Glycosaminoglycan synthesis by Dupuytren's cells in culture.

abstract：:The basic subunit of cartilage proteoglycan consists of multiple glycosaminoglycan chains covalently attached to a core protein. It is unclear as to whether there is a single core protein or multiple different core proteins, since previous studies using either chondroitinase or testicular hyaluronidase to enzymaticall...

journal_title：Connective tissue research

authors： Keiser HD,Hatcher VB

更新日期：1977-01-01 00:00:00

abstract：:The biological effects of isolated soluble dentin extracellular matrix components on the induction of reparative dentinogenesis in exposed cavities in ferret canine teeth have been shown to be blocked by immobilizing the extracellular matrix components on nitrocellulose or Millipore membranes during implantation. This...

journal_title：Connective tissue research

authors： Smith AJ,Tobias RS,Cassidy N,Bégue-Kirn C,Ruch JV,Lesot H

更新日期：1995-01-01 00:00:00

abstract：:The oxidation of an elastin substrate by highly purified bovine aortic lysyl oxidase (LO) is markedly influenced by amphiphilic molecules known to bind to elastin. Negatively charged elastin ligands, including fatty acids, bile salts or sodium dodecyl sulfate can completely inhibit the oxidation of lysine in elastin, ...

journal_title：Connective tissue research

authors： Kagan HM,Simpson DE,Tseng L

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Identify the healing outcomes following a partial-width, full-thickness injury to the rotator cuff tendon-bone attachment and establish if the adult attachment can regenerate the morphology of the healthy attachment. HYPOTHESIS:We hypothesized that a partial-width injury to the attachment would heal via fibros...

journal_title：Connective tissue research

authors： Lemmon EA,Locke RC,Szostek AK,Ganji E,Killian ML

更新日期：2018-09-01 00:00:00

abstract：:Activation of protein kinase C (PKC) can upregulate tooth eruption molecules such as osteoprotegerin (OPG) and vascular endothelial growth factor (VEGF). In this study, we examined the in vivo gene expression of classic isoforms of PKC in the dental follicle of postnatal rats. The expression level of PKC-alpha was sig...

journal_title：Connective tissue research

authors： Yao S,Wise G

更新日期：2004-01-01 00:00:00

abstract：:We have previously shown in a transgenic mouse line, in which 5.2 kb of the elastin promoter was linked to the reporter enzyme chloramphenicol acetyltransferase (CAT), that the highest levels of expression were found in embryonic lungs and aorta, while lower levels were detected in other elastin-containing tissues. Fu...

journal_title：Connective tissue research

authors： Lakkakorpi J,Li K,Decker S,Korkeela E,Piddington R,Abrams W,Bashir M,Uitto J,Rosenbloom J

更新日期：1999-01-01 00:00:00

abstract：:Raman spectra have been determined for hyaluronan, chondroitin-4-sulfate, chondroitin-6-sulfate, aggrecan monomers and aggregates. The nature of the saccharides and the pattern of sulfation can be discerned. There were only small spectral changes with pH and ionic composition. Differences between hydroxyl vibrations, ...

journal_title：Connective tissue research

authors： Ellis R,Green E,Winlove CP

更新日期：2009-01-01 00:00:00

abstract：:Purpose: In our previous study, we demonstrated that hyaluronan induces odontoblastic differentiation of dental pulp stem cells via interactions with CD44. However, it remains unclear whether CD44 expression by dental pulp stem cells is required for odontoblastic differentiation. Methods: We searched for a compound ot...

journal_title：Connective tissue research

authors： Kajiura K,Umemura N,Ohkoshi E,Ohta T,Kondoh N,Kawano S

更新日期：2021-01-12 00:00:00

abstract：:The diameter of collagen fibrils has been measured in electron micrographs of the tunica media and adventitia of the common carotid artery of 14 rats (19,262 counts). The fibrils of the media were measured in each of its three interlamellar spaces. The mean fibril diameters in the innermost space and the middle space ...

journal_title：Connective tissue research

authors： Buck RC

更新日期：1987-01-01 00:00:00

abstract：:Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured") from tissue sections for molecular analyses. In this study, chondrocyt...

