Prognostic value of adenosine deaminase compared to other markers for progression to acquired immunodeficiency syndrome among intravenous drug users.

Abstract:

:This study was designed to determine the prognostic value of erythrocyte adenosine deaminase (ADA) as a possible indicator of progression to AIDS, and compare this with other known cellular and serological markers. At the end of a 3-year study, a cohort of 114 human immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users (IVDUs) from the five different Center for Disease Control (CDC) groups was examined in order to estimate the prognostic relevance with respect to the progression to acquired immunodeficiency syndrome (AIDS) of each of the following markers at baseline value: number and percentage of CD4+ T cells, number of CD8+ T cells, CD4+/CD8+ ratio, IgA and beta 2 microglobulin and ADA levels, and the presence of HIV antigens. Moreover, 57 IVDUs belonging to II and III CDC groups were analyzed in a follow-up study at 6-month intervals, in order to evaluate and compare the behavior of each marker over time. The prognostic significance of each marker was assessed by computing the survival distribution and the Cox analysis in a multivariate model providing the set of markers with greatest predictive value. The levels of ADA and the CD4+/CD8+ ratio showed a linear association with disease staging, whereas beta 2 microglobulin and CD4+/CD8+ ratio were the best predictors for AIDS progression. A highly significant increase in ADA and beta 2 microglobulin was observed during follow-up. The results obtained among HIV-positive IVDUs clearly indicate that the erythrocyte ADA may be considered a reliable marker of the development of HIV infection from the intermediate stages of the disease onwards.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Med Virol

authors

Casoli C,Lisa A,Magnani G,Starcich R,Fiaccadori F,Bertazzoni U,Zei G

doi

10.1002/jmv.1890450216

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

203-10

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

45

pub_type

临床试验,杂志文章
  • Metagenomic analysis of viral diversity in respiratory samples from patients with respiratory tract infections in Kuwait.

    abstract::A metagenomic approach based on target independent next-generation sequencing has become a known method for the detection of both known and novel viruses in clinical samples. This study aimed to use the metagenomic sequencing approach to characterize the viral diversity in respiratory samples from patients with respir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24984

    authors: Madi N,Al-Nakib W,Mustafa AS,Habibi N

    更新日期:2018-03-01 00:00:00

  • Neutralization epitope diversity of coxsackievirus B4 isolates detected by monoclonal antibodies.

    abstract::Only recently have we begun to fully realize the diversity of virions within a single human isolate of the group B Coxsackieviruses. These intratypic (strain) differences may be one of the important factors influencing pathogenesis, e.g., myocarditis vs. pancreatitis. Yet, until the virion strains within a type can be...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200103

    authors: Webb SR,Kearse KP,Foulke CL,Hartig PC,Prabhakar BS

    更新日期:1986-09-01 00:00:00

  • Gender disparity in distribution of the major hydrophilic region variants of hepatitis B virus genotype C according to hepatitis B e antigen serostatus.

    abstract::Hepatitis B virus (HBV) e antigen (HBeAg) seroconversion during chronic HBV infection is known to play an important role in disease progression and patient response to antiviral agents. The aim of the present study was to analyze gender disparity in distribution of major hydrophilic region (MHR) variants according to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21988

    authors: Lee SA,Cho YK,Lee KH,Hwang ES,Kook YH,Kim BJ

    更新日期:2011-03-01 00:00:00

  • Interleukin-28B polymorphisms and interferon gamma inducible protein-10 serum levels in seronegative occult hepatitis C virus infection.

    abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24322

    authors: Bartolomé J,Castillo I,Quiroga JA,Carreño V

    更新日期:2016-02-01 00:00:00

  • The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

    abstract::Although many reports have already shown RSV outbreaks among hemato-oncology patients, genomic studies detecting similar RSV strains prior to an outbreak in the hospital are rare. In 2014, the University of the Ryukyus hospital hemato-oncology unit experienced, and successfully managed, a respiratory syncytial virus (...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24800

    authors: Nabeya D,Kinjo T,Parrott GL,Uehara A,Motooka D,Nakamura S,Nahar S,Nakachi S,Nakamatsu M,Maeshiro S,Haranaga S,Tateyama M,Tomoyose T,Masuzaki H,Horii T,Fujita J

