Changes in the state of ionization of carboxyl groups in elastin in response to the binding of sodium dodecyl sulfate.

abstract：:Muscle development in the embryonic chick involves the interfacing of two different cell types: myogenic cells forming the contractile network and connective tissue cells which wrap this network into discrete morphologies. Previous reports from this laboratory detailed the characterization of large extracellular matri...

journal_title：Connective tissue research

authors： Young HE,Carrino DA,Caplan AI

更新日期：1988-01-01 00:00:00

abstract：:Human skin fibroblasts cultured with 4-methylumbelliferone (MU), a hyaluronan synthesis inhibitor, produce a hyaluronan-deficient extracellular matrix (See [9]). Our present study investigated the effects of MU on proteoglycan, which is the other main component of the extracellular matrix, and interacts with hyalurona...

journal_title：Connective tissue research

authors： Funahashi M,Nakamura T,Kakizaki I,Mizunuma H,Endo M

更新日期：2009-01-01 00:00:00

abstract：:An immunohistochemical analysis of the eggshell membranes shows the occurrence of type X collagen while type I collagen was not detected by using an appropriate monoclonal antibody with untreated shell membranes. A positive immuno-reaction for type I collagen was obtained after digestion of the shell membranes with pe...

journal_title：Connective tissue research

authors： Arias JL,Fernandez MS,Dennis JE,Caplan AI

更新日期：1991-01-01 00:00:00

abstract：:Oral mandibular epithelium determines the position and number of tooth organs. Cranial neural crest-derived ectomesenchyme provides inductive signals for (i) tooth shape, and (ii) sequential determination and expression of several different epithelial-derived enamel proteins. Inductive signalling follows a precise seq...

journal_title：Connective tissue research

authors： Slavkin HC

更新日期：1989-01-01 00:00:00

abstract：:The effect of I- and C1- on the enzymatic degradation of elastin pancreatic elastase has been studied. At low halide concentrations both ions show a marked stimulation of elastolysis, I- being significantly more effective than Cl-. Kinetic plots of enzyme activity indicate that anions enhance the susceptibility of the...

journal_title：Connective tissue research

authors： Winkler RH

更新日期：1978-01-01 00:00:00

abstract：:In our previous developmental study on skin we reported that correlations existed between the collagen fibril diameter distribution, glycosaminoglycan content and composition, and mechanical role. In this work we present new but related electron microscope data on the ultrastructure of skins from flounder, marlin, cod...

journal_title：Connective tissue research

authors： Craig AS,Eikenberry EF,Parry DA

更新日期：1987-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a ubiquitous regulator of cellular growth and differentiation. The present study investigated the effects of TGF-beta on chick growth plate chondrocyte proliferation, matrix synthesis, and alkaline phosphatase activity in short term cultures. TGF-beta markedly stimulated D...

journal_title：Connective tissue research

authors： Rosier RN,O'Keefe RJ,Crabb ID,Puzas JE

更新日期：1989-01-01 00:00:00

abstract：:For many years we have investigated the earliest crystal formations of different developing hard tissues (matrix vesicle, bone, dentine, enamel, etc.) by different electron microscopic measurements. It was observed that primarily Ca-phosphate (apatite) "chains," composed of nanometer sized particles (dots, islands), e...

journal_title：Connective tissue research

authors： Höhling HJ,Arnold S,Barckhaus RH,Plate U,Wiesmann HP

更新日期：1995-01-01 00:00:00

abstract：:Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects about 1 in 50,000 children worldwide. MHE, also known as hereditary multiple exostoses (HME) or multiple osteochondromas (MO), is characterized by cartilage-capped outgrowths called osteochondromas that develop adjacent to the growth pl...

journal_title：Connective tissue research

authors： Phan AQ,Pacifici M,Esko JD

更新日期：2018-01-01 00:00:00

abstract：:Purpose: In experimental models of equine joint-injury and osteoarthritis synovial fluid (SF) composition (proteoglycan-4, hyaluronan) can vary, along with changes to SF mechanical function (lubrication, viscosity). The study hypotheses were a) clinical equine joint-injury and disease results in altered SF composition...

