Abstract:
:This is an audit of a new technique to improve the colposcopy service. Samples were tested for high risk HPV DNA using Digene Hybrid Capture II. Sixty-four percent of the sampled women under 30 had detectable high risk HPV DNA, decreasing to 44% in 30--39 year olds and to 27% in women over 40. High risk HPV prevalence increased with severity of cytology, although 22% with normal colposcopy had detectable high risk HPV. Of those women treated for cervical dysplasia, 83% had detectable high risk HPV prior to treatment, compared to only 32% afterwards. The audit has shown that high risk HPV testing has considerable discriminatory value. It has been integrated successfully into the service, particularly to manage low grade cervical abnormalities and to add valuable information following treatment for cervical dysplasia. Results need to be interpreted alongside colposcopy, cytology, and histology, and care must be taken in the interpretation of a single high risk HPV result.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Perrons C,Brink N,Jalal H,Watts P,Jelley Rdoi
10.1002/jmv.20401keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
576-82issue
4eissn
0146-6615issn
1096-9071journal_volume
76pub_type
杂志文章abstract::Interleukin 33 (IL-33) and soluble form of ST2 (sST2) are involved in inflammation. This study aimed to assess the role of serum IL-33 and sST2 in neonates with HCMV infection. The concentration of serum IL-33 and sST2 in 20 patients and 16 healthy controls were measure by enzyme-linked immune-sorbent assay (ELISA). T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25187
更新日期:2018-08-01 00:00:00
abstract::We have attempted to reactivate human herpesvirus 6 (HHV-6) by infection with HHV-7 using childhood exanthem subitum patients in vitro. Peripheral blood mononuclear cells (PBMCs) were collected from children who had a history of exanthem subitum(ES) by HHV-6 and were infected by human herpesvirus 7 (HHV-7) in vitro. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200003)60:3<284::aid-jmv6>
更新日期:2000-03-01 00:00:00
abstract::Screening for high-risk human papillomavirus (HPV) types allows the detection of women at a high risk of cervical squamous carcinomas, thereby defining a subset of patients targeted for more intensive screening and follow-up. Thirty-four cervical biopsy specimens and isolated cells from cervical smears of normal women...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199602)48:2<161::AID-JMV8>
更新日期:1996-02-01 00:00:00
abstract::There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21819
更新日期:2010-08-01 00:00:00
abstract::To determine the seroprevalence of antibodies against dengue virus (DENV) and West Nile virus (WNV) in the human population of the Bolivian Chaco, we tested 256 inhabitants of two rural communities. The seroprevalence, confirmed by plaque reduction neutralization test, was 7.8% and 2.7% for DENV and WNV, respectively....
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25283
更新日期:2019-01-01 00:00:00
abstract::GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of heterogeneous virus ha...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Regulatory T cells (T(reg)) provide a balance to immune T cell activation thereby protecting the body from pathogen-induced immunopathology. Several persistent viruses induce T(reg) that subvert protective immune mechanisms and promote viral persistence. Epstein-Barr virus (EBV) generally infects children subclinicall...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21445
更新日期:2009-05-01 00:00:00
abstract::The presence of therapy-associated hepatitis B virus (HBV) variants is the main drawback of antiviral therapy for HBV infection. Moreover, drug-resistant variants are more insensitive to a second agent and more therapy-associated mutations will be present. To apply better nucleos(t)ide analogues (NA) and reduce the oc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24006
更新日期:2015-09-01 00:00:00
abstract::Guinea pigs infected with Argentine hemorrhagic fever virus (Junin) were treated with pooled, homologous convalescent sera. Use of 15,000 or 5,000 therapeutic units of immune sera prevented all signs of illness when administered within 24 hr of infection. We could also prevent illness and death in infected guinea pigs...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200303
更新日期:1986-11-01 00:00:00
abstract::Neutralization of virus is likely to be necessary for development of an effective prophylactic vaccine against genital human papillomavirus (HPV) infection. Two New Zealand white rabbits were immunized with purified HPV type 11 (HPV 11) virions in Freund's adjuvant. An enzyme linked immunoassay (ELISA) was used to det...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199711)53:3<185::aid-jmv1>
更新日期:1997-11-01 00:00:00
abstract::The λ-carrageenan (λ-car) is a potent and selective inhibitor of dengue virus (DENV) infection targeted to virus adsorption and internalization, due to the structural similarities with the mammalian cell receptor heparan sulfate. To further characterize the antiviral activity of λ-car, the selection and the phenotypic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24457
更新日期:2016-07-01 00:00:00
abstract::The metastasis status of pelvic lymph nodes (PLNs) seems to be a predictive factor of survival. It was suggested that the presence of HPV DNA and other biological markers in PLN may indicate a sub clinical early metastasis. The aim was to describe the prevalence and distribution patterns of HPV DNA and H-ras mutations...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21076
