Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective.

Abstract:

:Brefeldin A has been recently characterized to act as an inhibitor of intracellular protein export with profound effects on the structure and function of the Golgi apparatus in animal cells. Manifold activities of the antibiotic (under different names) published in the 1960's and 1970's are reviewed: effects on fungal growth and morphogenesis, inhibition of mitosis in plant cells, cytotoxicity, cancerostatic, antiviral and antinematodal activity and peculiar effects on DNA, RNA and protein synthesis in microbial and animal cells.

journal_title

Folia microbiologica

authors

Betina V

doi

10.1007/BF02814572

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

3-11

issue

1

eissn

0015-5632

issn

1874-9356

journal_volume

37

pub_type

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