Abstract:
:Dengue virus (DV) infection can result in either a mild febrile illness known as dengue fever (DF) or a life-threatening disease called dengue hemorrhagic fever (DHF). DHF is more prevalent in patients undergoing secondary DV infection. This observation has led to the hypothesis that DHF may be the result of immune reactions to the secondary DV infection; an event termed immunopathology. Two cellular factors, MIP-1 alpha and MIP-1 beta, have been found to be induced by infection with DV. MIP-1 induction by DV infection was observed in a myelomonocytic cell line, as well as in peripheral blood mononuclear cells isolated from a dengue naive donor. MIP-1 induction was not due to factors secreted by infected cells. In fact, replication-competent virus was required to induce MIP-1. Evidence is also provided that MIP-1 genes are expressed in patients with dengue disease. It is hypothesized that these chemokines may have roles in the immunopathology of dengue infections and may contribute to fever and bone marrow suppression observed in patients with DV infections.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Spain-Santana TA,Marglin S,Ennis FA,Rothman ALdoi
10.1002/jmv.2037keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
324-30issue
2eissn
0146-6615issn
1096-9071pii
10.1002/jmv.2037journal_volume
65pub_type
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