Distributions of types I, II and III collagen by region in the human supraspinatus tendon.

Abstract:

:The mechanical properties of the human supraspinatus tendon (SST) are highly heterogeneous and may reflect an important adaptive response to its complex, multiaxial loading environment. However, these functional properties are associated with a location-dependent structure and composition that have not been fully elucidated. Therefore, the objective of this study was to determine the concentrations of types I, II and III collagen in six distinct regions of the SST and compare changes in collagen concentration across regions with local changes in mechanical properties. We hypothesized that type I collagen content would be high throughout the tendon, type II collagen would be restricted to regions of compressive loading and type III collagen content would be high in regions associated with damage. We further hypothesized that regions of high type III collagen content would correspond to regions with low tensile modulus and a low degree of collagen alignment. Although type III collagen content was not significantly higher in regions that are frequently damaged, all other hypotheses were supported by our results. In particular, type II collagen content was highest near the insertion while type III collagen was inversely correlated with tendon modulus and collagen alignment. The measured increase in type II collagen under the coracoacromial arch provides evidence of adaptation to compressive loading in the SST. Moreover, the structure-function relationship between type III collagen content and tendon mechanics established in this study demonstrates a mechanism for altered mechanical properties in pathological tendons and provides a guideline for identifying therapeutic targets and pathology-specific biomarkers.

journal_name

Connect Tissue Res

authors

Buckley MR,Evans EB,Matuszewski PE,Chen YL,Satchel LN,Elliott DM,Soslowsky LJ,Dodge GR

doi

10.3109/03008207.2013.847096

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

374-9

issue

6

eissn

0300-8207

issn

1607-8438

journal_volume

54

pub_type

杂志文章
  • The glycosaminoglycans of Dupuytren's disease.

    abstract::The total and individual glycosaminoglycan (GAG) content at various stages of the Dupuytren disease process and in samples of normal palmar connective tissue (palmar dermis, palmar fascia and digital flexor tendon) from the hands of uninvolved age-matched controls have been assayed and compared. Morphological comparis...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208209160258

    authors: Flint MH,Gillard GC,Reilly HC

    更新日期:1982-01-01 00:00:00

  • Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis.

    abstract::Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high morbidity. It is predicted to be the single greatest cause of disability in the general population by 2030. The development of disease-modifying therapy for OA currently face great obstacle mainly because the onset and developme...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.1080/03008207.2016.1177036

    authors: Wei Y,Bai L

    更新日期:2016-07-01 00:00:00

  • Regulation of statoconia mineralization in Aplysia californica in vitro.

    abstract::Statoconia are calcium carbonate inclusions in the lumen of the gravity-sensing organ, the statocyst, of Aplysia californica. The aim of the present study was to examine the role of carbonic anhydrase and urease in statoconia mineralization in vitro. The experiments were performed using a previously described culture ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209609029206

    authors: Pedrozo HA,Schwartz Z,Dean DD,Wiederhold ML,Boyan BD

    更新日期:1996-01-01 00:00:00

  • JNK MAPK is involved in BMP-2-induced odontoblastic differentiation of human dental pulp cells.

    abstract::Bone morphogenetic protein-2 (BMP-2) is a multi-functional growth factor belonging to the transforming growth factor β superfamily that has a broad range of activities that affect many different cell types. BMP-2 induces odontoblastic differentiation of human dental pulp cells (DPCs), but the underlying mechanism rema...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2014.882331

    authors: Qin W,Liu P,Zhang R,Huang S,Gao X,Song Z,Wang R,Chen L,Guo B,Lin Z

    更新日期:2014-06-01 00:00:00

  • Removal of dentin non-collagenous structures results in the unraveling of microfibril bundles in collagen type I.

    abstract:AIMS:The structural organization of collagen from mineralized tissues, such as dentin and bone, has been a topic of debate in the recent literature. Recent reports have presented novel interpretations of the complexity of collagen type I at different hierarchical levels and in different tissues. Here, we investigate th...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2016.1235566

    authors: Bertassoni LE,Swain MV

    更新日期:2017-09-01 00:00:00

  • Effects of age and diabetes mellitus on cyanogen bromide digestion of human dura mater collagen.

    abstract::To extend previous studies on the apparent acceleration of collagen aging in diabetes mellitus, dura collagen from human adults of different ages, with and without diabetes, was processed to yield soluble and insoluble fractions. Insoluble fractions were cleaved by cyanogen bromide. Release of peptides from insoluble ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208309004852

    authors: Kohn RR

    更新日期:1983-01-01 00:00:00

  • Medial collagen organization in human arteries of the heart and brain by polarized light microscopy.

