Abstract:
:To elucidate the mechanism of heterologous antibody responses to herpes simplex virus (HSV) and varicella-zoster virus (VZV) which occur in some patients with HSV or VZV infections, stronger evidence was sought for the existence of cross-reacting antibodies to these viruses, using antibody absorption procedures. Absorption of sera from initial HSV infections with HSV antigen was found to abolish heterologous antibody titer rises to VZV, as demonstrated in complement fixation, neutralization, and anti-complement immunofluorescence test systems. In most instances, convalescent-phase titers to heterologous VZV were reduced by HSV absorption to levels comparable to those in the acute-phase serum, indicating that cross-reacting antibodies were, in fact, responsible for the heterologous antibody titer rises. Absorption of convalescent-phase sera from HSV or VZV patients with homologous antigen also abolished or greatly diminished immunoprecipitating activity with the heterologous antigen, furnishing additional evidence of the existence of cross-reacting antibodies. Absorption of sera with insolubilized IgG to re-remove rheumatoid factor, which was present in a number of the sera studied, had no effect on either homologous or heterologous antibody titer increases. The demonstration of cross-reacting antibodies to HSV and VZV supports the concept that these two human herpesviruses share common antigen(s).
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Schmidt NJdoi
10.1002/jmv.1890090105subject
Has Abstractpub_date
1982-01-01 00:00:00pages
27-36issue
1eissn
0146-6615issn
1096-9071journal_volume
9pub_type
杂志文章abstract::A diabetogenic strain of coxsackievirus B4 of human origin has been purified to study its biochemistry and diabetogenicity. Tissue culture cells infected with the virus contain two distinct types of particles--virions and membrane-bound virions (MBV). MBVs are lighter (p = 1.29) than virions (p = 1.34), and they conta...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890260109
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journal_title:Journal of medical virology
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abstract::Hantaviruses is an emerging infectious disease. Although HCPS has been reported in several regions of Brazil, more cases of HCPS have recently been reported in Minas Gerais than in any other state. In 2009, we analyzed 27 samples presenting antibodies against hantaviruses. These samples originated from 688 symptomatic...
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abstract::It is well documented that perinatal transmission is the major cause of chronic HBV infection in China. However, the mechanisms of HBV perinatal transmission are not defined clearly. It is not known whether hepatitis B e antigen can cross the human placenta, and the rate of HBeAg decay in babies with and without HBV b...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
abstract::Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised individuals and is recognized as a major viral cause of birth defects. HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. Apoptosis is an innate cellular defense response to vir...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
abstract::Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral-specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV-DNA seropositivity greater than 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biop...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890290214
更新日期:1989-10-01 00:00:00
abstract::GB virus C (GBV-C) is related to hepatitis C virus (HCV) and has a similar genomic structure. Some predictors for the efficacy of interferon (IFN) therapy on HCV have been reported: genotype, viral load, IFN dose, and the amino acid substitutions in the NS5A region, designated as the interferon sensitivity determining...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199904)57:4<376::aid-jmv9>
更新日期:1999-04-01 00:00:00
abstract::Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence of resistance-associated substitutions (RAS) at baseline has occasionally been associated with impaired treatment response. Herein, we examined the impact of baseline RAS at the HCV NS5A gene region on treatment response in a r...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24971
更新日期:2018-03-01 00:00:00
abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...
