A homeodomain protein binding element in the bone sialoprotein promoter is critical for tissue-specific expression in bone.

abstract：:Currently, the mechanism governing the regeneration of the soft tissue-to-bone interface, such as the transition between the anterior cruciate ligament (ACL) and bone, is not known. Focusing on the ACL-to-bone insertion, this study tests the novel hypothesis that interactions between cells from the ligament (fibroblas...

journal_title：Connective tissue research

authors： Wang IE,Bogdanowicz DR,Mitroo S,Shan J,Kala S,Lu HH

更新日期：2016-11-01 00:00:00

abstract：:The present study details structural aspects of the cells of the rat intra-articular disc (IAD) of the temporomandibular joint. At the light and electron microscope level, the outline of the cells varied, although a number appeared oval/rounded. Ultrastructurally, the cells contained moderate amounts of the intracellu...

journal_title：Connective tissue research

authors： Berkovitz BK,Becker D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoa...

journal_title：Connective tissue research

authors： Fernández-Torres J,Martínez-Nava GA,Oliviero F,López-Reyes AG,Martínez-Flores K,Garrido-Rodríguez D,Francisco-Balderas A,Zamudio-Cuevas Y

更新日期：2019-05-01 00:00:00

abstract：:Osteoarthritis (OA) is typically managed in late stages by replacement of the articular cartilage surface with a prosthesis as an effective, though undesirable outcome. As an alternative, hydrogel implants or growth factor treatments are currently of great interest in the tissue engineering community, and scaffold mat...

journal_title：Connective tissue research

authors： McCreery KP,Calve S,Neu CP

更新日期：2020-05-01 00:00:00

abstract：:To study the glycoproteins and transglutaminase substrates involved in healing, wounds were made in the skin of anesthetized rats with a biopsy punch. Explants made 1-5 days later were incubated with [3H]-labelled putrescine, fucose or proline. As compared with unwounded skin there was an increased incorporation of la...

journal_title：Connective tissue research

authors： Bowness JM,Henteleff H,Dolynchuk KN

更新日期：1987-01-01 00:00:00

abstract：:X-Ray diffraction and scanning electron microscopy show that collagen fibrils tend to be oriented parallel to the surface of the vertebral end plates in pig, rat and man. It is suggested that this orientation allows the end plate to withstand the pressure exerted on it by the nucleus pulposus. Scanning electron micros...

journal_title：Connective tissue research

authors： Aspden RM,Hickey DS,Hukins DW

更新日期：1981-01-01 00:00:00

abstract：AIM OF THE STUDY:To further elucidate the pathogenesis of systemic sclerosis (SSc) an experimental avian model was used. The University of California at Davis line 200 (UCD-200) chickens spontaneously develop a SSc-like disease that has most features of human SSc with vascular effects, inflammation, autoimmunity, and f...

journal_title：Connective tissue research

authors： Kerje S,Hellman U,Do L,Larsson G,Kämpe O,Engström-Laurent A,Lindqvist U

更新日期：2016-09-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are two extracellular bone matrix proteins that have the ability to modulate the growth of hydroxyapatite in vitro. Studies of BSP/OPN hydroxyapatite interactions in the past have been directed toward the identification of essential structural elements that allow these two...

journal_title：Connective tissue research

authors： Stubbs JT 3rd

更新日期：1996-01-01 00:00:00

abstract：:Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects about 1 in 50,000 children worldwide. MHE, also known as hereditary multiple exostoses (HME) or multiple osteochondromas (MO), is characterized by cartilage-capped outgrowths called osteochondromas that develop adjacent to the growth pl...

journal_title：Connective tissue research

authors： Phan AQ,Pacifici M,Esko JD

更新日期：2018-01-01 00:00:00

abstract：:Although bone is a nanocomposite of mineral and collagen, mineral has been the more elusive component of study. A standard for bone mineral is clearly needed. We hypothesized that the most natural, least-processed bone mineral could be retrieved from the most highly mineralized bone. We therefore studied the rostrum o...

journal_title：Connective tissue research

authors： Li Z,Pasteris JD,Novack D

更新日期：2013-01-01 00:00:00

abstract：: Purpose/Aim of the study mice are the most often used pre-clinical lab models for studying the pathologies of bone mineralization. However, recent evidence suggests that two of the most often used mice strains (C57BL/6J and CD-1) might show differences in the bone minerali...

