Aortic smooth muscle cells migration and the role of metalloproteinases and hyaluronan.

abstract：:Solutions of type I acid soluble collagen were studied in light and electron microscopy at concentrations over 40 mg/ml. Banded patterns spontaneously emerge in samples observed between crossed polars between slide and coverslip. The textures are interpreted as precholesteric, appearing at the transition between the i...

journal_title：Connective tissue research

authors： Giraud-Guille MM,Besseau L

更新日期：1998-01-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to promote periodontal tissue regeneration, while noggin inhibits the biological activities of BMP-2, -4, and -7. To investigate the effect of BMPs and noggin gene transfer on cementogenesis, we used cloned murine cementoblasts (OCCM). Cells were transduced using adenovirus...

journal_title：Connective tissue research

authors： Jin QM,Zhao M,Economides AN,Somerman MJ,Giannobile WV

更新日期：2004-01-01 00:00:00

abstract：:Radiation therapy is one of the routine treatment modalities for cancer patients. Ionizing radiation (IR) can induce bone loss, and consequently increases the risk of fractures with delayed and nonunion of the bone in the cancer patients who receive radiotherapy. The orchestrated bone remodeling can be disrupted due t...

journal_title：Connective tissue research

authors： Zhang J,Qiu X,Xi K,Hu W,Pei H,Nie J,Wang Z,Ding J,Shang P,Li B,Zhou G

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:We investigated whether COMP may modify cartilage metabolism and play a role as an endogenous disease aggravating factor in OA. MATERIALS AND METHODS:Full-length and momomeric COMP was recombinantly expressed in human embryonic kidney cells and purified it via affinity chromatography. Purified COMP was used ...

journal_title：Connective tissue research

authors： Ruthard J,Kamper M,Renno JH,Kühn G,Hillebrand U,Höllriegl S,Johannis W,Zaucke F,Klatt AR

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Excessive apoptosis plays an important role in the progression of intervertebral disc degeneration. However, the effect of autophagy, another type of programmed cell death, on the pathogenesis of disc degeneration is still unclear. Macroautophagy and chaperone-mediated autophagy (CMA) change and intervertebra...

journal_title：Connective tissue research

authors： Ye W,Xu K,Huang D,Liang A,Peng Y,Zhu W,Li C

更新日期：2011-01-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC)s are characterized by their acute growth inhibition by heparin and heparan sulfates; however, recently the isolation of VSMCs which display greatly diminished sensitivity to the antiproliferative action of heparin have been reported. These heparin resistant (HR) VSMCs have been deri...

journal_title：Connective tissue research

authors： San Antonio JD,Verrecchio A,Pukac LA

更新日期：1998-01-01 00:00:00

abstract：:The mechanical properties of the human supraspinatus tendon (SST) are highly heterogeneous and may reflect an important adaptive response to its complex, multiaxial loading environment. However, these functional properties are associated with a location-dependent structure and composition that have not been fully eluc...

journal_title：Connective tissue research

authors： Buckley MR,Evans EB,Matuszewski PE,Chen YL,Satchel LN,Elliott DM,Soslowsky LJ,Dodge GR

更新日期：2013-01-01 00:00:00

abstract：:The effects of two forms of elastase on the Young's Modulus of elastic tissue have been studied. The monomeric, calcium poor form of the enzyme lowers the value of the Young's Modulus before an appreciable amount of protein is taken into solution. The polymeric, calcium rich enzyme on the other hand degrades the prote...

journal_title：Connective tissue research

authors： Hall DA

更新日期：1976-01-01 00:00:00

abstract：:Tobacco smoking is considered a major risk factor for the development and progression of periodontal diseases (Haber, J. and Wattles, J. (1994). J. Periodontol., 64, 16-23). The purpose of this study was to determine the effects of nicotine on rat gingival fibroblasts (RGF) cultured in vitro. After ether anesthesia, r...

journal_title：Connective tissue research

authors： Lahmouzi J,Simain-Sato F,Defresne MP,De Pauw MC,Heinen E,Grisar T,Legros JJ,Legrand R

更新日期：2000-01-01 00:00:00

abstract：:Epithelial-mesenchymal interactions are required for tissue growth and gene expression patterns during odontogenesis. We showed previously that Sonic hedgehog (SHH) is detectable in both dental epithelium and mesenchyme, while Shh transcripts are present in dental epithelium only, suggesting that SHH functions as an a...

