Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma.

abstract：BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

journal_title：Journal of medical virology

authors： Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

更新日期：2019-07-01 00:00:00

abstract：:The presence of therapy-associated hepatitis B virus (HBV) variants is the main drawback of antiviral therapy for HBV infection. Moreover, drug-resistant variants are more insensitive to a second agent and more therapy-associated mutations will be present. To apply better nucleos(t)ide analogues (NA) and reduce the oc...

journal_title：Journal of medical virology

authors： Su F,Dai J,Yang S,Jiang X,Cui X,Ning H,Li J,Huang M

更新日期：2015-09-01 00:00:00

abstract：:Thirty-nine children without previous cytomegalovirus (CMV) infection received blood transfusion in the National Taiwan University Hospital. The overall transfusion-acquired CMV infection rate was 36% (14/39). Donor CMV seropositive rate was 70%. None of the nine children who had received seronegative blood became inf...

journal_title：Journal of medical virology

authors： Lee PI,Chang MH,Hwu WL,Kao CL,Lee CY

更新日期：1992-01-01 00:00:00

abstract：:Adenovirus infections are usually mild or even asymptomatic, but infections with the virus are being recognized increasingly as a major cause of mortality and morbidity in the immunocompromised, particularly hematological stem cell transplant patients where infections can be life threatening and mortality may reach 60...

journal_title：Journal of medical virology

authors： Al Qurashi YM,Guiver M,Cooper RJ

更新日期：2011-11-01 00:00:00

abstract：:Thirty-two cerebrospinal fluid (CSF) samples from eighteen patients with confirmed herpes simplex encephalitis (HSE) were assayed by an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of viral antigens. The results are expressed as an antigen ratio distinguishing between herpes simplex virus (HSV) ...

journal_title：Journal of medical virology

authors： Bos CA,Olding-Stenkvist E,Wilterdink JB,Scheffer AJ

更新日期：1987-02-01 00:00:00

abstract：:The use of quantitative assays for hepatitis C virus specific antibodies (anti-HCV) as a prognostic marker was evaluated in 31 patients with chronic hepatitis C treated with interferon (IFN). Changes in titers of serum HCV-RNA and anti-HCV antibodies; anti-C11 (anti-core), anti-C100 (anti-NS3), and anti-C7 (anti-NS3) ...

journal_title：Journal of medical virology

authors： Urushihara A,Sodeyama T,Matsumoto A,Tanaka E

更新日期：1994-04-01 00:00:00

abstract：:To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidir...

journal_title：Journal of medical virology

authors： da Costa Marques Borges LF,Zalis MG,Santoro-Lopes G,Varella RB

更新日期：2019-03-01 00:00:00

abstract：:The various strains of human polyomavirus BK (BKV) show a marked heterogeneity in the non-coding control region (NCCR), which includes the origin of replication and the regulatory region for early and late transcription. A new BKV strain (DDP, U91605) was identified by direct detection and sequencing of PCR products o...

journal_title：Journal of medical virology

authors： Degener AM,Pietropaolo V,Di Taranto C,Jin L,Ameglio F,Cordiali-Fei P,Trento E,Sinibaldi L,Orsi N

更新日期：1999-08-01 00:00:00

abstract：:Sera from 31 human immunodeficiency virus (HIV)-infected patients, representing different clinical stages of HIV infection, were assayed for antibodies against measles and mumps viruses by various serological tests and compared to 23 healthy controls. Sera from four patients (two primary, one asymptomatic, and one acq...

journal_title：Journal of medical virology

authors： Kövamees J,Sheshberadaran H,Chiodi F,Schwartz S,Orvell C,Fenyö EM,Norrby E

更新日期：1988-09-01 00:00:00

abstract：:Physicochemical studies of hepatitis B e antigen (HBeAg) revealed a clear cut difference between e1 and e2 antigen. The e1 antigen was found to have a MW of Ca 150,000 and a pI of 6.4-7.2, whereas both the MW and pI of the e2 antigen were heterogeneous depending upon the source of serum. Sera obtained from asymptomati...

journal_title：Journal of medical virology

authors： Yamada E,Ohori H,Ishida N

更新日期：1979-01-01 00:00:00

abstract：:Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species including humans and is a potential contaminant in MLV vector preparations for human gene transfer studies. In general, MLV replication depends on the expression of viral genes under the control of 75 bp enhancer elements in the...

