Evidence for persistence of parvovirus B19 DNA in livers of adults.

Abstract:

:Recent studies have suggested a pathogenic role of human parvovirus B19 (B19) in the development of acute fulminant liver failure in children. The hypothesis was based on the detection of B19 DNA in 8 of 10 explanted livers of children requiring liver transplantation. In the present study, explanted livers from 43 adults selected at random undergoing orthotopic liver transplantation for various reasons were examined. Pre-transplant sera were available from 40 patients of whom 35 (88%) were anti-B19 IgG-seropositive. All but one serum were negative for anti-B19 IgM antibody. By polymerase chain reaction, B19 DNA was detected in the livers of 15/35 (43%) anti-B19 IgG-positive patients, in 2/3 livers of patients with unknown anti-B19 antibody status, and in the initial transplant of an anti-B19 IgG-positive patient who underwent liver retransplantation, and whose own liver was negative for B19 DNA. In a second study group, liver and bone marrow samples from 23 autopsied adults selected at random were tested. Serum specimens were available from 22 individuals, of whom 17 (77%) were anti-B19 IgG-seropositive. All sera were negative for anti-B19 IgM antibody. B19 DNA was detected in the livers of 4/17 (24%) anti-B19 IgG-positive individuals, three of whom had also B19 DNA in their bone marrow. This is the first report demonstrating that B19 DNA is frequently present in livers of anti-B19 seropositive adults suggesting persistence of B19 in the liver. Further studies are needed to address whether B19 is an innocent bystander in the liver or whether the presence of B19 in liver is of biological and clinical significance.

journal_name

J Med Virol

authors

Eis-Hübinger AM,Reber U,Abdul-Nour T,Glatzel U,Lauschke H,Pütz U

doi

10.1002/jmv.2047

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

395-401

issue

2

eissn

0146-6615

issn

1096-9071

pii

10.1002/jmv.2047

journal_volume

65

pub_type

杂志文章
  • The acyclovir legacy: its contribution to antiviral drug discovery.

    abstract::The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demons...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.1890410526

    authors: Darby G

    更新日期:1993-01-01 00:00:00

  • Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag-1.

    abstract::Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised individuals and is recognized as a major viral cause of birth defects. HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. Apoptosis is an innate cellular defense response to vir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24259

    authors: Li HP,Yuan CL,Zho YC

    更新日期:2015-11-01 00:00:00

  • Induction of apoptosis in HT-29 cells infected with SA-11 rotavirus.

    abstract::Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>

    authors: Superti F,Ammendolia MG,Tinari A,Bucci B,Giammarioli AM,Rainaldi G,Rivabene R,Donelli G

    更新日期:1996-12-01 00:00:00

  • Typing of human papillomaviruses in condylomata acuminata from Greece.

    abstract::DNA samples from recurrent condylomata acuminata biopsies of Greek males and females were examined for the presence of human papillomavirus (HPV) DNA using high-stringency Southern blot hybridization analysis. Of the twenty-six biopsies, 25 were positive for the HPV 6/11-related DNA sequences, and when further analyze...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420311

    authors: Labropoulou V,Balamotis A,Tosca A,Rotola A,Mavromara-Nazos P

    更新日期:1994-03-01 00:00:00

  • Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induces replication of human immunodeficiency virus type 1 in dually infected cells.

    abstract::Human herpesvirus 6 (HHV-6) and human immunodeficiency virus type 1 (HIV-1) may interact during transplacental transmission of HIV-1. The placental syncytiotrophoblast layer serves as the first line of defense of the fetus against viruses. Patterns of replication of HHV-6 variant A (HHV-6A) and HIV-1 were analyzed in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2194

    authors: Csoma E,Bácsi A,Liu X,Szabó J,Ebbesen P,Beck Z,Kónya J,Andirkó I,Nagy E,Tóth FD

    更新日期:2002-05-01 00:00:00

  • Lineage analysis of human papillomavirus type 18 based on E6 region in cervical samples of Iranian women.