journal_title：Connective tissue research

authors： Wu C,Shimo T,Liu M,Pacifici M,Koyama E

更新日期：2003-01-01 00:00:00

abstract：:Short term cultures were carried out with chondrocytes and tissue fragments from fetal guinea pig epiphyseal cartilage. Proteoglycans were isolated from these cultures and their properties were compared with those of proteoglycans from adult hyaline cartilage. It was concluded that the proteoglycans synthesized in cul...

journal_title：Connective tissue research

authors： Madsen K,Lohmander S,Moskalewski S,Hinek A

更新日期：1978-01-01 00:00:00

abstract：:Two populations of primary osteoblasts and the cloned murine osteoblast cell line MC3T3 were activated with osteotropic agents and the conditioned media tested for the presence of macrophage colony stimulating factor (M-CSF). Differences in ability of the three populations to secrete the cytokine as well as in the eff...

journal_title：Connective tissue research

authors： Horowitz MC,Einhorn TA,Philbrick W,Jilka RL

更新日期：1989-01-01 00:00:00

abstract：:Degeneration of the intervertebral discs, a natural progression of the aging process, is strongly implicated as a cause of low back pain. Aggrecan is the major structural proteoglycan in the extracellular matrix of the intervertebral disc. It is large, possessing numerous glycosaminoglycan chains and the ability to fo...

journal_title：Connective tissue research

authors： Wei Q,Zhang X,Zhou C,Ren Q,Zhang Y

更新日期：2019-05-01 00:00:00

abstract：:Quantitative levels of mRNAs coding for elastin, types I and III procollagen and gamma-actin were measured in porcine vascular material following balloon catheterization. A balloon catheter was introduced into the thoracic aorta and jugular vein of 3-6 week old pigs; following distention and six days of postoperative ...

journal_title：Connective tissue research

authors： Boyd CD,Kniep AC,Pierce RA,Deak SB,Karboski C,Miller DC,Parker MI,Mackenzie JW,Rosenbloom J,Scott GE

更新日期：1988-01-01 00:00:00

abstract：:The matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are often coordinately expressed, and their promoters contain similar regulatory elements, including an AP-1 site at about -70. There are, however, additional sequences including an adjacent ETS site at about -90 in both promoters, and a NIP (nu...

journal_title：Connective tissue research

authors： White LA,Maute C,Brinckerhoff CE

更新日期：1997-01-01 00:00:00

abstract：:Several studies have highlighted the lack of age changes in the extracellular matrix of the periodontal ligament, but more needs to be known about cellular and functional changes (including the effects upon eruption). For this study, impeded and unimpeded eruption rates were measured over a 2-week period for the mandi...

journal_title：Connective tissue research

authors： Moxham BJ

更新日期：2002-01-01 00:00:00

abstract：:Ligaments have limited regenerative potential and as a consequence, repair is protracted and results in a mechanically inferior tissue more scar-like than native ligament. We previously reported that a single injection of interleukin-1 receptor antagonist (IL-1Ra) delivered at the time of injury, decreased the number ...

journal_title：Connective tissue research

authors： Chamberlain CS,Leiferman EM,Frisch KE,Duenwald-Kuehl SE,Brickson SL,Murphy WL,Baer GS,Vanderby R

更新日期：2014-06-01 00:00:00

abstract：:Oral mandibular epithelium determines the position and number of tooth organs. Cranial neural crest-derived ectomesenchyme provides inductive signals for (i) tooth shape, and (ii) sequential determination and expression of several different epithelial-derived enamel proteins. Inductive signalling follows a precise seq...

journal_title：Connective tissue research

authors： Slavkin HC

更新日期：1989-01-01 00:00:00

abstract：:Anterior cruciate ligament (ACL) has poor healing ability and an injured ACL would induce the degeneration of other intra-articular connective tissues. However, the coordinated expression and activities of matrix metalloproteinase (MMPs) in intra-articular tissues induced by ACL rupture were poorly understood. With a ...

journal_title：Connective tissue research

authors： Tang Z,Yang L,Zhang J,Xue R,Wang Y,Chen PC,Sung KL

更新日期：2009-01-01 00:00:00

abstract：:Proteoglycans extracted from articular cartilage of large joints of humans aged 4, 11, 70 and 75, were fractionated on associative density gradients. The top fraction (A3) was purified by ion-exchange chromatography and subsequent gel filtration on Sepharose CL 4B in 4 M GuCl, 0.5% Triton x 100. Proteoglycans from you...