journal_title：Connective tissue research

authors： Landis WJ,Jacquet R,Hillyer J,Zhang J

更新日期：2003-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a ubiquitous regulator of cellular growth and differentiation. The present study investigated the effects of TGF-beta on chick growth plate chondrocyte proliferation, matrix synthesis, and alkaline phosphatase activity in short term cultures. TGF-beta markedly stimulated D...

journal_title：Connective tissue research

authors： Rosier RN,O'Keefe RJ,Crabb ID,Puzas JE

更新日期：1989-01-01 00:00:00

abstract：:Ultrasound is a therapeutic agent commonly used to treat sports-related tendinopathy. Tendon healing requires tendon cells migration to the repair site, followed by the proliferation and synthesis of extracellular matrix. This study was designed to determine the effect of ultrasound on migration of tendon cells intrin...

journal_title：Connective tissue research

authors： Tsai WC,Chen JY,Pang JH,Hsu CC,Lin MS,Chieh LW

更新日期：2008-01-01 00:00:00

abstract：:To address the molecular mechanisms of cementogenesis, we have isolated dental follicle cells and examined them to see if they contain cementoblast progenitors. Dental follicle tissue was dissected from the root surface of bovine tooth germ and cells were released by digestion with bacterial collagenase. The released ...

journal_title：Connective tissue research

authors： Handa K,Saito M,Tsunoda A,Yamauchi M,Hattori S,Sato S,Toyoda M,Teranaka T,Narayanan AS

更新日期：2002-01-01 00:00:00

abstract：:Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the body. The oim model has a natural collagen mutation, converting its heterotrimeric structure (two α1 and one α2 chains)...

journal_title：Connective tissue research

authors： Bart ZR,Hammond MA,Wallace JM

更新日期：2014-08-01 00:00:00

abstract：:Sonic hedgehog (Shh) expression is highly localized to the epithelium at the future sites of tooth development. This restricted expression suggests that inhibition of Shh in areas where teeth do not form may be an important mechanism in tooth germ localization. Recently, Hip, a putative vertebrate antagonist of Shh, h...

journal_title：Connective tissue research

authors： Cobourne MT,Sharpe PT

更新日期：2002-01-01 00:00:00

abstract：:To explore crucial early molecular events involved in contact healing of the intrasynovial flexor tendon, integrin expression was evaluated at the transcriptional and post-transcriptional levels during the first two weeks following injury, repair and controlled passive motion in a canine model. Specifically, immunohis...

journal_title：Connective tissue research

authors： Harwood FL,Monosov AZ,Goomer RS,Gelberman RH,Winters SC,Silva MJ,Amiel D

更新日期：1998-01-01 00:00:00

abstract：:Of more than 2 million segmental bone defects repaired annually with bone autografts and allografts, 15-40% fail. Improving healing rates may be approached with tissue engineering and use of periosteum overlying an allograft. The present study documents gene expression in human periosteum-allograft constructs compared...

journal_title：Connective tissue research

authors： Kemppainen J,Yu Q,Alexander J,Jacquet R,Scharschmidt T,Landis W

更新日期：2014-08-01 00:00:00

abstract：:The matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are often coordinately expressed, and their promoters contain similar regulatory elements, including an AP-1 site at about -70. There are, however, additional sequences including an adjacent ETS site at about -90 in both promoters, and a NIP (nu...

journal_title：Connective tissue research

authors： White LA,Maute C,Brinckerhoff CE

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Excessive apoptosis plays an important role in the progression of intervertebral disc degeneration. However, the effect of autophagy, another type of programmed cell death, on the pathogenesis of disc degeneration is still unclear. Macroautophagy and chaperone-mediated autophagy (CMA) change and intervertebra...

journal_title：Connective tissue research

authors： Ye W,Xu K,Huang D,Liang A,Peng Y,Zhu W,Li C

更新日期：2011-01-01 00:00:00

abstract：:Epithelial-mesenchymal interactions are required for tissue growth and gene expression patterns during odontogenesis. We showed previously that Sonic hedgehog (SHH) is detectable in both dental epithelium and mesenchyme, while Shh transcripts are present in dental epithelium only, suggesting that SHH functions as an a...