journal_title：Journal of medical virology

authors： Reuss FU,Berdel B,Heber R,Bantel-Schaal U

更新日期：2002-10-01 00:00:00

abstract：:To determine the influence of ageing per se as well as of priming histories on the antibody response to influenza vaccination, haemagglutination inhibition (HI), ELISA IgG, IgA, IgM and neutralizing antibody titres were studied in 43 healthy young subjects (mean age 23 years) and 55 healthy elderly people (mean age 79...

journal_title：Journal of medical virology

authors： Remarque EJ,de Bruijn IA,Boersma WJ,Masurel N,Ligthart GJ

更新日期：1998-05-01 00:00:00

abstract：UNLABELLED:Viral respiratory tract infections in lung transplant recipients may be severe. During three consecutive winter-spring seasons, 49 symptomatic lung transplant recipients with suspected respiratory viral infection, and 26 asymptomatic patients were investigated for presence of respiratory viruses either in 56...

journal_title：Journal of medical virology

authors： Gerna G,Vitulo P,Rovida F,Lilleri D,Pellegrini C,Oggionni T,Campanini G,Baldanti F,Revello MG

更新日期：2006-03-01 00:00:00

abstract：:During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta-response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3)...

journal_title：Journal of medical virology

authors： Germi R,Guigue N,Lupo J,Semenova T,Grossi L,Vermeulen O,Epaulard O,de Fraipont F,Morand P

更新日期：2016-10-01 00:00:00

abstract：:It have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (H...

journal_title：Journal of medical virology

authors： Yeung P,Wong DK,Lai CL,Fung J,Seto WK,Yuen MF

更新日期：2010-11-01 00:00:00

abstract：:From November 2004 to April 2007, specimens were obtained from 2,281 patients with acute respiratory tract illness in Normandy, France. Eighteen strains of influenza C virus were detected in these samples using a combined tissue culture/RT-PCR diagnostic method. Most patients with influenza C virus infection (13/18) w...

journal_title：Journal of medical virology

authors： Gouarin S,Vabret A,Dina J,Petitjean J,Brouard J,Cuvillon-Nimal D,Freymuth F

更新日期：2008-08-01 00:00:00

abstract：:The incidence of perinatal transmission of hepatitis B virus (HBV) depends on the HBeAg/anti-HBe status of the mother. While children of HBeAg-positive mothers have a 90% probability of acquiring a chronic hepatitis B virus carrier state, babies of anti-HBe-positive mothers are more likely to develop fulminant hepatit...

journal_title：Journal of medical virology

authors： Bahn A,Hilbert K,Martiné U,Westedt J,von Weizsäcker F,Wirth S

更新日期：1995-12-01 00:00:00

abstract：:The L1 gene encodes for the major capsid protein of human papillomaviruses (HPV). There is limited information on the polymorphism of L1 for types related to HPV-16. This report explores the polymorphism of L1 in phylogenetically related types 31, 33, and 35 compared to HPV-16. Genital specimens collected from 732 HIV...

journal_title：Journal of medical virology

authors： Cornut G,Gagnon S,Hankins C,Money D,Pourreaux K,Franco EL,Coutlée F,Canadian Women's HIV Study Group.

更新日期：2010-07-01 00:00:00

abstract：:To determine the seroprevalence of antibodies against dengue virus (DENV) and West Nile virus (WNV) in the human population of the Bolivian Chaco, we tested 256 inhabitants of two rural communities. The seroprevalence, confirmed by plaque reduction neutralization test, was 7.8% and 2.7% for DENV and WNV, respectively....

journal_title：Journal of medical virology

authors： Bartoloni A,Remoli ME,Farchi F,Zammarchi L,Fortuna C,Benedetti E,Ciufolini MG,Macchioni F,Rojas P,Lara Y,Padilla C,Roselli M,Mantengoli E,Mantella A,Tolari F,Paredes GA,Monasterio J,Valdarchi C,Venturi G,Rezza G

更新日期：2019-01-01 00:00:00

abstract：:The presence of antibody to hepatitis A virus (anti-HAV) in 60% of procured owl monkeys (Aotus trivirgatus) held within the United States prompted a study of recently captured A trivirgatus in Panama. Only 2 of 145 newly captured monkeys, but all of 35 A trivirgatus held within a colony for over 100 days, were found t...

