Analysis of virus and host factors in a study of A/Peking/2/79 (H3N2) cold-adapted vaccine recombinant in which vaccine-associated illness occurred in normal volunteers.

abstract：:Human respiratory syncytial virus (HRSV) is major pathogen of lower respiratory tract infections in infants and young children worldwide. There have been many studies regarding HRSV subgroup A (HRSV-A) G protein genetic variability but little information about HRSV subtype B (HRSV-B) G protein genetic diversity and mo...

journal_title：Journal of medical virology

authors： Ren L,Xiao Q,Zhou L,Xia Q,Liu E

更新日期：2015-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) are both retroviruses with similar routes of transmission. A number of reports suggest variable clinical outcomes in HIV and HTLV co-infected individuals. There is no published information regarding the prevalence of HIV and HTLV co-infectio...

journal_title：Journal of medical virology

authors： Cooke FJ,Geretti AM,Zuckerman M

更新日期：2005-06-01 00:00:00

abstract：:There are numerous ongoing studies assessing treatment options for preventing, treating, and managing complications of coronavirus disease-2019 disease. The objective of this study was to do a systematic review and critical appraisal of the ongoing clinical trials with an aim to provide insight into the various interv...

journal_title：Journal of medical virology

authors： Venkatesulu BP,Thoguluva Chandrasekar V,Giridhar P,V P,Patel HK,Manteuffel J

更新日期：2021-02-01 00:00:00

abstract：:GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of heterogeneous virus ha...

journal_title：Journal of medical virology

authors： Kato T,Mizokami M,Nakano T,Orito E,Ohba K,Kondo Y,Tanaka Y,Ueda R,Mukaide M,Fujita K,Yasuda K,Iino S

更新日期：1998-06-01 00:00:00

abstract：:This study was designed to determine the prognostic value of erythrocyte adenosine deaminase (ADA) as a possible indicator of progression to AIDS, and compare this with other known cellular and serological markers. At the end of a 3-year study, a cohort of 114 human immunodeficiency virus-1 (HIV-1) seropositive intrav...

journal_title：Journal of medical virology

authors： Casoli C,Lisa A,Magnani G,Starcich R,Fiaccadori F,Bertazzoni U,Zei G

更新日期：1995-02-01 00:00:00

abstract：:Using immunodiffusion, a major cross-reactivity had been previously demonstrated between hepatitis B(HBe/3 Ag) and the antigen reported in the serum on non A, non-B hepatitis patients, therefore redesignated NANBe Ag. By direct immunofluorescence a new antigen associated with, but distinct from, NANBe Ag has now been ...

journal_title：Journal of medical virology

authors： Trépo C,Vitvitski L,Hantz O

更新日期：1981-01-01 00:00:00

abstract：:Ideally, long-term lamivudine therapy should not induce tyrosine-methionine-aspartate-aspartate (YMDD) mutants (reverse transcription [rt]; rt M204I/V) in patients with chronic hepatitis B. There is little or no information on the clinical features of patients who do not develop such mutants. We analyzed 368 patients ...

journal_title：Journal of medical virology

authors： Hashimoto Y,Suzuki F,Hirakawa M,Kawamura Y,Yatsuji H,Sezaki H,Hosaka T,Akuta N,Kobayashi M,Saito S,Suzuki Y,Kobayashi M,Arase Y,Ikeda K,Kumada H

更新日期：2010-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 07_BC strain has caused serious outbreaks among injection drug users in Taiwan since 2004. The objective of this study was to conduct a molecular epidemiological study of HCV genotypes in intravenous drug users in Taiwan. Blood samples and ...

journal_title：Journal of medical virology

authors： Lee YM,Lin HJ,Chen YJ,Lee CM,Wang SF,Chang KY,Chen TL,Liu HF,Chen YM

更新日期：2010-01-01 00:00:00

abstract：:Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with ...

journal_title：Journal of medical virology

authors： Dash S,Rao KV,Panda SK

更新日期：1992-06-01 00:00:00

abstract：:Serial blood and faecal samples were collected from patients and family contacts during an outbreak of hepatitis A in a village and tested by a solid-phase competitive type radioimmunoassay for hepatitis A antigen and hepatitis A antibody. The amount and duration of excretion of hepatitis A antigen was correlated with...

journal_title：Journal of medical virology

authors： Frösner GG,Overby LR,Flehmig B,Gerth HJ,Haas H,Decker RH,Ling CM,Zuckerman AJ,Frösner HR