    更新日期:2017-08-01 00:00:00

  • Serological responses to human papillomavirus type 16 antigens in women before and after renal transplantation.

    abstract::Female renal transplant recipients have an increased incidence of human papillomavirus (HPV) associated lesions, such as cervical dysplasia and neoplasia [Schneider et al., 1983]. In this study we tested the serological responses by enzyme-linked immunoadsorbent assays (ELISA) to 3 different antigenic regions of HPV t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400304

    authors: Lewensohn-Fuchs I,Wester D,Bistoletti P,Elfgren K,Ohlman S,Dillner J,Dalianis T

    更新日期:1993-07-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470418

    authors: Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期:1995-12-01 00:00:00

  • Molecular epidemiology of hepatitis A in St. Petersburg, Russia, 1997-2003.

    abstract::The molecular epidemiology of hepatitis A virus (HAV) strains circulating in the St. Petersburg and Karelia regions was studied during 1997-2003. Hepatitis A virus RNA was isolated from both clinical samples (stools or sera) and environmental samples (sewage water). RT-PCR was carried out using different primer pairs ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20843

    authors: Davidkin I,Zheleznova N,Jokinen S,Gorchakova O,Broman M,Mukomolov S

    更新日期:2007-06-01 00:00:00

  • Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia.

    abstract::HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC +...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24361

    authors: Avi R,Pauskar M,Karki T,Kallas E,Jõgeda EL,Margus T,Huik K,Lutsar I

    更新日期:2016-03-01 00:00:00

  • Clinical outcome of frequent exposure to Torque Teno virus (TTV) through blood transfusion in thalassemia patients with or without hepatitis C virus (HCV) infection.

    abstract::As a consequence of the high prevalence of TorqueTeno virus (TTV) in blood donors, thalassemia patients frequently acquire various genotypes of this virus through therapeutic blood transfusions. At present, the clinical consequences of TTV infection remain indeterminate for these patients. Here, several hundred thalas...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21070

    authors: Hu YW,Al-Moslih MI,Al Ali MT,Uzicanin S,Perkins H,Yi QL,Rahimi Khameneh S,Wu J,Brown EG

    更新日期:2008-02-01 00:00:00

  • Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

    abstract::Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25915

    authors: Paniz-Mondolfi A,Bryce C,Grimes Z,Gordon RE,Reidy J,Lednicky J,Sordillo EM,Fowkes M

    更新日期:2020-07-01 00:00:00

  • Cycling probe-based real-time PCR for the detection of Human herpesvirus 6A and B.

    abstract::Human herpesvirus 6 (HHV-6) is classified as two distinct species: HHV-6A and B. HHV-6B infection can cause several clinical manifestations in transplant recipients including encephalitis, bone marrow suppression, and pneumonitis. In contrast to HHV-6B, the clinical features of HHV-6A infection remain largely undefine...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24513

    authors: Ihira M,Yamaki A,Kato Y,Higashimoto Y,Kawamura Y,Yoshikawa T

    更新日期:2016-09-01 00:00:00

  • Genotyping of acute hepatitis a virus isolates from China, 2003-2008.

    abstract::Hepatitis A virus (HAV) is usually transmitted by an oral-fecal route and is prevalent not only in developing countries but also in developed countries. In the present study, the phylogenetic characterization of the VP1/2A junction region (321 nucleotides) of China HAV isolates was examined. Anti-HAV IgM-positive seru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22086

    authors: Cao J,Bi S,Meng Q,Shen L,Zheng H,Zhang Y

    更新日期:2011-07-01 00:00:00

  • Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders.

    abstract::Infection with human polyomaviruses BKV and JCV is asymptomatic, and lifelong and widespread, among the general population. However, in the setting of immunosuppression, secondary to medications or viral infection, for example, with HIV, reactivation can occur and result in severe disease. In this study, stool specime...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21559

    authors: Babakir-Mina M,Ciccozzi M,Alteri C,Polchi P,Picardi A,Greco F,Lucarelli G,Arcese W,Perno CF,Ciotti M