    abstract::The mechanical properties of collagen as a biopolymer ensures that collagen has a significant influence on the mechanical behavior of the host tissue. Structural organization is a key to that influence. We have assessed this relationship quantitatively in the tunica media of arteries from the heart and brain, using th...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209109152168

    authors: Canham PB,Talman EA,Finlay HM,Dixon JG

    更新日期:1991-01-01 00:00:00

  • Cell-tissue interactions in osteoarthritic human hip joint articular cartilage.

    abstract::Volume and morphology of chondrocytes in osteoarthritic human hip joint articular cartilage were characterized, and their relationship to tissue structure and function was determined. Human osteochondral articular cartilage samples (n=16) were obtained from the femoral heads of nine patients undergoing total hip arthr...

    journal_title:Connective tissue research

    pub_type: 临床试验,杂志文章

    doi:10.3109/03008207.2014.912645

    authors: Huttu MR,Puhakka J,Mäkelä JT,Takakubo Y,Tiitu V,Saarakkala S,Konttinen YT,Kiviranta I,Korhonen RK

    更新日期:2014-08-01 00:00:00

  • Expression and regulation of hedgehog-interacting protein during early tooth development.

    abstract::Sonic hedgehog (Shh) expression is highly localized to the epithelium at the future sites of tooth development. This restricted expression suggests that inhibition of Shh in areas where teeth do not form may be an important mechanism in tooth germ localization. Recently, Hip, a putative vertebrate antagonist of Shh, h...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200290000907

    authors: Cobourne MT,Sharpe PT

    更新日期:2002-01-01 00:00:00

  • Registering 2D and 3D imaging data of bone during healing.

    abstract:UNLABELLED:PURPOSE/AIMS OF THE STUDY: Bone's hierarchical structure can be visualized using a variety of methods. Many techniques, such as light and electron microscopy generate two-dimensional (2D) images, while micro-computed tomography (µCT) allows a direct representation of the three-dimensional (3D) structure. In ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2015.1005210

    authors: Hoerth RM,Baum D,Knötel D,Prohaska S,Willie BM,Duda GN,Hege HC,Fratzl P,Wagermaier W

    更新日期:2015-04-01 00:00:00

  • Collagens of the chicken eggshell membranes.

    abstract::An immunohistochemical analysis of the eggshell membranes shows the occurrence of type X collagen while type I collagen was not detected by using an appropriate monoclonal antibody with untreated shell membranes. A positive immuno-reaction for type I collagen was obtained after digestion of the shell membranes with pe...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209109152162

    authors: Arias JL,Fernandez MS,Dennis JE,Caplan AI

    更新日期:1991-01-01 00:00:00

  • Characterization of a porcine amelogenin preparation, EMDOGAIN, a biological treatment for periodontal disease.

    abstract::EMDOGAIN is derived from porcine developing enamel matrix and has been shown to facilitate regeneration of the periodontium, although its mechanism of action is unknown. The aim of the present study was to identify enamel matrix proteins and proteolytic enzymes present in EMDOGAIN and compare them with those extracted...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200290000880

    authors: Maycock J,Wood SR,Brookes SJ,Shore RC,Robinson C,Kirkham J

    更新日期:2002-01-01 00:00:00

  • Expression of the elastin promoter in novel tissue sites in transgenic mouse embryos.

    abstract::We have previously shown in a transgenic mouse line, in which 5.2 kb of the elastin promoter was linked to the reporter enzyme chloramphenicol acetyltransferase (CAT), that the highest levels of expression were found in embryonic lungs and aorta, while lower levels were detected in other elastin-containing tissues. Fu...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209909029111

    authors: Lakkakorpi J,Li K,Decker S,Korkeela E,Piddington R,Abrams W,Bashir M,Uitto J,Rosenbloom J

    更新日期:1999-01-01 00:00:00

  • Abnormal dermal proteoglycan in aspartylglycosaminuria: a possible mechanism for ultrastructural changes of collagen fibrils in a glycoprotein storage disorder.

    abstract::Changes in the structure and organization of collagen fibrils were recently described in the skin of aspartylglycosaminuria patients. The skin of the patients contained a normal amount and distribution of glycosaminoglycans, but the dermatan sulfate of aspartylglycosaminuria skin was more sensitive to chondroitinase A...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208709005621

    authors: Näntö-Salonen K,Larjava H,Säämanen AM,Heino J,Penttinen R,Pelliniemi LJ,Tammi M

