Abstract:
:G1P[8] rotaviruses are predominant in causing diarrheal infections in humans all over the world. This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from Rotarix™ vaccine recipients and non-recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains showed a genogroup-1 backbone with intra-genotypic diversity in the VP7 and VP4 gene segments and a homogeneous constellation of the internal gene segments. A divergence in the range of 1.4-17.3% from Rotarix™ vaccine strain was revealed by structural and non-structural genes of the strains at nucleotide and amino acid level. These data reflect ability of such G1P[8] strains to cause rotavirus infections in humans.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Pradhan GN,Chitambar SDdoi
10.1002/jmv.25007subject
Has Abstractpub_date
2018-04-01 00:00:00pages
772-778issue
4eissn
0146-6615issn
1096-9071journal_volume
90pub_type
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