Abstract:
:Monoclonal antibodies were raised against hepatitis B core antigen (HBcAg) synthesized in Escherichia coli. They identified a single immunodominant determinant on both liver-derived and E. coli-derived HBcAg. Cross-inhibition studies demonstrated that HBsAg-containing human sera which contained antibodies to HBcAg (anti-HBc) together with either hepatitis B e antigen (HBeAg) or its antibody (anti-HBe) essentially only recognised the same single determinant as the murine antibodies. The identification of a single dominant HBcAg determinant may be important if future hepatitis B virus vaccines contain HBcAg.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Ferns RB,Tedder RSdoi
10.1002/jmv.1890190213subject
Has Abstractpub_date
1986-06-01 00:00:00pages
193-203issue
2eissn
0146-6615issn
1096-9071journal_volume
19pub_type
杂志文章abstract::Nitric oxide is well accepted as one of the defenses for inhibiting viral dissemination. Macrophages and cells in the macrophage lineage are professional nitric oxide producers which sub-serve as target for dengue virus. The interaction between nitric oxide and dengue virus in such target cell is unknown. In this repo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20418
更新日期:2005-09-01 00:00:00
abstract::At present eight hepatitis B virus (HBV) genotypes have been characterized: A to H. The most common genotype in Northern Europe is genotype A. So far there is no record of the specific HBV genotype distribution in Iceland. Iceland has a small population whose homogeneity has changed due to increasing migration during ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20480
更新日期:2005-12-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
abstract::The human foamy virus is a complex retrovirus that codes for several regulatory bel genes in addition to the conventional gag, pol, and env genes. The bel 3 gene is located in the 3' part of the viral genome comparable to that of the superantigen of the mouse mammary tumor virus. Superantigens bound to major histocomp...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440112
更新日期:1994-09-01 00:00:00
abstract::Human metapneumovirus (hMPV) is considered an important cause of acute respiratory infections. hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of havin...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
abstract::Stool specimens from 334 infants and young children hospitalized with diarrhea in the General Hospital, Kuala Lumpur, Malaysia between August and November, 1987 were analyzed for the presence of rotavirus double-stranded (ds) RNA by polyacrylamide gel electrophoresis. Of the 334 specimens analyzed, 32 (9.6%) were posi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430302
更新日期:1994-07-01 00:00:00
abstract::As the coronavirus disease 2019 pandemic keep tackling global public health systems worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) genome keeps mutating. In that regard, the recent emergence of the B.1.1.7 lineage in the UK has called the attention of global authorities. One point of concer...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2021-01-28 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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更新日期:2012-02-01 00:00:00
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doi:10.1002/jmv.24184
更新日期:2015-08-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26
更新日期:2000-05-01 00:00:00
abstract::Seventeen out of 30 patients with chronic hepatitis type B with hepatitis B e antigen (HBeAg) in serum remained persistently positive for e antigen, while 13 seroconverted to antibody (anti-HBe) when followed over a period of one to five years. Initial levels of serum hepatitis B virus (HBV) markers, such as the hepat...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890100208
更新日期:1982-01-01 00:00:00
abstract::A possible new subgroup of human rotavirus was found by crossed immunoelectrophoresis and enzyme-linked immunosorbent assay. The epidemiology of the established subgroups 1 and 2 and this new variant was studied in two different communities. Of 398 rotavirus isolates from Malmö, Sweden, 26.8% were of type 1, 71.7% of ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890120205
更新日期:1983-01-01 00:00:00
abstract::Group A rotaviruses are the main cause of acute gastroenteritis in children worldwide. The intermediate capsid protein VP6 encoded by segment 6 of the dsRNA genome is the major structural component of the virus and it is highly antigenic and immunogenic. VP6 is responsible for group and subgroup (SG) specificities, al...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21306
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The unprecedented demand for testing for the ongoing coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has led to an acute shortage and limited availability of test reagents for which pooling of samples has been recommended in areas with low prevalence. Considering the possibility of dilution ...