    abstract::Distinct human papillomavirus (HPV) 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional variants of HPV 18 would be of great importance for evolutionary, epidemiological, and biological analysis. In this regard, the sequence variations of E6 gene we...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26283

    authors: Salavatiha Z,Shoja Z,Heydari N,Marashi SM,Younesi S,Nozarian Z,Jalilvand S

    更新日期:2020-07-09 00:00:00

  • The detection of SRAS-CoV-2 in outpatient clinics and public facilities during the COVID19 pandemic.

    abstract::The transmission of the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) can occur through airborne route, in addition to contaminated surfaces and objects. In hospitals, it has been confirmed by several studies that SRAS-CoV-2 can contaminate surfaces and medical equipment especially in hospitals dedicat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26819

    authors: Elbadawy HM,Khattab A,Alalawi A,Aljohani F,Sundogji H,Mahmoud AS,Abouzied M,Eltahir HM,Alahmadey Z,Bahashwan S,Suliman BA

    更新日期:2021-01-26 00:00:00

  • Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.

    abstract:AIMS:To investigate the association between two RIG-I-like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population. METHODS:The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25398

    authors: Zhu XB,Zhuo LY,Yue M,Liu M,Zang F,Fan HZ,Wu JJ,Xia XS,Zhang AM,Yu RB,Huang P

    更新日期:2019-06-01 00:00:00

  • Modification of rotavirus multiplex RT-PCR for the detection of G12 strains based on characterization of emerging G12 rotavirus strains from South India.

    abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20872

    authors: Banerjee I,Ramani S,Primrose B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

    更新日期:2007-09-01 00:00:00

  • Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

    abstract::Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25915

    authors: Paniz-Mondolfi A,Bryce C,Grimes Z,Gordon RE,Reidy J,Lednicky J,Sordillo EM,Fowkes M

    更新日期:2020-07-01 00:00:00

  • JCV/BKV and SV40 viral load in lymphoid tissues of young immunocompetent children from an area of north-east Italy.

    abstract::Polyomavirus infection occurring during childhood is followed by a lifelong latency in immunocompetent subjects. The major site of polyomavirus persistence are the uroepithelial cells which leads to oral transmission. It has recently been hypothesized that tonsils could be a possible reservoir. The role of tonsil, ade...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21786

    authors: Comar M,Zanotta N,Bovenzi M,Campello C

    更新日期:2010-07-01 00:00:00

  • MIP-1 alpha and MIP-1 beta induction by dengue virus.

    abstract::Dengue virus (DV) infection can result in either a mild febrile illness known as dengue fever (DF) or a life-threatening disease called dengue hemorrhagic fever (DHF). DHF is more prevalent in patients undergoing secondary DV infection. This observation has led to the hypothesis that DHF may be the result of immune re...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2037

    authors: Spain-Santana TA,Marglin S,Ennis FA,Rothman AL

    更新日期:2001-10-01 00:00:00

  • Development and validation of a new serum standard for the measurement of anti-HEV antibodies in animals.

    abstract::Although hepatitis E virus (HEV) infection is a zoonosis, there is, currently, no standardized assay for quantitatively measuring anti-HEV antibody levels in HEV animal reservoirs. In this study, anti-HEV antibody positive serum from a rabbit (RS26) was calibrated by dose-response parallel line assay using the World H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24651

    authors: Zhang Y,Wang L,Zeng H,Gong W,Wang L,Zhuang H

    更新日期:2017-03-01 00:00:00

  • Evaluation of an immunochromatography method for rapid detection of noroviruses in clinical specimens in Thailand.

    abstract::Norovirus (NoV) is a causative agent of gastroenteritis in children and adults worldwide. Although reverse transcription-polymerase chain reaction (RT-PCR) has been accepted as the standard method for diagnosis of NoV infection, it requires well-trained personnel and sophisticated equipments. Performance of a commerci...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21916

    authors: Thongprachum A,Khamrin P,Chaimongkol N,Malasao R,Okitsu S,Mizuguchi M,Maneekarn N,Ushijima H

    更新日期:2010-12-01 00:00:00

  • Carcinogenic ability quantification of human papilloma virus subtypes in eastern China.

