Rotavirus fecal IgA antibody response in adults challenged with human rotavirus.


:Our studies of rotavirus challenge in adult volunteers enabled us to evaluate the relationship of pre-existing antirotavirus fecal IgA antibody to infection and illness and to investigate the local response to this infection. No relationship could be found between the pre-existing levels of fecal antirotavirus IgA antibody and protection from infection or illness. A greater than six-fold increase in the level of antibody was seen in 16/19 infected volunteers with determinable increases but in 0/15 controls who received less than the minimal infectious dose of rotavirus. Antibody levels increased rapidly in infected volunteers and were consistent with an anamnestic response. Two of seven volunteers who received an infectious dose of rotavirus but were considered uninfected on the basis of other laboratory methods had greater than or equal to six-fold increases of fecal antibody and one of these experienced symptoms compatible with a rotavirus infection. This finding indicates that an increase in fecal antibody may be a reliable indicator of rotavirus infection even in the absence of detectable shedding or seroconversion.


J Med Virol


Bernstein DI,Ziegler JM,Ward RL




Has Abstract


1986-12-01 00:00:00












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    authors: De Paschale M,Ceriani C,Cerulli T,Cagnin D,Cavallari S,Ndayaké J,Zaongo D,Priuli G,Viganò P,Clerici P

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  • Human metapneumovirus-associated hospital admissions over five consecutive epidemic seasons: evidence for alternating circulation of different genotypes.

    abstract::Human metapneumovirus (hMPV) is a pathogen of the respiratory tract with a worldwide distribution. The purpose of this study was to identify hMPV as the cause of acute respiratory diseases in children admitted at Spedali Civili, a public hospital in Brescia, Italy. Eight hundred forty-six nasopharyngeal aspirate sampl...

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    abstract::The seroprevalence of viral hepatitis in healthcare workers has important public health implications. To assess the risk factors for the acquisition of viral hepatitis in an unvaccinated cohort from an hyperendemic region, 567 healthcare workers from a large hospital in the capital of the Republic of Yemen were interv...

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    authors: Shidrawi R,Ali Al-Huraibi M,Ahmad Al-Haimi M,Dayton R,Murray-Lyon IM

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    abstract::The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the f...

    journal_title:Journal of medical virology

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    authors: Papp D,Prohászka Z,Kocsis J,Füst G,Bánhegyi D,Raynes DA,Guerriero V

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    pub_type: 杂志文章


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    journal_title:Journal of medical virology

    pub_type: 杂志文章


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    更新日期:1994-05-01 00:00:00

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    authors: Schätzl HM,Sieger E,Jäger G,Nitschko H,Bader L,Ruckdeschel G,Jäger G

    更新日期:1994-02-01 00:00:00

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    authors: Grohmann GS,Greenberg HB,Welch BM,Murphy AM

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    authors: Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen B

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of medical virology

    pub_type: 杂志文章


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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Yilmaz H,Yilmaz G,Menteşe A,Kostakoğlu U,Karahan SC,Köksal İ

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Kimura Y,Hayashida K,Ishibashi H,Niho Y,Yanagi Y

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Newbound GC,O'Rourke JP,Collins ND,Andrews JM,DeWille J,Lairmore MD

    更新日期:2000-10-01 00:00:00

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Kajino K,Ohta Y,Miyamura T,Saito I

    更新日期:1991-01-01 00:00:00