journal_title:Journal of medical virology
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doi:10.1002/jmv.26618
更新日期:2020-10-21 00:00:00
abstract::The risk and clearance of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection was investigated in a cohort of homosexual men (n=180; median follow-up time, 7 years). The interaction between GBV-C/HGV RNA and antibodies against the E2 region of the virus, and the clinical impact of chronic GBV-C/HGV infection wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199911)59:3<303::aid-jmv7>
更新日期:1999-11-01 00:00:00
abstract::Resistance to adamantanes for treating influenza A(H3N2) has increased dramatically, worldwide, over the past 5 years. A comprehensive 10-year data set on the rise of adamantane-resistance in Hong Kong is reported. Nucleotide sequences encoding the M2-ion channel of influenza A(H3N2) were obtained from 281 H3N2 isolat...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21155
更新日期:2008-05-01 00:00:00
abstract::The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430207
更新日期:1994-06-01 00:00:00
abstract::The reliability of the polymerase chain reaction (PCR) for prenatal diagnosis of human cytomegalovirus (HCMV) infection was determined by retrospective testing of 35 amniotic fluids identified previously as positive or negative for HCMV by virus isolation. Amniocentesis was performed in 26 pregnant women with primary ...
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doi:10.1002/jmv.1890470428
更新日期:1995-12-01 00:00:00
abstract::Varicella in the immunocompetent adult is an infrequent but potentially serious infection. Previous studies in immunocompetent hosts and normal adults have demonstrated the value of intravenous acyclovir in the treatment of varicella-zoster virus infections. Oral acyclovir has also shown efficacy in both normal adults...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.1890410517
更新日期:1993-01-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24440
更新日期:2016-07-01 00:00:00
abstract::Antigenic drift of the hemagglutinin (HA) and neuraminidase (NA) proteins of the influenza virus cause a decrease in vaccine efficacy. Since the information about the evolution of these viruses in Saudi is deficient so we investigated the genetic diversity of circulating H1N1 viruses. Nasopharyngeal aspirates/swabs co...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25759
更新日期:2020-03-11 00:00:00
abstract::The ability to detect type-specific high risk HPV (HR-HPV) infections in samples from females and males is important for monitoring the epidemiology of HPV and the impact of vaccination. Type-specific detection concordance between paired urine and genital samples from females (n = 264) undergoing routine colposcopy an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22167
更新日期:2011-10-01 00:00:00
abstract::A cDNA copy of the HCV229E nucleocapsid protein gene was isolated and characterized. Sequence analysis predicts a nucleocapsid polypeptide of 389 amino acids with a molecular weight (mol. wt.) of 43,450. Single strand RNA probes derived from the cDNA copy hybridize specifically to HCV229E RNA and approximately 50 pg o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310216
更新日期:1990-06-01 00:00:00
abstract::Neutralization of virus is likely to be necessary for development of an effective prophylactic vaccine against genital human papillomavirus (HPV) infection. Two New Zealand white rabbits were immunized with purified HPV type 11 (HPV 11) virions in Freund's adjuvant. An enzyme linked immunoassay (ELISA) was used to det...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:1997-11-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 07_BC strain has caused serious outbreaks among injection drug users in Taiwan since 2004. The objective of this study was to conduct a molecular epidemiological study of HCV genotypes in intravenous drug users in Taiwan. Blood samples and ...
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pub_type: 杂志文章
doi:10.1002/jmv.21658
更新日期:2010-01-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420311
更新日期:1994-03-01 00:00:00
abstract::Nineteen Chinese patients with chronic hepatitis B virus (HBV) infection, seropositive for HBV e antigen (HBeAg) and HBV DNA on at least three occasions in 6 months, were randomised to receive either recombinant human interferon-gamma (rIFN gamma) 0.1 mg/m2 intramuscularly thrice weekly for 16 weeks (n = 11) or no ant...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jmv.1890340310
更新日期:1991-07-01 00:00:00
abstract::The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the inter...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199905)58:1<11::aid-jmv2>3
更新日期:1999-05-01 00:00:00