Abstract：
:Nutrient starvation is a common phenomenon that occurs during T cell activation. Upon pathogen infection, large amounts of immune cells migrate to infection sites, and antigen-specific T cells are activated; this is followed by rapid proliferation through clonal expansion. The dramatic expansion of cells will commonly lead to nutrient shortage. Cellular autophagy is often upregulated as a way to sustain the body's energy requirements. During infection, human immunodeficiency virus (HIV) co-opts a series of host cell metabolic pathways for replication. Several HIV proteins, such as Env, Nef, and Vpr, have already been reported as being involved in autophagy-related processes. In this report, we identified that the HIV p17 protein acts as a major factor in suppressing the autophagic process in T cells, especially under glucose starvation condition. HIV p17 interacts with Obg-like ATPase 1 (OLA1) and disrupts OLA1-glycogen synthase kinase-3 beta (GSK3β) complex, leading to GSK3β hyperactivation. Consequently, a prior proliferation of HIV-infected T cells under glucose starvation will occur. The inhibition of autophagy also aids HIV replication by antagonizing the antiviral effect of autophagy. Our study shows a new cellular pathway that HIV can hijack for viral spreading by a prior proliferation of HIV-loaded T cells and may provide new therapeutic targets for acquired immunodeficiency syndrome intervention.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Lu J,Jia J,Zhang J,Liu Xdoi
10.1002/jmv.26423subject
Has Abstractpub_date
2020-08-13 00:00:00eissn
0146-6615issn
1096-9071pub_type
杂志文章abstract：:Outbreaks of gastroenteritis are a major public health problem in New Zealand. The introduction of molecular detection methods has now shown that the 'Norwalk-like viruses' (NLVs) are the major cause of food and waterborne nonbacterial gastroenteritis. Reverse transcription and polymerase chain reaction (RT-PCR) were ...
journal_title：Journal of medical virology
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journal_title：Journal of medical virology
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journal_title：Journal of medical virology
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of medical virology
pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-24 00:00:00
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journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890300407
更新日期：1990-04-01 00:00:00
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journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21752
更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1002/jmv.1890290214
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doi：
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journal_title：Journal of medical virology
pub_type： 杂志文章
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abstract：:Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...
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