs seemed to be important for the optimal folding of the glycoproteins, as evaluated by...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：

    authors： Kallio-Kokko H,Leveelahti R,Brummer-Korvenkontio M,Lundkvist A,Vaheri A,Vapalahti O

    更新日期：2001-11-01 00:00:00

  • Latent membrane protein-1 of Epstein-Barr virus inhibits cell growth and induces sensitivity to cisplatin in nasopharyngeal carcinoma cells.

    abstract：:Nasopharyngeal carcinoma is closely associated with Epstein-Barr virus (EBV) and the EBV encoded latent membrane protein-1 expression (LMP1) is commonly found in the tumour cells. LMP1 has been shown to be involved in modulation of cell growth in B cells but the biological properties of LMP1 expression in nasopharynge...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.2112

    authors： Liu Y,Wang X,Lo AK,Wong YC,Cheung AL,Tsao SW

    更新日期：2002-01-01 00:00:00

  • MxA protein in capillary blood of children with viral infections.

    abstract：:Capillary blood of febrile children was lysed by using a lysis buffer containing ascorbic acid. MxA quantitation was performed by an immunochemiluminescent assay. The MxA values were significantly higher in capillary blood of infants with viral infections due to adenovirus (n = 5), rotavirus (n = 15), or respiratory s...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：

    authors： Chieux V,Hober D,Chehadeh W,Harvey J,Alm G,Cousin J,Ducoulombier H,Wattre P

    更新日期：1999-12-01 00:00:00

  • Risk factors associated with hepatitis C virus (HCV) infection among prostitutes and their clients in the city of Santos, São Paulo State, Brazil.

    abstract：:We studied the role of sexual transmission in the epidemiology of HCV by a cross-sectional study comparing prostitutes and HCV seropositive and seronegative sexual clients recruited from the bordellos of the docks of Santos, São Paulo State. The average age in the prostitute group was 27.2 years. The median time spent...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：

    authors： Mesquita PE,Granato CF,Castelo A

    更新日期：1997-04-01 00:00:00

  • Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis B virus infection in Taiwan.

    abstract：:This study aimed to examine the application of hepatitis B surface antigen (HBsAg) confirmatory testing when diagnosing hepatitis B infection among young persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg status, the presence of antibodies against HBsAg (anti-HBs), and the presence of antibod...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.22127

    authors： Chu FY,Su FH,Cheng SH,Lin YS,Li CY,Chien CC,Lin YC,Chiang SY

    更新日期：2011-09-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract：:Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890470418

    authors： Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期：1995-12-01 00:00:00

  • Molecular epidemiology of astroviruses in Japan from 1995 to 1998 by reverse transcription-polymerase chain reaction with serotype-specific primers (1 to 8).

    abstract：:In addition to the serotype-specific primers described previously (1 to 7), a new serotype 8-specific primer has been designed, allowing detection of all astrovirus serotypes. A total of 1,382 diarrheal stool samples in 5 regions in Japan were examined by reverse transcription-polymerase chain reaction (RT-PCR). The i...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：

    authors： Sakamoto T,Negishi H,Wang QH,Akihara S,Kim B,Nishimura S,Kaneshi K,Nakaya S,Ueda Y,Sugita K,Motohiro T,Nishimura T,Ushijima H

    更新日期：2000-07-01 00:00:00

  • Hepatitis C virus genotypes in French blood donors.

    abstract：:The prevalence of different hepatitis C virus (HCV) genotypes in HCV infected individuals and the relation between the HCV genotypes and the source of the infection are controversial. The aim of this study was to determine the HCV genotypes in French blood donors. Fifty-one anti-HCV positive blood donors were studied ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890450408

    authors： Gournay J,Marcellin P,Martinot-Peignoux M,Degott C,Gabriel F,Courtois F,Branger M,Wild AM,Erlinger S,Benhamou JP

    更新日期：1995-04-01 00:00:00

  • Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir.

    abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.21165

    authors： Yoshizaki T,Wakisaka N,Kondo S,Murono S,Shimizu Y,Nakashima M,Tsuji A,Furukawa M

    更新日期：2008-05-01 00:00:00

  • Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts.

    abstract：:Varicella zoster virus (VZV) causes varicella (chickenpox), after which virus becomes latent in ganglia along the entire neuraxis. Virus reactivation produces zoster (shingles). Infectious VZV is found in vesicles of patients with zoster and varicella, but virus shed in the absence of disease has not been documented. ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.21173

    authors： Cohrs RJ,Mehta SK,Schmid DS,Gilden DH,Pierson DL

    更新日期：2008-06-01 00:00:00

  • Repeated HIV-1 resistance genotyping external quality assessments improve virology laboratory performance.

    abstract：:The performance of French virology laboratories belonging to the ANRS network has been assessed annually for 3 years. The performance of these laboratories was compared between the years 2002 and 2003. Ten and 7 coded samples were sent to 38 virology laboratories in 2002 and 45 virology laboratories in 2003, respectiv...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.20522

    authors： Descamps D,Delaugerre C,Masquelier B,Ruffault A,Marcelin AG,Izopet J,Chaix ML,Calvez V,Brun-Vézinet F,Costagliola D

    更新日期：2006-02-01 00:00:00

  • Adenoviruses in faeces of children with acute gastroenteritis in Rio de Janeiro, Brazil.

    abstract：:Faeces from 746 children less than 5 years old with acute gastroenteritis were screened for the presence of adenovirus particles or antigens by immunoelectron microscopy (IEM) and enzyme immunoassay (EIA). Thirty-five samples were positive by both IEM and EIA, two only by IEM, and two only by EIA, giving a total of 39...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890150213

    authors： Leite JP,Pereira HG,Azeredo RS,Schatzmayr HG

    更新日期：1985-02-01 00:00:00

  • Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey.

