Abstract:
:The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5'-untranslated region (5'-UTR)-Core and the NS5B regions of HCV was carried out in this study. An HCV strain (SE-03-07-1689) collected in Metro Manila, Philippines, belonged to discordant subtypes, 2b and 1b in 5'-UTR-Core and NS5B regions, respectively. The 9.3 kb sequence of this strain including the entire open reading frame was compared with those of the reference strains retrieved from the HCV sequences database (GenBank/EMBL/DDBJ) and indicated a recombination event. The computation of the sequence similarity mapped a crossover point within the NS3 region. This is the second report on the inter-genotype recombinant of HCV and the third when an intra-genotype recombinant is included. This recombinant strain, SE-03-07-1689, is designated tentatively as RF3_2b/1b according to the suggestions used for the other two HCV recombinants.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Kageyama S,Agdamag DM,Alesna ET,Leaño PS,Heredia AM,Abellanosa-Tac-An IP,Jereza LD,Tanimoto T,Yamamura J,Ichimura Hdoi
10.1002/jmv.20714subject
Has Abstractpub_date
2006-11-01 00:00:00pages
1423-8issue
11eissn
0146-6615issn
1096-9071journal_volume
78pub_type
杂志文章abstract::Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25390
更新日期:2019-05-01 00:00:00
abstract::Shedding of herpes simplex virus type 1 (HSV-1) into saliva was studied in 83 patients with orofacial fractures. Infectious virus was isolated from 14 of 83 patients (16.8%) with no detectable herpetic lesion during hospitalization. Of the 83 patients, 44 (53%) had HSV-1 specific antibody. Virus shedding into saliva w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890280205
更新日期:1989-06-01 00:00:00
abstract::Early estimates of the prevalence of TTV viremia in healthy adults of developed countries were in the order of 1--10 %, while similar estimates in Third World countries were considerably higher. Using three different PCRs, TTV-related DNA was detected in serum from 180 out of the 201 Norwegian blood donors tested, ind...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1062
更新日期:2001-07-01 00:00:00
abstract::The human foamy virus is a complex retrovirus that codes for several regulatory bel genes in addition to the conventional gag, pol, and env genes. The bel 3 gene is located in the 3' part of the viral genome comparable to that of the superantigen of the mouse mammary tumor virus. Superantigens bound to major histocomp...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440112
更新日期:1994-09-01 00:00:00
abstract::The efficacy of interferon (IFN) monotherapy for non-responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who received low-dose intermittent IFN-...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21224
更新日期:2008-08-01 00:00:00
abstract::Guinea pig infection with a highly passaged XJ prototype strain of Junín virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junín antigens as shown by im...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890150208
更新日期:1985-02-01 00:00:00
abstract::Virological studies were carried out on 3 to 36-month-old patients admitted to the Children's Hospital of the University of Modena with febrile syndrome from September 1990 to February 1991. Virological tests were carried out for human herpesvirus-6 (HHV-6), Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simp...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890390211
更新日期:1993-02-01 00:00:00
abstract::Only recently have we begun to fully realize the diversity of virions within a single human isolate of the group B Coxsackieviruses. These intratypic (strain) differences may be one of the important factors influencing pathogenesis, e.g., myocarditis vs. pancreatitis. Yet, until the virion strains within a type can be...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200103
更新日期:1986-09-01 00:00:00
abstract::To compare characteristics and outcomes of patients who had COVID-19 with Mycoplasma pneumoniae immunoglobulin M (IgM) antibodies to those without M. pneumoniae antibodies. We retrospectively reviewed cases admitted over a 4-week period between 17 March 2020 and 14 April 2020 to the Hoboken University Medical Center, ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26467
更新日期:2021-02-01 00:00:00
abstract::A reverse transcription-polymerase chain reaction (RT-PCR) was developed for the detection of Chikungunya virus infection. Based on the nonstructural protein 1 (nsP1) and glycoprotein E1 (E1) genes of Chikungunya, two primer sets were designed. Total RNA were extracted from the cell culture fluid of Aedes albopictus C...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10085
更新日期:2002-07-01 00:00:00
abstract::Hepatitis C Virus (HCV) NS3 protease is an attractive target for antiviral agent development because it is required for viral replication. Because a stable cell culture system or small animal model to study HCV replication is not readily available, we constructed an in vitro model allowing the investigation of NS3 tra...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2089
更新日期:2001-12-01 00:00:00
abstract::Human hepatitis B virus (HBV) and hepatitis C virus (HCV) are two major etiologic agents of chronic hepatitis, which is closely related to the development of hepatocellular carcinoma (HCC). A possible involvement of HBV co-infection was investigated in ongoing HCV-related liver diseases in HCV-infected patients. A pre...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract::The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25035
更新日期:2018-05-01 00:00:00