journal_title：Connective tissue research

authors： Wu C,Shimo T,Liu M,Pacifici M,Koyama E

更新日期：2003-01-01 00:00:00

abstract：AIM:miR-155 is a pro-inflammatory or anti-inflammatory factor depending on the cell type in which it is expressed. miR-155 controls apoptosis and matrix degradation in nucleus pulposus (NP) cells in vitro. The aim of this study is to explore the effect of miR-155 in vivo and further investigate the mechanism of miR-155...

journal_title：Connective tissue research

authors： Zhou J,Liang A,Hong J,Sun J,Lin X,Peng Y,Wang X,Sun S,Xiao D,Xu K,Ye W

更新日期：2019-03-01 00:00:00

abstract：:The composition of glycosaminoglycans (GAGs) was analyzed in skin samples of eight patients suffering from localized scleroderma, i.e., three having generalized morphoea and five localized morphoea plaques. From each patients, biopsies were obtained from sclerotic and perilesional areas, and from clinically uninvolved...

journal_title：Connective tissue research

authors： Møller R,Serup J,Ammitzbøll T

更新日期：1985-01-01 00:00:00

abstract：:Genetic diseases affecting tooth structure have been classified by the tissue affected enamel versus dentin, and their pattern of inheritance autosomal dominant, autosomal recessive, or X-linked. Advances in molecular genetics and the Human Genome Project have provided substantial progress regarding the identification...

journal_title：Connective tissue research

authors： MacDougall M

更新日期：2003-01-01 00:00:00

abstract：:Syndecan-4 is emerging as an important player in cell interaction with the extracellular environment and has been shown to be involved in the progression of intervertebral disc degeneration. However, the mechanism of syndecan-4 regulation by TNF-α and the role of TGF-β1 in regulating syndecan-4 expression remain poorl...

journal_title：Connective tissue research

authors： Yang H,Liu H,Li X,Pan H,Li Z,Wang J,Zheng Z

更新日期：2015-01-01 00:00:00

abstract：:To extend previous studies on the apparent acceleration of collagen aging in diabetes mellitus, dura collagen from human adults of different ages, with and without diabetes, was processed to yield soluble and insoluble fractions. Insoluble fractions were cleaved by cyanogen bromide. Release of peptides from insoluble ...

journal_title：Connective tissue research

authors： Kohn RR

更新日期：1983-01-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are two extracellular bone matrix proteins that have the ability to modulate the growth of hydroxyapatite in vitro. Studies of BSP/OPN hydroxyapatite interactions in the past have been directed toward the identification of essential structural elements that allow these two...

journal_title：Connective tissue research

authors： Stubbs JT 3rd

更新日期：1996-01-01 00:00:00

abstract：:Large joint arthrofibrosis and scarring, involving the shoulder, elbow, hip, and knee, can result in the loss of function and immobility. The pathway of joint contracture formation is still being elucidated and is due to aberrations in collagen synthesis and misorientation of collagen fibrils. Novel antibodies are bei...

journal_title：Connective tissue research

authors： Chen AF,Lee YS,Seidl AJ,Abboud JA

更新日期：2019-01-01 00:00:00

abstract：:To study the glycosylation of glomerular basement membrane collagen (GBMC) in diabetes, kidneys were obtained at autopsy from 5 patients with insulin-requiring diabetes of long duration and diabetic complications, and from 5 control subjects. Glomeruli were prepared by sieving and collagen was isolated by limited peps...

journal_title：Connective tissue research

authors： Uitto J,Perejda AJ,Grant GA,Rowold EA,Kilo C,Williamson JR

更新日期：1982-01-01 00:00:00

abstract：:Solutions of type I acid soluble collagen were studied in light and electron microscopy at concentrations over 40 mg/ml. Banded patterns spontaneously emerge in samples observed between crossed polars between slide and coverslip. The textures are interpreted as precholesteric, appearing at the transition between the i...

journal_title：Connective tissue research

authors： Giraud-Guille MM,Besseau L

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to examine the hypoxic and inflammatory conditions after immobilization in the joint capsule of rat knees. The unilateral knee joints of adult male rats were immobilized with an internal fixator (Im group) for 1 day, 3 days, and 1, 2, 4, 8, and 16 weeks. Sham-operated animals had holes dr...

journal_title：Connective tissue research

authors： Yabe Y,Hagiwara Y,Suda H,Ando A,Onoda Y,Tsuchiya M,Hatori K,Itoi E

更新日期：2013-01-01 00:00:00