journal_title：Connective tissue research

authors： Matheson A,Regmi SC,Martin-Alarcon L,Jay GD,Scott WM,Schmidt TA

更新日期：2020-04-20 00:00:00

abstract：:An agarose gel matrix was utilized to grow chondrocytes from human donors of various ages in cell culture. The chondrocytes produced the pericellular matrix characteristic for such cells and synthesized collagen type II as well as glyco-saminoglycans. The latter exhibit the typical distribution pattern of the respecti...

journal_title：Connective tissue research

authors： Delbrück A,Dresow B,Gurr E,Reale E,Schröder H

更新日期：1986-01-01 00:00:00

abstract：:In the absence of ascorbic acid, confluent human skin fibroblasts incubated in 0.5% serum-supplemented medium had one-third of the level of lysyl hydroxylase activity of cells incubated in media containing high serum concentrations (5-20%). This difference appeared to be due to a decline in the enzyme activity followi...

journal_title：Connective tissue research

authors： Murad S,Sivarajah A,Pinnell SR

更新日期：1985-01-01 00:00:00

abstract：:To explore crucial early molecular events involved in contact healing of the intrasynovial flexor tendon, integrin expression was evaluated at the transcriptional and post-transcriptional levels during the first two weeks following injury, repair and controlled passive motion in a canine model. Specifically, immunohis...

journal_title：Connective tissue research

authors： Harwood FL,Monosov AZ,Goomer RS,Gelberman RH,Winters SC,Silva MJ,Amiel D

更新日期：1998-01-01 00:00:00

abstract：:Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due t...

journal_title：Connective tissue research

authors： Zhang J,Qiu X,Xi K,Hu W,Pei H,Nie J,Wang Z,Ding J,Shang P,Li B,Zhou G

更新日期：2018-11-01 00:00:00

abstract：:Collagen type I fiber-based scaffolds for anterior cruciate ligament (ACL) replacement were evaluated for their mechanical properties and their ability to promote cellular proliferation. Prior to scaffold formation, two crosslinking methods were investigated on individual reconstituted collagen type I fibers, ultravio...

journal_title：Connective tissue research

authors： Walters VI,Kwansa AL,Freeman JW

更新日期：2012-01-01 00:00:00

abstract：:Degeneration of the intervertebral discs, a natural progression of the aging process, is strongly implicated as a cause of low back pain. Aggrecan is the major structural proteoglycan in the extracellular matrix of the intervertebral disc. It is large, possessing numerous glycosaminoglycan chains and the ability to fo...

journal_title：Connective tissue research

authors： Wei Q,Zhang X,Zhou C,Ren Q,Zhang Y

更新日期：2019-05-01 00:00:00

abstract：:EMDOGAIN is derived from porcine developing enamel matrix and has been shown to facilitate regeneration of the periodontium, although its mechanism of action is unknown. The aim of the present study was to identify enamel matrix proteins and proteolytic enzymes present in EMDOGAIN and compare them with those extracted...

journal_title：Connective tissue research

authors： Maycock J,Wood SR,Brookes SJ,Shore RC,Robinson C,Kirkham J

更新日期：2002-01-01 00:00:00

abstract：:Part of the hyaluronic acid (HA) synthesized in peripheral tissues enters the blood circulation through the lymph. It is rapidly taken up by the endothelial cells in the liver (half-life in blood is 2.5-5.5 minutes) and degraded. Pure primary cultures of liver endothelial cells were obtained by a newly developed techn...

journal_title：Connective tissue research

authors： Laurent TC,Dahl IM,Dahl LB,Engström-Laurent A,Eriksson S,Fraser JR,Granath KA,Laurent C,Laurent UB,Lilja K

更新日期：1986-01-01 00:00:00

abstract：:The desmoplastic response to breast carcinoma is being studied. The stimulation of stromal cell proliferation by a preformed breast tumor matrix was shown. An additional mechanism for stimulating scleroprotein deposition is described here. On a per-cell basis, the synthesis of collagen and elastin was increased by 50%...

journal_title：Connective tissue research

authors： Kao RT,Hall J,Stern R

更新日期：1986-01-01 00:00:00

abstract：:The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee and are associated with an increased risk of deve...