journal_title：Connective tissue research

authors： Stanescu V,Chaminade F,Muriel MP

更新日期：1988-01-01 00:00:00

abstract：:Two overlapping clones encompassing 8.5 kb of the human elastin gene were isolated from two genomic libraries constructed by partial digestion with either HaeIII/AluI or Sau3A and contained in lambda Charon 4A or EMBL3, respectively. The 6 kb of DNA comprising the most 3' portion of the gene were sequenced demonstrati...

journal_title：Connective tissue research

authors： Indik Z,Yoon K,Morrow SD,Cicila G,Rosenbloom J,Rosenbloom J,Ornstein-Goldstein N

更新日期：1987-01-01 00:00:00

abstract：:Muscle-derived cells can differentiate into chondrogenic cells. In our present study, we investigated the pattern of expression of Sox9, a transcription factor known to play a key role in chondrogenesis, in a rat myoblastic cell line, L6. In addition, we evaluated expression of type II collagen and myogenic regulatory...

journal_title：Connective tissue research

authors： Matsushita T,Matsui N,Fujioka H,Kubo S,Kuroda R,Kurosaka M,Yoshiya S

更新日期：2004-01-01 00:00:00

abstract：:Experimental lathyrism was induced by feeding newborn chicks a diet containing 0.2 and 0.4% DL-Penicillamine, with or without CuSO4 (10 mg/Kg diet) and Vitamin B6 (100 mg/Kg diet), or 0.015 and 0.1% beta-aminopropionitrile fumarate (beta-APN). After 7, 15, 25 and 55 days of treatment the animals were killed, the aorta...

journal_title：Connective tissue research

authors： Ronchetti IP,Contri MB,Fornieri C,Quaglino D Jr,Mori G

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t 1/2 beta) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is...

journal_title：Connective tissue research

authors： Verma PS,Hoyt RF Jr,Jackson AJ,Phillips YY

更新日期：1984-01-01 00:00:00

abstract：:The effect of intra-bone injection of differentiated rat bone marrow mesenchymal stem cells (BMMSCs) into the femur of osteoporotic female rats was studied. Osteoporosis was induced in Wistar female rats by bilateral ovariectomy. Then, 0.75 million BMMSCs isolated from healthy rats were injected into the femurs of ost...

journal_title：Connective tissue research

authors： Ocarino Nde M,Boeloni JN,Jorgetti V,Gomes DA,Goes AM,Serakides R

更新日期：2010-12-01 00:00:00

abstract：:Since cartilage is mainly an avascular tissue, chondrocytes exist in a low-level oxygen environment in vivo. In the present study, we investigated the effect of oxygen tension (20%, 5% and 1% gas phase oxygen concentrations) over a 20-day period on the extracellular matrix accumulation of bovine articular chondrocytes...

journal_title：Connective tissue research

authors： Murphy CL,Sambanis A

更新日期：2001-10-01 00:00:00

abstract：:Many organisms from a wide variety of taxa produce amorphous calcium carbonate (ACC), despite the fact that it is inherently unstable and relatively soluble in its pure state. These properties also make it difficult to detect and characterize ACC. Raman spectroscopy is a particularly useful method for investigating AC...

journal_title：Connective tissue research

authors： Weiner S,Levi-Kalisman Y,Raz S,Addadi L

更新日期：2003-01-01 00:00:00

abstract：:Bioprinting is a promising tool to fabricate organized cartilage. This study aimed to investigate the printability of gelatin-methacryloyl/gellan gum (gelMA/gellan) hydrogels with and without methacrylated hyaluronic acid (HAMA), and to explore (zone-specific) chondrogenesis of chondrocytes, articular cartilage progen...

journal_title：Connective tissue research

authors： Mouser VHM,Levato R,Mensinga A,Dhert WJA,Gawlitta D,Malda J

更新日期：2020-03-01 00:00:00

abstract：:This study evaluated the effect of short bouts of stretching on the soleus muscle after immobilization, by measuring the birefringence of the intramuscular connective tissue (ICT) and the muscle fiber area. Thirty rats were divided into five groups: the left soleus was immobilized in the shortened position; after immo...

journal_title：Connective tissue research

authors： Coutinho EL,DeLuca C,Salvini TF,Vidal BC

更新日期：2006-01-01 00:00:00

abstract：:We demonstrated the cells producing collagenase and the time course of collagenase-production at early stages of wound healing, using histology and two immunohistochemical procedures on cross sections of rat skin harvested 0, 3, 5, 7 and 12 days after full-thickness incisions. A monospecific rabbit polyclonal antibody...

journal_title：Connective tissue research

authors： Porras-Reyes BH,Blair HC,Jeffrey JJ,Mustoe TA

更新日期：1991-01-01 00:00:00