The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice.

Abstract:

:One-week dextran sulfate treatment of conventional (CV) immunodeficient (SCID) mice gave rise to acute colitis in the colon mucosa; germ-free (GF) SCID mice did not exhibit any changes in colon morphology. Dextran sulfate application to CV immunocompetent (BALB/c) mice did induce substantial changes in the colon mucosa (grade 4); GF BALB/c mice showed mild changes in the colon morphology (grade 1) only. GF SCID mice and CV SCID mice died during the second round of dextran sulfate treatment suffering from chronic colitis; GF BALB/c mice exhibited mild crypt distortion while CV BALB/c mice showed a complete loss of the surface epithelium (grade 4), accompanied by T and B lymphocyte infiltration.

journal_title

Folia microbiologica

authors

Hudcovic T,Stĕpánková R,Cebra J,Tlaskalová-Hogenová H

doi

10.1007/BF02818004

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

565-72

issue

6

eissn

0015-5632

issn

1874-9356

journal_volume

46

pub_type

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