    更新日期:1987-01-01 00:00:00

  • Is low molecular weight hyaluronan an early indicator of disease in avian systemic sclerosis?

    abstract:AIM OF THE STUDY:To further elucidate the pathogenesis of systemic sclerosis (SSc) an experimental avian model was used. The University of California at Davis line 200 (UCD-200) chickens spontaneously develop a SSc-like disease that has most features of human SSc with vascular effects, inflammation, autoimmunity, and f...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2016.1182997

    authors: Kerje S,Hellman U,Do L,Larsson G,Kämpe O,Engström-Laurent A,Lindqvist U

    更新日期:2016-09-01 00:00:00

  • Hypermineralized whale rostrum as the exemplar for bone mineral.

    abstract::Although bone is a nanocomposite of mineral and collagen, mineral has been the more elusive component of study. A standard for bone mineral is clearly needed. We hypothesized that the most natural, least-processed bone mineral could be retrieved from the most highly mineralized bone. We therefore studied the rostrum o...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2013.769973

    authors: Li Z,Pasteris JD,Novack D

    更新日期:2013-01-01 00:00:00

  • Pharmacokinetics of intravenously administered desmosine in sheep.

    abstract::The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t 1/2 beta) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208409013681

    authors: Verma PS,Hoyt RF Jr,Jackson AJ,Phillips YY

    更新日期:1984-01-01 00:00:00

  • Substance P enhanced titanium particles-induced RANKL expression in fibroblasts from periprosthetic membrane.

    abstract::Aseptic loosening remains the primary cause of failure in total joint arthroplasty. Implant-derived particles are thought to be a main cause of osteolysis that leads to the failure. Substance P (SP) immunoreactive nerve fibers have been detected in the periprosthetic membrane of aseptic loose hip prostheses. We isolat...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207.2013.823953

    authors: Qian Y,Zhang XL,Zeng BF,Jiang Y,Shen H,Wang Q

    更新日期:2013-01-01 00:00:00

  • Young adult chondrocytes proliferate rapidly and produce a cartilaginous tissue at the gel-media interface in agarose cultures.

    abstract::Primary chondrocytes cultured in agarose can escape the gel, accumulate at the interface between agarose and the culture medium, and form an outgrowing tissue. These outgrowths can appear as voluminous cartilage-like nodules that have never been previously investigated. In the present study, bovine articular chondrocy...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200903281683

    authors: Tran-Khanh N,Chevrier A,Lascau-Coman V,Hoemann CD,Buschmann MD

    更新日期:2010-06-01 00:00:00

  • Structural relationship between the primary crystal formations and the matrix macromolecules in different hard tissues. Discussion of a general principle.

    abstract::For many years we have investigated the earliest crystal formations of different developing hard tissues (matrix vesicle, bone, dentine, enamel, etc.) by different electron microscopic measurements. It was observed that primarily Ca-phosphate (apatite) "chains," composed of nanometer sized particles (dots, islands), e...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.3109/03008209509016998

    authors: Höhling HJ,Arnold S,Barckhaus RH,Plate U,Wiesmann HP

    更新日期:1995-01-01 00:00:00

  • Response of plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts.

    abstract::Effects of applied hydrostatic pressure on transmembrane potentials were investigated in sheep articular chondrocytes and human skin fibroblasts in non-confluent monolayer cultures. Resting potentials in chondrocytes (about -12 mv) and in fibroblasts (about -15 mV) were increased and decreased respectively by over 40%...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209209014227

    authors: Wright MO,Stockwell RA,Nuki G

    更新日期:1992-01-01 00:00:00

  • Biochemical characterization of collagen in alveolar mucosa and attached gingiva of pig.

    abstract::Alveolar mucosa and attached gingiva are two continuous but functionally distinct connective tissues covering alveolar bone of the jaw. In this study, the major matrix component of these tissues, collagen, was biochemically characterized and compared. The tissues were obtained from mature pigs and analyzed for collage...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200601143508

    authors: Katafuchi M,Matsuura T,Atsawasuwan P,Sato H,Yamauchi M

    更新日期:2007-01-01 00:00:00

  • Enamel matrix proteins and ameloblast biology.