abstract::Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890370208
更新日期:1992-06-01 00:00:00
abstract::Persistent Epstein-Barr virus (EBV) infection is controlled tightly by virus-specific T cells. EBV infection is reactivated intermittently over time, even in apparently healthy carriers. Changes in frequency and reactivity of memory T cells, particularly of CD8(+) origin, have not been assessed in this context. It is ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22258
更新日期:2012-01-01 00:00:00
abstract::To recognize the period of exaggerated cytokine response in patients with coronavirus disease 2019 (COVID-19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. The data of 12 adult COVID-19 pneumonia patients who were followed in the inpatient clinics of Biruni University Med...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26111
更新日期:2020-11-01 00:00:00
abstract::Epstein-Barr virus is present in the saliva of most persistently infected individuals and is generally thought to be spread by close oral contact. However, there are now several reports of EBV in genital secretions, suggesting the possibility of sexual transmission between adults. The present study was undertaken to i...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.20682
更新日期:2006-09-01 00:00:00
abstract::Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130208
更新日期:1984-01-01 00:00:00
abstract::During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10393
更新日期:2003-06-01 00:00:00
abstract::Since outbreaks of severe acute hemorrhagic conjunctivitis occur worldwide [Hierholzer and Hatch, 1985] and the majority of the epidemics are caused by enterovirus 70 (EV-70), we developed an EV-70 IgM ELISA to simplify the diagnosis of these outbreaks. The test is based on the capture antibody technique and the use o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890210404
更新日期:1987-04-01 00:00:00
abstract::The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21227
更新日期:2008-09-01 00:00:00
abstract::Dried blood spots collected on filter paper are considered potential clinical specimens for measles surveillance because of their ease of collection, storage, and transport. The usefulness of these samples for surveillance of measles was evaluated in a field setting. Blood spots were collected by finger-prick from 316...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20136
更新日期:2004-08-01 00:00:00
abstract::COVID-19 pandemic has affected over 100 countries in a matter of weeks. People's response toward social distancing in the emerging pandemic is uncertain. In this study, we evaluated the influence of information (formal and informal) sources on situational awareness of the public for adopting health-protective behavior...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25840
更新日期:2020-07-01 00:00:00
abstract::Total RNA from normal adult woodchucks was analyzed using membrane arrays containing human cDNA clones, and the gene expression patterns were compared to human liver. Various hybridization and wash conditions were examined. In both the woodchuck and human livers, 352 genes were identified as highly expressed (Z-scores...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20186
更新日期:2004-10-01 00:00:00
abstract::Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high-risk HPV in cervical and vaginal samples during the early follow-up of patients treated for invasive cervical cancer and correlate the results...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23303
更新日期:2012-07-01 00:00:00
abstract::HCV replication in extra-hepatic reservoirs has been suggested to occur in many tissues including PBMCs. A recent study showed evidence for compartmentalization and evolution of HCV in PBMCs. However, the cells that support HCV replication in PBMCs have not been identified. In this study we have fractionated the PBMC ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21906
更新日期:2010-12-01 00:00:00
abstract::Incarcerated persons have high rates of infectious diseases. Few data on the prevalence of sexually transmitted diseases in prisoners are available. This multi-center cross-sectional study enrolled 973 inmates from eight Italian prisons. Demographic and behavioral data were collected using an anonymous standardized qu...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.20774
更新日期:2007-02-01 00:00:00
abstract::To establish gut immunity in monkeys to polio-virus type 1, we fed four juvenile bonnet monkeys (Macaca radiata) with 100 median infectious doses of the Mahoney strain of virus. The duration of viral shedding in the throat and faeces and the titre of virus in faeces were measured. Eighteen days after the last monkey s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890270208
更新日期:1989-02-01 00:00:00
abstract::Hepatitis A virus (HAV) is the leading cause of acute viral hepatitis worldwide, with HAV infection being restricted to humans and nonhuman primates. In this study, HAV infection status was serologically determined in domestic pigs and experimental infections of HAV were attempted to verify HAV infectivity in pigs. An...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24386
更新日期:2016-04-01 00:00:00
abstract::Many patients with mixed cryoglobulinemia and chronic HCV infection experience symptoms, such as dyspnea, which sometimes do not seem to indicate the involvement of the liver but rather the symptoms of heart failure. To our knowledge, there has been no other study evaluating the serum levels of N-terminal pro-brain na...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21636
更新日期:2010-02-01 00:00:00