Real-life 3D therapy failure: Analysis of NS5A 93H RAS plus 108 K polymorphism in complex with ombitasvir by molecular modeling.

abstract：:Cytomegalovirus (CMV) infection remains a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a retrospective study to determine the clinical and economic burden of pre-emptive therapy (PET) for CMV infection in 100 consecutive hospitalized adult CMV positive serostatus allo...

journal_title：Journal of medical virology

authors： El Haddad L,Ghantoji SS,Park AK,Batista MV,Schelfhout J,Hachem J,Lobo Y,Jiang Y,Rondon G,Champlin R,Chemaly RF

更新日期：2020-01-01 00:00:00

abstract：:Twenty marmosets, male Callithrix jacchus, were used during this study. Fifteen of the marmosets were inoculated with 5,000 TCID50 of the attenuated XJC13 strain of Junin virus by intramuscular route and five were left as uninoculated controls. Animals were observed for a 420-day period. In order to carry out virologi...

journal_title：Journal of medical virology

authors： Avila MM,Frigerio MJ,Weber EL,Rondinone S,Samoilovich SR,Laguens RP,de Guerrero LB,Weissenbacher MC

更新日期：1985-01-01 00:00:00

abstract：:Polyomavirus BK (BKV) is a common human polyomavirus that rarely causes clinical symptoms in immunocompetent individuals. However, BK virus reactivation occurs in 20-40% of kidney transplant patients and 1-10% of cases present with BK virus-associated nephropathy (BKVN) and reduced kidney allograft survival. In this s...

journal_title：Journal of medical virology

authors： Girmanova E,Brabcova I,Bandur S,Hribova P,Skibova J,Viklicky O

更新日期：2011-08-01 00:00:00

abstract：:SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their ...

journal_title：Journal of medical virology

authors： Romero-López JP,Carnalla-Cortés M,Pacheco-Olvera DL,Ocampo-Godínez JM,Oliva-Ramírez J,Moreno-Manjón J,Bernal-Alferes B,López-Olmedo N,García-Latorre E,Domínguez-López ML,Reyes-Sandoval A,Jiménez-Zamudio L

更新日期：2020-09-28 00:00:00

abstract：:The λ-carrageenan (λ-car) is a potent and selective inhibitor of dengue virus (DENV) infection targeted to virus adsorption and internalization, due to the structural similarities with the mammalian cell receptor heparan sulfate. To further characterize the antiviral activity of λ-car, the selection and the phenotypic...

journal_title：Journal of medical virology

authors： Talarico LB,Damonte EB

更新日期：2016-07-01 00:00:00

abstract：:A total of 402 fecal specimens collected during July 2003-June 2004 from infants and children with acute gastroenteritis, encompassing five localities (Maizuru, Tokyo, Sapporo, Saga, and Osaka) of Japan, were tested for the presence of norovirus by RT-PCR. It was found that 58 (14.4%) fecal specimens were positive for...

journal_title：Journal of medical virology

authors： Phan TG,Kuroiwa T,Kaneshi K,Ueda Y,Nakaya S,Nishimura S,Yamamoto A,Sugita K,Nishimura T,Yagyu F,Okitsu S,Müller WE,Maneekarn N,Ushijima H

更新日期：2006-07-01 00:00:00

abstract：:To determine risk factors responsible for primary cytomegalovirus (CMV) infection in Taiwan, samples of blood for antibody to CMV were obtained from 362 children aged 4 to 12 years: 58% were found to be positive for anti-CMV IgG antibody. Logistic regression analysis showed that seropositivity correlated with age, met...

journal_title：Journal of medical virology

authors： Shen CY,Chang WW,Chang SF,Chao MF,Huang ES,Wu CW

更新日期：1992-05-01 00:00:00

abstract：:Recently, several clusters of hepatitis A have been observed among hemophiliacs linked to factor VIII concentrates treated for virus inactivation solely with the solvent/detergent (S/D) method, a procedure that does not affect nonenveloped viruses such as the hepatitis A virus (HAV). A new outbreak of hepatitis A in s...

journal_title：Journal of medical virology

authors： Chudy M,Budek I,Keller-Stanislawski B,McCaustland KA,Neidhold S,Robertson BH,Nübling CM,Seitz R,Löwer J

更新日期：1999-02-01 00:00:00

abstract：:Eastern equine encephalitis (EEE) is rare, but the most severe of the mosquito-borne encephalitides in the United States with a high case fatality rate of 30%. Here, we present a patient with EEE. EEE virus causes sporadic human disease in the Eastern parts of the United States, but the case we describe was a Scottish...

journal_title：Journal of medical virology

authors： Harvala H,Bremner J,Kealey S,Weller B,McLellan S,Lloyd G,Staples E,Faggian F,Solomon T