更新日期:2008-04-01 00:00:00
abstract::Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22057
更新日期:2011-05-01 00:00:00
abstract::The ability of hepatitis A virus (HAV) to agglutinate human erythrocytes was used to develop IgM and IgG antibody capture haemadherence tests (MACHAT and GACHAT). Haemadherence was dependent on the pH of the red cell suspension and was best in the pH range 5.4 to 5.8. The tests were applied to serum, urine, and saliva...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890390106
更新日期:1993-01-01 00:00:00
abstract::Live attenuated cold-adapted influenza vaccine is undergoing evaluation in man. Several strains have proven to be safe, immunogenic, nontransmissible, and protective against experimental challenge. In this study of A/Peking/2/79(H3N2), with six internal genes from the cold-adapted (Ca) parent A/Ann Arbor/6/60(H2N2), w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890260209
更新日期:1988-10-01 00:00:00
abstract::Exacerbations of chronic hepatitis B have been associated with accumulation of mutations in the HBV core gene, with amino acid (aa) substitutions clustering between aa 50 and 69. This region of the nucleocapsid protein is known as an immunodominant epitope for CD4+ T-lymphocytes, however the impact of these mutations ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20016
更新日期:2004-03-01 00:00:00
abstract::Deletions and insertions in the hepatitis B virus (HBV) X region have been associated with severe forms of liver disease, including hepatocellular carcinoma (HCC). However, the molecular epidemiologic features of this virus have been described rarely. Deletions and insertions in the X region were determined by direct ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21938
更新日期:2011-01-01 00:00:00
abstract::Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cell...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890240312
更新日期:1988-03-01 00:00:00
abstract::Previously, it was reported that productive viral infection, viral protein synthesis, and viral RNA replication of respiratory syncytial virus (RSV) operated efficiently in two human epithelial cell lines (HEp-2 and A549), but not in a human mast-cell line, HMC-1. Based on these observations, it was hypothesized that ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23196
更新日期:2012-02-01 00:00:00
abstract::Identification of high-risk HPV genotypes in patients is essential for vaccination and prevention programs while the geographic distribution of cervical cancer varies widely. HPV 16 is the major cause of cervical cancer followed by HPV 18, HPV 31, HPV 52, or HPV 58 depending on geographic area. In this study, the dist...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23769
更新日期:2014-04-01 00:00:00
abstract::Natural history of anal intraepithelial neoplasia and anal cancer is not fully understood. Factors associated with cytological abnormalities and predictors of progression to high-grade anal intraepithelial neoplasia still deserve investigation. The aim of this cross-sectional study was to assess the prevalence of HPV ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23831
更新日期:2014-03-01 00:00:00
abstract::The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24339
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AND AIM:The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limb...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25457
更新日期:2019-08-01 00:00:00
abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23384
更新日期:2012-10-01 00:00:00
abstract::Swabbing the surface of a genital lesion to obtain a sample for HPV DNA testing is less invasive than a biopsy, but may not represent HPV types present in the lesion tissue. The objective of this study was to examine the concordance of HPV types detected in swab and biopsy samples from 165 genital lesions from men age...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23635
更新日期:2013-09-01 00:00:00
abstract::Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be a possible reservoir. The role of tonsil, ade...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21786
更新日期:2010-07-01 00:00:00
abstract::To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok...
journal_title:Journal of medical virology
pub_type: 评论,杂志文章
doi:10.1002/jmv.25693
更新日期:2020-04-01 00:00:00
abstract::Ultra violet (UV) light-inactivated measles virus was used for the lymphocyte proliferation assay, where it caused consistently adult human peripheral blood monolymphocytes (PBML) proliferation which was not dependent on the measles virus complement fixation titre in the donor's sera. When the cord blood lymphocytes f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460209
更新日期:1995-06-01 00:00:00
abstract::Previous studies demonstrated that in vitro infection with influenza A viruses altered several functions of human monocytes-macrophages but did not detectably alter functions of human lymphocytes. However, both types of cells were infected, as determined by production and surface expression of viral antigens. In the c...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890270302
更新日期:1989-03-01 00:00:00
abstract::A rapid technique for the detection of hepatitis C virus (HCV) RNA in liver section using nonisotopic in situ hybridization was described. Only 3 of the 10 patients seropositive for antibody to HCV and HCV RNA had detectable HCV RNA in the hepatocytes (1%, 2%, and 15% of cells positive). No specific signal was detecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420313
更新日期:1994-03-01 00:00:00