    更新日期:2009-09-01 00:00:00

  • Comparison of characteristics between patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA and those with GBV-C/HGV E2-antibody in patients with hemophilia.

    abstract::We compared characteristics of patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA to those of patients with GBV-C/HGV E2-antibody. GBV-C/HGV RNA and GBV-C/HGV antibody were assayed in 83 persons with hemophilia using a reverse transcription-polymerase chain reaction and an enzyme-linked immunosorbent assay, re...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200001)60:1<34::aid-jmv6>3

    authors: Toyoda H,Takahashi I,Fukuda Y,Hayakawa T,Takamatsu J

    更新日期:2000-01-01 00:00:00

  • Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment.

    abstract::The putative interferon sensitivity determining region (ISDR) in the NS5a region of the hepatitis C virus (HCV) was analyzed in 13 interferon alpha (IFN-alpha) treated patients representing genotypes 1a, 1b, and 2b. These patients had previously been followed longitudinally during treatment with respect to viral load ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199809)56:1<33::aid-jmv6>3

    authors: Odeberg J,Yun Z,Sönnerborg A,Weiland O,Lundeberg J

    更新日期:1998-09-01 00:00:00

  • Quantitative analysis of cytomegalovirus load using a real-time PCR assay.

    abstract::A novel real-time PCR assay system was developed to quantify the cytomegalovirus (CMV) genome load. The real-time PCR assay could detect from 6 to over 10(6) copies of CMV-DNA with a wide linear range. The virus load of immunocompromised patients with symptomatic CMV infections was quantified and compared to that of a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200004)60:4<455::aid-jmv14

    authors: Tanaka N,Kimura H,Iida K,Saito Y,Tsuge I,Yoshimi A,Matsuyama T,Morishima T

    更新日期:2000-04-01 00:00:00

  • Activation of a varicella-zoster virus-specific IgA response during acute Epstein-Barr virus infection.

    abstract::The influence of an acute Epstein-Barr virus (EBV) infection on the serological parameters of persistent varicella-zoster virus (VZV) and herpes simplex virus (HSV) was studied. Sera from 161 patients with infectious mononucleosis caused by EBV and 178 age-matched controls were tested for HSV- and VZV-specific IgA. 98...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440308

    authors: Karner W,Bauer G

    更新日期:1994-11-01 00:00:00

  • Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women.

    abstract::Hantavirus infection during pregnancy can influence both maternal and fetal outcomes. Here, we describe four cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant Chinese women. The HFRS put these women at increased risk for severe illness, despite the patients' symptomologies in the onset phase were simil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24856

    authors: Ji F,Zhao W,Liu H,Zheng H,Wang S,He C,Wang W,Zhang R,Bai D,Tian C,Zhao W,Deng H

    更新日期:2017-10-01 00:00:00

  • Molecular epidemiology of 'Norwalk-like viruses' associated with gastroenteritis outbreaks in New Zealand.

    abstract::Outbreaks of gastroenteritis are a major public health problem in New Zealand. The introduction of molecular detection methods has now shown that the 'Norwalk-like viruses' (NLVs) are the major cause of food and waterborne nonbacterial gastroenteritis. Reverse transcription and polymerase chain reaction (RT-PCR) were ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1018

    authors: Greening GE,Mirams M,Berke T

    更新日期:2001-05-01 00:00:00

  • Influence of antigenic drift on the intensity of influenza outbreaks: upper respiratory tract infections of military conscripts in Finland.

    abstract::A total of 102,600 upper respiratory infections (URI) were recorded among young military conscripts in the Finnish Defence Forces during the study period from October 1991 to March 1994. This period covered three outbreaks caused by H3N2-subtype influenza A virus and one outbreak of influenza B. During the 1991/92 out...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10552

    authors: Pyhälä R,Visakorpi R,Ikonen N,Kleemola M

    更新日期:2004-02-01 00:00:00

  • Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of Echovirus 11.

    abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890090202

    authors: Mertens T,Hager H,Eggers HJ

    更新日期:1982-01-01 00:00:00

  • Inactivation of hepatitis A virus by heat treatment in aqueous solution.

    abstract::Hepatitis A virus infections have been reported recently among hemophilic patients in Italy and Germany, leading to speculation that infectious hepatitis A virus (HAV) might have been present in some factor VIII concentrates. In both cases, the implicated factor concentrates had been treated by a solvent/detergent met...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890410113

    authors: Murphy P,Nowak T,Lemon SM,Hilfenhaus J

    更新日期:1993-09-01 00:00:00

  • Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.

    abstract::Virus variants escaping from host immunity may be implicated in the pathogenesis of hepatitis B virus (HBV) infection. In this cross-sectional study, the association was evaluated of the frequency of amino acid variation within the immunogenic epitopes of surface gene with different disease stages of chronic HBV infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10169

    authors: Liu CJ,Kao JH,Shau WY,Chen PJ,Lai MY,Chen DS

    更新日期:2002-09-01 00:00:00

  • Influence of HCV genotype and co-infection with human immunodeficiency virus on CD4(+) and CD8(+) T-cell responses to hepatitis C virus.

    abstract::The role of T-cells in clearance of hepatitis C virus (HCV) during acute infection is critical. The relevance of the immunological response in the control of HCV replication is less clear in chronic HCV infection. HCV-specific T-cell responses were examined in 92 interferon-naive individuals with chronic hepatitis C. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20856

    authors: Capa L,Soriano V,García-Samaniego J,Nuñez M,Romero M,Cascajero A,Muñoz F,González-Lahoz J,Benito JM

    更新日期:2007-05-01 00:00:00

  • Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

    abstract::The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21366

    authors: Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

    更新日期:2009-01-01 00:00:00

  • Measles virus genotype B2 is not inactive: evidence of continued circulation in Africa.

    abstract::This study describes two measles outbreaks--one in Cape Town, South Africa in November 2002, and the other in Luanda, Angola in March 2003. The outbreaks were notable because they were caused by closely related genotype B2 viruses. This genotype was first described in an outbreak in Libreville, Gabon in the 1980s and ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20491

    authors: Smit SB,Hardie D,Tiemessen CT

    更新日期:2005-12-01 00:00:00

  • Antigenic relationships among human herpesvirus-6 isolates.

    abstract::Human herpesvirus 6 (HHV-6) prototype isolate GS is a newly identified lymphotropic herpesvirus and several subsequent herpes isolates were recognized as HHV-6 by their hybridization to a HHV-6(GS) DNA probe pZVH14. DNA restriction analysis and in vitro tropism studies show that HHV-6 isolates can be divided into two ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890370403

    authors: Chandran B,Tirawatnapong S,Pfeiffer B,Ablashi DV

    更新日期:1992-08-01 00:00:00

  • Improved methods for quantification of human immunodeficiency virus type 1 RNA and hepatitis C virus RNA in blood using spin column technology and chemiluminescent assays of PCR products.

    abstract::The quantification of human immunodeficiency virus type 1 (HIV-1) RNA or hepatitis C virus (HCV) RNA has been facilitated by adapting a spin column procedure for sample preparation and the use of chemiluminescent detection of polymerase chain reaction (PCR) products in microtiter plate format. All materials were comme...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Lin HJ,Tanwandee T,Hollinger FB

    更新日期:1997-01-01 00:00:00

  • Amino acid changes in the attachment G glycoprotein of human respiratory syncytial viruses (subgroup A) isolated in Italy over several epidemics (1997-2006).

    abstract::The human respiratory syncytial virus (HRSV) is the most important cause of admission to hospital for acute lower respiratory tract infections in infants and young children worldwide. Only few studies have investigated the molecular evolution of HRSV, and none has been conduct ed in Italy. The genetic diversity of the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21012

    authors: Montieri S,Puzelli S,Ciccozzi M,Calzoletti L,Di Martino A,Milia MG,Rossi A,Piro F,Rezza G,Donatelli I

    更新日期:2007-12-01 00:00:00