Human and monoclonal antibodies to hepatitis B core antigen recognise a single immunodominant epitope.

Abstract:

:Monoclonal antibodies were raised against hepatitis B core antigen (HBcAg) synthesized in Escherichia coli. They identified a single immunodominant determinant on both liver-derived and E. coli-derived HBcAg. Cross-inhibition studies demonstrated that HBsAg-containing human sera which contained antibodies to HBcAg (anti-HBc) together with either hepatitis B e antigen (HBeAg) or its antibody (anti-HBe) essentially only recognised the same single determinant as the murine antibodies. The identification of a single dominant HBcAg determinant may be important if future hepatitis B virus vaccines contain HBcAg.

journal_name

J Med Virol

authors

Ferns RB,Tedder RS

doi

10.1002/jmv.1890190213

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

193-203

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

19

pub_type

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