Abstract:
:Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due to the affected behaviors of bone cells, including bone mesenchymal stem cells (BMSCs), osteoblasts and osteoclasts. BMSCs and osteoblasts are relatively radioresistant compared with osteoclasts and its progenitors. Owing to different radiosensitivities of bone cells, unbalanced bone remodeling caused by IR is closely associated with the dose absorbed. For doses less than 2 Gy, osteoclastogenesis and adipogenesis by BMSCs are enhanced, while there are limited effects on osteoblasts. High doses (>10 Gy) induce disrupted architecture of bone, which is usually related to decreased osteogenic potential. In this review, studies elucidating the biological effects of IR on bone cells (BMSCs, osteoblasts and osteoclasts) are summarized. Several potential preventions and therapies are also proposed.
journal_name
Connect Tissue Resjournal_title
Connective tissue researchauthors
Zhang J,Qiu X,Xi K,Hu W,Pei H,Nie J,Wang Z,Ding J,Shang P,Li B,Zhou Gdoi
10.1080/03008207.2018.1439482subject
Has Abstractpub_date
2018-11-01 00:00:00pages
509-522issue
6eissn
0300-8207issn
1607-8438journal_volume
59pub_type
杂志文章abstract::Objective: Interleukin-17 (IL-17), produced by T helper (Th)-17 cells, is a potent regulator of bone homeostasis. Osteoblasts are key cells that orchestrate inflammatory bone destruction and bone remodeling. This study examines the effect of different concentrations of IL-17 on osteogenesis and receptor activator of n...
journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008207.2020.1759562
更新日期:2020-05-05 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008200802143141
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008209009009812
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008200701692800
更新日期:2007-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008207809152287
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008209909005282
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008207.2016.1276177
更新日期:2017-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208809016808
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008209509010825
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journal_title:Connective tissue research
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208109152380
更新日期:1981-01-01 00:00:00
abstract::In our previous developmental study on skin we reported that correlations existed between the collagen fibril diameter distribution, glycosaminoglycan content and composition, and mechanical role. In this work we present new but related electron microscope data on the ultrastructure of skins from flounder, marlin, cod...
journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208709006977
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208909050015
更新日期:1989-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008207.2014.882331
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Our previous study showed that partial-thickness articular cartilage defects (PTCDs) created in immature rats spontaneously healed to resemble normal hyaline cartilage, but that of mature rats did not. To identify molecules involved in the spontaneous cartilage repair observed in this model, gene expression was...
journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008207.2015.1121250
更新日期:2016-05-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008200600995940
更新日期:2006-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008200490278142
更新日期:2004-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008207.2019.1601186
更新日期:2019-11-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208209160266
更新日期:1982-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208709005621
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journal_title:Connective tissue research
pub_type: 杂志文章
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journal_title:Connective tissue research
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208609001971
更新日期:1986-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008207.2017.1306060
更新日期:2018-03-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208909002417
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008209709160231
更新日期:1997-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008208409013681
更新日期:1984-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.1080/03008200601143508
更新日期:2007-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008200009005643
更新日期:2000-01-01 00:00:00
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journal_title:Connective tissue research
pub_type: 杂志文章
doi:10.3109/03008207.2011.634532
更新日期:2012-01-01 00:00:00