更新日期：2009-02-01 00:00:00

abstract：:Infection with putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was surveyed in 286 patients with chronic liver disease in Japan. RNA of GBV-C was detected, by reverse-transcription polymerase chain reaction with nested primers from the 5'-noncoding region, in 19 patients (6.6%) at a frequency highe...

journal_title：Journal of medical virology

authors： Sugai Y,Nakayama H,Fukuda M,Sawada N,Tanaka T,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

更新日期：1997-03-01 00:00:00

abstract：:Passively administered antibodies to conserved epitopes on the attachment (G) glycoprotein of human respiratory syncytial virus (hRSV) have potential in the immunoprophylaxis of human infections. This study set out to generate monoclonal antibodies (MAbs) recognizing all prevalent lineages of HRSV and capable of immun...

journal_title：Journal of medical virology

authors： Robinson MJ,Tan CS,Fenwick F,Chambers CJ,Routledge EG,Toms GL

更新日期：2014-07-01 00:00:00

abstract：:The role of Epstein-Barr virus (EBV) in the pathogenesis of gastric lymphoma of mucosa-associated lymphoid tissue (MALT) has not been well understood. The aim of the study was to investigate EBV infection and its gene expression in this tumor in order to understand its role in the pathogenesis. EBV infection was scree...

journal_title：Journal of medical virology

authors： Xu WS,Chan AC,Lee JM,Liang RH,Ho FC,Srivastava G

更新日期：1998-12-01 00:00:00

abstract：:Coronavirus-like particle(s) (CVLP) are faecal-derived pleomorphic membrane bound virus-like particles characterised by a fringe of club-shaped spikes that measure about 27 nm in length. The association of CVLP with a variety of social, clinical, and epidemiological factors was examined after a 69 month survey of faec...

journal_title：Journal of medical virology

authors： Marshall JA,Thompson WL,Gust ID

更新日期：1989-12-01 00:00:00

abstract：:Although neutralizing antibodies against Hantaan virus (HTV) can protect hosts from viral infection, T-cell responses to HTV are also important in host defense against HTV. However, much less is known about cytotoxic T lymphocyte (CTL) responses to HTV. To identify CTL epitopes in the HTV nucleocapsid protein (NP), we...

journal_title：Journal of medical virology

authors： Park JM,Cho SY,Hwang YK,Um SH,Kim WJ,Cheong HS,Byun SM

更新日期：2000-02-01 00:00:00

abstract：:In October 1977 an outbreak of acute infectious diarrhea occurred in an infant home in the city of Sapporo, Japan. Of 34 residents aged two to 20 months, 26 (77%) suffered from diarrhea. In ten of these patients the diarrhea was accompanied by vomiting. Electron microscopic examinations revealed typical calicivirus pa...

journal_title：Journal of medical virology

authors： Chiba S,Sakuma Y,Kogasaka R,Akihara M,Horino K,Nakao T,Fukui S

更新日期：1979-01-01 00:00:00

abstract：:Concomitant infection with TT virus and hepatitis B virus (HBV) or hepatitis C virus (HCV) is common. However, the effect of TTV infection on chronic hepatitis B or C is unknown. The prevalence of TTV infection, the effect of TTV infection on the clinical, histological and virological features of patients with chronic...

journal_title：Journal of medical virology

authors： Kao JH,Chen W,Chen PJ,Lai MY,Chen DS

更新日期：2000-04-01 00:00:00

abstract：:The kinetics of hepatitis B virus (HBV) and its surface antigen (HBsAg) during acute hepatitis has not yet been studied accurately in a representative number of patients. The influence of coinfecting hepatitis viruses during the acute phase of infection is not known. Three to four serum samples from 21 patients with a...

journal_title：Journal of medical virology

authors： Chulanov VP,Shipulin GA,Schaefer S,Gerlich WH

更新日期：2003-03-01 00:00:00

abstract：:Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. Thi...

journal_title：Journal of medical virology

authors： Mäki J,Paavilainen H,Kero K,Hukkanen V,Syrjänen S

更新日期：2018-03-01 00:00:00

abstract：:Analysis of 505 cases history of patients among men with viral hepatitis demonstrates that HBV infected patients represent 68.9% of the total and that a non-parenteral rate of transmission is the most likely means of hepatitis B infection. Saliva and serum testing for the presence of specific HBV markers (HBsAg, HBeAg...

journal_title：Journal of medical virology

authors： Zhevachevsky NG,Nomokonova NY,Beklemishev AB,Belov GF

更新日期：2000-08-01 00:00:00

abstract：:Some international guidelines recommend evaluating the need to confirm positive anti-hepatitis C virus (HCV) antibody screening results by means of a more specific antibody or molecular biology test on the basis of a screening threshold value (such as the sample signal/cut-off ratio) that can predict the positivity of...