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pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
abstract::Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AF...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26804
更新日期:2021-01-17 00:00:00
abstract::Human parechoviruses (HPeV) are associated with central nervous system (CNS) infections and sepsis-like illnesses. However, data from China are not available. The aim of this study was to determine the prevalence, age, and seasonal distributions and genotypes of HPeV infections in children with CNS related disease in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23449
更新日期:2013-02-01 00:00:00
abstract::HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in ad...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21887
更新日期:2010-11-01 00:00:00
abstract::A cDNA copy of the HCV229E nucleocapsid protein gene was isolated and characterized. Sequence analysis predicts a nucleocapsid polypeptide of 389 amino acids with a molecular weight (mol. wt.) of 43,450. Single strand RNA probes derived from the cDNA copy hybridize specifically to HCV229E RNA and approximately 50 pg o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890310216
更新日期:1990-06-01 00:00:00
abstract::To characterize cytotoxic T lymphocytes (CTLs) that appeared in circulation during lamivudine therapy, we analyzed HBV-specific CTLs using HLA-A24 tetramer and HBcAg-specific Th1 cells in patients receiving lamivudine therapy. Six patients (HLA-A24(+)) with chronic hepatitis B, six patients (HLA-A24(-)) with chronic h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20194
更新日期:2004-11-01 00:00:00
abstract::The efficacy of interferon therapy for hepatitis C virus (HCV) infection improved remarkably. However, virologic relapse occurs in a substantial proportion of patients with virologic response (defined as an HCV RNA level below 50 IU/ml at the end-of-treatment). A highly sensitive RT-nested PCR assay capable of detecti...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20908
更新日期:2007-08-01 00:00:00
abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199608)49:4<283::AID-JMV5>
更新日期:1996-08-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV-1)-infected patients and healthy controls were measured longitudinally using real-time polymerase chain reaction to evaluate the effects of antiretroviral agents on mtDNA synthesis in vivo and to ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10423
更新日期:2003-08-01 00:00:00
abstract::Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) have similar transmission routes, implying that patients infected with HIV are at particular risk for HBV infection. Patients who are co-infected with HIV and HBV progress more rapidly to end-stage liver disease and different HBV genotypes may have a disti...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
abstract::The presence of hepatitis GB virus C (GBV-C), also known as hepatitis G virus (HGV), and hepatitis C virus (HCV) were investigated in sera from 45 hemophiliacs from nine locations in Nicaragua using a nested polymerase chain reaction (PCR). Primers used to detect GBV-C and HCV derived from the helicase region and 5'UT...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890040204
更新日期:1979-01-01 00:00:00
abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25620
更新日期:2020-03-01 00:00:00
abstract::The paper describes the results of preclinical testing of the preparation "Vaccine allantoic split-virus inactivated against seasonal influenza." Acute toxicity and local irritating effect, anaphylactic reactions to different antigens (vaccine and ovalbumin), delayed-type hypersensitivity to ram erythrocytes, humoral ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24771
更新日期:2017-07-01 00:00:00
abstract::Nasal washings were collected from 27 normal adults during 38 naturally acquired colds. The washings were exhaustively tested using tissue cultures, organ cultures and electron microscopy. Washings yielding no identifiable agent were inoculated into human volunteers, and further specimens obtained from the latter were...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890050306
更新日期:1980-01-01 00:00:00
abstract::Acute hepatitis B virus (HBV) infection was diagnosed in 57 adults admitted to Toranomon Hospital in Tokyo, Japan. Genotypes of HBV were determined by a serological method and compared to those in 1,077 patients with chronic hepatitis B. The distribution of genotypes were: genotype A (acute, 22.8% vs. chronic, 1.9%; P...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10239
更新日期:2002-12-01 00:00:00
abstract::The criterion standard for the diagnosis of occult hepatitis C virus (HCV) infection is detection of HCV-RNA in liver cells. However, because of the invasive nature of liver biopsy, other methods have been studied. The present study aimed to identify subjects with occult HCV-4 infection among healthy sexual partners o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24074
更新日期:2015-03-01 00:00:00
abstract::Although occult hepatitis B virus (HBV) infection in individuals without detectable hepatitis B surface antigen (HBsAg) may occur and has been reported to be common in patients with chronic hepatitis C, the related molecular mechanisms remain unknown. With the polymerase chain reaction, serum HBV DNA was sought in 100...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10188
更新日期:2002-10-01 00:00:00
abstract::In October 1977 an outbreak of acute infectious diarrhea occurred in an infant home in the city of Sapporo, Japan. Of 34 residents aged two to 20 months, 26 (77%) suffered from diarrhea. In ten of these patients the diarrhea was accompanied by vomiting. Electron microscopic examinations revealed typical calicivirus pa...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890040402
更新日期:1979-01-01 00:00:00
abstract::In order to assess the efficacy of interferon-alpha on hepatitis C viral RNA in patients with chronic hepatitis C, we analyzed the levels of HCV RNA in sera and liver tissues of 16 patients pre- and posttreatment using a semiquantitative polymerase chain reaction method. Fifteen of 16 patients were positive for anti-H...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/jmv.1890400114
更新日期:1993-05-01 00:00:00