    abstract::The paper reviews the changes in ameloblast ultrastructure, concomitant with the changes in its functions across the major stages of amelogenesis. It describes the mechanisms associated with the major events in biosynthesis and degradation of the major enamel proteins (amelogenins and tuftelin/enamelins) and with the ...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.3109/03008209509013710

    authors: Deutsch D,Catalano-Sherman J,Dafni L,David S,Palmon A

    更新日期:1995-01-01 00:00:00

  • The physical properties of elastic fibers and elastolysis.

    abstract::The effects of two forms of elastase on the Young's Modulus of elastic tissue have been studied. The monomeric, calcium poor form of the enzyme lowers the value of the Young's Modulus before an appreciable amount of protein is taken into solution. The polymeric, calcium rich enzyme on the other hand degrades the prote...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008207609152217

    authors: Hall DA

    更新日期:1976-01-01 00:00:00

  • Alterations of elastin fibrogenesis by inhibition of the formation of desmosine crosslinks. Comparison between the effect of beta-aminopropionitrile (beta-APN) and penicillamine.

    abstract::Experimental lathyrism was induced by feeding newborn chicks a diet containing 0.2 and 0.4% DL-Penicillamine, with or without CuSO4 (10 mg/Kg diet) and Vitamin B6 (100 mg/Kg diet), or 0.015 and 0.1% beta-aminopropionitrile fumarate (beta-APN). After 7, 15, 25 and 55 days of treatment the animals were killed, the aorta...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008208509015021

    authors: Ronchetti IP,Contri MB,Fornieri C,Quaglino D Jr,Mori G

    更新日期:1985-01-01 00:00:00

  • Geometry of artificial ECM: sizes of pores controlling phenotype expression in BMP-induced osteogenesis and chondrogenesis.

    abstract::This study aims to elucidate the feasible geometry of the scaffolds in bone and periodontal tissue engineering. Several biomaterials with different geometries are compared in terms of their patterns of ectopic BMP-induced chondrogenesis and osteogenesis. The materials include a honeycomb-shaped hydroxyapatite (HCHAP) ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008200290001104

    authors: Kuboki Y,Jin Q,Kikuchi M,Mamood J,Takita H

    更新日期:2002-01-01 00:00:00

  • Evolutionary and functional significance of hominoid tooth enamel.

    abstract::The purpose of this investigation is to evaluate enamel thickness in extant and extinct hominoids. The material used in this study spans the evolutionary history of this group, from 20 million years ago to the present. The objectives of this investigation are to test three hypotheses: (1) the Loading Hypothesis: loadi...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008209809023927

    authors: Gantt DG,Rafter JA

    更新日期:1998-01-01 00:00:00

  • Bio-ink development for three-dimensional bioprinting of hetero-cellular cartilage constructs.

    abstract::Bioprinting is a promising tool to fabricate organized cartilage. This study aimed to investigate the printability of gelatin-methacryloyl/gellan gum (gelMA/gellan) hydrogels with and without methacrylated hyaluronic acid (HAMA), and to explore (zone-specific) chondrogenesis of chondrocytes, articular cartilage progen...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.1080/03008207.2018.1553960

    authors: Mouser VHM,Levato R,Mensinga A,Dhert WJA,Gawlitta D,Malda J

    更新日期:2020-03-01 00:00:00

  • Modulation of growth factor action by the extracellular matrix.

    abstract::Growth factors were historically defined as molecules produced by the body to regulate cell growth and proliferation. After the identification of their receptors and the intracellular signaling machinery they activate, it is now clear that they are involved in the regulation of multiple processes essential for develop...

    journal_title:Connective tissue research

    pub_type: 杂志文章,评审

    doi:10.1080/03008200802148629

    authors: Oehrl W,Panayotou G

    更新日期:2008-01-01 00:00:00

  • Ectopic osteogenesis of hBMP-2 gene-transduced human bone mesenchymal stem cells/BCB.

    abstract::We determined the feasibility of using scaffolds of adenoviral human BMP2 gene (AdBMP2)-modified human bone marrow mesenchymal stem cells (hBMSCs) and antigen-free bovine cancellous bone (BCB) to construct bone tissue. hMSCs were infected with AdBMP-2. Expression of BMP-2 and alkaline phosphatase confirmed successful ...

    journal_title:Connective tissue research

    pub_type: 杂志文章

    doi:10.3109/03008200903318295

    authors: Han D,Li J,Guan X

    更新日期:2010-08-01 00:00:00