journal_title：Journal of medical virology

authors： De Paschale M,Manco MT,Arpino O,Ricucci V,Paganini A,Belvisi L,Cagnin D,Cerulli T,Cianflone A,Agrappi C,Mirri P,Clerici P

更新日期：2017-10-01 00:00:00

abstract：:Since outbreaks of severe acute hemorrhagic conjunctivitis occur worldwide [Hierholzer and Hatch, 1985] and the majority of the epidemics are caused by enterovirus 70 (EV-70), we developed an EV-70 IgM ELISA to simplify the diagnosis of these outbreaks. The test is based on the capture antibody technique and the use o...

journal_title：Journal of medical virology

authors： Wulff H,Anderson LJ,Pallansch MA,de Souza Carvalho RP

更新日期：1987-04-01 00:00:00

abstract：:Lack of recognition of human immunodeficiency virus (HIV) infection especially in children and delayed implementation of effective control programs makes HIV infection as a major cause for concern. Information on HIV epidemiology in Iran as well as other Islamic countries is limited. The aim of our study was to descri...

journal_title：Journal of medical virology

authors： Movahedi Z,Mahmoudi S,Pourakbari B,Keshavarz Valian N,Sabouni F,Ramezani A,Bahador A,Mamishi S

更新日期：2016-01-01 00:00:00

abstract：:A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...

journal_title：Journal of medical virology

authors： Than VT,Kang H,Lim I,Kim W

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS-CoV-2 RNA in anal swabs and to explore the association with disease severity. METHODS:We...

journal_title：Journal of medical virology

authors： Lin W,Xie Z,Li Y,Li L,Wen C,Cao Y,Chen X,Ou X,Hu F,Li F,Tang X,Cai W,Li L

更新日期：2021-02-01 00:00:00

abstract：:Dried blood spots collected on filter paper are considered potential clinical specimens for measles surveillance because of their ease of collection, storage, and transport. The usefulness of these samples for surveillance of measles was evaluated in a field setting. Blood spots were collected by finger-prick from 316...

journal_title：Journal of medical virology

authors： El Mubarak HS,Yüksel S,Mustafa OM,Ibrahim SA,Osterhaus AD,de Swart RL

更新日期：2004-08-01 00:00:00

abstract：:The complete RNA sequences of hepatitis delta viruses (HDV) isolated at 3 years apart from a chronic delta hepatitis patient in Taiwan were determined. The sequence analysis showed an overall evolution rate of 3.18 x 10(-3) substitutions/nucleotide/year. The evolution rates in different parts of HDV RNA varied. The hy...

journal_title：Journal of medical virology

authors： Chao YC,Tang HS,Hsu CT

更新日期：1994-08-01 00:00:00

abstract：:Antibodies to herpes simplex virus and Epstein-Barr virus were sought in the sera of 33 patients with endoscopically proved duodenal ulcer and 33 healthy controls. Neither the prevalence nor the antibody levels to both viruses were significantly different between the two groups. These results suggest that herpes virus...

journal_title：Journal of medical virology

authors： Kottaridis SD,Mihas TA,Goula I,Mihas AA

更新日期：1989-11-01 00:00:00

abstract：:During the 1976 Ebola virus outbreak in Sudan, the investigations team gained the impression that fewer haemorrhagic manifestations and few fatalities occurred during the later stages of the epidemic after the virus had undergone several generations in man. This impression was also noted in guinea pigs experimentally ...

journal_title：Journal of medical virology

authors： Bowen ET,Platt GS,Lloyd G,Raymond RT,Simpson DI

更新日期：1980-01-01 00:00:00

abstract：:Epstein-Barr virus (EBV) reactivation and cell-mediated immune (CMI) responses were followed in 16 Antarctic expeditioners during winter-over isolation at 2 Australian National Antarctic Research Expedition stations. Delayed-type hypersensitivity (DTH) skin testing was used as an indicator of the CMI response, that wa...

journal_title：Journal of medical virology

authors： Mehta SK,Pierson DL,Cooley H,Dubow R,Lugg D

更新日期：2000-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma is closely associated with Epstein-Barr virus (EBV) and the EBV encoded latent membrane protein-1 expression (LMP1) is commonly found in the tumour cells. LMP1 has been shown to be involved in modulation of cell growth in B cells but the biological properties of LMP1 expression in nasopharynge...

journal_title：Journal of medical virology

authors： Liu Y,Wang X,Lo AK,Wong YC,Cheung AL,Tsao SW

更新日期：2002-01-01 00:00:00