journal_title：Journal of medical virology

authors： Lemon SM,LeDuc JW,Binn LN,Escajadillo A,Ishak KG

更新日期：1982-01-01 00:00:00

abstract：:Human papilloma virus (HPV) infection is a precursor of cervical cancer. This study aimed to introduce a method to quantify the risk of cervical cancer resulting from infection by different HPV subtypes, to help guide patient treatment. Nucleic acid molecule flow-through hybridization and gene chip technology were use...

journal_title：Journal of medical virology

authors： Zhu X,Liu H,Wu H,Liu W,Yin L,Sun X

更新日期：2015-12-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within the context of certain flanking bases (CpG motifs) have been shown to induce potent innate and adaptive immune responses. Vaginal delivery of CpG ODN alone protects mice from vaginal herpes simplex virus type-2 (HSV-2) challenge. He...

journal_title：Journal of medical virology

authors： Sajic D,Ashkar AA,Patrick AJ,McCluskie MJ,Davis HL,Levine KL,Holl R,Rosenthal KL

更新日期：2003-12-01 00:00:00

abstract：:Human polyomaviruses HPyV6, HPyV7, TSPyV, HPyV9, MWPyV, and KIPyV have been discovered between 2007 and 2012. TSPyV causes a rare skin disease trichodysplasia spinulosa in immunocompromised patients, the role of remaining polyomaviruses in human pathology is not clear. In this study, we assessed the occurrence of seru...

journal_title：Journal of medical virology

authors： Šroller V,Hamšíková E,Ludvíková V,Musil J,Němečková Š,Saláková M

更新日期：2016-07-01 00:00:00

abstract：:Saliva and peripheral blood samples from 20 healthy adults were examined for the presence of human herpesvirus-6 (HHV-6) DNA sequences using the polymerase chain reaction. Eighteen out of 20 whole saliva samples contained detectable HHV-6 genomes. The majority of peripheral blood samples were also positive; however, t...

journal_title：Journal of medical virology

authors： Jarrett RF,Clark DA,Josephs SF,Onions DE

更新日期：1990-09-01 00:00:00

abstract：:HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti-nef, and anti-p24. Viral load in peripheral blood appeared to incre...

journal_title：Journal of medical virology

authors： O'Shea S,Cordery M,Barrett WY,Richman DD,Bradbeer C,Banatvala JE

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:The data on the seasonality of respiratory viruses helps to ensure the optimal vaccination period and to monitor the possible outbreaks of variant type. OBJECTIVES:This study was designed to describe the molecular epidemiology and seasonality of acute respiratory infection (ARI)-related respiratory viruses ...

journal_title：Journal of medical virology

authors： Jeon JH,Han M,Chang HE,Park SS,Lee JW,Ahn YJ,Hong DJ

更新日期：2019-08-01 00:00:00

abstract：:A multiplex polymerase chain reaction (PCR) assay that is capable of detecting and typing six serotypes of respiratory adenovirus (Ad) was developed, using multiple sets of type-specific primers. The detection of each different serotype depended on distinguishing different numbers and sizes of amplification products o...

journal_title：Journal of medical virology

authors： Na BK,Kim JH,Shin GC,Lee JY,Lee JS,Kang C,Kim WJ

更新日期：2002-04-01 00:00:00

abstract：:Pregnant women are not screened for HBsAg and anti-HCV antibodies in many African countries. As there are few data concerning the prevalence of HBV, HDV, and HCV serological markers in Benin, the aim of this study was to evaluate their 2011 prevalence in pregnant women undergoing HIV screening in a rural area of north...

journal_title：Journal of medical virology

authors： De Paschale M,Ceriani C,Cerulli T,Cagnin D,Cavallari S,Ndayaké J,Zaongo D,Priuli G,Viganò P,Clerici P

更新日期：2014-08-01 00:00:00

abstract：:In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...

journal_title：Journal of medical virology

authors： Coulombié FC,Alché LE,Lampuri JS,Coto CE

更新日期：1986-03-01 00:00:00

abstract：:The seroprevalence of antibodies to hepatitis E virus (HEV) and hepatitis A virus (HAV) was determined in a community-based sample in innercity London where socioeconomic conditions were expected to result in a high prevalence of antibodies to HAV, and in which the presence of immigrants from the developing world pose...

journal_title：Journal of medical virology

authors： Bernal W,Smith HM,Williams R

更新日期：1996-07-01 00:00:00