    abstract::Human papilloma virus (HPV) infection is a precursor of cervical cancer. This study aimed to introduce a method to quantify the risk of cervical cancer resulting from infection by different HPV subtypes, to help guide patient treatment. Nucleic acid molecule flow-through hybridization and gene chip technology were use...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24280

    authors: Zhu X,Liu H,Wu H,Liu W,Yin L,Sun X

    更新日期:2015-12-01 00:00:00

  • Heterogeneity in E2 region of GBV-C/hepatitis G virus and hepatitis C virus.

    abstract::GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of heterogeneous virus ha...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Kato T,Mizokami M,Nakano T,Orito E,Ohba K,Kondo Y,Tanaka Y,Ueda R,Mukaide M,Fujita K,Yasuda K,Iino S

    更新日期:1998-06-01 00:00:00

  • Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis B virus infection in Taiwan.

    abstract::This study aimed to examine the application of hepatitis B surface antigen (HBsAg) confirmatory testing when diagnosing hepatitis B infection among young persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg status, the presence of antibodies against HBsAg (anti-HBs), and the presence of antibod...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22127

    authors: Chu FY,Su FH,Cheng SH,Lin YS,Li CY,Chien CC,Lin YC,Chiang SY

    更新日期:2011-09-01 00:00:00

  • Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

    abstract::Studies of hepatitis B virus (HBV) infection in non-human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV infectivity in serial stages of acu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21320

    authors: Tabuchi A,Tanaka J,Katayama K,Mizui M,Matsukura H,Yugi H,Shimada T,Miyakawa Y,Yoshizawa H

    更新日期:2008-12-01 00:00:00

  • Antigenic relationships among human herpesvirus-6 isolates.

    abstract::Human herpesvirus 6 (HHV-6) prototype isolate GS is a newly identified lymphotropic herpesvirus and several subsequent herpes isolates were recognized as HHV-6 by their hybridization to a HHV-6(GS) DNA probe pZVH14. DNA restriction analysis and in vitro tropism studies show that HHV-6 isolates can be divided into two ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890370403

    authors: Chandran B,Tirawatnapong S,Pfeiffer B,Ablashi DV

    更新日期:1992-08-01 00:00:00

  • Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese.

    abstract::Multiple determinants are involved in the progression of human papillomavirus (HPV)-infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLA-DRB1 polymorphism, high-risk HPV infection, and the development of cervical n...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20805

    authors: Chan PK,Cheung TH,Lin CK,Siu SS,Yim SF,Lo KW,Cheung JL,Tam AO,Tang JW

    更新日期:2007-07-01 00:00:00

  • Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers.

    abstract::Phleboviruses are a large and widespread group of viruses that are transmitted by arthropods. Toscana virus is one of the principal agents that causes meningitis in humans during the summer in Italy and, possibly, in other Mediterranean countries. Rift Valley Fever virus can cause serious illness in both animals and h...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10465

    authors: Sánchez-Seco MP,Echevarría JM,Hernández L,Estévez D,Navarro-Marí JM,Tenorio A

    更新日期:2003-09-01 00:00:00

  • HCV and HIV co-infection in pregnant women attending St. Camille Medical Centre in Ouagadougou (Burkina Faso).

    abstract::Five hundred and forty-seven pregnant women with less than 32 weeks of amenorrhoea, attending an antenatal clinic of St. Camille Medical Centre (SCMC) of Ouagadougou were enrolled for a hepatitis C virus (HCV) and HIV co-infection study. Fifty-eight (10.6%) were HIV positive and 18 (3.3%) were anti-HCV positive. Only ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20258

    authors: Simpore J,Ilboudo D,Samandoulougou A,Guardo P,Castronovo P,Musumeci S

    更新日期:2005-02-01 00:00:00

  • Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections.

    abstract::An enzyme-linked immunosorbent assay (ELISA) using recombinant nucleoprotein (rNP) was reported for the detection of immunoglobulin G (IgG) antibodies to Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV). The immunoglobulin M (IgM)-capture ELISA was developed for the diagnosis of CCHFV infections, using CCHFV rNP a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20270

    authors: Saijo M,Tang Q,Shimayi B,Han L,Zhang Y,Asiguma M,Tianshu D,Maeda A,Kurane I,Morikawa S