journal_title：Connective tissue research

authors： Fayolle C,Labrune M,Berteau JP

更新日期：2020-09-01 00:00:00

abstract：:Sonic hedgehog (Shh) expression is highly localized to the epithelium at the future sites of tooth development. This restricted expression suggests that inhibition of Shh in areas where teeth do not form may be an important mechanism in tooth germ localization. Recently, Hip, a putative vertebrate antagonist of Shh, h...

journal_title：Connective tissue research

authors： Cobourne MT,Sharpe PT

更新日期：2002-01-01 00:00:00

abstract：:The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. One of these was found to have similar molecular ...

journal_title：Connective tissue research

authors： Hincke MT

更新日期：1995-01-01 00:00:00

abstract：:??Although injuries to the medial collateral ligament (MCL) can heal functionally without surgical intervention, the collagen fibers in the healing tissue remain compromised. The molecular basis for this poor healing potential was investigated by examining extracellular matrix-modifying molecules such as bone morphoge...

journal_title：Connective tissue research

authors： Achari Y,Chin JW,Heard BJ,Rattner JB,Shrive NG,Frank CB,Hart DA

更新日期：2011-01-01 00:00:00

abstract：AIM:miR-155 is a pro-inflammatory or anti-inflammatory factor depending on the cell type in which it is expressed. miR-155 controls apoptosis and matrix degradation in nucleus pulposus (NP) cells in vitro. The aim of this study is to explore the effect of miR-155 in vivo and further investigate the mechanism of miR-155...

journal_title：Connective tissue research

authors： Zhou J,Liang A,Hong J,Sun J,Lin X,Peng Y,Wang X,Sun S,Xiao D,Xu K,Ye W

更新日期：2019-03-01 00:00:00

abstract：AIM OF THE STUDY:Tendons are exposed to mechanical stress constantly during movements and thus they are frequently subjected to injuries. Rotator cuff tears are common musculoskeletal disorders, mainly involving the supraspinatus tendon. The characterization of the tenocytes derived from this tendon and the comparison ...

journal_title：Connective tissue research

authors： Viganò M,Lugano G,Orfei CP,Menon A,Ragni E,Colombini A,de Luca P,Talò G,Randelli PS,de Girolamo L

更新日期：2020-09-14 00:00:00

abstract：PURPOSE:Our previous study showed that partial-thickness articular cartilage defects (PTCDs) created in immature rats spontaneously healed to resemble normal hyaline cartilage, but that of mature rats did not. To identify molecules involved in the spontaneous cartilage repair observed in this model, gene expression was...

journal_title：Connective tissue research

authors： Ikegawa N,Sasho T,Yamaguchi S,Saito M,Akagi R,Muramatsu Y,Akatsu Y,Fukawa T,Nakagawa K,Nakajima A,Suzuki T,Takahashi K

更新日期：2016-05-01 00:00:00

abstract：:This study aims to elucidate the feasible geometry of the scaffolds in bone and periodontal tissue engineering. Several biomaterials with different geometries are compared in terms of their patterns of ectopic BMP-induced chondrogenesis and osteogenesis. The materials include a honeycomb-shaped hydroxyapatite (HCHAP) ...

journal_title：Connective tissue research

authors： Kuboki Y,Jin Q,Kikuchi M,Mamood J,Takita H

更新日期：2002-01-01 00:00:00

abstract：:Hyperhomocysteinemia causes connective tissue pathology. Several theories on the mechanism of homocysteine toxicity in connective tissue are reviewed briefly. A possible new mechanism was revealed recently in the discovery of a reaction in which homocysteine thiolactone is converted to mercaptopropionaldehyde. The rea...

journal_title：Connective tissue research

authors： Toohey JI

更新日期：2008-01-01 00:00:00

abstract：:Studies were designed to test the hypothesis that plasma- and serum-deprived embryonic cells and tissues in vitro are capable of producing growth regulating factors which augment cartilage, bone and tooth induction during mouse mandibular process development. Embryonic mouse first branchial arch-derived mandibular pro...

journal_title：Connective tissue research

authors： Slavkin HC,Sasano Y,Kikunaga S,Bessem C,Bringas P Jr,Mayo M,Luo W,Mak G,Rall L,Snead ML