journal_title：Connective tissue research

authors： Melrose J,Fuller ES,Little CB

更新日期：2017-01-01 00:00:00

abstract：:The ultrastructural features of the cells and of the oxytalan fibers within the periodontal ligaments of aged rats (2 year old) were quantified and compared with data for tissues obtained from younger animals (8 week old). Sections of the mid-root regions of the mandibular first molars were prepared for examination by...

journal_title：Connective tissue research

authors： Moxham BJ,Evans IL

更新日期：1995-01-01 00:00:00

abstract：:Proteodermatan sulfate was isolated from the skin of human, female breast in 6-M urea and proteolytic inhibitors at 70 degrees C and purified on Sephacryl S-200. It was composed of 55% protein and 45% dermatan sulfate, displayed one protein and carbohydrate-stainable band on agarose-polyacrylamide gels, yielded dermat...

journal_title：Connective tissue research

authors： Longas MO,Fleischmajer R

更新日期：1985-01-01 00:00:00

abstract：:The critical remembrance of my research activity displays aspects of inconsequence and mental rigidity. Particular probative examples are called to mind. Unpublished observations concerning immortalized dental cells are summarized. As a consequence, if I could start again, I would improve several aspects of my behavio...

journal_title：Connective tissue research

authors： Ruch JV

更新日期：2002-01-01 00:00:00

abstract：:A detailed analysis of the D-period and axial electron density distribution of cornea and tendon collagen was carried out by means of X-ray diffraction and electron microscopy. Ultrastructural observations were made on replicas of freeze fractured and deep-etched specimens. Synchrotron radiation was used to obtain hig...

journal_title：Connective tissue research

authors： Marchini M,Morocutti M,Ruggeri A,Koch MH,Bigi A,Roveri N

更新日期：1986-01-01 00:00:00

abstract：AIM OF THE STUDY:To further elucidate the pathogenesis of systemic sclerosis (SSc) an experimental avian model was used. The University of California at Davis line 200 (UCD-200) chickens spontaneously develop a SSc-like disease that has most features of human SSc with vascular effects, inflammation, autoimmunity, and f...

journal_title：Connective tissue research

authors： Kerje S,Hellman U,Do L,Larsson G,Kämpe O,Engström-Laurent A,Lindqvist U

更新日期：2016-09-01 00:00:00

abstract：:The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t 1/2 beta) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is...

journal_title：Connective tissue research

authors： Verma PS,Hoyt RF Jr,Jackson AJ,Phillips YY

更新日期：1984-01-01 00:00:00

abstract：:Raman spectra have been determined for hyaluronan, chondroitin-4-sulfate, chondroitin-6-sulfate, aggrecan monomers and aggregates. The nature of the saccharides and the pattern of sulfation can be discerned. There were only small spectral changes with pH and ionic composition. Differences between hydroxyl vibrations, ...

journal_title：Connective tissue research

authors： Ellis R,Green E,Winlove CP

更新日期：2009-01-01 00:00:00

abstract：:Muscle-derived cells can differentiate into chondrogenic cells. In our present study, we investigated the pattern of expression of Sox9, a transcription factor known to play a key role in chondrogenesis, in a rat myoblastic cell line, L6. In addition, we evaluated expression of type II collagen and myogenic regulatory...

journal_title：Connective tissue research

authors： Matsushita T,Matsui N,Fujioka H,Kubo S,Kuroda R,Kurosaka M,Yoshiya S

更新日期：2004-01-01 00:00:00

abstract：:Glycosaminoglycan synthesis by cells cultured from nodule or band tissues of patients with Dupuytren's disease was compared with that of skin fibroblasts cultured from uninvolved areas of the palm. No differences were observed in culture which could account either for the abnormal glycosaminoglycan content or the incr...

journal_title：Connective tissue research

authors： Slack C,Flint MH,Thompson BM

更新日期：1982-01-01 00:00:00

abstract：:The binding of highly purified bovine aortic lysyl oxidase to native fibrils of type I collagen has been measured by assay of unbound lysyl oxidase activity in the supernatants of enzyme-collagen mixtures after centrifugation. The apparent binding affinity of lysyl oxidase for native fibrils is quite similar to that f...

journal_title：Connective tissue research

authors： Cronlund AL,Smith BD,Kagan HM

更新日期：1985-01-01 00:00:00