Abstract:
:The paper describes the results of preclinical testing of the preparation "Vaccine allantoic split-virus inactivated against seasonal influenza." Acute toxicity and local irritating effect, anaphylactic reactions to different antigens (vaccine and ovalbumin), delayed-type hypersensitivity to ram erythrocytes, humoral immune response in hemaggtination reaction, immunogenic activity was studied in laboratory animals of various species (mice, rats, guinea pigs). Comparative analysis of the results from testing immunogenic activity of the preparation under study and the commercial influenza vaccines was performed. The preclinical testing has demonstrated safety and immune response of the seasonal split influenza vaccine, so it may be recommended for clinical study on limited contingent of volunteers.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Sarsenbayeva G,Volgin Y,Kassenov M,Issagulov T,Bogdanov N,Nurpeisova A,Sagymbay A,Abitay R,Stukova M,Sansyzbay A,Khairullin Bdoi
10.1002/jmv.24771subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1168-1173issue
7eissn
0146-6615issn
1096-9071journal_volume
89pub_type
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