Abstract:
:Human papilloma virus (HPV) infection is a precursor of cervical cancer. This study aimed to introduce a method to quantify the risk of cervical cancer resulting from infection by different HPV subtypes, to help guide patient treatment. Nucleic acid molecule flow-through hybridization and gene chip technology were used to test 6,510 non-cervical cancer healthy volunteers (≤CIN-I) and 204 cervical cancer patients (≥CIN-III) from Dongying City for 21 HPV subtypes (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 6, 11, 42, 43, 44, 53, 66 and CP8304) in exfoliated cervical cells. The positive proportion of HPV subtypes was calculated, excluding or including patients with multiple subtype infections. The lower (L) and upper (H) limits of the carcinogenic risk score range were calculated, respectively. The values of carcinogenic index ± uncertainty in the carcinogenic ability (CI ± U) were also calculated. CI = (H + L)/2 represents the carcinogenic risk of the different subtypes, and U =(H - L)/2 represents the probability of each subtype being present in multiple infections. Infection rates were 15.87 and 96.57%, and HPV subtypes with high infection rates were HPV-16, 52, 58, 33, 18, and 31 and HPV-16, 31, 58, 18, 68, and 33 in the non-cervical cancer and cervical cancer groups, respectively. HPV subtypes with high risk of cervical cancer were HPV-31 (3.71 ± 0.68), 51 (2.65 ± 0.44), 18 (2.03 ± 0.43), 68 (1.76 ± 0.40), 58 (1.68 ± 0.49), and 16 (1.39 ± 0.33). We have provided a quantitative method for expressing HPV subtype carcinogenic risk.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Zhu X,Liu H,Wu H,Liu W,Yin L,Sun Xdoi
10.1002/jmv.24280subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2106-13issue
12eissn
0146-6615issn
1096-9071journal_volume
87pub_type
杂志文章abstract::Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130208
更新日期:1984-01-01 00:00:00
abstract::Clinical, virological, and histological findings in four HBsAg chronic carriers who cleared HBV markers from both serum and liver following HDV superinfection are described. The patients were long-term HBsAg carriers and all were HBV-DNA/HBeAg positive. Liver biopsy, obtained from three of the patients between 5 and 1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310408
更新日期:1990-08-01 00:00:00
abstract::To study the association between hepatitis B and schistosomiasis, 1,234 Egyptian males, ages 18 to 24, were interviewed, examined, and tested for Schistosoma mansoni infection and HBsAg. Sera from 91 (7.4%) of the study subjects were positive for HBsAg, and S. mansoni was found in the stools of 26.3%. There was no cor...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230203
更新日期:1987-10-01 00:00:00
abstract::The presence of antibody to hepatitis A virus (anti-HAV) in 60% of procured owl monkeys (Aotus trivirgatus) held within the United States prompted a study of recently captured A trivirgatus in Panama. Only 2 of 145 newly captured monkeys, but all of 35 A trivirgatus held within a colony for over 100 days, were found t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890100105
更新日期:1982-01-01 00:00:00
abstract::Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25390
更新日期:2019-05-01 00:00:00
abstract::High risk types of human papillomaviruses E6/E7 oncogenes and their association with tumor suppressor genes products are the key factors of cervical carcinogenesis. This study proposed them as specific markers for cervical dysplasia screening. The aim of the study is to compare the clinical and prognostic significance...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24199
更新日期:2015-09-01 00:00:00
abstract::Nucleotide sequences of the hypervariable region of hepatitis C virus genomes obtained from plasma change rapidly during the course of infection and are believed to play a part in immunological escape and consequently in the development of persistent infection. It is not known, however, whether these changes also occu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460103
更新日期:1995-05-01 00:00:00
abstract::Hepatitis E virus (HEV) infection is considered a neglected disease of major concern in developed countries. Clinically, HEV occurs as an acute and self-limited disease, though chronic cases mostly associated to HEV-3 are now being commonly reported in immunocompromised individuals and solid organ transplant recipient...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26231
更新日期:2020-06-27 00:00:00
abstract::Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>
更新日期:1996-12-01 00:00:00
abstract::To evaluate the variation over time of seroreactivity to human papillomavirus type 11 (HPV-11) according to disease outcome, we selected a sample of 42 condyloma acuminatum patients from a group of subjects enrolled in a placebo-controlled trial of three alpha-interferon preparations administered parenterally for the ...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/jmv.1890390414
更新日期:1993-04-01 00:00:00
abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890090202
更新日期:1982-01-01 00:00:00
abstract::To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20936
更新日期:2007-08-01 00:00:00
abstract::A novel simultaneous detection system for human viruses was developed using a real-time polymerase chain reaction (PCR) system to identify causes of infection in clinical samples from patients with uncertain diagnoses. This system, designated as the "multivirus real-time PCR," has the potential to detect 163 human vir...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21962
