Minimal reactivation of Kaposi's sarcoma-associated herpesvirus by corticosteroids in latently infected B cell lines.

Abstract:

:Corticosteroid use in transplant recipients increases the incidence and severity of Kaposi's sarcoma (KS), a disease associated with KS-associated herpesvirus (KSHV) infection. Recently, the prototypic corticosteroid, hydrocortisone, was shown to directly induce lytic cycle reactivation of KSHV in latently-infected BCBL-1 cells. The purpose of this study was to examine this phenomenon in further detail. After incubation with dexamethasone (

journal_name

J Med Virol

authors

Zoeteweij JP,Rinderknecht AS,Davis DA,Yarchoan R,Blauvelt A

doi

10.1002/jmv.2155

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

378-83

issue

3

eissn

0146-6615

issn

1096-9071

pii

10.1002/jmv.2155

journal_volume

66

pub_type

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