    更新日期:2005-02-01 00:00:00

  • Poliovirus serotype 2 and coxsackievirus A promote the natural recombination of poliovirus.

    abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25620

    authors: Qian Y,Pu X,Yu Y,Yu X,Kong L,Liu L,Wang H,Shen H

    更新日期:2020-03-01 00:00:00

  • Prevalence of HIV-1 non-B subtypes, syphilis, HTLV, and hepatitis B and C viruses among immigrant sex workers in Madrid, Spain.

    abstract::Sexually transmitted disease (STD) remains a major public health challenge in developed countries, exacerbated by the advent of the HIV epidemic. The objectives of this study were to assess the prevalence of serological markers of syphilis, HIV-1/2, HTLV-I/II, HBV, and HCV infections among immigrant sex workers in Mad...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20208

    authors: Gutiérrez M,Tajada P,Alvarez A,De Julián R,Baquero M,Soriano V,Holguín A

    更新日期:2004-12-01 00:00:00

  • Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data.

    abstract::Enterovirus (EV) infections are common. There are more than 60 known serotypes, and each has different epidemiologic or medical importance. Over 700 physicians from 75% of basic administrative units of Taiwan participated in the "Sentinel Physician Surveillance of Infectious Disease" and reported weekly to the Center ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21006

    authors: Tseng FC,Huang HC,Chi CY,Lin TL,Liu CC,Jian JW,Hsu LC,Wu HS,Yang JY,Chang YW,Wang HC,Hsu YW,Su IJ,Wang JR,CDC-Taiwan Virology Reference Laboratories and Sentinel Physician Network.

    更新日期:2007-12-01 00:00:00

  • Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010.

    abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23436

    authors: Than VT,Kang H,Lim I,Kim W

    更新日期:2013-01-01 00:00:00

  • Tocilizumab for the treatment of adult patients with severe COVID-19 pneumonia: A single-center cohort study.

    abstract::Coronavirus disease 2019 (COVID-19) can lead to a massive cytokine release. The use of the anti-interleukin-6 receptor monoclonal antibody tocilizumab (TCZ) has been proposed in this hyperinflammatory phase, although supporting evidence is limited. We retrospectively analyzed 88 consecutive patients with COVID-19 pneu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26308

    authors: Fernández-Ruiz M,López-Medrano F,Pérez-Jacoiste Asín MA,Maestro de la Calle G,Bueno H,Caro-Teller JM,Catalán M,de la Calle C,García-García R,Gómez C,Laguna-Goya R,Lizasoáin M,Martínez-López J,Origüen J,Pablos JL,Ripoll M,

    更新日期:2021-02-01 00:00:00

  • Nitric oxide and Coxsackievirus B3 myocarditis: differential expression of inducible nitric oxide synthase in mouse heart after infection with virulent or attenuated virus.

    abstract::Increased expression of inducible nitric oxide synthase (iNOS) has been found in inflammatory myocardial disease and increased production of nitric oxide (NO) has both an inhibitory effect on virus replication and a cytotoxic effect on host cells. To investigate the relationship between severity of enteroviral myocard...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1033

    authors: Bevan AL,Zhang H,Li Y,Archard LC

    更新日期:2001-06-01 00:00:00

  • Algorithm based on CMV kinetics DNA viral load for preemptive therapy initiation after hematopoietic cell transplantation.

    abstract::Preemptive therapy in hematopoietic cell transplantation is initiated by a diagnostic technique at first detection of cytomegalovirus (CMV). The aim of this study was to use the viral dynamics of CMV DNA viral to start preemptive therapy, and to prospectively compare the CMV viral load kinetics to pp65 antigenemia. Tw...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21996

    authors: Halfon P,Berger P,Khiri H,Martineau A,Pénaranda G,Merlin M,Faucher C

    更新日期:2011-03-01 00:00:00