更新日期：1977-01-01 00:00:00

abstract：:There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) w...

journal_title：Journal of medical virology

authors： Arden KE,Chang AB,Lambert SB,Nissen MD,Sloots TP,Mackay IM

更新日期：2010-08-01 00:00:00

abstract：:Dual infection with hepatitis B and C viruses is often encountered in endemic areas of both viruses. However, understanding of the clinical and virological implications is limited. The aim of this study was to investigate the role of each virus in liver injury and the interaction between the two viruses in dual infect...

journal_title：Journal of medical virology

authors： Ohkawa K,Hayashi N,Yuki N,Masuzawa M,Kato M,Yamamoto K,Hosotsubo H,Deguchi M,Katayama K,Kasahara A

更新日期：1995-07-01 00:00:00

abstract：:Cervical cancer development has been mainly associated with persistent human papillomavirus (HPV) infections. However, HPV infection is unlikely to be sufficient to cause cervical cancer, and the contribution of other sexually transmitted infections (STIs) could be the determining factor for cervical lesion-progressio...

journal_title：Journal of medical virology

authors： Magaña-Contreras M,Contreras-Paredes A,Chavez-Blanco A,Lizano M,De la Cruz-Hernandez Y,De la Cruz-Hernandez E

更新日期：2015-12-01 00:00:00

abstract：:In addition to the serotype-specific primers described previously (1 to 7), a new serotype 8-specific primer has been designed, allowing detection of all astrovirus serotypes. A total of 1,382 diarrheal stool samples in 5 regions in Japan were examined by reverse transcription-polymerase chain reaction (RT-PCR). The i...

journal_title：Journal of medical virology

authors： Sakamoto T,Negishi H,Wang QH,Akihara S,Kim B,Nishimura S,Kaneshi K,Nakaya S,Ueda Y,Sugita K,Motohiro T,Nishimura T,Ushijima H

更新日期：2000-07-01 00:00:00

abstract：:From 10(1) to 10(6) TCID50 (mean tissue culture infective doses) per ml HSV I and II can be quantitatively recorded from vaginal tampons. Tampons and sterile cotton swabs are equally sensitive in recovering HSV I and II. Direct cotton swab cultures of the cervix and cervicovaginal tampon cultures from the same patient...

journal_title：Journal of medical virology

authors： Ekwo EE,Myers MG

更新日期：1978-01-01 00:00:00

abstract：:Lymphocytic choriomeningitis virus (LCMV), which is one of several arenaviruses that are pathogenic for humans, causes encephalitis and meningitis in man. In this study, single-stage and nested reverse transcription-polymerase chain reaction (RT-PCR) assays were developed that targeted the GPC and N genes of LCMV. Bot...

journal_title：Journal of medical virology

authors： Park JY,Peters CJ,Rollin PE,Ksiazek TG,Gray B,Waites KB,Stephensen CB

更新日期：1997-02-01 00:00:00

abstract：:To characterize cytotoxic T lymphocytes (CTLs) that appeared in circulation during lamivudine therapy, we analyzed HBV-specific CTLs using HLA-A24 tetramer and HBcAg-specific Th1 cells in patients receiving lamivudine therapy. Six patients (HLA-A24(+)) with chronic hepatitis B, six patients (HLA-A24(-)) with chronic h...

journal_title：Journal of medical virology

authors： Kondo Y,Asabe S,Kobayashi K,Shiina M,Niitsuma H,Ueno Y,Kobayashi T,Shimosegawa T

更新日期：2004-11-01 00:00:00

abstract：:This study aimed to examine the baseline prevalence of genital human papillomavirus (HPV) infection among human immunodeficiency virus (HIV)-seropositive men who have sex with men in Taiwan and to determine the association of age and CD4+ T cell counts with HPV infection. In 2010, 305 men who have sex with men infecte...

journal_title：Journal of medical virology

authors： Cheng SH,Chu FY,Lin YS,Hsueh YM

更新日期：2012-12-01 00:00:00

abstract：:Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...

journal_title：Journal of medical virology

authors： Superti F,Ammendolia MG,Tinari A,Bucci B,Giammarioli AM,Rainaldi G,Rivabene R,Donelli G

更新日期：1996-12-01 00:00:00

abstract：:Hepatitis E is endemic in India. It was recently noted that although all the Indian human hepatitis E virus (HEV) isolates (1976-2001) were placed in genotype I, the swine HEV recovered from western India (2000) belonged to genotype IV. This was in contrast to reports from the United States and Taiwan wherein both hum...