更新日期:2011-02-01 00:00:00
abstract::The incidence of perinatal transmission of hepatitis B virus (HBV) depends on the HBeAg/anti-HBe status of the mother. While children of HBeAg-positive mothers have a 90% probability of acquiring a chronic hepatitis B virus carrier state, babies of anti-HBe-positive mothers are more likely to develop fulminant hepatit...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470408
更新日期:1995-12-01 00:00:00
abstract::This prospective study aimed to determine factors associated with detection of very low-level viremia in patients infected with HIV-1 with virological success following HAART introduction. Fifty-seven patients, mostly (n = 51, 89%) treated with a protease inhibitor-based regimen, were included and followed for 2 years...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23553
更新日期:2013-06-01 00:00:00
abstract::A novel coronavirus associated with acute respiratory disease (named SARS-CoV-2) is recently identified in Wuhan city, China, spread rapidly worldwide. Early identification of this novel coronavirus by molecular tools is critical for surveillance and control of the epidemic outbreak. We aimed to establish a simple met...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26171
更新日期:2020-11-01 00:00:00
abstract::Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24654
更新日期:2017-03-01 00:00:00
abstract::Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AF...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26804
更新日期:2021-01-17 00:00:00
abstract::We studied the role of sexual transmission in the epidemiology of HCV by a cross-sectional study comparing prostitutes and HCV seropositive and seronegative sexual clients recruited from the bordellos of the docks of Santos, São Paulo State. The average age in the prostitute group was 27.2 years. The median time spent...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND AND AIM:The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limb...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25457
更新日期:2019-08-01 00:00:00
abstract::Although cytomegalovirus (CMV) has been detected in the inner ear fluid of patients who succumbed to the complications of symptomatic congenital CMV infection, it has not been detected in the inner ear fluid of living patients. In this study, real-time polymerase chain reaction (PCR) was used to measure CMV DNA in cli...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10263
更新日期:2003-01-01 00:00:00
abstract::A quantitative polymerase chain reaction (PCR) assay for hepatitis C viral RNA (HCV-RNA) was used to monitor viraemia levels in six patients at multiple time points before, during, and after interferon therapy for chronic non-A, non-B hepatitis (NANBH). Prior to therapy, serum HCV-RNA was detected in all patients at a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890370311
更新日期:1992-07-01 00:00:00
abstract::The effect on cellular (c) oncogene RNA levels was investigated after infection of permissive cells with cell culture adapted strains (AD-169, C-87, Davis) and unadapted clinical isolates (82-1, 84-2, 85-1) of human cytomegalovirus (HCMV). The results indicate that both adapted and unadapted strains of HCMV induce sub...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890340409
更新日期:1991-08-01 00:00:00
abstract::The rapid spread of the epidemic has aroused widespread concern in the international community. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) was first reported in China, with bats as the likely original hosts and pangolins as potential intermediate hosts. The current source of the disease is mainly pat...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.25813
更新日期:2020-07-01 00:00:00
abstract::An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890330107
更新日期:1991-01-01 00:00:00
abstract::Phleboviruses are a large and widespread group of viruses that are transmitted by arthropods. Toscana virus is one of the principal agents that causes meningitis in humans during the summer in Italy and, possibly, in other Mediterranean countries. Rift Valley Fever virus can cause serious illness in both animals and h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10465
更新日期:2003-09-01 00:00:00
abstract::Two major variables may cause false-negative results in prenatal diagnosis of congenital human cytomegalovirus (HCMV) infection: sensitivity of the techniques(s) used; and time elapsed between maternal infection and antenatal testing. Previous results indicated that rapid HCMV isolation from amniotic fluid samples and...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199809)56:1<99::aid-jmv16>
更新日期:1998-09-01 00:00:00
abstract::The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21227
更新日期:2008-09-01 00:00:00
abstract::Simian immunodeficiency virus (SIV) as well as human immunodeficiency virus (HIV) induce polyclonal B-cell activation and are associated with the appearance of lymphomas in their respective hosts in either the presence or the absence of other co-infecting viruses such as Epstein-Barr virus (EBV). However, the pathogen...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10179
更新日期:2002-09-01 00:00:00
abstract::In vitro incubation of human cytomegalovirus (Towne strain) with 8 U/ml human recombinant myeloperoxidase plus sodium chloride and glucose nearly abolished viral infectivity. To assay the effect on intracellular infection, cell toxicity of the enzymes was first studied. Even the high dose of 16 U/ml of recombinant mye...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00