    abstract：:In April 2004, two patients were admitted to hospital in Berlin, Germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of Turkey. They were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.20441

    authors： Chmielewicz B,Benzler J,Pauli G,Krause G,Bergmann F,Schweiger B

    更新日期：2005-10-01 00:00:00

  • Current seroepidemiology of hepatitis D virus infection among hepatitis B surface antigen carriers of general and high-risk populations in Taiwan.

    abstract：:In order to assess the current seroepidemiology of hepatitis D virus (HDV) infection in Taiwan where hepatitis B virus (HBV) is hyperendemic, a total of 756 voluntary blood donors, 641 prostitutes, 1,014 patients with sexually transmitted diseases (STDs), and 628 drug abusers were studied. Radioimmunoassays were used ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890380205

    authors： Chen CJ,Tseng SF,Lu CF,Lin HC,You SL,Chen CS,Hwang SJ,Hsieh SF,Hsu ST

    更新日期：1992-10-01 00:00:00

  • Detection of viral antigens in cerebrospinal fluid of patients with herpes simplex virus encephalitis.

    abstract：:Thirty-two cerebrospinal fluid (CSF) samples from eighteen patients with confirmed herpes simplex encephalitis (HSE) were assayed by an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of viral antigens. The results are expressed as an antigen ratio distinguishing between herpes simplex virus (HSV) ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890210209

    authors： Bos CA,Olding-Stenkvist E,Wilterdink JB,Scheffer AJ

    更新日期：1987-02-01 00:00:00

  • Threshold value of LIAISON XL anti-HCV screening assay predicting positive immunoblotting results.

    abstract：:Some international guidelines recommend evaluating the need to confirm positive anti-hepatitis C virus (HCV) antibody screening results by means of a more specific antibody or molecular biology test on the basis of a screening threshold value (such as the sample signal/cut-off ratio) that can predict the positivity of...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.24831

    authors： De Paschale M,Manco MT,Arpino O,Ricucci V,Paganini A,Belvisi L,Cagnin D,Cerulli T,Cianflone A,Agrappi C,Mirri P,Clerici P

    更新日期：2017-10-01 00:00:00

  • Significance of postnatal mother-to-child transmission of human T-lymphotropic virus type-I on the development of adult T-cell leukemia/lymphoma.

    abstract：:In order to shed light on the mode of HTLV-I infection by mother-to-child transmission, we examined sera of school children in a highly endemic town on two separate occasions at a 6-year interval. The carrier rates in ages 15-17, 8.7 and 2.1%, were significantly higher than that in ages 6-8, 1.7 and 0.4%, in studies. ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890200307

    authors： Sugiyama H,Doi H,Yamaguchi K,Tsuji Y,Miyamoto T,Hino S

    更新日期：1986-11-01 00:00:00

  • Human T-cell lymphotropic virus types I and II (HTLV-I and -II) infection among seroindeterminate cases in Argentina.

    abstract：:Human T-cell lymphotropic virus (HTLV) seroindeterminate cases have been reported among blood donors (BD) and in at-risk populations worldwide, including Argentina. The objective of the present work was to study the presence of HTLV-I/II infection and its association to specific Western blot (WB) patterns among health...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.20731

    authors： Berini CA,Eirin ME,Pando MA,Biglione MM

    更新日期：2007-01-01 00:00:00

  • The mechanistic rationale of drugs, primary endpoints, geographical distribution of clinical trials against severe acute respiratory syndrome-related coronavirus-2: A systematic review.

    abstract：:There are numerous ongoing studies assessing treatment options for preventing, treating, and managing complications of coronavirus disease-2019 disease. The objective of this study was to do a systematic review and critical appraisal of the ongoing clinical trials with an aim to provide insight into the various interv...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.26338

    authors： Venkatesulu BP,Thoguluva Chandrasekar V,Giridhar P,V P,Patel HK,Manteuffel J

    更新日期：2021-02-01 00:00:00

  • Human platelet antigens polymorphisms; association to the development of liver fibrosis in patients with chronic hepatitis C.

    abstract：:Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.25423

    authors： Ghasemi A,Zadsar M,Shaiegan M,Samiei S,Namvar A,Rasouli M,Moosanejad M

    更新日期：2020-01-01 00:00:00

  • Culture-amplified detection of dengue virus from serum in an outbreak of dengue fever.

    abstract：:An outbreak of dengue type 2 occurred in North Queensland, Australia, between December 1996 and April 1997. Culture of serum in the Aedes albopictus C6/36 cell line with detection using immunofluorescent staining was compared with a culture-amplified detection system using an immunoperoxidase staining method in a micr...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：

    authors： Gleeson F,McBride J,Norton R

    更新日期：1999-02-01 00:00:00

  • Effect of antiviral substances on hepatitis A virus replication in vitro.

    abstract：:The effect of protamine, atropine, selenocystamine, taxifolin, and catechin on the infectivity and antigenicity of the cell culture-adapted hepatitis A virus (HAV) strain CF 53 was studied. The toxicity on uninfected PLC/PRF/5 cells was examined for each antiviral compound by morphological and biochemical methods, in ...

    journal_title：Journal of medical virology

    pub_type： 杂志文章

    doi：10.1002/jmv.1890220108

    authors： Biziagos E,Crance JM,Passagot J,Deloince R

    更新日期：1987-05-01 00:00:00