journal_title：Journal of medical virology

authors： Arankalle VA,Chobe LP,Walimbe AM,Yergolkar PN,Jacob GP

更新日期：2003-03-01 00:00:00

abstract：:A highly sensitive one-step real-time RT-PCR method using a minor-groove-binding (MGB) probe was developed for detection and quantitation of severe febrile with thrombocytopenia syndrome virus (SFTSV). The assay could discriminate SFTSV infection from other related viral diseases in human with a minimum detection limi...

journal_title：Journal of medical virology

authors： Li Z,Cui L,Zhou M,Qi X,Bao C,Hu J,Shan J,Wu B,Wang S,Guo X,Jiao Y,Tang F,Wang H

更新日期：2013-02-01 00:00:00

abstract：:Intramuscular (IM) influenza vaccines are about 50% effective in preventing clinical illness among the elderly and their effectiveness in eliciting mucosal response may be even lower. The aim of the present study was to evaluate the immunological effect of a novel inactivated intranasal (IN) trivalent whole influenza ...

journal_title：Journal of medical virology

authors： Muszkat M,Yehuda AB,Schein MH,Friedlander Y,Naveh P,Greenbaum E,Schlesinger M,Levy R,Zakay-Rones Z,Friedman G

更新日期：2000-05-01 00:00:00

abstract：:Herpes simplex virus can be quantitatively recovered from vaginal tampons suspended in tissue culture medium and stored over a wide range of temperatures. Because herpes simplex virus is stable for several days with refrigeration or after freezing, this method of culture of cervicovaginal virus lends itself to epidemi...

journal_title：Journal of medical virology

authors： Myers MG,Ekwo EE,Pitts AK

更新日期：1979-01-01 00:00:00

abstract：:The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demons...

journal_title：Journal of medical virology

authors： Darby G

更新日期：1993-01-01 00:00:00

abstract：:Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7-30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia. Interferon (IFN) is currently th...

journal_title：Journal of medical virology

authors： Rizzetto M

更新日期：2002-04-01 00:00:00

abstract：:The Balkan Peninsula and Bulgaria in particular, is a well-known endemic region for Crimean-Congo hemorrhagic fever (CCHF). This study describes the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) among tick populations from areas, previously recognized with emerging cases of CCHF disease in humans. These ...

journal_title：Journal of medical virology

authors： Gergova I,Kunchev M,Kamarinchev B

更新日期：2012-04-01 00:00:00

abstract：:Although risk factors for cirrhosis in chronic hepatitis C virus (HCV) infection have been identified, the role of HCV-genotype 3 remains controversial, and limited data are available in drug users. The aim of the study was to assess risk factors for severe liver disease (cirrhosis/hepatocellular carcinoma) in HCV-inf...

journal_title：Journal of medical virology

authors： Larsen C,Bousquet V,Delarocque-Astagneau E,Pioche C,Roudot-Thoraval F,HCV Surveillance Steering Committee.,HCV Surveillance Group.,Desenclos JC

更新日期：2010-10-01 00:00:00

abstract：:The efficacy of interferon (IFN) monotherapy for non-responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy is still unclear. To evaluate the impact of IFN monotherapy on biochemical response, 200 consecutive patients infected with HCV genotype 1b, who received low-dose intermittent IFN-...

journal_title：Journal of medical virology

authors： Akuta N,Suzuki F,Kawamura Y,Yatsuji H,Sezaki H,Suzuki Y,Hosaka T,Kobayashi M,Kobayashi M,Arase Y,Ikeda K,Kumada H

更新日期：2008-08-01 00:00:00

abstract：:Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

journal_title：Journal of medical virology

authors： Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

更新日期：1995-12-01 00:00:00

abstract：:The TD97 strain vaccine virus was prepared from the Tanabe strain measles virus by low-temperature passages in primary cell cultures and ultraviolet (UV) mutagenesis. The TD97 strain exhibited the following characteristics: highly temperature sensitive, neither multiplying nor forming any plaques at 40 degrees C in Ve...

journal_title：Journal of medical virology

authors： Suzuki K,Morita M,Katoh M,Kidokoro M,Saika S,Yoshizawa S,Hashizume S,Horiuchi K,Okabe N,Shinozaki T

更新日期：1990-11-01 00:00:00