The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics.

Abstract:

:The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee and are associated with an increased risk of developing osteoarthritis (OA). While this risk has been largely attributed to loss of the biomechanical functions of the menisci, there is accumulating evidence suggesting that other aspects of meniscal biology may play a role in determining the long-term consequences of meniscal damage for joint health. In this narrative review, we examine the existing literature and present some new data implicating synthesis and secretion of enzymes and other pro-catabolic mediators by injured and degenerate menisci, contributing to the pathological change in other knee joint tissues in OA.

journal_name

Connect Tissue Res

authors

Melrose J,Fuller ES,Little CB

doi

10.1080/03008207.2017.1284824

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

282-294

issue

3-4

eissn

0300-8207

issn

1607-8438

journal_volume

58

pub_type

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