更新日期：1990-01-01 00:00:00

abstract：:Parietal yolk sacs isolated from 14.5-day rat embryos and incubated in vitro with either [14C]proline, [3H]mannose or 3H-labeled amino acid mixture synthesized and secreted basement membrane collagenous and noncollagenous glycoprotein components with relative molecular weights of 350,000 (350K), 220,000 (220K), 185,00...

journal_title：Connective tissue research

authors： Clark CC,Kefalides NA

更新日期：1982-01-01 00:00:00

abstract：:Rat bone marrow cells were cultured in vitro in a collagen-gel medium at 0.5% fetal bovine serum concentration for 10 days in the presence of recombinant human transforming growth factor-beta-1, genetically engineered to contain a collagen binding domain (rhTGF-beta1-F2), or a commercial rhTGF-beta1. To compare the ef...

journal_title：Connective tissue research

authors： Andrades JA,Han B,Nimni ME,Ertl DC,Simpkins RJ,Arrabal MP,Becerra J

更新日期：2003-01-01 00:00:00

abstract：:The total and individual glycosaminoglycan (GAG) content at various stages of the Dupuytren disease process and in samples of normal palmar connective tissue (palmar dermis, palmar fascia and digital flexor tendon) from the hands of uninvolved age-matched controls have been assayed and compared. Morphological comparis...

journal_title：Connective tissue research

authors： Flint MH,Gillard GC,Reilly HC

更新日期：1982-01-01 00:00:00

abstract：:Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured") from tissue sections for molecular analyses. In this study, chondrocyt...

journal_title：Connective tissue research

authors： Landis WJ,Jacquet R,Hillyer J,Zhang J

更新日期：2003-01-01 00:00:00

abstract：:A high frequency restriction fragment length polymorphism (RFLP) at the 3'-end of the pigeon pro alpha 2(1) collagen gene was detected using the restriction endonuclease EcoR1. The distribution of this allelic variant was analyzed in DNA isolated from White Carneau pigeons genetically susceptible to the development of...

journal_title：Connective tissue research

authors： Boyd CD,Song JY,Kniep AC,Park HS,Fastnacht C,Smith EC,Smith SC

更新日期：1991-01-01 00:00:00

abstract：:Aseptic loosening remains the primary cause of failure in total joint arthroplasty. Implant-derived particles are thought to be a main cause of osteolysis that leads to the failure. Substance P (SP) immunoreactive nerve fibers have been detected in the periprosthetic membrane of aseptic loose hip prostheses. We isolat...

journal_title：Connective tissue research

authors： Qian Y,Zhang XL,Zeng BF,Jiang Y,Shen H,Wang Q

更新日期：2013-01-01 00:00:00

abstract：:Purpose: Complications including arthrofibrosis have been reported after anterior cruciate ligament reconstruction (ACLR) even under accelerated rehabilitation. To overcome this, we developed an animal model of ACLR-induced arthrofibrosis without immobilization.Materials and Methods: Thirteen male Wistar rats were div...

journal_title：Connective tissue research

authors： Kaneguchi A,Ozawa J,Minamimoto K,Yamaoka K

更新日期：2019-11-26 00:00:00

abstract：:The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee and are associated with an increased risk of deve...

journal_title：Connective tissue research

authors： Melrose J,Fuller ES,Little CB

更新日期：2017-01-01 00:00:00

abstract：:Since cartilage is mainly an avascular tissue, chondrocytes exist in a low-level oxygen environment in vivo. In the present study, we investigated the effect of oxygen tension (20%, 5% and 1% gas phase oxygen concentrations) over a 20-day period on the extracellular matrix accumulation of bovine articular chondrocytes...

journal_title：Connective tissue research

authors： Murphy CL,Sambanis A

更新日期：2001-10-01 00:00:00

abstract：:The interaction of sodium dodecyl sulfate with elastin has been studied by complexometric titration. Approximately 1.2 mumoles of protons with a pKapp of 5.45 are taken up by 10 milligrams of insoluble elastin upon the binding of detergent, apparently due to the protonation of normally ionized carboxylate functions in...

journal_title：Connective tissue research

authors： Kagan HM

更新日期：1978-01-01 00:00:00